个人简介

朱依谆博士为澳门科技大学药学院首任院长， 讲座教授(Chair Professor), 澳门注 册西医师， 复旦大学兼职讲座教授。上海交通大学医学院 6 年制医学学士、 德国海 德堡大学医学院博士、曾任复旦大学药学院院长(全球招聘)近 10 年、教育部长江学者 特聘教授、国家杰出青年基金获得者、国家重大科学研究计划（973）首席科学家、国 家重大新药创制大平台负责人，国家精品课程《药理学》负责人、全国高等药学院校 国家规划教材《药理学》（第 7 和 8 版）主编、《药理学》（双语）主编、《中国临床用 药》主编、国家药典委员会委员、 国务院侨办科技创新委员会委员、上海市领军人物、 上海市优秀学科带头人、全国百名华侨华人杰出创新奖、上海市白玉兰荣誉奖获得者 和 2014 获评‘健康中国’10 大年度人物、2018 年获得澳门自然科学奖（二等奖， 一等 奖空缺）， 2018 年获中珠医疗生命科学科研特等奖（2018 年度仅 1 人）， 2017 年获四 川省科技进步一等奖，2018 年获教育部高等学校自然科学类一等奖。先后担任美国 Cardiovascular Regenerative Medicine 主编(Editor-in-chief), J Alzheimer Disease 副主编 (Associate Editor)和 Life Sci. 副主编(Associate Editor)，PLoS One 科学编辑(Academic editor) 及 Biosci. Reports 副主编(Associate Editor), CNS Neuroscience & Therapeutics, Journal of Pharmacology and Drug Metabolism, Frontiers in Neurotrauma 等数本国际 学术期刊编委。主要研究方向为心脑血管、炎症免疫保护机制和新药开发研究。目前, 兼任国际天然产物协会（ISDNP）主席， 中国高等医学教育学会药学教育研究会副理 事长等职。先后主持国家重点研发计划、国家重大新药创制、澳门重大研究计划等课题项目 16 项，总经费超过 1.8 亿元。益母草碱的原创性研究（以 1.5 亿人民币转让给 企业）作为 I 类新药获得 CFDA 2 项临床批文并开始临床 II 期研究， 2012 年 9 月份 美国 Sciences 杂志报导中国生物医药发展时评述朱教授为最成功的中国海归科学家之 一(2012 年 9 月 28 日出版第 1692 页) 。2017 年美国化学会的新闻期刊 C&EN 专题报 导朱教授在药物研发的成果经验并赞誉其为中国创新药物研究的先驱之一（2017 年 4 月 3 号 27-29）。 学历 1972 －1977 上海黄浦区凤阳路第一小学 1977 －1983 上海市光明中学 1983 －1989 上海交通大学医学院（原上海第二医科大学）医学系6 年制 医学本科/医学学士学位1989 －1990 上海中医药大学附属龙华医院/外科住院医生 1990 －1994 德国海德堡大学医学院内科博士生/医学博士学位 [1992 美国华盛顿大大学生化系（HHMI）访问交流学生] 1994 －1996 德国基尔大学医学院药理系/博士后 工作履历1996 －1997 德国基尔大学医学院药理系分子高血压课题研究组组长1998.1－1998.7 德国赫美罗制药公司（原Hoechst Marion Roussel 现Sanofil 赛诺非）, 科学研究部中国区经理（负责中国地区药品开发、 推广及应用）。1998.7－2015.12 新加坡国立大学/医学院药理系/李光耀科研奖研究员/副教 授/教授(兼职) 2005.9 至2016.02 复旦大学/药学院院长(2005.9-2014.12)/博导/长江特聘教授 2016.3 起澳门科技大学药学院首任院长/讲座教授 珠海澳科大科技研究院院长

研究领域

分子药理和中药有效成分的开发研究

近期论文

近年发表的主要SCI 期刊论文: (* Corresponding author) 1. Xiong Q., Wang Z., Yu Y., Wen Y., Suguro R., Mao Y., Zhu YZ*. Hydrogen sulfide stabilizes atherosclerotic plaques in apolipoprotein E knockout mice. Pharmacol. Res.2019, 144： 90-98 (IF: 5.574) 2. Qin M, Long F, Wu W, Yang D, Huang M, Xiao C, Chen X, Liu X, Zhu YZ*.Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.Free Radic Biol Med. 2019 Jun;137:99-109. doi: 10.1016/j.freeradbiomed.2019.04.025. (IF:5.736) 3. Wu W, Qin M, Jia W, Huang Z, Li Z, Yang D, Huang M, Xiao C, Long F, Mao J, Moore PK, Liu X, Zhu YZ*.Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3mediated autoimmune response in rheumatoid arthritis.Cell Mol Immunol. 