个人简介

黄锦伟博士于 2006 年在香港大学取得化学博士学位，继而转往香港浸会大学中 医药学院担任博士后研究一职，并于 2009 年获晋升为研究助理教授，致力于抗 炎及抗癌研究。2011 年 9 月获聘任为澳门科技大学中药质量研究国家重点实验 室助理教授，并担任组学技术与创新药物研究中心副主任一职，在 2015 年更破 格升职为副教授。 黄锦伟博士的研究范畴主要在肿瘤分子生物学，化学分子生物学与结构活性关系， 以及 IKK-– NF-B 传递信号通路等。同时，黄博士也专注于研究细胞自体吞噬 与抗癌抗脑神经退化及对抗耐药耐凋亡等问题，如天然化合物的自噬抗癌抗炎功 效，天然小分子 SERCA 抑制剂及 AMPK 激活剂的抗耐药耐凋亡作用，人参总提取 物及其单一小分子衍生物的抗癌疗效，发现及剖析在 IKK-蛋白酶上最新的药靶 点等，并分别于多个国际期刊上发表超过 100 篇 SCI 研究文章。在现阶段，黄博 士专注于研究抗癌基因 p53 及 P-糖蛋白(P-gp)导致关节炎耐药等问题；同时亦发 掘更多中药小份子透过自体吞噬机制产生抗癌或抗脑神经退化的作用。黄博士亦 是 20 个国际专利拥有者之一。在 2013-2018 年间，分别荣获澳门中银学术研究 优秀奖、高等学校科学研究优秀成果奖自然科学奖一等奖(团体奖)、并先后获得 澳门特别行政区科学技术奖自然科学奖二等奖及一等奖(团体奖)。教学科目: 生物化学、现代生物科技、中药药理实验方法学、药理实验方法学、分子及生物学、临床药理学、药理学实验、生物化学及分子生物学、生物化学及分子生物学实验、中医学 / 生物医学专题项目之医学实验方法学历2006. 9 香港大学化学博士学位2002. 8 香港科技大学生物学硕士学位1999. 6 香港科技大学生物化学学士学位教学经验2015.7 –今 澳门科技大学中药质量研究国家重点实验室副教授2011.9 –2015.6 澳门科技大学中药质量研究国家重点实验室助理教授2009.10 – 2011.8 香港浸会大学中医药学院研究助理教授2006.12 – 2009.10 香港浸会大学中医药学院博士后研究员

研究领域

炎症及癌症、分子生物学、化学生物学

近期论文

1.Mohit K.Tiwari,†, Paolo Coghi,†, PrakharAgrawal,†, Bharti Rajesh K. Shyamlal, Li Jun Yang, Lalit Yadav, Yuzhong Peng, Richa Sharma, Dharmendra K. Yadav, Dinkar Sahal*, Vincent Kam Wai Wong*, Sandeep Chaudhary*. Design, Synthesis, Structure-Activity Relationship and Docking Studies of Novel Functionalized Arylvinyl-1,2,4-Trioxanes as Potent Antiplasmodial as well as Anticancer Agents. ChemMedChem. 2020 May 11. doi: 10.1002/cmdc.202000045. 2. Na-Na Tao; Zhen-Zhen Zhang; Ji-Hua Ren; Juan Zhang; Yu-Jiao Zhou; Vincent Kam Wai Wong; Betty Yuen Kwan Law; Sheng-Tao Cheng; Hong-Zhong Zhou; Wei-Xian Chen; Hong-Mei Xu; Juan Chen. Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3/p65 pathway. Cancer Letters. DOI: 10.1016/j.canlet.2020.03.028 3. Yu Zhong Peng, Li Jun Yang, Hang Hong Lo, Betty Yuen Kwan Law, Vincent Kam Wai Wong*. Tumor Therapeutic Modes (Chapter 7), ebook “New Nanomaterials and Techniques for Tumor-targeted Systems”. Editors: Huang,Rongqin, Wang, Yi (Eds.). Publisher: Springer Singapore; ISBN: 978-981-15-5158-1. 4. Zheng Li, HuixiaZhang,YanLi, Hongwei Chen, CaiyunWang,Vincent KamWai Wong, Zhihong Jiang and Wei Zhang. Phytotherapy using blueberry leaf polyphenols to alleviate non-alcoholic fatty liver disease through improving mitochondrial function and oxidative defense. Phytomedicine. 2020 Mar 18;69:153209.doi:10.1016/j.phymed.2020.153209. 5. BinTang, Hang Hong Lo,W.L.WendyHsiao, Cheng Lei, KaIn U,LuYu,Vincent Kam Wai Wong* and Betty Yuen Kwan Law*. Adjuvant Herbal Therapy for Targeting Susceptibility Genes to Kawasaki Disease: An Overview of Epidemiology, Pathogenesis, Diagnosis and Pharmacological Treatment of KawasakiDiseasePhytomedicine.https://doi.org/10.1016/j.phymed.2020.153208. 6. Ivan A. Yaremenko‡, Paolo Coghi‡, Parichat Prommana, Congling Qiu, Peter S. Radulov, Yuanqing Qu, Yulia Yu Belyakova, Enrico Zanforlin, Vladimir A. Kokorekin, Yuki Yu Jun Wu, Fabrice Fleury, Chairat Uthaipibull*, Vincent Kam Wai Wong*, andAlexander O. Terent’ev*. Synthetic peroxides promote apoptosis of cancer cells inhibiting of P-glycoprotein ABCB5. ChemMedChem.: 10.1002/cmdc.202000042,FrontCover 7. Yun Zhang*, Linlin Guo*, Betty Yuen Kwan Law, Xiaobo Liang, Ning Ma, Guofeng Xu, Xiaoyun Wang, Xiefang Yuan, Hongmei Tang, Qi Chen, Vincent Kam Wai Wong# and Xing Wang#. Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells. International Journal of MolecularMedicineDOI:10.3892/ijmm.2020.45398. Ni Zhang1, Hui Zhang1, Betty Yuen Kwan Law1, Ivo Ricardo De Seabra Rodrigues Dias1, Cong Ling Qiu1, Wu Zeng1, Hu Dan Pan1, Jin Yun Chen2, Yan Fu Bai3, Jing Lv4, Li Qun Qu1, Xi Chen1, Qi Huang1, Wei Zhang1, Li Jun Yang1, LuYu1,Yu Han1, Guo Xin Huang1, Hui Miao Wang1, Xiao Lei Sun1,Yun Zhang1, Hu Qiang He1, Wei Dan Luo1, Yao Xiao1, Jian Zhou5, Ting Xu2, Qing Chun Huang6, MinWu2, Zhi Sheng Huang3,Wei Liu4,Vincent KamWaiWong1*, Liang Liu1*. Sirtuin 5 Deficiency Increases the Severity in Rat with Adjuvant-Induced Arthritis. Cellular & Molecular Immunology. (2020). https://doi.org/10.1038/s41423-020-0380-4 9. Su-Wei Xu1,7, Betty Yuen Kwan Law1, Steven Li Qun Qu1, Sami Hamdoun1,2, Juan Chen3, Wei Zhang1, Jian-Ru Guo1, An-Guo Wu4, Simon Wing Fai Mok1, DavidWei Zhang1, Chenglai Xia5,Yoshikazu Sugimoto6,Thomas Efferth2*,Liang Liu1* and Vincent Kam Wai Wong1*. SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death andcollateral sensitivity in multidrug-resistant tumor cells. Pharmacological Research.153(2020)104660. 10.Jin-Feng Teng, Qi-Bing Mei, Xiao-Gang Zhou, Yong Tang, Wen-Qiao Qiu,Rui Xiong,Rong Pan,BettyYuen-Kwan Law,VincentKamWaiWong,Chong-LinYu. Feng Zhang, Jian-Ming Wu *, Da-Lian Qin *, An-Guo Wu *. Polyphyllin VI Induces Caspase 1-Mediated Pyroptosis viathe Induction,Cancers 2020,12,193; doi:10.3390/cancers12010193. 11.Simon Wing-Fai Mok#, Vincent Kam-Wai Wong#, Hang-Hong Lo, Ivo Ricardo de SeabraRodrigues Dias,ElaineLai-Han Leung, BettyYuen-Kwan Law* andLiang Liu*. Natural products-based polypharmacological modulation of the peripheral immune system for the treatment of neuropsychiatric disorders. Pharmacology & Therapeutics.https://doi.org/10.1016/j.pharmthera.2020.107480.12.Betty Yuen Kwan Lawa, Francesco Michelangelib,c, Yuan Qing Qua, Su-Wei Xud, Yu Hana, Simon Wing Fai Moka, Ivo Ricardo de Seabra Rodrigues Diasa, Masood-ul-Hassan Javede, Wai-Kit Chana, Wei-Wei Xuef, Xiao-Jun Yaoa,f, Wu Zenga, Hui Zhanga, Jing-Rong Wanga, Liang Liua* and Vincent Kam Wai Wonga*. Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers via ryanodine receptor and Ca2+ dependent mechanism. Scientific Reports. (2019) 9:20034 13.Imran Khan, Sabrina Pathan, XiaoAng Li, Wai Kit Leong, Wei Lin Liao, Vincent Kam WaiWong and W.L. Wendy Hsiao. Far infrared radiation induces changes in gut microbiota and activates host’s GPCRs in mice. Journal of Advanced Research(2019),doi:https://doi.org/10.1016/j.jare.2019.12.003 14.Fang Ren; Zhong-Wen Hu; Xiao Yang; Vincent K Wong; Hong-Yan Xu; Ji-Hua Ren; Shan Zhong; Xiao-Jiong Jia; Hui Jiang; Jie-Li Hu; Xue-Fei Cai; Wen-Lu Zhang; Fang-Long Yao; Hai-Bo Yu; Sheng-Tao Cheng; Hong-Zhong Zhou; Ai-Long Huang; Betty Y Law. Niacin analogue, 6-Aminonicotinamide, a novel inhibitor of hepatitis B virus and HBsAg secretion. EBioMedicine. 