个人简介

王静蓉博士, 2007 年获得香港浸会大学博士学位。其博士论文集中于对中药毛冬青 的化学和药理研究, 研究成果申请了两项美国专利幷获得授权。攻读博士期间作为访问学 者赴美国休斯顿大学进行药物的吸收与转运研究。2008 年至 2010 年期间在香港浸会大 学中医药学院进行博士后研究工作, 后为香港浸会大学中医药学院助理研究教授。2011 年 9 月加入澳门科技大学中药质量研究国家重点实验室及澳门药物与健康应用研究院，任助 理教授。2013年 7月被委任爲澳门药物及健康应用研究院助理院长。 王静蓉博士多年来专注于中药，特别是人参等中药材的化学、分析与质量控制方法以 及体内代谢产物等研究工作，在国内外期刊上发表 SCI 论文 30 多篇；作爲编委及副主编 参加了两本植物化学专著的编写。王静蓉博士近年来更专注于天然産物中具有抗癌活性成 分的研究，以及 LC-MS 分析技术在脂组学和糖组学中的应用。她集中于以多元分析技术 建立创新的鞘脂组和 N-糖链分析平台，研究成果发表在 Analytical Chemistry, Scientific Reports 以及 Molecular BioSystems 等期刊上。王博士目前集中于以上述分析平台进行 中药的相关研究。其研究已获得澳门科技发展基金和国家自然科学基金的资助。 教学科目: 中药药代动力学；中药化学选论；中药学研究进展； 中药化学 学历2008.11 香港浸会大学哲学博士学位 1997.6 中国药科大学理学硕士学位 1994. 7 中国药科大学工学士学位 教学经历 2011.9 - 现在 澳门科技大学 助理教授2011.1 - 2011.8 香港浸会大学中医药学院 研究助理教授 2008.1 - 2011.1 香港浸会大学中医药学院 博士后研究人员2006.12 - 2007.6 美国休斯敦大学 药学院 访问学者 2003.6 - 2004.6 香港浸会大学中医药学院 研究助理 1997.7 - 2004.4 中国药科大学 助理研究员/讲师

