个人简介

谢莹博士, 副教授， 2007年获香港浸会大学哲学博士学位，随后前往美 国马里兰大学医学院进行博士后研究工作。2009至 2012年间在美国北卡罗来 纳大学教堂山分校药学院任副研究员。2012年8 月，加入中药质量研究国家重 点实验室(澳门科技大学)，2016年兼任澳门科技大学葯学院课程主任。谢莹博 士目前主要从事在结合生物医学和化学分析研究前沿方法开发中药新药研究的 各个领域，具体包括：用新的组学技术进行疾病的病理以及药物治疗代谢综合 征疾病的药效和机制研究；中药对转运蛋白的影响；中药药代动力学及药理学 等。近年来，谢莹博士研究成果发表于 Pharmacological Research, Scientific Reports, Journal of Experimental Medicine, Talanta, Journal of Chromatography A 等世界著名杂志，迄今已发表 SCI收录论文 90多篇，主持多项澳门和国家研 究基金项目。她亦担任国际标准组织 ISO/TC249工作组委员，«药学进展»杂志 青年编委，多个国际期刊的特邀审稿人，并于 2010年获得 ElsevierB.V.评出的 最佳评审人奖（药理学）。2012年获得国家科技进步二等奖，李时珍药学发明 奖，2014年获得澳门科技进步特别奖，2017年获得中国药理学会优秀青年科 技工作者奖，2018年度澳门科学技术奖（自然科学奖）二等奖，2018年度中 国高校科研优秀成果奖（自然科学奖）一等奖，2019年中银学术研究奖，2020 年度澳门科学技术奖（科技进步奖）二等奖。学历 2007.11 香港浸会大学药学博士学位2001.7 中国药科大学理学硕士学位1998.7 中国药科大学理学学士学位 工作经验2017.07- 今 澳门科技大学 副教授 2016.07- 今 澳门科技大学葯学院 课程主任 2012.08- 2017.6 澳门科技大学 助理教授2009.09-2012.07 美国北卡罗莱纳州大学药学院 副研究员 2007.11-2009.09 美国马里兰大学药理学系 博士后教学科目：生物制剂；生物制剂与葯代动力学；药物分析；药物分析实验；分 析化学；分析化学实验；专题研究；中药葯代动力学；仪器分析；中药专题导 读；药学专题导读；专业英语。

