个人简介

陈美婉，博士，副教授，博士生导师。国家自然科学基金优秀青年科学基金获得者。主要从事中药活性成分递送系统的研究，通过设计基于生物医用高分子的药物载体，提高中药活性成分递送效率并探索其在肿瘤治疗中的作用及机制。发表第一/通讯作者SCI论文共90多篇，成果发表于Advanced Materials、ACS Nano、Nano Letters 和 Biomaterials 等药剂学和生物材料领域的国际权威期刊。6篇论文入围“ESI高被引论文”。所有论文他引>2900次， H因子34。主持国家自然科学基金优秀青年科学基金项目、澳门科学技术发展基金和澳门大学基金等13项研究项目。参与5部中英文学术著作的编写和7项专利的申请。荣获第一/二/四届澳门特别行政区自然科学奖（2012/2014/2018）。担任Current Drug Delivery、Chinese Chemical Letters、Acta Pharmaceutica Sinica B 等期刊（青年）编委，世界中联中药药剂委员会第三届理事会常务理事兼副秘书长、中国生物材料学会生物医用高分子材料分会委员和中国医药生物技术协会纳米生物技术分会委员等。指导博硕士20多名：荣获1项第四届中国科协青年人才托举工程，1项第九届中国青少年科技创新奖、7项澳门研究生科研奖和30多项海内外会议奖励等。Academic QualificationsPhD Sun Yat-sen UniversityMSc Jinan UniversityTeachingMaster Courses: Systems Biology (CMED719), Pharmaceutical Science (CMED718)Ph.D. Courses: Pharmaceutical Engineering and Biomaterials Science (CMED812)

研究领域

主要从事中药活性成分递送系统的研究

Patents酸性当归多糖ASP3、酸性当归多糖-阿霉素共聚物纳米粒以及两者的制备方法和应用。申请号：201810900357.3基于聚氨基酸的药物体系及其制备方法与用途。申请号：201810723852.1一种阴道用纳米银靶向温敏喷雾凝胶及其制备方法。申请号： 200810029201.9一种妇女用温敏凝胶型纳米银泡沫气雾剂及其制备方法。专利号：ZL200910037397.0IC-4在抗血管新生中的应用。申请号：201210100743.7一种烟豆水提取物及其用途。申请号：201710386666.9烟豆或其提取物在制备治疗和/或预防关节炎的药物中的用途。申请号：201710386672.4

