个人简介

EducationPh.D. University of Science and Technology of China (2004)M.Sc. Anhui University, China (2001)B.Sc. Shandong Institute of Light Industry, China (1998) Positions2015-present Assistant Professor, Faculty of Health Sciences, University of Macau2011-2014 Assistant Professor, Linköping University, SwedenObtained Docent (equivalent to Associate Professor) in 2014.052010-2011 Visiting Scientist, University of Washington, USA2009-2010 Post-doctoral Fellow, Linköping University, Sweden2006-2009 Post-doctoral Fellow, National University of Singapore2004-2006 Post-doctoral Fellow, Shantou University, China

研究领域

Synthetic Chemistry × Nanoscience × Semiconducting Polymers × Metal-organic Materials × Luminescent Probes × Bioimaging and SensingMy research focuses on the molecular design of multifunctional probes for specific biomedical imaging and sensing. Our recent interests: (1) Small molecular probes and nanoprobes for biological microenvironment monitoring, including the detection of local pH value, temperature, and bio-related molecules. (2) Design of new luminescent and photoacoustic materials and study the structure-property relationship, including small organic molecules, semiconducting polymers, and metal-organic hybrid materials. Chemistry is the central science. We use the knowledge of chemistry to resolve challenging problems in material sciences with the aim of biomedical applications.