49 (2019), 232-24615.Sara Abdelfatah, Edmond Fleischer, Anette Klinger, Vincent Kam Wai Wong, Thomas Efferth. Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynthetic compounds. Investigational New Drugs 2019Mar15.doi:10.1007/s10637-019-00752-0. 16.Moses Andima*, Paolo Coghi, Li Jun Yang, Vincent Wong, Chrispus M Ngule, Matthias Heydenreich, Albert J Ndakala, Abiy Yenesew, Solomon Derese. Antiproliferative Activity of Secondary Metabolites from Zanthoxylum zanthoxyloides Lam: In vitro and in silico Studies. Pharmacogn. Commn. 2019; 10(1):44-51.17.Huqiang He, Betty Yuen Kwan Law, Ni Zhang, Congling Qiu, Yuanqing Qu, Anguo Wu, YU HAN, Qi Song, Wenlu Zheng, Yong Liu, Yanzheng He* and Vincent Kam Wai Wong*. Bavachin protects human aortic smooth muscle cells against β-glycerophosphate-mediated vascular calcification and apoptosis via activation of mTOR-dependent autophagy and suppression of Wnt signaling. Front.Pharmacol.,19December2019,https://doi.org/10.3389/fphar.2019.01427 18.Xiaolei Sun#1,2,3, Anguo Wu#1, 4, Betty Yuen Kwan Law1, Chaolin Liu2, Wu Zeng1, Alena Cong Ling Qiu1,Yu Han1, Yanzheng He2,3* & Vincent Kam Wai Wong1*. The active components derived from Penthorum chinense Pursh protect against oxidative-stressinducedvascularinjuryviaautophagyinduction.FreeRadicalBiology andMedicine.2019Nov2.pii:S0891-5849(19)31002-0. 19.Wu An-Guo*, Teng Jin-Feng*, Wong Vincent Kam-Wai*, Zhou Xiao-Gang, Qiu Wen-Qiao, Tang Yong, Wu Jian-Ming, Xiong Rui, Pan Rong, Wang Ying-Ling, Tang Bin, Ding Tian-Yi, Yu Lu, Zeng Wu, Qin Da-Lian# and Law Betty Yuen Kwan#. Novel Steroidal Saponin Isolated from Trillium tschonoskii Maxim. Exhibits Anti-Oxidative Effect via Autophagy Induction in cellular and Caenorhabditiselegansmodels.Phytomedicine.2019Sep16;65:153088.20.Teng Jinfeng, Qin Dalian, Mei Qibing, Qiu Wenqiao, Pan Rong, Xiong Rui, Zhao Ya, Betty Law, Vincent Kam Wai Wong, Tang Yong, Yu Chonglin, Jianming Wu, Feng Zhang and WuAn Gao. Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer. Pharmacology Research. 2019 Sep;147:104396. 21.Zhiyuan Zhu, Pingde Zhang, Ning Li, Karrie Mei-Yee Kiang,Yin Cheng, Vincent Wong and Gilberto Ka Kit Leung. Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells. BioMed ResearchInternational.2019Sep23;2019:2710693. 