近期论文

Selected International Peer-reviewed Journal articles (*co-/corresponding author)1.MW Chen*, XZ Zhou, RE Chen, JL Wang, R D. Ye, CB Wu, R I. Mahato. Nano-carriers for Delivery and Targeting of Active Ingredients of Chinese Medicine for Hepatocellular Carcinoma Therapy. Materials Today, 2019, 25: 66-87. (IF: 24.372)2.TT Pan, C Yang, JY Shi, CX Hao, Y Qiao, JZ Li, MY Deng, YQ Tian*, MW Chen*. Dual pH and Oxygen Luminescent Nanoprobes Based on Graft Polymers for Extracellular Metabolism Monitoring and Intracellular Imaging. Sensors and Actuators B: Chemical, 2019, 291: 306-318. (IF: 6.393)3.Y Yang, WJ Zhu, LZ Feng, Y Chao, X Yi, ZL Dong, K Yang, WH Tan, Z Liu*, MW Chen*. G-quadruplex based Nanoscale coordination-polymers to modulate tumor hypoxia and achieve nuclear-targeted drug delivery for enhanced photodynamic therapy. Nano letters, 2018, 18 (11): 6867-6875. (IF: 12.279)4.Y Yang, LG Xu, WJ Zhu, LZ Feng, JJ Liu, Q Chen, ZL Dong, JY Zhao, Z Liu*, MW Chen*. One-pot synthesis of pH-responsive charge-switchable PEGylated nanoscale coordination polymers for improved cancer therapy. Biomaterials, 2018, 156: 121-133. (IF: 10.273)5.ZP Guo, L Lin, J Chen, XZ Zhou, HF Chan, XS Chen, HY Tian*, MW Chen*. Poly (ethylene glycol)-poly-L-glutamate complexed with polyethyleneimine-polyglycine for highly efficient gene delivery in vitro and in vivo. Biomaterials Science, 2018, 6(11): 3053-3062. (IF: 5.251)6.XJ Song, J Xu, C Liang, Y Chao, QT Jin, C Wang, MW Chen*, Z Liu*. Self-supplied tumor oxygenation through separated liposomal delivery of H2O2 and catalase for enhanced radio-immunotherapy of cancer. Nano letters, 2018, 18 (10): 6360-6368. (IF: 12.279)7.JM Zhang†, JJ Li†, Z Shi, Y Yang, X Xie, SMY Lee*, YT Wang, KW Leong, MW Chen*. pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities. Acta Biomaterialia, 2017, 58: 349-364. (IF: 6.638)8.LZ Feng, DL Tao, ZL Dong, Q Chen, Y Chao, Z Liu*, MW Chen*. Near-infrared light activation of quenched liposomal Ce6 for synergistic cancer phototherapy with effective skin protection. Biomaterials, 2017, 127: 13-24. (IF: 10.273)9.Y Yang, WJ Zhu, ZL Dong, Y Chao, L Xu*, MW Chen*, Z Liu*. 1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy. Advanced Materials, 2017, 29(40): 1703588. (IF: 25.809)10.YE Cai, JM Zhang, NG. Chen, Z Shi, JG Qiu, CW He, MW Chen*. Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins. Medicinal Research Reviews, 2017, 37(4): 665-701. (IF: 9.791)11.ZP Guo†, XZ Zhou†, MZ Xu, HY Tian, XS Chen, MW Chen*. Dimeric camptothecin-loaded RGD-modified targeted cationic polypeptide-based micelles with high drug loading capacity and redox-responsive drug release capability. Biomaterials Science, 2017, 5(12): 2501-2510. (IF: 5.251)12.LZ Feng, L Cheng, ZL Dong, DL Tao, TE Barnhart, WB Cai*, MW Chen*, Z Liu*. Theranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic Therapy. ACS Nano, 2017, 11(1): 927-937. (IF: 13.903)13.Y Yang, Y Chao, JJ Liu, ZL Dong, WW He, R Zhang, K Yang, MW Chen*, Z Liu*. Core-shell and co-doped nanoscale metal-organic particles (NMOPs) obtained via post-synthesis cation exchange for multimodal imaging and synergistic thermo-radiotherapy. NPG Asia Materials, 2017, 9: e344. (IF: 8.052)14.ZP Guo†, J Chen†, L Lin, XW Guan, PJ Sun, MW Chen*, HY Tian*, XS Chen*. pH Triggered Size Increasing Gene Carrier for Efficient Tumor Accumulation and Excellent Anti-tumor Effect. ACS Applied Materials & Interfaces, 2017, 9(18): 15297–15306. (IF: 8.456)15.GJ Song, RF Sun, JQ Du, MW Chen*, YQ Tian*. A highly selective, colorimetric, and environment-sensitive optical potassium ion sensor. ChemIcal Communication, 2017, 53(41): 5602-5605. (IF: 6.164)16.XS Zou†, TT Pan†, JP Jiang, G Li, C Song, RF Sun, ZY Yang, DZ Sun, CH Hou, MW Chen*, YQ Tian*. Poly(ε-caprolactone)-containing graft copolymers for ratiometric extracellular oxygen sensing. Sensors