研究领域

天然产物化学；代谢组学；中药的化学分析及代谢研究

近期论文

1)Wang, J. R.; Guan, W. D.; Yau, L. F.; Gao, W. N.; Zhan, Y. Q.; Liu, L.; Yang, Z. F.; Jiang , Z. H., Glycomic signatures on serum IgGs for Prediction of Postvacccination Response. Sci Rep 2014, in press 2)Wang, J. R.; Zhang, H.; Yau, L. F.; Mi, J. N.; Lee, S.; Lee, K. C.; Hu, P.; Liu, L.; Jiang, Z. H., Improved sphingolipidomic approach based on ultra-high performance liquid chromatography and multiple mass spectrometries with application to cellular neurotoxicity. Anal Chem 2014, 86 (12), 5688-96. 3) Wang, J. R.; Yau, L. F.; Zhang, R.; Xia, Y.; Ma, J.; Ho, H. M.; Hu, P.; Hu, M.; Liu, L.; Jiang, Z. H., Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells. J Agric Food Chem 2014, 62 (12), 2558-73. 4) Wang, J. R.; Yau, L. F.; Gao, W. N.; Liu, Y.; Yick, P. W.; Liu, L.; Jiang, Z. H., Quantitative comparison and metabolite profiling of saponins in different parts of the root of Panax notoginseng. J Agric Food Chem 2014, 62 (36), 9024-34.5) Xie, H.; Wang, J. R.; Yau, L. F.; Liu, Y.; Liu, L.; Han, Q. B.; Zhao, Z.; Jiang, Z. H., Quantitative analysis of the flavonoid glycosides and terpene trilactones in the extract of Ginkgo biloba and evaluation of their inhibitory activity towards fibril formation of betaamyloid peptide. Molecules 2014, 19 (4), 4466-78. 6) Xie, H.; Wang, J. R.; Yau, L. F.; Liu, Y.; Liu, L.; Han, Q. B.; Zhao, Z.; Jiang, Z. H., Catechins and procyanidins of Ginkgo biloba show potent activities towards the inhibition of beta-amyloid peptide aggregation and destabilization of preformed fibrils. Molecules 2014, 19 (4), 5119-34. 7) Liang, X.; Wang, J. R.; Wong, K. W.; Hsiao, W. L.; Zhou, H.; Jiang, Z. H.; Kam, K. T.; Liu, L., Optimization of 2-dimensional gel electrophoresis for proteomic studies of solid tumor tissue samples. Mol Med Rep 2014, 9 (2), 626-32. 8) Law, B. Y.; Chan, W. K.; Xu, S. W.; Wang, J. R.; Bai, L. P.; Liu, L.; Wong, V. K., Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosisdefective cells. Sci Rep 2014, 4, 5510. 9) Kam, K. T.; Liang, X.; Wang, J. R.; Wong, K. W.; Hsiao, W. L.; Zhou, H.; Jiang, Z. H.; Liu, L., Evaluation on the effect of different in-gel peptide isoelectric focusing parameters in global proteomic profiling. Anal Biochem 2013, 443 (1), 27-33. 10) Kwok, H. H.; Guo, G. L.; Lau, J. K.; Cheng, Y. K.; Wang, J.-R.; Jiang, Z.-H.; Keung, M. H.; Mak, N. K.; Yue, P. Y.; Wong, R. N., Stereoisomers ginsenosides-20(S)-Rg₃ and 20(R)-Rg₃ differentially induce angiogenesis through peroxisome proliferator-activated receptor-gamma. Biochem Pharmacol 2012, 83 (7) , 893 - 902. 11) Zhang, H.; Yang, H.; Zhang, M.; Wang, Y.; Wang, J. R.; Yau, L.; Jiang, Z.; Hu, P., Identification of flavonol and triterpene glycosides in Luo-Han-Guo extract using ultrahigh performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Food Compos Anal 2012, 25 (2), 142-148.12) Zhang, H.†; Wang, J. R.†; Yau, L. F.; Ho, H. M.; Chan, C. L.; Hu, P.; Liu, L.; Jiang, Z. H., A cellular lipidomic study on the Abeta-induced neurotoxicity and neuroprotective effects of EGCG by using UPLC/MS-based glycerolipids profiling and multivariate analysis. Mol Biosyst 2012, 8 (12), 3208-15. (†: contribute equally) 13) Yang, Z.; Wang, J. R.; Niu, T.; Gao, S.; Yin, T.; You, M.; Jiang, Z. H.; Hu, M., Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora. Drug Metab Dispos 2012, 40 (8), 1538-44. 14) Wang, J. R.; Zhou, H.; Yi, X. Q.; Jiang, Z. H.; Liu, L., Total ginsenosides of Radix Ginseng modulates tricarboxylic acid cycle protein expression to enhance cardiac energy metabolism in ischemic rat heart tissues. Molecules 2012, 17 (11), 12746-57.15) Wang, J. R.; Tanaka, T.; Zhang, H.; Kouno, I.; Jiang, Z. H., Formation and conformation of baicalin-berberine and wogonoside-berberine complexes. Chem Pharm Bull (Tokyo) 2012, 60 (6), 706-11. 