个人简介

伍建林博士，男，现任澳门科技大学中药质量研究国家重点实验室副教授，博士生导师；兼任中国医药生物技术协会药物分析专业委员会常务委员、亚太医学生物免疫学会基础免疫分会常务委员、世界中医药学会联合会中医药免疫专业委员会常务理事、J Anal Testing和色谱杂志青年编委等学术职务。目前主要从事基于质谱的多组学整合分析方法研究消化道肿瘤、药物和食品化学等的分析新技术、新方法及应用。自2017年 – 至今，以第一和通讯作者 (含共同) 在Cell Res, Gastroenterology, Anal Chem, J Hazard Mater, Environ Int, Pediatr Allergy Immunol和Food Chem等Q1 Top，及合作在J Hepatol, Gut, Gastroenterology, Adv Sci, PNAS杂志上发表SCI文章70篇，授权国际发明专利5项。教育背景2009年 香港浸会大学化学系 分析化学专业 哲学博士 2004年 日本 Niigata大学工学部 工学硕士学位研究经验/工作经历2018.07 – 至 今 澳门科技大学，副教授，博士生导师 2011.11 – 2018.06 澳门科技大学，助理教授，博士生导师2010.04 – 2011.11 香港大学医学院病理系，博士后研究员2004.10 – 2005.10 香港浸会大学化学系，研究助理教学科目仪器分析、药物分析、药物分析实验、分析化学、分析化学实验、中药研究进 展、现代生物技术、药学基础化学实验。

研究领域

基於质谱的的多组学分析方法及其在消化道腫瘤、呼吸道疾病病理機制、藥物和食品分析領域的應用

近期论文

Q. Li, W. Hu, W.X. Liu, L.Y. Zhao, D. Huang, X. Liu, H. Chan, Y. Zhang, J. Zeng, O.O. Coker, W. Kang, S.S.M. Ng, L. Zhang, S.H. Wong, T. Gin, M.V. Chan*, J.L. Wu*, J. Yu*, W.K.K. Wu*. Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase. Gastroenterology 2021, 160, 1179-1193. (Q1 top, 4/92).K. Li#, J.L. Wu#, B.Qin, Z. Fan, Q. Tang, W. Lu, H. Zhang, F. Xing, M. Meng, S. Zou, W. Wei, H. Chen, J. Cai, H. Wang, H. Zhang, J. Cai, L. Fang, X. Bian, C. Chen, P. Lan, B. Ghesquière, L. Fang*, M.H. Lee*. ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer. Cell Res. 2020, 30, 163. (#These authors contributed equally to this work). (Q1 top, 8/195). Y. Ge, N. Li, Y. Fu, X. Yu, Y. Xiao, Z. Tang, J. Xiao, J.L. Wu*, Zhi-hong Jiang*. Deciphering superior quality of Pu-erh tea from thousands of years’ old trees based on chemical profile. Food Chem. 2021, 358, 129602. (Q1 top, 7/144).S. Chen, G. Huang, W. Liao, S. Gong, J.B. Xiao, J. Bai, W.L.W. Hsiao, N. Li*, J.L. Wu*. Discovery of the bioactive peptides secreted by Bifidobacterium using integrated MCX coupled with LC-MS and feature-based molecular networking. Food Chem. 2021, 347, 129008. (Q1 top, 7/144).Y. Zhuo, Y. Zhang, M. Li, H. Wu, S. Gong, X. Hu, Y. Fu, X. Shen, B. Sun, J.L. Wu*, N. Li*. Hepatotoxic Evaluation of Toosendanin via Biomarker Quantification and Pathway Mapping of Large-Scale Chemical Proteomics. Food Chem Toxicol. 2021, 153, 112257. (Q1 top, 9/93).Y. Luo, F. Gao, R. Chang, X. Zhang, J. Zhong, J. Wen*, J.L. Wu*, T. Zhou*. Metabolomics based comprehensive investigation of Gardeniae Fructus induced hepatotoxicity. Food Chem Toxicol. 2021, 153, 112250. (Q1 top, 9/93).P. Zheng, X. Bian, Y. Zhai, C. Li, C. Hao, H. Huang, W. Luo, Z. Huang, C. Liao, M. Xue, N. Li, M.Q. Guo, B. Sun*, J.L. Wu*. Metabolomics reveals a correlation between hydroxyeicosatetraenoic acids (HETEs) and allergic asthma: evidence from three years' immunotherapy. Pediatr Allergy Immunol. 