22.Yu Han1, Yuan Qing Qu1, Simon Wing Fai Mok1, Juan Chen2, Chenglai Xia3, Hu Qiang He1, Zheng Li1, Wei Zhang1, Cong Ling Qiu1, Liang Liu1*, Betty Yuen KwanLaw1* andVincentKamWaiWong1*.ANovelDrug ResistanceMechanism: Genetic loss of xeroderma pigmentosum complementation group C (XPC) enhances glycolysis-mediated drug resistance in DLD-1 colon cancer cells. FrontiersinPharmacology.2019Sep10;10:912.23.Daniel Buyinzaa, Li Jun Yang, Solomon Derese, Albert Ndakala, Paolo Coghi, Matthias Heydenreich, Vincent Kam Wai Wong, Heiko M. Möller, Abiy Yenesewa*. Cytotoxicity of Isoflavones from Millettia dura. Natural Product Research.Accepted 24.Vincent Kam Wai Wong#, Congling Qiu#, Su-Wei Xu#, Betty Yuen Kwan Law,Wu Zeng, Hui Wang, Francesco Michelangeli, Ivo Ricardo De Seabra Rodrigues Dias, Yu Han, Ni Zhang, Yuan Qing Qu, Tsz Wai Chan, Simon Wing Fai Mok, Xi Chen, Lu Yu, Hudan Pan, Sami Hamdoun, Thomas Efferth, Wen Jing Yu, Wei Zhang, Jian-Ru Guo, Yuesheng Xie, Riqiang Luo, Quan Jiang, Liang Liu*. Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats. Br J Pharmacol. 2019May23.doi:10.1111/bph.14718 25.Wan-Yu Lia, Hong-Zhong Zhou, Yao Chen, Xue-Fei Cai, Hua Tang, Ji-Hua Ren. Vincent Kam Wai Wong, Betty Yuen Kwan Law, Yong Chen, Sheng-Tao Cheng, Hai-Bo Yu, Hao-Yang Cai, Wei-Xian Chen, Ni Tang, Wen-Lu Zhang, Na-Na Tao, Qiu-Xia Yang, Fang Ren, Lin He, Hui Jiang, Ai-Long Huang, Juan Chen. NAD(P)H: quinone oxidoreductase 1 overexpression in Hepatocellular Carcinoma potentiates apoptosis evasion through regulating stabilization ofX-linked inhibitor of apoptosis protein. Cancer Letters. 2019 Jun 1;451:156-167. doi: 10.1016/j.canlet.2019.02.053. 26.Lu Yu, An-Guo Wu, Vincent Kam-Wai Wong, Da-Lian Qin, Bin Tang, Hui-Miao Wang, Qiong Wang*, Betty Yuen-Kwan Law*. The new application of UHPLC-DAD-TOF/MS in identification of inhibitors on β-amyloid fibrillation fromScutellaria baicalensis. Frontiers in Pharmacology. 2019 Mar 18;10:194. doi:10.3389/fphar.2019.00194. 27.Giovanni Ribaudo[a] §, Paolo Coghi[b] §, Enrico Zanforlin[a] §, Yuki Yu Jun Wu[b], Yu Han[b], Alena Congling Qiu[b], Betty Yuen Kwan Law[b], Giuseppe Zagotto*[a] and Vincent Kam Wai Wong*[b]. Semi-synthetic isoflavones as BACE-1 inhibitors againstAlzheimer’s disease. Bioorganic Chemistry. 2019 Mar 15;87:474-483.doi:10.1016/j.bioorg.2019.03.034.28.Xiaobo Zhou#, Yuan Qing Qu#, Zhiyuan Zheng, Betty Yuen Kwan Law, Simon Wing Fai Mok, Zhi-Hong Jiang*, Vincent Kam Wai Wong*, Li-Ping Bai*. Novel Dauricine Derivatives Suppress Cancer via Autophagy-dependent Cell Death. BioorganicChemistry.Volume83,March2019,Pages450-460. 29.SaraAbdelfatah1,Angela Berg2, Qi Huang3, Li JunYang3,Anette Klinger4, Henry J. Greten5, Edmond Fleischer4, Thorsten Berg2, Vincent K.W. Wong3, Thomas Efferth1*. MCC1019,ASelective Inhibitor of the Polo-Box Domain of Polo-Like Kinase 1 as Novel, Potent Anticancer Candidate. Acta Pharmaceutica Sinica B. https://doi.org/10.1016/j.apsb.2019.02.001. 30.Guodong Li, Joshua William Boyle, Chung-Nga Ko, Wu Zeng, Vincent Kam Wai Wong, Jian-Bo Wan, Philip Wai Hong Chan, Dik-Lung Ma and Chung-Hang Leung. Aurone derivatives as Vps34 inhibitors that modulate autophagy. Acta PharmaceuticaSinicaB.https://doi.org/10.1016/j.apsb.2019.01.016.31.Li Zhou, Ji‐Hua Ren, Sheng‐Tao Cheng, Hong‐Mei Xu, Wei‐Xian Chen, Da‐Peng Chen, Vincent Kam Wai Wong, Betty Yuen Kwan Law,Yi Liu, Xue‐Fei Cai, Hua Tang, Hai‐Bo Yu, Jie‐Li Hu,Yuan Hu, Hong‐Zhong Zhou, Fang Ren, Lin He, Zhong‐Wen Hu, Hui Jiang, Hong‐Yan Xu, Ai‐Long Huang#, Juan Chen#. A functional variant in UBE2L3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC3A protein. Hepatology. 