个人简介
Dr. Wei Zhang obtained his PhD from China pharmaceutical university in 2008. He proceeded to his post-doctoral training at Department of pharmacology from Yale University School of Medicine during 2008-2012. In the YaleUniversity, his study focused on phytochemical and Pharmacokinetic studies of PHY906 (Chinese botanical formulation of Huang Qin Tang). He participated in the PHY906 phase I/II clinical trials in U.S. as a modulator of capecitabine and Irinotecan. He has published several well-recognized research articles including identification of PHY906 chemicals and their metabolites in patient plasma and determination of all ribonucleotides and Deoxyribonucleotides. He also joined the study of mechanism of phy906 and published research article in the journal of Science Translational Medicine as a co-author, which has been reported by the Nature News & Comment and Science Daily News. In August 2012, he moved to Macau Institute for Applied Research in Medicine and Health,Macau University of Science and Technology as an assistant professor. Education: July, 2000, B.Sc.ChinaPharmaceuticalUniversity July, 2008, Ph. D ChinaPharmaceuticalUniversity Professional Chronology: Aug, 2008-Dec, 2011 Post-Doctoral Associate, School of Medicine, YaleUniversity Jan, 2012-Aug, 2012 Associate Research Scientists, School of Medicine, YaleUniversity Aug, 2011-Aug, 2012, Manager of core lab of YaleCancerCenter, YaleUniversity Aug, 2012-Present Assistant Professor, Macau Institute for Applied Research inMedicine and Health, Macau University of Science and Technology Teaching Subjects: Instrumentanalysis
研究领域
Use of chemometricsmethods to deal with all steps of analytical procedures; Pharmaceutical Analysis (Chemical and Instrumental Analysis); Pharmacokinetic and metabolism study of chemical drugs and traditionalChinesemedicines (TCM); Phytochemical analysis and quality assessment of traditionalChinesemedicines (TCM)based modern instruments;
近期论文
1. Wei Zhang, Bingren Xiang, Yanwei Wu, Erxin Shang. Stochastic resonance is applied to quantitative analysis for weakchromatographic signal of glyburide in plasma.AnalyticaChimicaActa,2005, 550:77–81. 2. Wei Zhang, Bingren Xiang, Yanwei Wu, Erxin Shang. Stochastic resonance is applied to quantitative analysis for weak chromatographic signal of roxithromycin in beagle dog plasma. Journal of Chromatography B,2006, 831(1-2):307-12. 3. Wei Zhang, Xiang Bing-ren.A new single-well potential stochastic resonancealgorithm to detect the weak signal .Talanta,2006, 70: 267–271. 4. Wei Zhang, Bing-RenXiang,ADuffing oscillator algorithm to detect the weak chromatographic signal.AnalyticaChimicaActa,2007, 585:55–59. 5. Wei Zhang, Xiang Bing-ren and Wang Cai-yun, Liquid chromatography–mass spectrometry methodfor the determination of venlafaxine in humanplasma and application to a pharmacokinetic study.Biomedical Chromatography2007,21: 266–272. 6. Wei Zhang, Bing-ren Xiang, Peng -chengMa,Determination of oxymatrine in human plasma by LC-MS and study on its Pharmacokinetics.Journal of Chromatographic Science, 2008, 46(6): 529-533. 7. Wei Zhang, Xiang Bing-ren,zhanying,Yuliyan,WangTeng,Wangcai-yun,High-performance Liquid chromatography method for the determination of bezafibrate in human plasma and application to a pharmacokinetic study of bezafibrate dispersible tablet.Journal of Chromatographic Science, 2008,46(9):844-847. 8. Wei Zhang, Xiang Bing-ren, Zhang Jing,High-performance Liquid chromatography method for the determination of Mycophenolic acid in human plasma and application to a pharmacokinetic study of Mycophenolic acid dispersible tablet.ArzneimittelForschungDrug Research, 2008, 7: 348-352. 9. Wei Zhang,Dutschman GE, Li X, Ye M, Cheng YC, Quantitation of Irinotecan and its two major metabolites using a liquid chromatography-electrospray ionization tandem mass spectrometric.Journal of Chromatography B,2009, 877(27):3038-44. 10. Wei Zhang, Muhammad W. Saif, ginger E Dutschman, xin li, Wing Lam, Scott Bussom, Zaoli Jiang, Min ye, Edward Chu, and Yung-Chi Cheng, Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass Spectrometry (LC/MS/MS), Journal of Chromatography A,2010,1217(37):5785 11. Wei Zhang, Shenglan Tan, Elijah Paintsil, Ginger E. Dutschman, Elizabeth A. Gullen and Yung-Chi Cheng，Analysis of deoxyribonucleotide pools in human cancer cell lines using a liquid chromatography coupled with tandem mass spectrometry technique, Biochemical Pharmacology，2011 82(4): 411-417. 12. Wei Zhang,Ginger E. Dutschman, Xin Li, Yung-Chi Cheng, Quantitation of Paclitaxel and its two major metabolites using a liquid chromatography–electrospray ionization tandem mass spectrometric,Journal of Chromatography B, 2011 879(22):2018-22. 13. Wing Lam, Scott Bussom, Fulan Guan, Zaolijiang,Wei Zhang, Elizabeth A. Gullen, Shwu-Huey Liu, and Yung-Chi Cheng. The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity. Science Translational Medicine, Med 18 2010,2(45):45. 14. Caiyun Wang, Bingren Xiang, Wei Zhang.Application of two-dimensional near-infrared correlation spectroscopy (2D-NIR) to the discrimination of three species of Dendrobium. Journal of Chemometrics,2009, 23(9):463-70. 15. Caiyun Wang, Wei Zhang,Bingren Xiang, Liyan Yu, Pengcheng Ma. Liquid Chromatography-Mass Spectrometry Method for the Determination of Gliclazide in Human Plasma and Application to a Pharmacokinetic Study of Gliclazide Sustained Release Tablets. ArzneimittelForschung Drug Research, 2008,12: 653-658. 16. Jia Xia, Bingren Xiang, Wei Zhang, Determination of metacrate in water samples using dispersive liquid-liquid microextraction and HPLC with the aid of response surface methodology and experimental design. AnalyticaChimicaActa,2008, 625:28-34. 17. YeYe; Xiang Bingren;Wei Zhang; Shang Erxin，Stochastic resonance is applied to quantitative analysis for weak chromatographic signal of Sudan I.Physics Letters A,2006,359:620-623. 18. Ying Zhan; Bingren Xiang; Wei Zhang; ShaofeiXie; HaishanDeng;Suyun Xiang, Single-well Potential Stochastic Resonance Applied to Quantitative Analysis for Weak Chromatographic Signals of Sudan IV.Analytical Letters,Analytical Letters, 40:12, 2415 – 2424.
