个人简介

EducationKnowledge Transfer Partnership (KTP) Postdoctoral FellowQueen’s University Belfast, UK (2004-2007)PhD in Biomedical SciencesUniversity of Ulster, UK (2003)BSc (1st Class Hons) in BiotechnologyUniversity of Ulster, UK (2000)NVQ Level 4 (Higher National Diploma) in ManagementChartered Management Institute, UK (2007)Academic and Professional Experience2018-Present Associate Professor, Faculty of Health Sciences, University of Macau2013-present Visiting Scientist, Cancer Research UK Cambridge Institute, University of Cambridge, UK2014-2018 Assistant Professor, Faculty of Health Sciences, University of Macau2007-2017 Visiting Research Fellow, School of Pharmacy, Queen’s University Belfast, UK2011-2014 Senior Research Associate / Fellow, Department of Oncology / Cancer Research UK Cambridge Institute, University of Cambridge, UK2007-2011 Senior Scientist, Fusion Antibodies Ltd., UKAd Hoc Invited External Examiner:School of Pharmacy, Queen’s University Belfast, UK — PhD programme and MPhil programmeLi Ka Shing Faculty of Medicine, University of Hong Kong — MMedSc programmeFaculty of Medicine, Nursing & Health Sciences, Monash University, Australia — PhD programmeSchool of Biomedical Sciences, Chinese University of Hong Kong – PhD programmeCourse OutlinesHSCI1003 General and Clinical Biochemistry HSCI4009 Toxicology

研究领域

Prof. Kwok’s research interests mainly focus on the development of novel monoclonal antibodies and natural biomolecules (including venom-based peptides, plant-derived molecules etc.) as prototype drugs for anticancer and anti-inflammatory therapies. In addition, Prof. Kwok’s research group also expands their research and scientific knowledge in the areas of existing and novel cancer biomarkers such as 1) matricellular protein — OPN, 2) metalloproteinase — ADAM17, ADAMTS5 and ADAMTS8, 3) DNA replication licensing factor — MCM proteins, 4) small GTP binding protein — RAN and RCC1, as well as immunotherapy markers (e.g. PD-1/PD-L1) in order to identify and validate their prognostic and therapeutic values according to the roles in hallmarks of cancer and chronic diseases.

Patents1. Kwok H. F., Rui M., Chen G. (2020) A venom-based peptide and its application. Patent CN 202010469590.82. Kwok H. F., Xie R. (2020) Use of anti-tumour effects of a’human & mouse cross-reactive’anti-adam17 antibody in treating pancreatic cancer. Patent US 20190375848A13. Kwok H. F. (2019) Method of Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Patent US 20190015505A14. Olwill S. A., Kwok H. F., Johnston J. A., Whelan C., Clarke J., Shuralev E. (2010) Diagnostic methods and kits – The identification of tuberculosis infection in animals such as badgers, cervids and wild boar. Patent WO 20100976255. Olwill S. A., Buick R., Kwok H. F., Scott C., Ward C. (2010) Antibody Therapy – Described are methods of inhibiting angiogenesis, the methods comprising the simultaneous, sequential or separate administration of (i) an anti- Cathepsin S antibody molecule, and (ii) an anti-VEGF antibody molecule. Also described are anti-Cathepsin S humanized antibodies, pharmaceutical compositions and methods of treatment using such antibodies. Patent WO 20100949816. Olwill S. A., Johnston J. A., Kwok H. F., Whelan C, Clarke J. (2009) Diagnostic method and kit – The invention relates to methods for diagnosis of tuberculosis comprising determining the presence or absence of, or an immune response to a group of antigens. Patent WO20090248227. Olwill S. A., Buick R. J., Kwok H. F., Johnston J. A. (2006) Assays for diagnosis of tuberculosis and uses thereof – The identification of mycobacterial antigens which are highly immunogenic and which may be used in assays and methods for the diagnosis of tuberculosis. Patent WO2006117538

