个人简介

EducationPhD University of Tokyo, Tokyo, JapanMS Central South University (formerly Xiangya Medical University), Changsha, ChinaBM South China University (formerly Hengyang Medical College), Hengyang, ChinaAcademic and Professional Experience2018-present Associate Dean (Research), Faculty of Health Sciences, University of Macau, Macau2014-present Professor, Faculty of Health Sciences, University of Macau, Macau2006-2014 Associate Professor, Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT, USA1999-2006 Senior Scientist, WiCell Research Institute, Madison, WI, USA1994-1996 Research Fellow, NCI-FCRDC, NIH, Frederick, MD, USACourse OutlinesHSCI4002 Stem Cell Biology and Regenerative Medicine GEST2001 Biology in Our Daily LifeReview ServicesStrategic Trailblazing Program, Chinese Academy of SciencesThousands Talents (Youth) Program, ChinaWomen’s Health Research, Yale UniversityNational Natural Science Foundation, ChinaKansas City Area Life Sciences InstituteNew York State Stem Cell Science (NYSTEM) ProgramMaryland State Stem Cell Research FundChangjiang Scholar Program, China

研究领域

Exploring novel therapeutic applications of EMSCs;Addressing the fate, immunogenicity, and biosafety of EMSCs;Studying the origin, development, and heterogeneity of MSCs.

PatentsJiang, B., Yan, L., Li, E.-Q., and Xu, R.-H. A method and medium for storing and transporting stem cells under ambient conditions. Patent application #CN107306936AXu, R.-H., Jiang, B., and Yan, L. Method of differentiating pluripotent stem cells into mesenchymal stem cells under 3D spheroidal culture conditions. Patent application publication # CN 2017/10965622.1, US 2019/0112573 A1Wang, X. and Xu, R.-H. Using mesenchymal-like stem cells derived from human embryonic stem cell-differentiated hemangioblast to treat multiple sclerosis. Patent # WO2014011881A2Wang, X. and Xu, R.-H. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof. Patent # WO2014011881A2​Xu, R.-H. and Thomson, J.A. Feeder-independent extended culture of embryonic stem cells. Patent # US 7,514,260 B2Xu, R.-H. and Thomson, J.A. Method for generating primate trophoblasts. Patent # US 7,148,062

