个人简介

Dr. Li obtained her Ph.D. degree from China Pharmaceutical University in 1999, and then worked as a post-doctoral research fellow in Institute of Materia Medica of Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC). In 2001, she was sponsored by Japan Society for the Promotion of Science to work as a post-doctoral research fellow in Niigata University, Japan. From 2003 to 2007, she engaged in the study of bioactive compounds in The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Her research in The Chinese University of Hong Kong during the period 2007 to 2011 mainly focused on the toxicity of natural products. She has rich experience in the research of natural product chemistry, and has published more than 30 research articles in number of international journals including Journal of Hepatology, PNAS, Molecular Pharmaceutics, Journal of Natural Products and etc. Education: July, 1994, B. Sc. (West China University of Medical Sciences, Chengdu, Sichuan Province, China ) July, 1999, Ph. D. (China Pharmaceutical University, Nanjing, Jiangsu Province, China) Professional Chronology: September, 1999 - October, 2001 Institute of Mataria Medica, CAMS & PUMC November, 2001 - November, 2003 Niigata University, Japan December, 2003 - October, 2007 The National Center for Drug Screening, Shanghai Institute of Materia Medica, CAS November, 2007 - August, 2011 The Chinese University of Hong Kong, Hong Kong September, 2011-present Assistant Professor, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology Teaching Subjects: Natural Product Chemistry

研究领域

Natural Product Chemistry, including the isolation, structural elucidation, and structural modification of natural products, and the qualification and quantification of bioactive natural products and metabolites.

近期论文

1) N. Li, Q. Xia, J.-Q. Ruan, et al. Hepatotoxicity and tumorigenicity induced by metabolic activation of pyrrolizidine alkaloids in herbs. Curr Drug Metab, (Epub ahead of print) 2) G. Lin,* J.-Y. Wang,* N. Li, et al. Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. J Hepatol, 54, 666-673, 2011. 3) B. Ma, H. Zha, N. Li, et al. Effect of structural modification of α-aminoxy peptides on their intestinal absorption and transport mechanism. Mol Pharmaceut, 8, 1073-1082, 2011. 4) Y. Zhou, N. Li, F.F.-K. Choi, et al. A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloidcontaining plants by using ultra performance liquid chromatography − tandem quadrupole mass spectrometry. Anal Chim Acta, 681, 33-40, 2010. 5) X. Zhou, P.H.-H. Leung, N. Li, et al. Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa. Planta Med, 75, 575-580, 2009. 6) G. Lin, S.-L. Li, M. Li, N. Li, et al. Qianliguang (Senecio scandens) safety dilemma: dose is the key? Planta Med, 75, 1107-1111, 2009. 7) G. Lin, Z. Zuo, N. Li, L. Zhang. Drug-Drug Interactions and Drug-Dietary Chemical Interactions, In Oral Bioavailability: Basic Principles, Advanced Concepts and Applications, Wiley Series in Drug Discovery and Development. John Wiley & Sons, Inc., Hoboken, USA, 2009. 8) N. Li,* J.-L. Wu, S. Xu, et al. Research progress on medicinal plants of Peperomia genus. Recent Progress in Medicinal Plants, 20, 419-431, 2008. 9) N. Li,* J.-L. Wu, T. Hasegawa, et al. Bioactive Polyketides from Peperomia duclouxii. J Nat Prod, 70, 998-1001, 2007. 10) N. Li,* J.-L. Wu, T. Hasegawa, et al. Bioactive Lignans from Peperomia duclouxii. J Nat Prod, 70, 544-548, 2007. 11) G.-L. Zhang, N. Li,* Y.-H. Wang, Y.-T. Zheng, Z. Zhang, and M.-W. Wang. Bioactive Lignans from Peperomia heyneana. J Nat Prod, 70, 662-664, 2007. 12) D.-S. Chen, J.-Y. Liao, N. Li, et al. A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice. PNAS, 104, 943-948, 2007. 13) C.-H. Zhou, S. Zhang, M. Nanamori, Y. Zhang, Q. Liu, N. Li, et al. Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol Pharmacol, 72, 976-983, 2007. 14) J.-L. Wu, N. Li,* T. Hasegawa, et al. Bioactive secolignans from Peperomia dindygulensis. J Nat Prod, 69, 790-794, 2006. 15) N. Li,* J.-L. Wu, T. Hasegawa, et al. Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii. J Nat Prod, 69, 234-239, 2006. 16) S. Xu, N. Li,* M.-M. Ning, et al. Bioactive compounds from Peperomia pellucida. J Nat Prod, 69, 247-250, 2006. 17) M. Zhao, S.-J. Zhang, L.-W. Fu, N. Li, et al. Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities. J Nat Prod, 69, 1164-1167, 2006. 18) P.-K. Yan, M. Nanamori, M.-L. Sun, C.-H. Zhou, N. Cheng, N. Li, et al. The Immunosuppressant Cyclosporin A Antagonizes Human Formyl Peptide Receptor through Inhibition of Cognate Ligand Binding. J Immunol, 177, 7050-7058, 2006. 19) J.-L. Wu, N. Li,* T. Hasegawa, et al. Bioactive tetrahydrofuran lignans from Peperomia dindygulensis. J Nat Prod, 68, 1656-1660, 2005. 20) L.-W. Fu, S.-J. Zhang, N. Li, et al. Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. J Nat Prod, 68, 198-206, 2005.