2021, doi.org/10.1111/pai.13569. (Q1 top, 5/129).X. Hu, X. Bian, W.Y. Gu, B. Sun, X. Gao, J.L. Wu*, Na Li*. Stand out from matrix: Ultra-sensitive LC−MS/MS method for determination of histamine in complex biological samples using derivatization and solid phase extraction. Talanta 2021, 225, 122056. J. Li, Z Yue, Y. Zhang, N. Li, J.L. Wu*. Size exclusion-reverse liquid column chromatography -mass spectrometry and its application in the identification of post-translationally modified proteins in rat kidney. Se Pu 2021, 39, 87-95.M. Liu, N. Li*, Y. Zhang, Z. Zheng, Y. Zhuo, B. Sun, L.P. Bai, M. Zhang, M.Q. Guo, J.L. Wu*. Characterization of Covalent Protein Modification by Triclosan in vivo and in vitro via Three-Dimensional Liquid Chromatography-Mass Spectrometry: New Insight into Its Adverse Effects. Environ Int. 2020, 136, 105423. (Q1 top, 14/274).M.Z. Zhu, N. Li, F. Zhou, J. Ouyang, D.M. Lu, W. Xu, J. Li, H.Y. Lin, Z. Zhang, J.B. Xiao, K.B. Wang, J.A. Huang, Z.H. Liu*, J.L. Wu*. Microbial bioconversion of the chemical components in dark tea. Food Chem. 2020, 312, 126043. (Q1 top, 7/144).X. Bian, Y. Qian, B. Tan, K. Li, X. Hong, C.C. Wong, L. Fu, J. Zhang, N. Li*, J.L. Wu*. In-depth Mapping Carboxylic Acid Metabolome Reveals the Potential Biomarkers in Colorectal Cancer through Characteristic Fragment Ions and Metabolic Flux. Anal Chim Acta 2020, 1128, 62-71. L. Li#, J.L. Wu#, X. Bian, G. Wu, P. Zheng, M. Xue, B. Sun. Analysis of serum polyunsaturated fatty acid metabolites in allergic bronchopulmonary aspergillosis. Respir Res. 2020, 21, 205. (#These authors contributed equally to this work).M. Xue, P. Zheng, X. Bian, Z. Huang, H. Huang, Y. Zeng, H. Hu, Xiaoqing Liu, L. Zhou , B. Sun*, J.L. Wu*, N. Zhong*. Exploration and correlation analysis of changes in Krebs von den Lungen-6 levels in COVID-19 patients with different types in China. Biosci Trends. 2020, 14, 290-6.J.L. Wu, F. Ji, H. Zhang, C. Hu, M.H. Wong, D. Hu, Z. Cai*. Formation of dioxins from triclosan with active chlorine: A potential risk assessment. J Hazard Mater. 2019, 367,128-136. (Q1 top, 10/274).M. Zhao*, X. Su, B. Nian, L. Chen, D. Zhang, S. Duan, L. Wang, X. Shi, B. Jiang, W. Jiang, C. Lv, D. Wang, Y. Shi, Y. Xiao, J.L. Wu*, Y. Pan*, Y. Ma*. Integrated meta-omics approaches to understand the microbiome of spontaneous fermentation of traditional Chinese pu-erh tea. mSystems 2019, 4, e00680-19. M. Zhang, Y. Pan, D. Tang, R.G. Dorfman, L. Xu, Q. Zhou, L. Zhou, Y. Wang, Y. Li, Y. Yin, B. Kong, H. Friess, S. Zhao, J.L. Wu*, L. Wang*, X. Zou*. Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis. Cell Commun Signal. 2019, 17, 23. L. Xu, L. Wang, L. Zhou, R.G. Dorfman, Y. Pan, D. Tang, Y. Wang, Y. Yin, C. Jiang, X.Zou, J.L. Wu*, M. Zhang*. The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming. Neoplasia 2019, 21, 429-441. Y. Ge, X. Bian, B. Sun, M. Zhao, Y. Ma, Y.P. Tang, N. Li*, J.L. Wu*. Dynamic profiling of phenolic acids during Pu-erh tea fermentation using derivatization LC-MS approach. J Agric Food Chem. 2019, 67, 4568-4577. (Q1 top, 5/58).X. Yan, Y. Zhuo, X. Bian, J. Li, Y. Zhang, L. Ma, G. Lu, M.Q. Guo, J.L. Wu*, N. Li*. Integrated Proteomics, Biological Functional Assessments, and Metabolomics Reveal Toosendanin-Induced Hepatic Energy Metabolic Disorders. Chem Res Toxicol. 2019, 32, 668-680. C. Luo, X. Bian, Q. Zhang, Z. Xia, B. Liu, Q. Chen, C. Ke, J.L. Wu*, Y. Zhao* Shengui Sansheng San Ameliorates Cerebral Energy Deficiency Via Citrate Cycle after Ischemic Stroke. Front Pharmacol. 2019, 10, 386. Y. Zhang, X. Bian, J. Yang, H. Wu*, J.L. Wu*, N. Li*. Metabolomics of Clinical Poisoning by Aconitum Alkaloids using derivatization LC-MS. Front Pharmacol. 2019 10, 275. C.X. Cai, X. Bian, X.Q. Liu, J.X. Wang, H.S. Hu, S.G. Zheng, B.Q. Sun*, J.L. Wu*. Eicosanoids metabolized through LOX distinguish Asthma-COPD Overlap from COPD by metabolomics study. Int J Chron Obstruct Pulmon Dis. 2019, 14, 1769-78. X. Bian, N. Li*, B. Tan, B. Sun, M. Q. Guo, G. Huang, L. Fu, W.L.W. Hsiao, L. Liu*, J.L. Wu*. Polarity-tuning Derivatization-LC-MS Approach for Probing Global Carboxyl-containing Metabolites in Colorectal Cancer. Anal Chem. 2018, 90, 11210-5. (Q1 top, 8/83).W.Y. Gu, M.X. Liu, B.Q Sun*, M.Q. Guo, J.L. Wu*, N. Li*. Profiling of polyunsaturated fatty acids using off-line and on-line solid phase extraction-nano-liquid chromatography-quadrupole-time-of-flight mass spectrometry in human serum. J Chromatogr A 2018, 1537, 141-6. Y. Zhuo#, J.L. Wu#, X. Yan, M.Q. Guo, N. Liu, H. Zhou, L. Liu, N. Li. Strategy for Hepatotoxicity Prediction Induced by Drug Reactive Metabolites Using Human Liver Microsome and Online 2D-Nano-LC-MS Analysis. Anal Chem. 2017, 89, 13167-75. (#These authors contributed equally to this work). (Q1 top, 8/83).X. Bian, B. Sun, P. Zheng, N. Li*, J.L. Wu*. Derivatization enhanced separation and sensitivity of long chain-free fatty acids: application to asthma using targeted and non-targeted liquid chromatography-mass spectrometry approach. Anal Chim Acta 2017, 989, 59-70. M.Z. Zhu, Na Li, Y.T. Wang, N. Liu, M.Q. Guo, H. Zhou, L. Liu* J.L. Wu*. Acid/Salt/pH Gradient Improved Resolution and Sensitivity in Proteomics Study Using 2D