个人简历

刘长青，生物科学系副主任，教授，博士，硕士生导师，主要研究方向为干细胞诱导分化与移植治疗。2017年-2018年在美国康涅狄格大学健康中心（UCONN）Xinming Ma教授实验室从事访问学者研究工作，利用人体诱导性的多能干细胞（iPSCs）研究人的精神分裂症(schizophrenia)发生的分子机制；2014年1月-5月在美国Bridgeport大学访问学者，从事干细胞功能基因组、干细胞诱导分化与组织修复研究。2008年-2017年在蚌埠医学院，从事小分子化合物诱导多能干细胞（神经前体细胞），移植治疗帕金森动物模型(大鼠/小型猪)的分子机制研究。2008年6月在中国海洋大学与中国农业科学院联合培养获理学博士学位，主要进行胚胎干细胞、骨髓间充质干细胞、神经干细胞培养与移植治疗等研究工作，相关成果被评为2006年国内十大科技新闻。近5年来主持承担或完成国家自然科学基金项目2项，安徽省自然科学基金项目1项，安徽省教育厅优秀青年人才基金重点项目1项，安徽省教育厅高校领军人才引进与培育计划项目1项，国家科技基础条件平台建设项目子课题1项，在《Journal of Pineal Research》、《Int. J. Biol.Sci》、《Int. J. Mol. Sci》、《BioMed Research International》、《Gene》、《Cryobiology》、《Cell Biology International》等期刊发表SCI论文26篇，其中第一作者或通讯作者发表19篇，获中国农业科学院科技成果一等奖1项，制定国家标准1项，国家第八届安徽省自然科学优秀学术论文评选二等奖、三等奖各1项，获安徽省教学成果二等奖1项，蚌埠医学院教学成果一等奖1项，参与出版学术论著1部，实验教材3部。

