个人简介
学习及工作简历：2014/07~至今，安徽大学，干细胞及转化医学研究中心，PI2011/07~2013/09，美国南加州大学，干细胞生物学，博士生联合培养2008/09~2014/07，复旦大学，生物化学与分子生物学，博士（硕博连读）2004/09~2008/09，安徽医科大学，生物技术，理学学士
研究领域
干细胞是能自我更新、高度增殖的一类细胞，可以进一步分化成为各种不同的组织细胞，干细胞研究及其转化应用为许多重大疾病的有效治疗提供了新的思路和工具，具有巨大的社会效益和经济效益。根据发育的阶段，干细胞分为胚胎干细胞和成体干细胞。本人主要的研究方向有：1. 胚胎干细胞自我更新及谱系定向分化的分子机制。2. 诱导多能性干细胞（iPS细胞）产生的分子机制及条件优化。
近期论文
1. Ye S, Zhang D, Cheng F, Wilson D, Mackay J, He K, Ban Q, Lv F, Huang S, Liu D, Ying QL. Wnt/β-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal. J Cell Sci. 2016，129(2):269-76. IF=5.432. Qiu D#, Ye S#, Ruiz B, Zhou X, Liu D, Zhang Q, Ying QL. Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency. Stem Cell Reports. 2015,5(3):314-22. (#并列共同第一作者). IF=5.373. Chen X, Ye S, Ying QL. Stem cell maintenance by manipulating signaling pathways: past, current and future. BMB Rep. 2015, 48(12):668-76. IF=2.604. Huang G#, Ye S#, Zhou X, Liu D, Ying QL. Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network. Cell Mol Life Sci. 2015, 72(9):1741-57. (#并列共同第一作者). IF=5.815. Ye S, Liu D, Ying QL. Signaling pathways in induced naïve pluripotency. Curr Opin Genet Dev. 2014, 28C:10-15. IF=7.576. Huang G, Yan H, Ye S, Tong C, Ying QL. STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ES cell fates. Stem Cells. 2014. 32(5):1149-60. IF=6.527. Ye S, Li P, Tong C, Ying QL. Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1. EMBO J. 2013,32(19):2548-60. IF=10.438. Kim H#, Wu J#, Ye S#, Tai CI, Zhou X, Yan H, Li P, Pera M, Ying QL. Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun. 2013,4:2403.( #并列共同第一作者). IF=11.479. Ye S, Tan L , Yang R, Fang B, Qu S, Schulze EN, Song H, Ying QL, Li P. Pleiotropy of glycogen synthase kinase 3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLos One. 2012;7(4):e35892. IF=3.2310. Lu J, Tan L, Li P, Gao H, Fang B, Ye S, Geng Z, Zheng P, Song H. All-trans retinoic acid promotes neural lineage entry by pluripotent embryonic stem cells via multiple pathways. BMC Cell Biol. 2009. 10:57. IF=2.34