研究领域

代谢与免疫研究；转运蛋白研究；药代动力学和药效及机制研究； 中药质量控制

近期论文

1) FengS-L,ZhouHF,WuDC,QuB,LiuRM,Li Z,XieY*,LuoH-B*.Nobiletinanditsderivatives overcomemultidrugresistance(MDR)incancer:totalsynthesisanddiscoveryofpotentMDRreversal agents,ActaPharmaceuticaSinicaB,2020Feb;10(2):327-343.2) Can-JianWang,FanHe,Yu-FengHuang,Hong-LiangMa,Ying-PingWang,Chun-SongCheng,JinLeCheng,Chi-ChouLao,Di-anChen,Zhi-FengZhang,ZhenSang,PeiLuo,Sheng-YuanXiao,Xie Y*,HuaZhou*.Discoveryofchemical markersforidentifyingspecies,growthmodeandproduction areaofAstragaliRadixbyusingultra-high-performanceliquidchromatographycoupledto triplequadrupolemassspectrometry,Phytomedicine,2020Feb;67:153155.3) FengS-L,TianY,HuoS,QuB,LiuRM,XuP,LiYZ,XieY*.Nobiletinpotentiatespaclitaxel anticancerefficacyinA549/Txenograftmodel:pharmacokineticandpharmacological study, Phytomedicine,2020Feb;67:153141.4) SuguroR,PangXC,YuanZW,ChenSY,ZhuYZ,XieY.*.Combinationalapplicatonofsilybinand tangeretinattenuatestheprogressionofnon-alcoholicsteatohepatitis(NASH)inmiceviamodulating lipidmetabolism,PharmacologicalResearch2019Nov6;151:104519.5) XieY*,ZhangDQ,ZhangJ,andYuanJL.Metabolism,TransportandDrug-DrugInteractionsof Silymarin.Molecules.2019Oct14;24(20).6) ZhangJ,WangZ,LiuH,CaiL,FengY,ZhouL,Wei H,XieY*,ChenY*.Invivoandinvitro evaluationof 177Lu-labeledDOTA-2-deoxy-D-glucoseinmice.Anovelradiopharmaceuticalagentfor cellsimagingandtherapy,HellenicJournalofNuclearMedicine2019May-Aug;22(2):103-110.7) LiYZ,XieY,HeY,HouWB, LiaoML,LiuCX*.QualityMarkersofTraditionalChineseMedicine: Concept,Progress,andPerspective, Engineering,2019,5(5):888-894.8) PanH-D,ZhengY-F,LiuZ-Q,YuanZ-W, ZhouH,RenR-T,XieY*,LiuL*.Decipheringthe pharmacologicalmechanismofGuan-Jie-Kangintreatingratadjuvant-inducedarthritisusingomics analysis,FrontiersofMedicine.Inpress20199) BiX-L,YuanZ-W,QuB,ZhouH,LiuZ-Q,XieY*,Piperineenhancesthebioavailabilityofsilybin viainhibitionofeffluxtransportersBCRPandMRP2,Phytomedicine.54:98-108,15February2019.10) Zhang X-J, Yuan Z-W, Qu C, Yu X-T, Huang T, Chen P-V, Su Z-R, Dou Y-X, Wu J-Z, Zeng H-F*, Xie Y* and Chen J-N*, Palmatine ameliorated murine colitis by suppressing tryptophan metabolism andregulatinggutmicrobiota,PharmacologyResearch.2018Nov;137:34-4611) Xu P, Zhou H, Li Y-Z, Yuan Z-W, Liu C-X, Liu L and Xie Y*. Baicalein enhances the oral bioavailability and hepatoprotective effects of Silybin through the inhibition of efflux transportersBCRPandMRP2.FrontierinPharmacology.9:1115.(2018)12) Feng S-L, Luo H-B, Cai L, Zhang J, Wang D, Chen Y-J, Zhan H-X, Jiang Z-H, Xie Y*, Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter: in vitro and in vivostudy,JournalofGinsengResearch.https://doi.org/10.1016/j.jgr.2018.10.00713) Yuan ZW, Li YZ, Liu ZQ, Feng SL, Zhou H, Liu CX, Liu L* and Xie Y. *. Role of tangeretin as a potential bioavailability enhancer for silybin: pharmacokinetic and pharmacological studies, PharmacologicalResearch.2017Sep27.pii:S1043-6618(17)30789-2.14) Qua C.†, Yuan Z.W.†, Yu X.T.†, Huang Y.F., Yang G.H., Chen J.N., Lai X.P., Sua Z.R., Zeng H.F.*, Xie Y.* , and Zhang X.J.*, Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitisandsuppressestryptophancatabolism, PharmacologicalResearch.2017(121):70-82.15) Tan B., Jin S,Sun JP, Gu ZK, SunXT, ZhuYC, HuoKK, Cao ZL, Yang P,Xin XM, Liu XH, Pan LL, Qiu FR, Jiang J, Jia YQ, Ye FY, Xie Y. *, and Zhu YZ*, New method for quantification of gasotransmitterhydrogensulfideinbiologicalmatricesbyLC-MS/MS,ScientificReports.2017:4627816) Xie Y., Miranda S., Hoskins J., and Hawke R. *, Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD, Molecules,2017,22(1),142.17) Wu J.†, Xie Y.†, Xiang Z., Wang C.J. Zhou H. *, Liu L.*, Simultaneous Determination of Multiple Components in Guanjiekang in Rat Plasma via the UPLC–MS/MS Method and Its Application in PharmacokineticStudy.Molecules2016,21(12),173218) FengSL,YuanZW,YaoXJ,MaWZ,LiuL,LiuZQ,XieY*.Tangeretin,acitruspentamethoxyflavone, antagonizesABCB1-mediatedmultidrugresistancebyinhibitingitstransportfunction.Pharmacological Research.2016；110:193-204. 19) Lin W, Huang J, Liao X, Yuan Z, Feng S, Xie Y*, Ma W*. Neo-tanshinlactone selectively inhibits the proliferation of estrogen receptor positive breast cancer cells through transcriptional down-regulation of estrogenreceptoralpha.PharmacologicalResearch.2016Aug1;111:849-858. 20) Ma W-Z, Feng S-L, Yao X-J, Yuan Z-W, Liu L, Xie Y*. Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells. Scientific Reports. 2015 Dec 22; 5:18789. 21) Yuan Z-W, Leung L-H, Fan X-X, Zhou H, Ma W-Z, Liu L*, Xie Y*. Quantitative evaluation of berberinesubcellulardistributionandcellularaccumulationinnon-smallcelllungcancercellsbyUPLC– MS/MS.Talanta.2015November,144:20–28. 22) Xie Y, Jiang Z-H, Zhou H, Ma W-Z, Wong Y-F, Liu Z-Q, Liu L*. The pharmacokinetic study of sinomenine, paeoniflorin and paeonol in rats after oral administration of an herbal product Qingfu GuanjiesucapsulebyHPLC.BiomedicalChromatography.2014Sep;28(9):1294-302 23) Xie Y, Akpinarli A, Maris C, Hipkiss E-L, Lane M, Kwon E-M, Antony P-A*. Naïve tumor-specific CD4+ T cells differentiated in vivo eradicate established melanoma in absence of vaccination. The JournalofExperimentalMedicine2010,207(3):651. 24) Xie Y, Todd N-W, Liu Z, Zhan M, Fang H, Peng H, AlattarM, Deepak J, StassS-A, Jiang F*. Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer. Lung Cancer. 2010, 67(2): 170-176. 25) XieY, ZhouH, WongY-F,XuH-X,JiangZ-H,LiuL*. Studyonthepharmacokineticsandmetabolism of paeonol in rats treated with pure paeonol and an herbal preparation containing paeonol by using HPLC-DAD-MSmethod.JournalofPharmaceuticalandBiomedicalAnalysis.2008,46(4):748-756. 26) Xie Y, Zhou H, Wong YF, Liu Z, Xu H, Jiang Z, Liu L*. An optimized high-performance liquid chromatography (HPLC) method for benzoylmesaconine determination in RadixAconitiLateralisPreparata(Fuzi,aconiteroots)anditsproducts.ChineseMedicine.20083:6-13. 27)XieY,JiangZ-H,ZhouH,CaiX,WongYF,LiuZ-Q,BianZ-X,XuH-X,LiuL*.Combinativemethod using HPLC quantitative and qualitative analyses for quality consistency assessment of an herbal medicinalpreparation.JournalofPharmaceuticalandBiomedicalAnalysis.,2007,43(1):204-212. 28) XieY,JiangZ-H,ZhouH,XuH-XandLiuL*.SimultaneousdeterminationofsixAconitumalkaloidsin proprietaryChinesemedicinesbyhigh-performanceliquidchromatography,J.ChromatographyA,2005, 1093:195-203.