个人简介

安徽大学学士（2004）与硕士（2007），上海交通大学博士（2012），其间在军事医学科学院、国家人类基因组南方中心进行学习；以博士后和访问学者身份在美国Boston大学和MIT进行研究与访学。主持两项国家自然科学基金项目和省重点研发计划等若干省部级项目，作为核心成员承担国家973项目子课题和国自然面上项目各一项。在ME,mBio, NAR, AEM, AMB等领域内主流期刊发表SCI论文20余篇，授权发明专利10余项。应邀为Current Opinion Biotechnol, Microbial Biotechnol,Frontiers in Bioengineering and Biotechnology,科学通报等国内外数十种学术期刊审稿，受邀在第十届国际DNA和基因组活动周-合成生物产业分会、中日韩第六届A3前瞻计划“天然产物化学与合成生物学”国际学术研讨会等作报告；获中国生物工程学会年会青年优秀论文二等奖和中国微生物学会年会优秀学术交流奖等。

研究领域

微生物遗传与系统生物工程。从事微生物代谢调控新机制及合成生物技术等方面的研发工作，研究兴趣涉及放线菌次级代谢调控、功能组学与代谢工程、工业菌种开发等。

近期论文

Polyketide starter and extender units serve as regulatory ligands to coordinate the biosynthesis of antibiotics in actinomycetes. mBio. 2021, 12(5): e0229821. Uncovering and engineering mini-regulatory network of the TetR-family regulator SACE_0303 for yield improvement of erythromycin in Saccharopolyspora erythraea. Frontiers in Bioengineering and Biotechnology. 2021, 9: 692901. Joint engineering of SACE_Lrp and its target MarR enhances the biosynthesis and export of erythromycin in Saccharopolyspora erythraea. Appl Microbiol Biotechnol. 2021; 105(7):2911-2924. Transcriptional regulation of a Leucine-responsive regulatory protein for directly controlling lincomycin biosynthesis in Streptomyces lincolnensis. Appl Microbiol Biotechnol. 2020; 104(6): 2575-2587. Nick-seq for single-nucleotide resolution genomic maps of DNA modifications and damage. Nucleic Acids Res. 2020; 48(12): 6715-6725. TetR-type regulator SLCG_2919 is a negative regulator of lincomycin biosynthesis in Streptomyces lincolnensis. Appl Environ Microbiol. 2019; 85(1). pii: e02091-18. Transcriptome-guided target identification of the TetR-like regulator SACE_5754 and engineered overproduction of erythromycin in Saccharopolyspora erythraea. Journal of Biological Engineering. 2019. 24; 13: 11.Enhanced lincomycin production by co-overexpression of metK1 and metK2 in Streptomyces lincolnensis. J Ind Microbiol Biotechnol. 2018, 45(5): 345-355. Engineering of an Lrp family regulator SACE_Lrp improves erythromycin production in Saccharopolyspora erythraea. Metab Eng. 2017; 39: 29-37. 放线菌亮氨酸应答调控因子的生物学功能与调控机理。微生物学报，2020，60(7): 1335-1344.