SCX-RP LC-MS. J Proteome Res. 2017, 16, 3470-5. M. Zhu, N. Li, M. Zhao, W Yu, J.L. Wu*. Metabolomic profiling delineate taste qualities of tea leaf pubescence. Food Res Int. 2017, 94, 36-44. (Q1 top, 9/144).Y. He, W. Liu, L. Chen, G. Lin, Q. Xiao, C. Gao, J.L. Wu*, Z. Lin*. Facile synthesis of Ti4+ -immobilized affinity silica nanoparticles for the highly selective enrichment of intact phosphoproteins. J Sep Sci. 2017, 40, 1516-23.J. Huang, D. Liu, Y. Wang, L. Liu, J. Li, J. Yuan, Z. Jiang, Z. Jiang, W.W. Hsiao, H. Liu, I. Khan, Y. Xie, J.L. Wu, Y. Xie, Y. Zhang, Y. Fu, J. Liao, W. Wang, H. Lai, A. Shi, J. Cai, L. Luo, R. Li, X. Yao, X. Fan, Q. Wu, Z. Liu, P. Yan, J. Lu, M. Yang, L. Wang, Y. Cao, H. Wei, E.L. Leung. Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy. Gut 2021, doi: 10.1136/gutjnl-2020-321031. (Q1 top, 3/92).S. Fakhri, M. Tomas, E. Capanoglu, Y. Hussain, F. Abbaszadeh, B. Lu, X. Hu, J.L. Wu, L. Zou, A. Smeriglio, J. Simal-Gandara, H. Cao, J. Xiao, H. Khan. Antioxidant and anticancer potentials of edible flowers: where do we stand? Crit Rev Food Sci Nutr. 2021, doi: 10.1080/10408398.2021.1931022. (Q1 top, 4/144).W. Liao, I. Khan, G. Huang, S. Chen, L. Liu, W.K. Leong, X.A. Li, J.L. Wu, W.L.W. Hsiao*. Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum. Gut Microbes 2021, 13, 1847629. (Q1 top, 11/137).C. C. Wong , J. Xu, X. Bian, J.L. Wu, W. Kang, Y. Qian, W. Li, H. Chen, H. Gou, D. Liu , S. T. Y. Luk, Q. Zhou, F. Ji, L.S. Chan, S. Shirasawa , J.J. Sung, J. Yu. In Colorectal Cancer Cells with Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance. Gastroenterology 2020, 159, 2163. (Q1 top, 4/92).R. Zhao, O.O. Coker, J.L. Wu, Y. Zhou, L. Zhao, G. Nakatsu, X. Bian, H. Wei, A.W. Chan, J.J. Sung, F.K. Chan, E. El-Omar, J. Yu. Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce Its Bioavailability and Chemopreventive Effects. Gastroenterology 2020, 159, 969. (Q1 top, 4/92).H.H. Choi, S. Zou, J.L. Wu, H. Wang, L. Phan, K. Li, P. Zhang, D. Chen, Q. Liu, B. Qin, TAT Nguyen, S.J. Yeung, L. Fang, M.H. Lee. EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis. Adv Sci. 2020, 7, 2000681. (Q1 top, 13/137).W. Xu, X. Zhang, J.L. Wu, L. Fu, D. Liu, N. Wong, J. Yu. O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress. J Hepatol. 2017, 67, 310-20. (Q1 top, 2/92).L. Fu, Y.R. Qin, X.Y. Ming, X. Zuo, Y.W. Diao, L.Y. Zhang, J. Ai, B.L. Liu, T.X. Huang, T.T. Cao, B.B. Tan, D. Xiang, C.M. Zeng, J. Gong, Q.C. Zhang, S.S. Dong, J. Chen, H. Liu, J.L. Wu, R.Z. Qi, D. Xie, L.D. Wang, X.Y. Guan. RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer. PNAS 2017, 114, E4631-40.