研究领域

干细胞诱导分化与移植治疗

近期论文

1. Wang, C., Liao, Y., Wang, S., Wang, D., Wu, N., Xu, Q., &Liu, C. (2018). Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage via activation of the Nrf2-ARE signaling pathway. Molecular Medicine Reports, 17(5), 7331-7338.
2. Ma C*, Liu C*, Li X, Lu T, Bai C, Fan Y, Guan W, Guo Y. (2017) Cryopreservation andmultipotential characteristics evaluation of a novel type of mesenchymal stemcells derived from Small Tailed Han Sheep fetal lung tissue. Cryobiology. 75: 7-14.(SCI, IF:1.992，Co-first author)
3. Liu Changqing,BaiChunyu, Guo Y, Liu D, Guan WJ. (2014) Construction and Preliminary Characterization Analysis of Siberian tiger Bacterial Artificial Chromosome Library with approximately 6.5-fold genome equivalent coverage. International Journal of Molecular Sciences,15: 4189-4200.(SCI, IF: 3.257)
4. Guo Yu*,Changqing Liu*,ChunyuBai, Yuehui Ma, Weijun Guan. (2014)Generation and Analysis of a Large-Scale Expressed Sequence Tags from a Full-Length Enriched cDNA Library of Siberian Tiger (Pantheratigrisaltaica). GENE, 541：75-81.（SCI, IF:2.186，Co-first author）
5. Changqing Liu*,Guo Y, Li XC, Ma YH, Guan WJ. (2014) Establishment and genetic characteristics analysis of in vitro culture a fibroblast cell line derived from Wuzhishan miniature pig. Cryobiology, 68:281-287. (SCI, IF:2.137)
6. Liu Changqing, Liu D, Guo Y, Lu T, Li X, Zhang M, Ma J, Ma Y, Guan W. (2013)Construction of a Full-Length Enriched cDNA Library and Preliminary Analysis of Expressed Sequence Tags from Bengal Tiger Pantheratigristigris. International Journal of Molecular Sciences, 4(6):11072-11083.(SCI, IF: 3.257)
7. Liu Changqing*,Guo Y, Lu T, Wu H, Na R, Li X, Guan W, Ma Y. (2013) Construction andpreliminary characterization analysis of wuzhishan miniature pig bacterialartificial chromosome library with approximately 8-fold genome equivalentcoverage. Biomed Res Int, 2013:587493. (SCI, IF: 2.880)
8. Chang-Qing Liu, Tao-Feng Lu, Dan Liu, Wei-Jun Guan, Yue-Hui Ma. (2010) Construction of cDNA library and preliminary analysis of expressed sequence tags from Siberian tiger. International Journal of Biological Sciences, 6(6):584-589. (SCI, IF: 3.215)
9. Y. Guo, C.Q. Liu*, L.S. Xu, T.F. Lu, D. Liu, X.C. Li, J.Z. Ma,Y.H. Ma, W.J. Guan. (2015) Primary analysis of the expressed sequence tags from a full-length enriched cDNA library of Siberian tiger (Pantheratigrisaltaica). J. Anim. Plant Sci25(1): 139-145.（SCI, IF: 0.638，Co-first author）.
10. Liu C*,Yu Guo*, Ma YH, Guan WJ*. (2013) Study on Genetic Characteristics of in vitro culture and intracellular transduction of exogenous fluorescent proteins in fibroblast cell line of Angora goat. J. Anim. Plant Sci. 23(6):1507-1515.(SCI, IF: 0.638)
11. Chang-Qing LIU*, Yu GUO*, Wei-Jun Guan, Yue-Hui MA. (2011) Establishment and Characterization of a fibroblast cell line derived from Mongolian sheep. Animal Science Journal, 82, 82(2):215-222.(SCI, IF: 0.857)
12. Changqing Liu*, Yu Guo,Dan Liu, Weijun Guan, Yuehui Ma. (2010) Establishment and Characterization of fibroblast cell line derived from Siberian tiger (Pantheratigrisaltaica). Biopreservation and biobanking, 8(2):99-105. (SCI, IF: 1.026)
13. Changqing Liu*, W.J.Guan*, C.Y.Li, D. Liu, W.X.Zhang, Y.H.Ma. (2010) Establishment and cryopreservation of a fibroblast cell line derived from Bengal tiger (pantheratigristigris).CryoLetters31 (2):130-138.(SCI, IF: 1.074)
2、通讯作者论文
14. Xiangchen Li, Yu Guo, Yaxin Yao, JinlianHua, Yuehui Ma, Changqing Liu#, Weijun Guan. Reversine Increases the Plasticity of Long-Term Cryopreserved Fibroblasts to Multipotent Progenitor Cells through Activation of Oct4. Int J Biol Sci. 2016; 12(1): 53–62.(SCI, IF:4.509)
15. Caiyun Ma, Yu Guo, Hao Liu, Kunfu Wang, Jinjuan Yang, Xiangchen Li, Changqing Liu#and Weijun Guan#. Isolation and biological characterization of a novel type of pulmonary mesenchymal stem cells derived from Wuzhishan miniature pig embryo. Cell Biology International, 2016, 40: 1041–1049. (SCI, IF:1.909)
16. Yu Guo, Li-ShaXu, Ding Zhang, Ya-Ping Liao, Hai-ping Wang, Zhi-HuiLan, Wei-Jun Guan, Chang-Qing Liu#.(2015) Effect of Betaine on Morphology, Proliferation, and p53-induced Apoptosis of Hela Cervical Carcinoma Cell in vitro. Asian Pacific journal of cancer prevention, 16: 3195-3201. (SCI, IF:2.514)
17. Yu Guo*, Liao Yaping*, Zhang D, Guan WJ,Liu Changqing#. (2014) In vitro Study of Nucleostemin as a potential Therapeutic Target for Human Breast Carcinoma SKBR-3 Cells. Asian Pacific journal of cancer prevention, 15(5):2291-2295. (SCI, IF:2.514)
18. Y.P. Liao, D Zhang, W. Zhou, C.Q. Liu#. Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China. Genetics and Molecular Research, 2014,13(1): 1764-1773.(SCI,IF:0.994)
3、其他代表性论文
19. ChunyuBai, Xiangchen Li, YuhuaGao, Changqing Liu, Weijun Guan, Yuehui Ma. Melatonin improves reprogramming efficiency and proliferation of bovine-induced pluripotent stem cells. Journal of Pineal Research, 2016, 61(2):154-67 (SCI, IF:9.314，生物一区)
20. Liao Y, Wang L, Zhang D, Liu C. Identification of a balanced complex chromosomal rearrangement involving chromosomes 3, 18 and 21 with recurrent abortion: case report. MolCytogenet. 2014; 7:39. (SCI, IF:2.662)