2019Jan7.doi:10.1002/hep.3049732.YongxinQiu 1,*,YiDai 2,3,*, ChiZhang 1,*,YeYang 2,*,MingJin 2,*,WenqiShan 2, JianShen 1,Ming Lu 1,ZhaoyangTang 1,YutingWang 2, RuonanJiao 2,Yunwei Xia 2, Guangming Huang 1, Lihua Yang 1, Yuan Li 2, 3, , Jianping Zhang 1, , Vincent Kam Wai Wong 3, , and Zhihong Jiang 3 . Arsenic Trioxide Reverses the Chemoresistance in Hepatocellular Carcinoma: A Targeted Intervention of 14-3-3η/NF-κB Feedback Loop. Journal of Experimental & Clinical Cancer Research.2018Dec20;37(1):321.doi:10.1186/s13046-018-1005-y.33.Zheng Li†∥, Hui-Xia Zhang†∥, Yan Li†, Christopher Wai Kei Lam†, Cai-Yun Wang†,Wei-JiaZhang‡,VincentKamWaiWong†,Su-SengPang§,Mei-CunYao*‡, and Wei Zhang*†. Method for Quantification of Ribonucleotides and Deoxyribonucleotides in Human Cells Using (Trimethylsilyl)diazomethane Derivatization Followed by Liquid Chromatography-Tandem Mass Spectrometry. AnalChem.2018Dec11.doi:10.1021/acs.analchem.8b04281. 34.Guan-Jun Yang, Wanhe Wang, Simon Wing Fai Mok, Chun Wu, Betty Yuen Kwan Law, Xiang-Min Miao, Ke-Jia Wu, Hai-Jing Zhong, Chun-Yuen Wong, Vincent Kam Wai Wong*, Dik-Lung Ma,* and Chung-Hang Leung*. Selective inhibition of lysine-specific demethylase 5A (KDM5A) using a rhodium(III) complex for triple-negative breast cancer therapy. Angewandte Chemie InternationalEdition.2018Jul1.doi:10.1002/anie.201807305.35.Wenjing Yu,* Yuancai Xiang,* Guosong Luo, Xiaofang Zhao, Bin Xiao, Ying Cheng, Chunhong Feng, Chunyan Duan, Xianming Xia, Vincent Kam Wai Wong# and Rongyang Dai#. Salubrinal Enhances Doxorubicin Sensitivity in Human Cholangiocarcinoma Cells Through Promoting DNA Damage. Cancer Biotherapy and Radiopharmaceuticals. 2018 Jun 29. doi: 10.1089/cbr.2018.2447. 36.Simon Wing Fai Mok, Wu Zeng, Yuzhen Niu, Paolo Coghi, Yujun Wu, Wai Man Sin, Sio Ian Ng, Flora Gordillo-Martinez, Jia Ying Gao, Betty Yuen Kwan Law, Liang Liu* , Xiao Jun Yao* and Vincent Kam Wai Wong*. A Method for Rapid Screening of Anilide-containing AMPK Modulators Based on Computational Docking and Biological Validation. Frontiers in Pharmacology. 2018, 12 June doi:10.3389/fphar.2018.0071037.Ren JH, Hu JL, Cheng ST, Yu HB, Wong VKW, Law BYK, Yang YF, Huang Y, Liu Y, Chen WX, Cai XF, Tang H, Hu Y, Zhang WL, Liu X, Long QX, Zhou L, Tao NN, Zhou HZ, Yang QX, Ren F, He L, Gong R, Huang AL, Chen J. SIRT3 restricts HBV transcription and replication via epigenetic regulation of cccDNA involving SUV39H1 and SETD1A histone methyltransferases. Hepatology. 2018 Apr6.doi:10.1002/hep.29912. 38.Simon Wing Fai Mok, Betty Yuen Kwan Law, Vincent Kam Wai Wong* and Liang Liu* (2018). Immunotherapeutic approaches of rheumatoid arthritis and the implication on novel interventions for refractoriness, Immunotherapy, Dr. Seyyed Shamsadin Athari (Ed.), InTech, ISBN 978-953-51-6100-4. Accepted on 16-2-2018. 