个人简介

Academic QualificationsBSc in Biochemistry, The Chinese University of Hong KongMPhil in Biochemistry, The Chinese University of Hong KongMSc in Artificial Intelligence, The University of Edinburgh, UKPhD in Informatics (AI), The University of Edinburgh, UKTeachingPhD coursesHealthcare Decision Analysis (2013-4 and 2016-)Research Ethics (2014-6)MSc coursesBiomedical Informatics (2009-)Computational Pharmacy (2015-)

研究领域

Medical informatics for evidence-based medicine, particularly in artificial intelligence and knowledge management for translational medicineDistributed multi-agent systems for scientific experimentation, particularly in automated experimentationData-intensive and social computing for evaluating scientific evidence, particularly in open systematic reviewing and open meta-analysis of clinical trials and omics experimentsSystems biology and pathway medicine, particularly in multi-level network modellingBioinformatics and structural biology, particularly in DNA linguistics for sequence assembly and structural modelling

近期论文

Journal papers and book chapters (peer-reviewed)Zhu H and Leung S (2017) Identification of MicroRNA biomarkers by meta-analysis. In Mohini Gore and Umesh B Jagtap (eds) Computational Drug Discovery and Design, Methods in Molecular Biology series, Springer. (In press)Yuen C, Zhu H, and Leung S (2017) Building molecular interaction networks from microarray data for drug target screening. In Mohini Gore and Umesh B Jagtap (eds) Computational Drug Discovery and Design, Methods in Molecular Biology series, Springer. (In press)Jia Y and Leung S (2017) How Efficacious is Danshen (Salvia miltiorrhiza) Dripping Pill in Treating Angina Pectoris? Evidence Assessment for Meta-Analysis of Randomized Controlled Trials. Journal of Alternative and Complementary Medicine, 26(6):676-684.Available at: http://online.liebertpub.com/doi/pdfplus/10.1089/acm.2017.0069.Leung S and Hu H (eds.) (2016) Evidence-based research methods for Chinese medicine. ISBN 978-9811022890, Springer.Sun Y, Zhou H, Zhu H and Leung S (2016) Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products. Scientific Reports, 6, 19312.Available at: http://www.nature.com/articles/srep19312Jia Y, Zhu H and Leung S (2016) Comparative efficacy of selective serotonin reuptake inhibitors (SSRI) in treating major depressive disorder: a protocol for network meta-analysis of randomized controlled trials. BMJ Open. 6:e010142.Available at: doi:10.1136/bmjopen-2015-010142.Zhou Y, Zhu Y, and Leung S (2016) PLS-frailty model for cancer survival analysis based on gene expression profiles. In Abdi et al. (eds) The Multiple Facets of Partial Least Methods. ISBN 978-3319406411, Springer.Zhu Y, Zhu H, Leung S (2016) Is self-monitoring of blood glucose effective in improving glycemic control in type 2 diabetes without insulin treatment: a meta-analysis of randomized controlled trials. BMJ Open. 6:e010524.Available at: doi:10.1136/bmjopen-2015-010524.Zhu H and Leung S (2015) Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies. Diabetologia. 58:900-911.Available at: http://link.springer.com/article/10.1007/s00125-015-3510-2Jia Y and Leung S (2015) Comparative efficacy of tongxinluo capsule and beta-blockers in treating angina pectoris: meta-analysis of randomized controlled trials. Journal of Alternative and Complementary Medicine. 21(11): 686-99. Available at: http://online.liebertpub.com/doi/10.1089/acm.2014.0290Lao Y, Jia, Y, Leung S (2015) Glycemic control efficacy of oral anti-diabetic drugs in treating type 2 diabetes: a protocol for network meta-analysis. BMJ Open.Available at: http://bmjopen.bmj.com/content/5/3/e006139.full.pdfChan K and Leung S (2015) Dynamic geometry software improves mathematical achievement: systematic review and meta-analysis. Journal of Educational Computing Research. 51(3): 311-325.Jia Y and Leung S (2014) Drug efficacy in treating angina pectoris: a protocol for network meta-analysis of randomised controlled trials. BMJ Open. 4:e005453.Available at: http://bmjopen.bmj.com/content/4/6/e005453.full.pdfSun Y, Zhou Y, Chen X, Che W, Leung S (2014) The efficacy of dapagliflozin combined with hypoglycemic drugs in treating type 2 diabetes: meta-analysis of randomized controlled trials. BMJ Open. 4:e004619.Available at: http://bmjopen.bmj.com/content/4/4/e004619.full.pdfZhu H, Zhu S, Zhang X, Guo Y, Shi Y, Chen Z, Leung S (2013) Comparative efficacy of glimepiride and metformin in monotherapy of type 2 diabetes mellitus: meta-analysis of randomized controlled trials. Diabetology & Metabolic Syndrome. 