近期论文

Journal Articles:Guo, L., Wei, R., Lin, Y., Kwok, H. F. (2020) Clinical and Recent Patents Applications of PD-1/PD-L1 Targeting Immunotherapy in Cancer Treatment — Current Progress, Strategy and Future Perspective. Frontiers in Immunology (In Press)Li, J. N., and Kwok, H. F. (2020) Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment. Cancers (Basel) 12 (6), E1587Ma, R., Ren, Z. L., Li, B., Siu, S. W. I., Chen, G. K., and Kwok, H. F. (2020) Novel Venom-Based Peptides (P13 and its Derivative-M6) to Maintain Self-Renewal of Human Embryonic Stem Cells by Activating FGF and TGFbeta Signaling Pathways. Stem Cell Res Ther 11 (1), 243Yeung, L., Anderson, J. M. L., Wee, J. L., Demaria, M. C., Finsterbusch, M., Liu, Y. S., Hall, P., Smith, B. C., Dankers, W., Elgass, K. D., Wicks, I. P., Kwok, H. F., Wright, M. D., and Hickey, M. J. (2020) Leukocyte Tetraspanin CD53 Restrains Alpha3 Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice. J Immunol 205Ma, R., Wong, S. W., Ge, L., Shaw, C., Siu, S. W. I., and Kwok, H. F. (2020) In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide. Mol Ther Oncolytics 16, 7-19Yang, Z., Chan, K. I., Kwok, H. F., and Tam, K. Y. (2019) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-Tki-Mediated Anticancer Activity in NSCLC. Transl Oncol 12 (11), 1516-1524Li, B., Lyu, P., Xie, S. P., Qin, H. X., Pu, W. Y., Xu, H. X., Chen, T., Shaw, C., Ge, L. L., and Kwok, H. F. (2019) Lfb: A Novel Antimicrobial Brevinin-Like Peptide from the Skin Secretion of the Fujian Large Headed Frog, Limnonectes Fujianensi. Biomolecules 9 (6), E242Ge, L. L., Li, B., Xu, H. X., Pu, W. Y., and Kwok, H. F. (2019) Backfilling Rolling Cycle Amplification with Enzyme-DNA Conjugates on Antibody for Portable Electrochemical Immunoassay with Glucometer Readout. Biosensors and Bioelectronics 132, 210-216Chen, P. C., Wang, Q. S., Xie, J. W., and Kwok, H. F. (2019) Signaling Networks and the Feasibility of Computational Analysis in Gastroenteropancreatic Neuroendocrine Tumors. Semin Cancer Biol 58, 80-89Wei, R., Wong, J. P. C., Lyu, P., Xi, X. P., Tong, O., Zhang, S. D., Yuen, H. F., Shirasawa, S., and Kwok, H. F. (2018) In Vitro and Clinical Data Analysis of Osteopontin as a Prognostic Indicator in Colorectal Cancer. J Cell Mol Med 22 (9), 4097-4105Rajendran, B. K., Xavier Suresh, M., Bhaskaran, S. P., Harshitha, Y., Gaur, U., and Kwok, H. F. (2018) Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, Bungarus Caeruleus. Computational and Structural Biotechnology Journal 16, 450-461Mughal, M. J., Mahadevappa, R., and Kwok, H. F. (2018) DNA Replication Licensing Proteins: Saints and Sinners in Cancer. Semin Cancer Biol 58, 11-21Mahadevappa, R., Neves, H., Yuen, S. M., Jameel, M., Bai, Y. C., Yuen, H. F., Zhang, S. D., Zhu, Y. Z., Lin, Y., and Kwok, H. F. (2018) DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer. Cancers (Basel) 10 (9), E282Li, B., Lyu, P., Xi, X. P., Ge, L. L., Mahadevappa, R., Shaw, C., and Kwok, H. F. (2018) Triggering of Cancer Cell Cycle Arrest by a Novel Scorpion Venom-Derived Peptide-Gonearrestide. J Cell Mol Med 22 (9), 4460-4473Huang, Y. D., Zhang, Y. F., Ge, L. L., Lin, Y., and Kwok, H. F. (2018) The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma. Cancers (Basel) 10 (3), E82Ye, J., Yuen, S. M., Murphy, G., Xie, R. Y., and Kwok, H. F. (2017) Anti-Tumor Effects of a ‘Human & Mouse Cross-Reactive’ Anti-ADAM17 Antibody in a Pancreatic Cancer Model in Vivo. Eur J Pharm Sci 110, 62-69Wong, J., Wei, R., Lyu, P., Tong, O., Zhang, S. D., Wen, Q., Yuen, H. F., El-Tanani, M., and Kwok, H. F. (2017) Clinical and in Vitro Analysis of Osteopontin as a Prognostic Indicator and Unveil Its Potential Downstream Targets in Bladder Cancer. Int J Biol Sci 13 (11), 1373Wei, R., Wong, J. P. C., and Kwok, H. F. (2017) Osteopontin — a Promising Biomarker for Cancer