39.Paolo Coghi§, Ivan A. Yaremenko§, Parichat Prommana§, Peter S. Radulov, Mikhail A. Syroeshkin, Yu Jun Wu, Jia Ying Gao, Floria M. Gordillo, Simon Mok, Vincent Kam Wai Wong*, Chairat Uthaipibull*, and Alexander O. Terent’ev*. Novel peroxides as promising anticancer agents with unexpected depressedantimalarialactivity. ChemMedChem.2018May8;13(9):902-908. 40.Yuan Qing Qu*, Flora Gordillo-Martinez*, Betty Yuen Kwan Law, Yu Han, Anguo Wu, Wu Zeng, Simon Wing Fai Mok, Vincent Kam Wai Wong*, Renxiao Wang*. 2-aminoethoxydiphenylborane (2-APB) suppresses bortezomib (BZM)-induced protective autophagy and sensitizes the anti-tumor effect of BZM invivo.Celldeath&Disease.20189:361DOI10.1038/s41419-018-0397-0 41.Elaine Lai Han Leung1#, Lian Xiang Luo1#, Zhong Qiu Liu, Vincent Kam Wai Wong, Lin Lin Lu, Ying Xie, Ni Zhang, Yuan Qing Qu, Xing Xing Fan, Ying Li, Min Huang, Dai Kai Xiao, Jun Huang, Yan Ling Zhou, Jian Xing He, Jian Ding, Xiao Jun Yao*, David C. Ward*, and Liang Liu*. Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity. Cell death & Disease. 9, Article number: 216 (2018) doi:10.1038/s41419-017-0065-9. 42.Ivo Ricardo de Seabra Rodrigues Dias#, Simon Wing Fai Mok#, Flora Gordillo Martínez, Imran Khan, Wendy Wen Luen Hsiao, Betty Yuen Kwan Law, Vincent Kam Wai Wong* and Liang Liu*. The calcium-induced regulation in the molecular and transcriptional circuitry of human inflammatory response and autoimmunity. Frontiers in Pharmacology. 2018 Jan 8;8:962. doi: 10.3389/fphar.2017.00962. 43.Jianru Guo, Zheng Li, Caiyun Wang, Christopher Lam, Qianqian Chen, Weijia Zhang, Vincent Kam Wai Wong, Meicun Yao and Wei Zhang. Profiling of ribonucleotides and deoxyribonucleotides pools in response to DNA damage andrepair induced by methyl methanesulfonate in cancer and normal cells. Oncotarget.2017Oct4;8(60):101707-101719.44.Xiao Lei Sun, Betty Yuen Kwan Law, Ivo Ricardo de Seabra Rodrigues Dias, Simon Wing Fai Mok, Yan-zheng He*, Vincent Kam-Wai Wong*. Pathogenesis of thromboangiitis obliterans: Gene polymorphism and immunoregulation of human vascular endothelial cells. Atherosclerosis 2017 Aug 18. pii: S0021-9150(17)31231-5.doi:10.1016 45.Hideaki Tsuyoshi, Vincent Kam Wai Wong, Yu Han, Makoto Orisaka, Yoshio Yoshida, Benjamin K. Tsang. Saikosaponin-d, a Calcium Mobilizing Agent, Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin-induced Apoptosis by Facilitating Mitochondrial Fission and G2/M Arrest. Oncotarget. September 2017;DOI:10.18632/oncotarget.2107646.Betty Yuen Kwan Law#, Yuan Qing Qu#, Simon Wing Fai Mok, Hauwei Liu, Zeng Wu, Yu Han, Flora Gordillo-Martinez, Wai-Kit Chan, Keith Man-Chung Wong*, Vincent Kam Wai Wong*. New perspectives of cobalt tris(bipyridine) system: Anti-cancer effect and its collateral sensitivity towards multidrug-resistant (MDR)cancers.Oncotarget.2017Jul5.doi:10.18632/oncotarget.18991.) 