2019 Aug;16(8):694-705. doi: 10.1038/s41423-018-0037-8. (IF: 5.897) 4. Yang D, Xiao C, Long F, Wu W, Huang M, Qu L, Liu X, Zhu Y*.Fra-1 plays a critical role in angiotensin II-induced vascular senescence.FASEB J. 2019 Jun;33(6):7603-7614. doi: 10.1096/fj.201801671RRRR. (IF: 5.498) 5. Guo W, Li D, You Y, Li W, Hu B, Zhang S, Miao L, Xian M, Zhu Y*, Shen X.Cystathionine γ-lyase deficiency aggravates obesity-related insulin resistance via FoxO1-dependent hepatic gluconeogenesis.FASEB J. 2019 Mar;33(3):4212-4224. doi: 10.1096/fj.201801894R. (IF: 5.498) 6. Wang ZJ, Chang LL, Wu Jian, Pan HM, Zhang QY, Wang MJ, Xin Xm, Lou SS, Chen JA, Gu XF, Guo W, YZ Zhu*. A novel rhynchophylline analog, Y396, inhibits endothelial dysfunction induced by oxidative stress through EGF receptor. Antioxid Redox Signal. In press DOI:10.1089/ars.2018.7721. (IF:5.828) 7. Qin, M, Long, F, Wu, WJ, Yang, D, Huang, MW, Xiao, CX, Chen, X, Liu, XH, Zhu YZ*. Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome. Free Radic Biol Med. 137:99-109. (IF: 7.576) 8. Zhu, YZ*; Wu, WJ; Zhu, Q ; Liu, XH. Discovery of Leonuri and therapeutical applications: From bench to bedside. Pharmacol. & Ther. 188 : 26-35. (IF: 9.36) 9. Wu D, Hu Q, Tan B, Rose P, Zhu D, Zhu YZ*. Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II. Redox Biol. 2018 Oct;19:250-262. doi: 10.1016/j.redox.2018.08.008. (IF: 7.216) 10. Suguro R, Chen S, Yang D, Yang Z, Miao L, Wu W, Zeng W, Liu X, Zhu YZ*. Antihypercholesterolemic Effects and a Good Safety Profile of SCM-198 in Animals: From ApoE Knockout Mice to Rhesus Monkeys. Front Pharmacol. 2018 Dec 13;9:1468. doi: 10.3389/fphar.2018.01468. eCollection 2018. 11. Wu WJ， Ji WW, Huang Z, Li ZZ, Yang D, Huang MW, Xiao CX, Long F, Mao JC, Moore PK, Liu XH and Zhu YZ*. Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis. Cell Mol Immunol. 2018 May 29. doi: 10.1038/s41423-018-0037-8. (IF:7.551) 12. Xiao-Ling Luo, Di Yang, Wei-Jun, Wu, Si-Yu Liu, Peng Xu, Wan-Wan Jia, Ming Qin, Betty Yuen-Kwan Law, Le-Feng Qu, Xin-Hua Liu, YZ Zhu*. Critical role of histone demethylase JMJD3 in the regulation of neointima formation following vascular injury. Cardiovasc Res. 2018 Dec 1;114(14):1894-1906. doi: 10.1093/cvr/cvy176. (IF:6.3) 13. Yang Di, Xiao ChenXi, Long Fen, Su ZhengHua, Jia WanWan, Qin Ming, Huang MengWei, Wu WeiJun, Suguro Rinkiko, Liu XinHua, Zhu YiZhun*.HDAC4 regulates vascular inflammation via activation of autophagy. Cardiovasc Res. 2018 Jun 1; 114(7):1016-1028. doi: 10.1093/cvr/cvy051. （IF: 6.3） 14. Jia W, Wu W, Yang D, Xiao C, Huang M, Long F, Su Z, Qin M, Liu X, Zhu YZ*. GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis. Cell Death Dis. 2018 May 2;9(5):503. doi: 10.1038/s41419-018-0570-5. （IF: 5.9） 15. Rose P, Moore PK, Zhu YZ. Garlic and Gaseous Mediators. Trends Pharmacol Sci. 2018 Jul;39(7):624-634．