5(1):70. Available at: http://www.biomedcentral.com/content/pdf/1758-5996-5-70.pdfSun Y, Zhou Y, Chen X, Che W, Leung S (2013) The efficacy of dapagliflozin combined with hypoglycemic drugs in treating type 2 diabetes: protocol for meta-analysis of randomized controlled trials. Systematic Reviews. 2(1):103. Available at: http://www.biomedcentral.com/content/pdf/2046-4053-2-103.pdfJia Y, Leung S, Lee MY, Cui G, Huang X, Pan F (2013) The efficacy of Guanxinning injection in treating angina pectoris: systematic review and meta-analysis of randomized controlled trials. Evidence-based Complementary and Alternative Medicine. 2013:282707.Available at: http://dx.doi.org/10.1155/2013/282707Jia Y, Chen C, Ng CS, Leung S (2012) Meta-Analysis of randomized controlled trials on the efficacy of di’ao xinxuekang capsule and isosorbide dinitrate in treating angina pectoris. Evidence-based Complementary and Alternative Medicine. 2012:9041-47. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgiartid=3310218&tool=pmcentrez&rendertype=abstractJia Y, Huang F, Zhang S, Leung S (2012) Is danshen (Salvia miltiorrhiza) dripping pill more effective than isosorbide dinitrate in treating angina pectoris? A systematic review of randomized controlled trials. International Journal of Cardiology. 157(3):330–40.Available at: http://www.ncbi.nlm.nih.gov/pubmed/21251721Leung S, Lee J, Johnson C, Robertson D (2012) Design preferences and cognitive styles: experimentation by automated website synthesis. Automated Experimentation. 4:2. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386886/?tool=pmcentrez&rendertype=abstractJia Y, Zhang S, Huang F, Leung S (2012) Could ginseng-based medicines be better than nitrates in treating ischemic heart disease? A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine. 20(3):155–66. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22500665Ng C, Wang S, Cheong J, et al. (2012) Systematic review and meta-analysis of randomized controlled trials comparing Chinese patent medicines compound danshen dripping pills and di’ao xinxuekang in treating angina pectoris. Journal of Chinese Integrative Medicine. 10(1):25–34. Available at: http://www.jcimjournal.com/en/showAbstrPage.aspx?articleID=jcim20120105Jia Y, Huang F, Zhang S, Leung S (2012) Assessment of the quality of randomized controlled trials in treating coronary heart disease by Chinese patent medicine. Chinese Journal of Integrated Traditional and Western Medicine. 32(4):560-68. Available at: http://www.ncbi.nlm.nih.gov /pubmed/22803444Jia Y, Bao F, Huang F, Leung S (2011) Is tongxinluo more effective than isosorbide dinitrate in treating angina pectoris? A systematic review and meta-analysis of randomized controlled trials. Journal of Alternative and Complementary Medicine. 17(12):1109–17. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22132707Jia Y, Zhang S, Bao F, Huang F, Leung S (2011) Indirect comparison of tongxinluo capsule and danshen dripping pill for angina pectoris: a systematic review. Chinese Journal of Evidence-based Medicine. 11(8):919-31.Available at: http://www.crd.york.ac.uk/crdweb/ShowRecord.asp? LinkFrom=OAI&ID=12011005718Leung S, Quan X, Besana P, et al. (2011) OpenKnowledge for peer-to-peer experimentation in protein identification by MS/MS. Automated Experimentation. 3(1):3.Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3377912&tool=pmcentrez&rendertype=abstractSelected conference presentationsJia Y and Leung S (2017) Efficacy of Chinese herbal drugs for angina pectoris: a frequentist network meta-analysis. The Lancet-CAMS Health Summit 2017. 10-12 December, Beijing, China. (Poster)Guo G, Jia Y, and Leung S (2017) Is Dengzhanxixin injection more effective than nitrates in treating angina pectoris? A meta-analysis of randomized controlled trials. The 16th Meeting of Consortium for Globalization of Chinese Medicine. 18-20 August, Guangzhou, China. (Invited talk and poster)Wei W, Zhu H, and Leung S (2017) Meta-analysis of differential expression of non-coding RNAs in ovarian cancer for discovering drug targets of natural products. The 16th Meeting of Consortium for Globalization of Chinese Medicine. 