47.Betty Yuen Kwan Law#, Simon Wing Fai Mok#, Juan Chen, Francesco Michelangeli, Zhi-Hong Jiang, Yu Han, Yuan Qing Qu, Alena Cong Ling Qiu, Su-WeiXu,Wei-WeiXue,Xiao-JunYao,JiaYingGao,Masood-ul-Hassan Javed, Paolo Coghi, Liang Liu* and Vincent Kam Wai Wong*. N-desmethyldauricine induces autophagic cell death in apoptosis-defective cells via Ca2+ mobilization. FrontiersinPharmacology.2017Jun16;8:388.doi:10.3389/fphar.2017.00388.48.Vincent Kam Wai Wong, Wu Zeng, Juan Chen, Xiao-Jun Yao, Elaine Lai-Han Leung, Qian Qian Wang, Pauline Chiu*, Ben C.B. Ko*, Betty Yuen-Kwan Law*. Tetrandrine, an activator of autophagy, induces autophagic cell death via PKC-α inhibition and mTOR-dependent mechanisms. Frontiers in Pharmacology. 2017 Jun8;8:351.doi:10.3389/fphar.2017.00351. 49.Onat Kadioglu, Betty Yuen Kwan Law, Simon Wing Fai Mok, Su-Wei Xu, Thomas Efferth*, Vincent Kam Wai Wong*. Mode of action analyses of neferine, a bisbenzylisoquinoline alkaloid of Lotus (Nelumbo nucifera) against multidrug-resistant tumor cells. Frontiers in Pharmacology 2017 May 5;8:238. doi:10.3389/fphar.2017.00238. 50.Tian-Shu Kang, Wanhe Wang, Hai-Jing Zhong, Zhen-Zhen Dong, Qi Huang, Simon Wing Fai Mok, Chung-Hang Leung*, Vincent Kam Wai Wong*, Dik-Lung Ma. An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-B. Cancer Letters. 2017 Jun 28;396:76-84.51.Vincent Kam-Wai Wong, Wu Zeng and Betty Yuen Kwan Law*. Perspective: Role of Autophagy in Neuroprotective Properties of Traditional Chinese Medicines. Journal of Neuroinfectious Diseases. 8: 239. doi:10.4172/2314-7326.1000239.52.Betty Yuen Kwan Law, Flora Gordillo-Martínez, Yuan Qing Qu, Ni Zhang, Su Wei Xu, Paolo Saul Coghi, Simon Wing Fai Mok, Jianru Guo, Wei Zhang, Elaine Lai Han Leung, Xing Xing Fan, An Guo Wu, Wai Kit Chan, Xiao Jun Yao, Jing Rong Wang, Liang Liu* and Vincent Kam Wai Wong*. Thalidezine, A Novel AMPK Activator, Eliminates Apoptosis-resistant Cancer Cells Through Energy-mediated Autophagic Cell Death. Oncotarget. 2017 May 2;8(18):30077-30091.53.An-Guo Wu*, Wu Zeng*, Vincent Kam-Wai Wong, Yi-Zhun Zhu, Amy C.Y. Lo, Liang Liu and Betty Yuen-Kwan Law. Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice. Pharmacological Research. Volume 115, January 2017, Pages 25–44 54.Betty Law Yuen Kwan and Vincent Wong Kam Wai* (2016). Autophagy in Multidrug-Resistant Cancers, Autophagy inCurrent Trends inCellularPhysiology and Pathology, Dr. Nikolai Gorbunov (Ed.), InTech, Available from: http://www.intechopen.com/books/autophagy-in-current-trends-in-cellular-physiol ogy-and-pathology/autophagy-in-multidrug-resistant-cancers 55.Vincent Kam-Wai Wong#, Betty Yuen-Kwan Law#, Xiao-Jun Yao, Xi Chen, Su Wei Xu, Liang Liu* and Elaine Lai-Han Leung*. Advanced research technology fordiscovery ofneweffective compounds from Chineseherbal medicineand their moleculartargets.PharmacologicalResearch.2016Sep;111:546-555. 56.Su-WeiXu,Betty YuenKwanLaw, Simon WingFai Mok, ElaineLai Han Leung, Xing Xing Fan, Paolo Saul Coghi, Wu Zeng, Chung-Hang Leung, Dik-Lung Ma, Liang Liu* and Vincent Kam Wai Wong*.Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol. Int J Oncol. 2016Aug3.doi:10.3892/ijo.2016.3644. 57.Betty Yuen Kwan Law, Simon Wing Fai Mok, An Guo Wu, Christopher Wai Kei Lam, Margaret Sum Yee Yu, Vincent Kam Wai Wong*. New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy. Molecules. 2016 Mar 17;21(3). pii: E359. doi: 10.3390/molecules21030359. 58.Klionsky DJ,,…….Betty Yuen Kwan Law,…Liang Liu,…Vincent Kam Wai Wong,…et al. Guidelines for the use and interpretation of assays for monitoring autophagy(3rdedition).Autophagy.2016Jan2;12(1):1-222.59.Betty Yuen Kwan Law, Simon Wing Fai Mok, Wai Kit Chan, Su Wei Xu, An Guo Wu, Xiao Jun Yao, Jing Rong Wang, Liang Liu* and Vincent Kam Wai Wong* Hernandezine, a Novel AMPK Activator Induces Autophagic Cell Death inDrug-resistantCancers.Oncotarget.2016Feb16;7(7):8090-104. 60.VincentKamWaiWong#,HangDong#, XuLiang#,LiPingBai,Zhi-HongJiang, YueGuo,TonyA.-NKong, RuiWang, RichardKinTingKam,BettyYuenKwan Law, Wendy Wen Luen Hsiao, Ka Man Chan, Jingrong Wang, Rick Wai Kit Chan, Jianru Guo, Wei Zhang, Feng Gen Yen, Hua Zhou, Elaine, Lai Han Leung, Zhiling Yu, Liang Liu*. Rh2E2, a Novel Metabolic Modulator, Specifically Suppresses Tumor Cell Growth by Inhibiting Energy-based Metabolism. Oncotarget. 2016 Jan 18. doi: 10.18632/oncotarget.6934. (# Authors with equal contribution).61.Ting Li#, Vincent Kam Wai Wong#, Zhi Hong Jiang, Shui Ping Jiang, Yan Liu, Ting Yu Wang, Xiao Jun Yao, Xiao Hui Su, Feng Gen Yan, Juan Liu, Elaine Lai-Han Leung, Xiao Qin Yi, Yuen Fan Wong, Hua Zhou*and Liang Liu*. Mutation of Cysteine 46 in IKK-beta Increases Inflammatory Responses. Oncotarget2015Oct13;6(31):31805-19.(#Authorswithequalcontribution)62.Vincent Kam Wai Wong, An Guo Wu, Jing Rong Wang, Liang Liu* and Betty Yuen-Kwan Law*. Neferine attenuates the protein level and toxicity of mutant huntingtin in PC-12 cells viainduction of autophagy.Molecules. 2015 Feb 18, 20, 3496-3514.学术书籍 1. BettyYuen-KwanLawandVincentKam-WaiWong*. Autophagy in Multidrug-Resistant Cancers, Autophagy in Current Trends in Cellular Physiology and Pathology, Dr. Nikolai Gorbunov (Ed.), InTech, Availablefrom: http://www.intechopen.com/books/autophagy-in-current-trends-in-cellular-physiol ogy-and-pathology/autophagy-in-multidrug-resistant-cancers Bookchapterin“Autophagy”ISBN978-953-51-4815-9.2. Simon Wing Fai Mok, Betty Yuen Kwan Law, Vincent Kam Wai Wong and LiangLiu* Immunotherapeutic approaches of rheumatoid arthritis and the implication on novel interventions for refractoriness, Immunotherapy, Dr. Seyyed Shamsadin Athari(Ed.), InTech,ISBN978-953-51-6100-4.Acceptedon16-2-2018.3. YuZhongPeng,LiJunYang,HangHongLo,BettyYuenKwanLaw,Vincent KamWaiWong*. Chapter7:TumorTherapeuticModes ebook“NewNanomaterialsandTechniquesforTumor-targetedSystems”. Editors:Huang,Rongqin,Wang,Yi(Eds.). Publisher:SpringerSingapore;ISBN:978-981-15-5158-1.