Therapy. J Cancer 8 (12), 2173-2183Wang, Q. S., Lin, W., Tang, X. Q., Li, S. H., Guo, L. B., Lin, Y., and Kwok, H. F. (2017) The Roles of Micrornas in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint. Int J Mol Sci 18 (12), 2540Neves, H., and Kwok, H. F. (2017) In Sickness and in Health: The Many Roles of the Minichromosome Maintenance Proteins. Biochim Biophys Acta 1868 (1), 295-308Mahadevappa, R., Ma, R., and Kwok, H. F. (2017) Venom Peptides: Improving Specificity in Cancer Therapy. Trends Cancer 3 (9), 611-614Kawai, T., Takayanagi, T., Forrester, S., Preston, K., Obama, T., Tsuji, T., Kobayashi, T., Boyer, M., Cooper, H., Kwok, H. F., Hashimoto, T., Scalia, R., Rizzo, V., and Eguchi, S. (2017) Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/Β-Aminopropionitrile–Induced Abdominal Aortic Aneurysm. Hypertension, HYPERTENSIONAHA. 117.09822Takayanagi, T., Forrester, S., Kawai, T., Obama, T., Tsuji, T., Elliott, K., Nuti, E., Rossello, A., Kwok, H. F., Scalia, R., Rizzo, V., and Eguchi, S. (2016) Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin Iinovelty and Significance. Hypertension 68 (4), 949-955Kwok, H. F., Zhang, S. D., McCrudden, C., Yuen, H. F., Ting, K. P., Wen, Q., Khoo, U. S., and Chan, K. Y. K. (2015) Prognostic Significance of Minichromosome Maintenance Proteins in Breast Cancer. Am J Cancer Res 5 (1), 52-71Kwok, H. F., Botkjaer, K., Tape, C., Huang, Y. C., McCafferty, J., and Murphy, G. (2014) Development of a ‘Mouse and Human Cross-Reactive’affinity-Matured Exosite Inhibitory Human Antibody Specific to TACE (ADAM17) for Cancer Immunotherapy. Protein Eng Des Sel 27 (6), 179-190Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A., Scott, C. J., Johnston, J. A., and Olwill, S. A. (2011) Antibody Targeting of Cathepsin S Induces Antibody-Dependent Cellular Cytotoxicity. Mol Cancer 10, 147Fry, B. G., Winter, K., Norman, J. A., Roelants, K., Nabuurs, R. J., van Osch, M. J., Teeuwisse, W. M., van der Weerd, L., McNaughtan, J. E., Kwok, H. F., Scheib, H., Greisman, L., Kochva, E., Miller, L. J., Gao, F., Karas, J., Scanlon, D., Lin, F., Kuruppu, S., Shaw, C., Wong, L., and Hodgson, W. C. (2010) Functional and Structural Diversification of the Anguimorpha Lizard Venom System. Mol Cell Proteomics 9 (11), 2369-2390Fry, B. G., Roelants, K., Winter, K., Hodgson, W. C., Griesman, L., Kwok, H. F., Scanlon, D., Karas, J., Shaw, C., Wong, L., and Norman, J. A. (2010) Novel Venom Proteins Produced by Differential Domain-Expression Strategies in Beaded Lizards and Gila Monsters (Genus Heloderma). Mol Biol Evol 27 (2), 395-407Fry, B. G., Wroe, S., Teeuwisse, W., van Osch, M. J., Moreno, K., Ingle, J., McHenry, C., Ferrara, T., Clausen, P., Scheib, H., Winter, K. L., Greisman, L., Roelants, K., van der Weerd, L., Clemente, C. J., Giannakis, E., Hodgson, W. C., Luz, S., Martelli, P., Krishnasamy, K., Kochva, E., Kwok, H. F., Scanlon, D., Karas, J., Citron, D. M., Goldstein, E. J., McNaughtan, J. E., and Norman, J. A. (2009) A Central Role for Venom in Predation by Varanus Komodoensis (Komodo Dragon) and the Extinct Giant Varanus (Megalania) Priscus. Proc Natl Acad Sci U S A 106 (22), 8969-8974Kwok, H. F., Chen, T., O’Rourke, M., Ivanyi, C., Hirst, D., and Shaw, C. (2008) Helokinestatin: A New Bradykinin B2 Receptor Antagonist Decapeptide from Lizard Venom. Peptides 29 (1), 65-72Books / Book Chapters:Kwok, H. F. (Ed.)* (2019) Venom Toxins as Potential Targeted Therapy (pp. 1-167). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI).Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 18 B-Type natriuretic peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 312-317). Oxford, UK: Oxford University Press.Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 11 Exendin peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 247-254). Oxford, UK: Oxford University Press.