18-20 August, Guangzhou, China. (Invited talk and poster)Leung S (2017) Promoting awareness of ethical authorship. 1st COPE (Committee on Publication Ethics) Beijing Seminar. 26 March, Beijing, China. (Invited talk) Leung S (2016) “Chinese Medicine” practices in publication ethics. Springer Nature Editors Conference. 28 April, Shanghai, China. (Invited talk)Jia Y and Leung S (2016) The assessment of evidence assessment from meta-analysis on Chinese herbal drugs. The 15th Meeting of Consortium for Globalization of Chinese Medicine. Taipei, Taiwan. (Invited talk and poster).Zhu H and Leung S (2016) Meta-analysis of case-controlled gene expression profiles to identify biomarkers for ovarian cancer. The 9th Asia-pacific Conference on Evidence-Based Medicine. 27-29 May, Chengdu, China. (Oral presentation honoured with the Excellent Presentation Award)Jia Y, Li N, and Leung S (2016) Efficacy of thiazolidinediones in treating type 2 diabetes: Bayesian and Frequentist multi-level meta-analyses of randomized control trials. The 9th Asia-Pacific Conference on Evidence-Based Medicine. 27-29 May, Chengdu, China. (Oral presentation)Leung S (2015) Publication ethics ensure research integrity: the roles of the Chinese Medicine journal. Springer Nature Open Research Day Workshop. 20 October, Beijing, China. (Invited talk)Zhu H and Leung S (2015) Meta-analysis on the association between microRNAs and type 2 diabetes mellitus. The 14th Meeting of Consortium on Globalization of Chinese Medicine. 17-20 August, London, Ontario, Canada. (Invited talk)Jia Y and Leung S (2015) Comparative efficacies of Chinese herbal medicine and nitrates in treating stable angina pectoris: network meta-analysis of randomized controlled trials. The 2nd International Conference of Traditional and Complementary Medicine on Health. Taipei, Taiwan. (Poster)Jia Y and Leung S (2015) Comparative efficacy of chemical drugs and Chinese herbal drugs in treating stable angina pectoris: a network meta-analysis of randomized controlled trials. The 8th Asia-Pacific Conference on Evidence-Based Medicine. Chongqing, China. (Oral presentation)Leung S (2014) Chinese medicine works. IEEE Conference on Medical Informatics for Chinese Medicine. 17-20 December, Guangzhou, China. (Invited keynote presentation)Jia Y and Leung S (2014) Efficacy of tongxinluo in treating angina pectoris: a meta-analysis of randomized controlled trials. The 13th Meeting of Consortium on Globalization of Chinese Medicine. 26-29 August, Beijing, China. (Invited talk)Zhou Y and Leung S (2014) Partial least squares components representing frailty improve survival analysis with gene expression profiles. International Conference on Partial Least Squares and Related Methods. 26-28 May, Paris, France. Li N, Lao Y, Jia, Y, Leung S (2013) A multilevel model framework for network meta-analysis. International Conference on Evaluation of Post-marketing of Chinese Medicine. 16-18 October, Beijing, China. (Invited plenary talk)Li N, Lao Y, Leung S (2013) Multilevel models for network meta-analysis. World Statistics Congress. 25-30 August, Hong Kong SAR, China.Leung S (2012) Open systematic reviewing for Chinese medicine. Summit Forum on Chinese Medicine and Natural Products. 2-4 November, Haikou, Hainan, China. (Invited plenary talk)Leung S (2012) Correcting statistical reporting errors of CHINESE MEDICINE. World Congress on Good Medical Research. 6-9 June, Vienna, Austria.Leung S (2011) Evidence-based, integrative, and systems approaches to Chinese medicine. The 4th CLSS-UK (Chinese Life Scientists Society in UK) North Life Science Symposium. 25 June. Edinburgh, UK. (Invited talk)Leung S (2010) Open systematic reviewing. International Workshop on Computational Ecology. 30 November-3 December, Okinawa, Japan. (Invited talk)Gerloff D, Quan X, de Pinninck A, Besana P, Leung S, Schorlemmer M, Robertson D (2009) Bioinformatics experimentation in a new agent-based infrastructure OpenKnowledge. Network Tools and Applications in Biology (NETTAB) Workshop. 10-13 June, Catania, Sicily, Italy.Leung S (2009) Open and distributed technologies for evidence-based medicine. Conference on Evidence-Based Medicine and Traditional Chinese Medicine. 22-24 May, Guangzhou, China. (Invited talk)Leung S (2008) Experimentation with DNA grammars in analysing E. coli promoter sequences. Living Texts: Textual Analysis and Biology. 16-17 October, Edinburgh, UK. (Invited talk)