近期论文

S. Wang, Z. Sheng*(corresponding author), Z. Yang, D. Hu, D. Hu, X. Long, G. Feng, Y. Liu, Z. Yuan, J. Zhang, H. Zheng, X. Zhang*(corresponding author), “Activatable Small-Molecule Photoacoustic Probes that Cross Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease”, Angew. Chem. Int. Ed. 2019, 58, DOI: 10.1002/anie.201904047.B. Zhang, F. Wang, H. Zhou, D. Gao, Z. Yuan, C. Wu*(corresponding author), X. Zhang*(corresponding author), “Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy”, Angew. Chem. Int. Ed. 2019, 58, 27442748. (Selected as VIP article)L. Chen, D. Che, Y. Jiang, J. Zhang, J. Yu, C. C. Dufort, S. R. Hingorani, X. Zhang, C. Wu, D. T. Chiu, “Bodipy-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features”, Angew. Chem. Int. Ed. 2019, 58, 7008-7012. (Selected as VIP article)J. Tan, C. Wang, H. K. Lao, W. Wang*(corresponding author), G. Feng, D. Yuan, C. Wu, X. Zhang*(corresponding author), “Spiro[pyrrol-benzopyran] Based Probe with High Asymmetry for Chiroptical Sensing via Circular Dichroism”, Chem. Commun. 2019, 55, 7438-7441.D. Gao, B. Zhang, Y. Liu, D. Hu, Z. Sheng,*(corresponding author), X. Zhang*(corresponding author), Z. Yuan*(corresponding author), “Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics”, Theranostics, 2019, 9, 5315-5331.Z. Ding, C. Wang, S. Wang, L. Wu, X. Zhang*(corresponding author), “Light-harvesting metal-organic framework nanoprobes for ratiometric fluorescence energy transfer-based determination of pH values and temperature”, Microchimica Acta, 2019, 186:474.C. Wang, X. Cheng, J. Tan, Z. Ding, W. Wang, D. Yuan, G. Li, H. Zhang*(corresponding author), X. Zhang*(corresponding author), “Reductive cleavage of C=C bond as a new strategy to turn on dual fluorescence for effective sensing H2S”, Chemical Science. 2018, 9, 8369 –8374. (2018 Hot Article)G. Feng, B. Zhang, C. Wang, J. Tan, S. Wang, Z. Ding, X. Zhang*(corresponding author), “Construction of Ratiometric Fluorescent Probe Based on Inverse Electron-demand Diels–Alder Reaction for pH Measurement in Living Cells”, Sensors and Actuators B: Chem 2018, 277, 320327.S. Wang, B. Zhang, W. Wang, G. Feng, D. Yuan*(corresponding author), X. Zhang*(corresponding author), “Elucidating the structure-reactivity correlation of phenothiazine based fluorescent probes toward ClO–”. Chem. Eur. J. 2018, 24, 8157 – 8166.K. Sun, Y. Yang, H. Zhou, S. Yin, W. Qin, J. Yu, D. T. Chiu, Z. Yuan, X. Zhang, C. Wu, “Ultrabright polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone”, ACS Nano, 2018, 12, 5176-5184.S. Wang, Z. Li, Y. Liu, G. Feng, J. Zheng*(corresponding author), Z. Yuan* (corresponding author), X. Zhang*(corresponding author), “Activatable Photoacoustic and Fluorescent Probe of Nitric Oxide for Cellular and in Vivo Imaging”. Sensors and Actuators B: Chem. 2018, 267, 403-411.W. Wang, Y. Li, P. V. Reddy, X. Zhang*(co-corresponding author), D. Yuan*(corresponding author), “A facile coordination-assisted method to fabricate a FRET-based fluorescent probe for ratiometric analysis with improved selectivity”. Sensors and Actuators B: Chem. 2017, 252, 159164.Z. Ding, J. Tan, G. Feng, Z. Yuan, C. Wu, X. Zhang*(corresponding author), “Nanoscale Metal-Organic Frameworks Coated with Poly(vinyl Alcohol) for Ratiometric Peroxynitrite Sensing through FRET”. Chemical Science 2017, 8, 5101-5106.C.-S. Ke, C.-C. Fang, J.-Y. Yan, P.-J. Tseng, J. R. Pyle, C.-P. Chen, S.-Y. Lin, J. Chen, X. Zhang*(corresponding author), Y.-H. Chan*(corresponding author), “Molecular Engineering and Design of Semiconducting Polymers to Develop Polymer Dots with Narrow-Band, Near-Infrared Emission for In Vivo Biological Imaging”. ACS Nano, 2017, 11, 3166-3177.Z. Hu*(corresponding author), J. Hu, H. Wang, Q. Zhang, M. Zhao, C. Brommesson, Y. Tian, H. Gao, X. Zhang*(corresponding author), K. Uvdal, “A TPA-caged precursor of (imino)coumarin for “turn-on” fluorogenic detection of Cu(I)”. Analy. Chim. Acta 2016, 993, 189195.G. Zhang, X. Zhang*(corresponding author), Y. Zhang, H. Wang, L. Kong, Y. Tian, X. Tao, H. Bi, J. Yang*(corresponding author), “Design and synthesis of an AIEE-active α-cyanostilbene derivative for Hg2+ detection in aqueous and living cells by coordination inducing aggregation”. Sensors & Actuators: B. Chem. 2015, 211, 730739.X. Zhang*(corresponding author), W. Wang, Z. Hu, G. Wang, K. Uvdal*(corresponding author), “Coordination polymers for energy transfer: preparations, properties, sensing applications, and perspectives”. Coord. Chem. Rev. 2015, 284, 206235.J. Hu, Z. Hu*(corresponding author), Y. Cui, X. Zhang*(corresponding author), H.-W. Gao, K. Uvdal, “A rhodamine-based fluorescent probe for Hg2+ and its application for biological visualization”. Sensors and Actuators B: Chem. 2014, 203, 452458.G. Zhang, A. Ding, Y. Zhang, L. Yang, L. Kong, X. Zhang*(corresponding author), X. Tao, Y. Tian, J. Yang*(corresponding author), “Schiff base modified α-cyanostilbene derivative with aggregation-induced emission enhancement characteristics for Hg2+ detection”. Sensors and Actuators B: Chem, 2014, 202, 209216.X. Zhang,† J. Yu†(co-first author), Y. Rong, F. Ye, D. T. Chiu, K. Uvdal, “High-intensity near-IR fluorescence in semiconducting polymer dots achieved by cascade FRET strategy”. Chemical Science 2013, 4, 21432151.