and Actuators B: Chemical, 2017, 248: 108-118. (IF: 6.393)17.Y Yang, JJ Liu, C Liang, LZ Feng, TT Fu, ZL Dong, Y Chao, YG Li, G Lu*, MW Chen*, Z Liu*. Nanoscale Metal-Organic Particles with Rapid Clearance for Magnetic Resonance Imaging-Guided Photothermal Therapy. ACS Nano, 2016, 10(2): 2774-2781. (IF: 903)18.LZ Feng, M Gao, DL Tao, Q Chen, HR Wang, ZL Dong, MW Chen*, Z Liu*. Cisplatin-Prodrug-Constructed Liposomes as a Versatile Theranostic Nanoplatform for Bimodal Imaging Guided Combination Cancer Therapy. Advanced Functional Materials, 2016, 26(13): 2207-2217. (IF: 15.621)19.Y Yang, JJ Liu, XQ Sun, LZ Feng, WW Zhu, Z Liu*, MW Chen*. Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures. Nano Research, 2016, 9(1): 139-148. (IF: 515)20.SP Wang, YQ Xu, HF Chan, HW Kim, YT Wang, KW Leong*, MW Chen*. Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy. Journal of Controlled Release, 2016, 240: 454-464. (IF: 7.901)21.QW Jiang†, MW Chen†, KJ Cheng, PZ Yu, X Wei, Z Shi*. Therapeutic potential of steroidal alkaloids in cancer and other diseases. Medicinal Research Reviews, 2016, 36(1): 119-143. (IF: 9.791)22.XJ Jia†, LS Ma†, P Li, MW Chen*, CW He*. Prospects of Poria cocos polysaccharides: isolation process, structural features and bioactivities. Trends in Food Science & Technology, 2016, 54: 52-62. (IF: 8.519)23.SP Wang†, JM Zhang†, YT Wang*, MW Chen*. Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy. Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12(2): 411-420. (IF: 5.57)24.JM Zhang, J Hu, HF Chan, M Skibba, G Liang*, MW Chen*. iRGD decorated lipid-polymer hybrid nanoparticles for targeted co-delivery of doxorubicin and sorafenib to enhance anti-hepatocellular carcinoma efficacy. Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12(5): 1303-1311. (IF: 5.57)25.FQ Chen†, JM Zhang†, Y He, XF Fang, YT Wang*, MW Chen*. Glycyrrhetinic acid-decorated and reduction-sensitive micelles to enhance the bioavailability and anti-hepatocellular carcinoma efficacy of tanshinone IIA. Biomaterials Science, 2016, 4(1): 167-182. (IF: 5.251)26.YP Li†, JM Zhang†, YZ Guo, MW Chen*, L Wang, RC Sun, XH Wang*. Cellulosic micelles as nanocapsules of liposoluble CdSe/ZnS quantum dots for bioimaging. Journal of Materials Chemistry B, 2016, 4(39): 6454-6461. (IF: 5.047)27.JM Zhang, RE Chen, XF Fang, FQ Chen, YT Wang*, MW Chen*. Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles for enhanced delivery and antitumor efficacy of paclitaxel. Nano Research, 2015, 8(1): 201-218. (IF: 8.515)28.FQ Chen†, JM Zhang†, L Wang, YT Wang*, MW Chen*. Tumor pHe-triggered charge-reversal and redox-responsive nanoparticles for docetaxel delivery in hepatocellular carcinoma treatment. Nanoscale, 2015, 7(38): 15763-15779. (IF: 6.97)29.SP Wang, JG Qiu, Z Shi*, YT Wang, MW Chen*. Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer. Biotechnology Advances, 2015, 33(1): 224-241. (IF: 12.831)30.Y Yang, T Liu, L Cheng, GS Song, Z Liu*, MW Chen*. MoS2-Based Nanoprobes for Detection of Silver Ions in Aqueous Solutions and Bacteria. ACS Applied Materials & Interfaces, 2015, 7(14): 7526-7533. (IF: 8.456)Book Chapters1.The chapter of “Novel nanoparticulate drug delivery systems for active ingredients of traditional Chinese medicine in cancer therapy” in the book ” Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology (First Edition)”, Taylor& Francis-CRC Press Publisher, 20182.《药物制剂工程（第三版）》第一章 绪论，化学工业出版社，20183.The chapter of “Preparation, self-assembly, and application of amphiphilic cellulose-based graft copolymers” in the book “Cellulose-Based Graft Copolymers: Structure and Chemistry”, Taylor& Francis-CRC Press Publisher, 20174.The chapter of “Novel formulations and drug delivery systems for phytotherapies” in the book “Phytotherapies: Efficacy, Safety and Regulation”, Wiley, USA, 20155.《中药抗肿瘤现代研究技术与进展》第一篇 第四章，人民卫生出版社，2012