个人简介

EducationPhD National University of Singapore (1996)Master of Medicine Zhejiang Medical University, China (1988)Bachelor of Medicine Zhejiang Medical University, China (1985)Academic and Professional ExperienceJan 2020 to present Chair Professor, Faculty of Health Sciences, University of MacauJuly 2016 to Dec 2019 Professor (tenured), Department of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeJuly 2007 to June 2016 Associate Professor (tenured), Department of Physiology/EPH, Yong Loo Lin School of Medicine, National University of SingaporeDec 2002 to June 2007 Assist Professor, Dept. of COFM, Yong Loo Lin School of Medicine, National University of SingaporeApr 2002 to July 2003 Exchange Scientist, National Cancer Institute (NCI), NIH, USAFeb 2001-Nov 2002 Research Fellow, Dept. of COFM, Faculty of Medicine, National University of SingaporeJan 1996 to Jan 2001 Postdoc Research Fellow, Dept. of COFM, Faculty of Medicine, National University of SingaporeExternal Grant Review:As panel member:National Medical Research Council (NMRC), SingaporeUniversity Research Committee (URC) Expert Panel, NUSNatural Science Foundation of China (NSFC) (panel member for Phase II review)As ad-hoc memberResearch Grants Council, Hong Kong, since 2008(ii)National Health and Medical Research Council (NHMRC), Australia, since 2008Cancer Research UK, since 2011CARIPARO Foundation, Italy, since 2012Israel Science Foundation, since 2010Austrian Science Fund (FWF), since 2013Health Research Board (HRB) of Ireland, since 2014Research Foundation Flanders # FWO, Belgium, since 2014National Science Centre-Poland, since 2015Hong Kong City University, since 2014CARIPARO Foundation, Italy, since 2012Netherlands Organisation for Scientific Research (NWO), since 2013Course OutlinesAdvanced Molecular Cell Biology

研究领域

Autophagy and lysosome in cancer cell biologyMitophagy: novel mechanisms and biological importance in health and diseaseCancer metabolism and targeted therapy