16) Saw, C. L.; Yang, A. Y.; Cheng, D. C.; Boyanapalli, S. S.; Su, Z. Y.; Khor, T. O.; Gao, S.; Wang, J. R.; Jiang, Z. H.; Kong, A. N., Pharmacodynamic of Ginsenosides: Antioxidant Activities, Activation of Nrf2, and Potential Synergistic Effects of Combinations. Chemical Research in Toxicology. Chem Res Toxicol 2012, 25(8):1574-80.17)Yang, Z.; Gao, S.; Wang, J. R. ; Yin, T.; Teng, Y.; Wu, B.; You, M.; Jiang, Z.; Hu, M., Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms. Drug Metab Dispos 2011, 39 (10), 1866-72. 18) Dong, H.; Bai, L. P.; Wong, V. K.; Zhou, H.; Wang, J. R.; Liu, Y.; Jiang, Z. H.; Liu, L., The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives. Molecules 2011, 16 (12), 10619-30.19) Yi, X. Q.; Li, T.; Wang, J. R.; Wong, V. K.; Luo, P.; Wong, I. Y.; Jiang, Z. H.; Liu, L.; Zhou, H., Total ginsenosides increase coronary perfusion flow in isolated rat hearts through activation of PI3K/Akt-eNOS signaling. Phytomedicine 2010, 17 (13), 1006-15. 20) Wong, V. K.; Cheung, S. S.; Li, T.; Jiang, Z. H.; Wang, J. R.; Dong, H.; Yi, X. Q.; Zhou, H.; Liu, L., Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-kappaB signaling. J Cell Biochem 2010, 111 (4), 899-910. 21) Wang, J. R.; Leung, C. Y.; Ho, H. M.; Chai, S.; Yau, L. F.; Zhao, Z. Z.; Jiang, Z. H., Quantitative comparison of ginsenosides and polyacetylenes in wild and cultivated American ginseng. Chem Biodivers 2010, 7 (4), 975-83. 22) Wang, S. W.; Kulkarni, K. H.; Tang, L.; Wang, J. R.; Yin, T.; Daidoji, T.; Yokota, H.; Hu, M., Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities. J Pharmacol Exp Ther 2009, 329 (3), 1023-31. 23) Wang, J. R.; Yamasaki, Y.; Tanaka, T.; Kouno, I.; Jiang, Z. H., Dammarane-type triterpene saponins from the flowers of Panax notoginseng. Molecules 2009, 14 (6), 2087-94. 24) Zeng, Z. D.; Liang, Y. Z.; Jiang, Z. H.; Chau, F. T.; Wang, J. R., Quantification of target components in complex mixtures using alternative moving window factor analysis and two-step iterative constraint method. Talanta 2008, 74 (5), 1568-78. 25) Wang, J. R.; Zhou, H.; Jiang, Z. H.; Wong, Y. F.; Liu, L., In vivo anti-inflammatory and analgesic activities of a purified saponin fraction derived from the root of Ilex pubescens. Biol Pharm Bull 2008, 31 (4), 643-50.26) Wang, J. R.; Zhou, H.; Jiang, Z. H.; Liu, L., Two new triterpene saponins from the antiinflammatory saponin fraction of Ilex pubescens root. Chem Biodivers 2008, 5 (7), 136976. 27) Ma, H. Y.; Kou, J. P.; Wang, J. R.; Yu, B. Y., Evaluation of the anti-inflammatory and analgesic activities of Liu-Shen-Wan and its individual fractions. J Ethnopharmacol 2007, 112 (1), 108-14. 28) Joseph, T. B.; Wang, S. W.; Liu, X.; Kulkarni, K. H.; Wang, J. R. ; Xu, H.; Hu, M., Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Mol Pharm 2007, 4 (6), 883-94.29) Du, J.; Tang, Y. Y.; Wang, J. R.; Jiang, Z., Improving feature extraction in fingerprint of medicinal herbs via wavelet transform and fractal technique. J Chemom 2007, 20 (1112), 476-483. 30) Jiang, Z. H.; Xie, Y.; Zhou, H.; Wang, J. R.; Liu, Z. Q.; Wong, Y. F.; Cai, X.; Xu, H. X.; Liu, L., Quantification of Aconitum alkaloids in aconite roots by a modified RP-HPLC method. Phytochem Anal 2005, 16 (6), 415-21.31) Jiang, Z. H.; Wang, J. R.; Li, M.; Liu, Z. Q.; Chau, K. Y.; Zhao, C.; Liu, L., Hemiterpene glucosides with anti-platelet aggregation activities from Ilex pubescens. J Nat Prod 2005, 68 (3), 397-9. 专著 1) 王静蓉 (副主编). 何兰，姜志宏主编：天然产物资源化学。科学出版社，北京， 2008 2) 王静蓉 (编委). 周荣汉 主编：植物化学分类学。上海科学技术出版社， 2005.