doi: 10.1016/j.tips.2018.03.009. [Epub ahead of print] Review. （IF: 12.7） 16. Jia W, Wu W, Yang D, Xiao C, Su Z, Huang Z, Li Z, Qin M, Huang M, Liu S, Long F, Liu X, Zhu YZ*. Histone demethylase JMJD3 regulates fibroblast-like synoviocytemediated proliferation and joint destruction in rheumatoid arthritis. FASEB J. 2018 Feb 26:fj201701483R. doi: 10.1096/fj.201701483R. [Epub ahead of print] （IF: 5.595） 17. Wu D, Hu Q, Xiong Y, Zhu D, Mao Y, Zhu YZ*. Novel H2S-NO hybrid molecule (ZYZ803) promoted synergistic effects against heart failure. Redox Biol. 2018 May;15:243-252. doi: 10.1016/j.redox.2017.11.020. Epub 2017 Dec 14. (IF: 7.216) 18. Wang Y, Zhang Q, Zhong L, Lin M, Luo X, Liu S, Xu P, Liu X, Zhu YZ*. Apoptotic Protease Activating Factor-1 Inhibitor Mitigates Myocardial Ischemia Injury via Disturbing Procaspase-9 Recruitment by Apaf-1. Oxid Med Cell Longev. 2017;2017:9747296. doi: 10.1155/2017/9747296. Epub 2017 Nov 27. （IF: 4.5） 19. Wang M, Tang W, Zhu YZ*. An Update on AMPK in Hydrogen Sulfide Pharmacology. Front Pharmacol. 2017 Nov 8; 8:810. doi: 10.3389/fphar.2017.00810. eCollection 2017. Review. （IF: 4.4） 20. Pan LL, Qin M, Liu XH, Zhu YZ*. The Role of Hydrogen Sulfide on Cardiovascular Homeostasis: An Overview with Update on Immunomodulation. Front Pharmacol. 2017 Sep 26;8:686. doi: 10.3389/fphar.2017.00686. eCollection2017. Review. （IF: 4.4） 21. Minjun Wang, Hong Xin, Wenbo Tang, Yiming Li, Zhaoyun Zhang, Linling Fan, LeiMiao, Bo Tan, Xiling Wang, and Zhu YZ*. cAMPK Serves as a Therapeutic Target Against Anemia of Inflammation. Antioxid Redox Signal. 2017 10;27(5):251-268. (IF: 7.1) 22. Rose P, Moore PK, Zhu YZ. H2S biosynthesis and catabolism: new insights from molecular studies. Cell Mol Life Sci. 2016 Nov 14. [Epub ahead of print] (IF: 5.7) 23. Wu WJ, Jia WW, Liu XH, Pan LL, Zhang QY, Yang D, Shen XY, Liu L, Zhu YZ*. Spropargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway. Redox Biol.2016 Dec;10:157-167. (IF:6.3) 24. Wu J, Lin SZ, Guo W, Kan JT, Wang ZJ, Chen SY, Mao YC, Zhu YZ*. Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide modulator, reduces doxorubicin-induced cardiotoxicity. Cell Death and Disease 2016 Aug 18;7(8):e2339.. (IF: 5.5) 25. Ying Wang, Yang Cao, Qing Zhu, Xianfeng Gu, Yi Zhun Zhu*. The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification. Sci Rep. 6, Article number: 29820 (2016). (IF: 5.3) 26. Hu Q, Wu D, Ma F, Yang S, Tan B, Xin H, Gu X, Chen X, Chen S, Mao Y, Zhu YZ*. Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule. Antioxid Redox Signal. 2016, 25(8); 498–514. (IF: 7.1) 27. Miao L, Xin X, Xin H, Shen X, Zhu YZ*. Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction. Sci Rep. 2016;6:22363. (IF: 5.3) 28. Lei Miao, Xiaoyan Shen, Matt Whiteman, Hong Xin, Yaqi Shen, Xiaoming Xin, PhilipK. Moore, Zhu YZ*. Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages. Antioxid Redox Signal. 2016, 25, 268–281. (IF: 7.1) 29. Liu XH, Zhang QY, Liu SY, Xu P, Luo XL, Zou SL, Xin H, Qu LF,Zhu YZ*. NADPH Oxidase 4 Contributes to Connective Tissue Growth Factor Expression through Smad3Dependent Signaling Pathway. Free Radic Biol Med.2016 May;94:174-84.(IF: 5.6) 30. Xin H, Wang M, Tang W, Shen Z, Miao L, Wu W, Li C, Wang X, Xin X, Zhu YZ*.Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation.Antioxid Redox Signal. 2016 Jan 10;24(2):70-83 (IF: 7.7) 31. Luo SS, Liu CH, Shen YQ, Ma LM, Gao H, Yang XH, Gu XF, Zhu YZ*. LeonurineSPRC conjugate ameliorates damage after Myocardial Infarction by reducing mitochondrial ROS via STAT3-MnSOD Pathway. Free Radic Biol Med. 2016 Mar;92:114. (IF: 5.6) 32. Shen YQ, Shen ZQ, Miao L, Xin XM，Lin SZ，Zhu YC, Guo W, Zhu YZ*. miRNA-30 family inhibition protects against cardiac ischemic injury by regulating cystathioninegama-lyase expression. Antioxid Redox Signal. 2015 Jan 20;22(3):224-40. (IF: 7.7) 33. Kan JT, Guo W, Huang CR, Zhu YZ*. S-Propargyl-Cysteine (SPRC) Promote Angiogenesis Through a Possible H2S/VEGFR2/STAT3-mediated Mechanism. Antioxid Redox Signal. 2014 May 20; 20(15): 2303-16 (IF: 7.7) 34. Tao BB, Liu SY, Zhang CC, Fu W, Cai WJ, Wang Y, Shen Q, Wang MJ, Chen Y, Zhang LJ, Zhu YZ, Zhu YC. VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells. Antioxid Redox Signal. 2013 Aug 10; 19(5): 448-64. (IF: 7.7) 35. Pan LL, Liu XH, Jia YL, Wu D, Xiong QH, Gong QH, Wang Y, Zhu YZ*.A novel compound derived from danshensu inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells. Biochim Biophys Acta. 2013; 1830(4): 286171. (IF 5.0) 36. Pan LL, Liu XH, Shen YQ, Wang NZ, Xu J, Xiong QH, Wu D, Deng HY, Huang GY, Zhu YZ*. Inhibition of NADPH oxidase 4-related signaling by hydrogen sulfide inhibits myocardial fibrotic response. Int. J Cardiol. 2013; 168(4): 3770-8. (IF 7.1) 37. Wang MW, Ye RD, Zhu YZ. Pharmacology in China: a brief overview. Trends Pharmacol Sci.2013 Oct;34(10):532-3. (IF: 11) 38. Liu XH, Pan LL, Deng HY, Xiong QH, Wu D, Huang GY, Gong QH, Zhu YZ*. Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NAPDH oxidase 4. Free Radic Biol Med.2013 Jan; 54:93-104. (IF 5.4)