近期论文

Recent representative publications (all as corresponding author):Wang L, Qi H, Tang YC, Shen HM*. Post-Translational Modifications of Key Machinery in Control of Mitophagy. Trend in Biochem Sci 2019 Oct 9. pii: S0968-0004(19)30178-1.Lu G, Yi J, Gubas A, Wang YT, Wu Y, Ren Y, Wu M, Shi Y, Ouyang C, Tan HWS, Wang T, Wang L, Yang N, Deng S, Xia D, Chen RY, Tooze SA, Shen HM*. Suppression of autophagy during mitosis via CRL4s-mediated WIPI2 polyubiquitination and proteasomal degradation. Autophagy 2019 Mar 22:1-18.Zhang J, Wang J, Zhou Z, Park JE, Wang L, Wu S, Sun X, Lu L, Wang T, Lin Q, Sze SK, Huang D, Shen HM*. Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors. Autophagy. 2018;14(6):1043-1059.Wang L, Cho YL, Tang Y, Wang J, Park JE, Wu Y, Wang C, Tong Y, Chawla R, Zhang J, Shi Y, Deng S, Lu G, Wu Y, Tan HW, Pawijit P, Lim GG, Chan HY, Zhang J, Fang L, Yu H, Liou YC, Karthik M, Bay BH, Lim KL, Sze SK, Yap CT, Shen HM*. PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell Res. 2018 Aug;28(8):787-802. doi: 10.1038/s41422-018-0056-0 (cover story)Wang JG#*, Zhang JB#, Shi Y#, Xu CC#, Zhang CJ, Wong YK, Lee YM, Krishna S, He YK, Lim TK, Liu B, Hua ZC, Shen HM*, Lin QS*. Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anti-colorectal Cancer Activity. ACS Central Sciences (cover story), 2017, Jul 26;3(7):743-750.Wong YK, Zhang JB, Hua ZC, Lin QS, Shen HM*, Wang JG*. Recent Advances in Quantitative and Chemical Protoemics for Autophagy Studies (review). Autophagy. 2017, Sep 2;13(9):1472-1486Wang J, Zhang J, Lee YM, Ng S, Shi Y, Hua ZC, Lin Q, Shen HM*. Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling. Nat Protoc. 2017; 12(2):279-288.Wang J, Zhang J, Lee YM, Koh PL, Ng S, Bao F, Lin Q, Shen HM*. Quantitative chemical proteomics profiling of de novo protein synthesis during starvation-mediated autophagy. Autophagy. 2016 Oct 2;12(10):1931-1944.Shi Y, Tan SH, Ng S, Zhou J, Yang ND, McMahon KA, del Pozo MA, Hill MA, Parton RG, Kim YS, Shen HM*. Caveolin-1 and lipid rafts play a critical role in determining cell stress responses in human breast cancer cells via modulation of autophagy and lysosomal function. Autophagy 2015;11(5):769-784.Zhang J, Ng S, Wang J, Tan SH, Zhou J, Yang N, Lin Q, Xia D, Shen HM*. Histone deacetylase inhibitors induce autophagy through FoxO1-dependent pathways. Autophagy 2015 Apr 3;11(4):629-42Yang ND, Tan SH, Ng S, Shi Y, Zhou J, Tan KS, Wong WS, Shen HM*. Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem. 2014 Oct 10. pii:jbc.M114.564567. [Epub ahead of print] PubMed PMID: 25305013.Zhang J, Wang J, Ng S, Lin Q, Shen HM*. Development of a novel method for quantification of autophagic protein degradation by AHA labeling. Autophagy. 2014 May;10(5):901-12. PubMed PMID: 24675368Tan SH, Shui G, Zhou J, Shi Y, Huang J, Xia D, Wenk MR, Shen HM*. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014 Feb;10(2):226-42Shen HM*, Mizushima N. At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy. Trends Biochem Sci. 2014 Feb;39(2):61-71.Zhou J, Tan SH, Codogno P, Shen HM*. Dual suppressive effect of MTORC1 on autophagy: tame the dragon by shackling both the head and the tail. Autophagy. 2013 May;9(5):803-5.Zhou J, Tan SH, Nicolas V, Bauvy C, Yang ND, Zhang J, Xue Y, Codogno P, Shen HM*. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res. 2013 Apr;23(4):508-23.Shen HM*, Codogno P. Cross talks between autophagy and necrotic cell death. Exp Cell Res (invited review), 2012, 318 (11): 1304-1308.Tan SH, Shui GH, Zhou J, Wenk MR*, Shen HM*. Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin). J Biol Chem 2012, 287 (18):14364-14376.Zhou J, Hu SE, Tan SH, Cao R, Chen Y, Xia DJ, Zhu XQ, Yang XF, Ong CN, Shen HM*. Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells. Autophagy 2012, 8:338-349.Ng SK, Chen B, Wu YT, Zhou J, Shen HM*. Constitutive mTOR activation suppresses autophagy and sensitizes TSC2-null cells to cell death. Autophagy 2011, Oct 1; 7(10):1173-86.Wu YT, Ouyang W, Lazorchak AS, Liu D, Shen HM*, Su B. mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif. J Biol Chem. 2011, 286:14190-14198.Wu YT, Tan HL, Huang Q, Ong CN, Shen HM*. ZVAD-induced necroptosis in L929 cells depends on autocrine production of TNF? mediated by the PKC-MAPKs-AP-1 pathway. Cell Death and Differentiation 2011, 18:26-37.Shen HM*, P Codogno. Autophagic cell death: Loch Ness monster or endangered species? (review) Autophagy, 2011, 7:457-465.Wu YT, Tan HL, Shi GH, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM*. Dual role of 3-methyladenine on modulation of autophagy via different temporal patterns on Class I and III PI3K. J Biol Chem 2010, 285:10850-10861, (this article was featured in Faulty of 1000 Biology (http://f1000biology.com/article/id/3091959/evaluation)Wu YT, Tan HL, Huang Q, Kim YS, Pan N, Ong WY, Liu ZG, Ong CN, Shen HM*. Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy 2008, 4:457-466. This article was accompanied by a Commentary from the Associate Editor published together in the same issue White E. Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis. Autophagy. 2008 May 16;4(4):399-401. Epub 2008 Mar 13.Wu YT, Zhang SY, Kim YS, Tan HL, Whiteman M, Ong CN, Liu ZG, Ichijo H, Shen HM*. Signaling Pathways from Membrane Lipid Rafts to JNK1 Activation in Reactive Nitrogen Species-Induced Non-Apoptotic Cell Death. Cell Death Differ 2008, 15:386-397.Zhang, S.Y.; Lin Y; Kim, Y.,S.; Liu, Z.,G.; Ong, C.N.; Shen, HM*. c-Jun N-terminal Kinase Mediates Hydrogen Peroxide-Induced Cell Death via Sustained Poly(ADP-ribose) Activation. Cell Death Differ 2007, 14:1001-1010.Shen, HM*; Liu, Z.G. JNK Signaling Pathway is a Key Modulator in Cell Death Mediated by Reactive Oxygen and Nitrogen Species (review). Free Radic. Biol. Med. 2006, 40:928-939.Shi, R. X.; Ong, C. N.; Shen, HM*. Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells. Cancer Res. 2005, 65:7815-7823;.Shi, R. X.; Ong, C. N.; Shen, HM* Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Oncogene. 2004, 23:7712-7721.