近期论文

Representative Publications(from more than 70)Wang, X., Jiang, B., Sun, H., Zheng, D., Zhang, Z., Yan, L., Li, E., Wu, Y., and Xu, R.-H. Noninvasive application of mesenchymal stem cell spheres derived from hESC accelerates wound healing in a CXCL12-CXCR4 axis-dependent manner. Theranostics 9(21):6112-28, 2019.Jiang, B., Fu, X., Yan, L., Li, S., Zhao, D., Wang, X., Duan, Y., Yan, Y., Li, E., Wu, K., Inglis, B.M., Ji, W., Xu, R.-H.*, and Si, W. Transplantation of human ESC-derived mesenchymal stem cell spheroids ameliorates spontaneous osteoarthritis in rhesus macaques. Theranostics 9(22):6587-​600, 2019.*Co-corresponding authorJiang, B., Yan, L., Wang, X., Li, E., Murphy, K., Vaccaro, K., Li, Y., and Xu, R.-H. Mesenchymal stem cells derived from human pluripotent stem cells, an unlimited and quality-controllable source, for therapeutic applications. Stem Cells Dec. 18, 2018.Jiang, B., Yan, L., Miao, Z., Li, E., Wong, K.H., and Xu, R.-H.Spheroidal formation preserves human stem cells for prolonged time under ambient conditions for facile storage and transportation. Biomaterials 133:275-86, 2017.Zheng, D., Wang, X., and Xu, R.-H. One stone for multiple birds: generating universally compatible human embryonic stem cells. Stem Cells. 34(9):2269-75, Sept. 2016.Wang, X., Lazorchak, A.S., Song, L., Li, E., Jiang, B., Zhang, Z., and Xu, R.-H.Immune modulatory mesenchymal stem cells derived from human embryonic stem cells through a trophoblast-like stage. Stem Cells 34(2):380-91, 2016.Wang, X., Kimbrel, E.A., Ijichi, K. Paul, D., Lazorchak, A.S., Chu, J., Kouris, N.A., Yavanian, G., Lu, S.-J., Pachter, J.S., Crocker, S.J., Lanza, R., and Xu, R.-H.Human ES cell-derived MSC outperform bone marrow MSC in the treatment of an EAE model of multiple sclerosis. Stem Cell Reports 3(1):115-30, 2014.Wang, J., Park, J.W., Drissi, H., Wang, X., and Xu, R.-H.Epigenetic regulation of miR-302 by JMJD1C inhibits neural differentiation of human embryonic stem cells. J. Biol. Chem. 289(4):2384-95, 2014.Martins-Taylor, K. Schroeder, D.I., LaSalle, J.M., Lalande, M., and Xu, R.-H.Role of DNMT3B in the regulation of early neural and neural crest specifiers. Epigenetics 7(1):71-82, 2012.Martins-Taylor, K. and Xu, R.-H.Genomic stability of human induced pluripotent stem cells (invited review). Stem Cells 30(1):22-7, 2012.Luong, M.X., Auerbach, J., Crook, J.M., Daheron, , Hei, D., Lomax, J., Loring, J.F., Ludwig, T., Rooke, H.M., Schlaeger, T.M., Smith, K.P., Stacey, G., Xu, R.-H., and Zeng, F. A call for standardized naming and reporting of human ES and iPS cell lines.Cell Stem Cell 8(4):357-9, 2011.Martins-Taylor, K., Nisler, B.S., Taapken, S.M., Compton, T., Crandall, L., Montgomery, K.D., Lalande, M., and Xu, R.-H.Recurrent copy number variations in human induced pluripotent stem cells. Nat. Biotechnol. 29(6):488-91, 2011.Wang, X., Lin, G., Martins-Taylor, K., Zeng, H., and Xu, R.-H.Inhibition of caspase-mediated anoikis is critical for bFGF-sustained culture of human pluripotent stem cells. J. Biol. Chem. 284(49):34054-64, 2009.Li, Y., Zeng, H., Xu, R.-H., Liu, B., and Li, Z. Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical response against colon cancer. Stem Cells 27(12):3103-11, 2009.Zeng, H., Park, J.W., Guo, M., Lin, G., Crandall, L., Compton, T., Wang, X., Li, X.-J., Chen, F.-P., and Xu, R.-H.Lack of ABCG2 expression and side population properties in human pluripotent stem cells. Stem Cells 27(10):2435-45, 2009.Xu, R.-H., Sampsell-Barron, T.L., Gu, F., Root, S., Peck, R.M., Pan, G., Yu, J., Antosiewicz-Bourget, J., Tian, S., Stewart, and Thomson, J.A. NANOGis a direct target of TGF-beta/Activin mediated SMAD signaling in human ES cells. Cell Stem Cell 3(2):196-206, 2008.Shen, Y., Matsuno, Y., Fouse, S.D., Rao, N., Root, S., Xu, R.-H., Pellegrini, M., Riggs, A.D., and Fan, G. X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alternations. Proc. Natl. Acad. Sci. U.S.A. 105(12):4709-14, 2008.Xu, R.-H., Peck, R.M., Li, D.S., Feng, X., Ludwig, T., and Thomson, J.A. Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat. Methods 2(3):185-190, 2005.Xu, R.-H., Chen, X., Li, D.S., Li, R., Addicks, G.C., Glennon, C., Zwaka, T.P., and Thomson, J.A. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat. Biotechnol. 20(12):1261-4, 2002.Xu, R.-H., Dong, Z., Maeno, M., Kim, J., Suzuki, A., Ueno, N., Sredni, B., Colburn, N.H., and Kung, H.-f.: Involvement of Ras/Raf/AP-1 in BMP-4 signaling during Xenopusembryonic development. Proc. Natl. Acad. Sci. U.S.A. 93:834-838, 1996.