个人简介

Professor Jiye Cai, man, PhD, supervisor of doctoral students. 1962-1968 studied and graduated from Beijing University, Department of Physics;1983-1985, visiting scholar at Columbia University, Columbia Radiation laboratory; He finished his PhD degree from Chinese Academy of Sciences, supervised by professor George W Flynn and Songhao Liu;1992-1994 was senior visiting scholar at Stanford University, Department of Chemistry. He was a major contributor for high resolution, high speed and high sensitivity diode laser probe, and by using this new method, for the first time, obtained vibrationally and rotationally resolved dynamic spectrum of three atom molecule. He participated “hither to the most sophisticated experiment” in physical chemistry----impact parameter dependence of chemical reaction. He and his collaborator had published more than 100 SCI papers, and 6 patents and a book. He was invited to give talks at more than 10 universities and his papers were quoted more than 500 times by other researchers. He had finished 6 Chinese National Natural Science Foundations and Special Foundations by Chinese Department of Science and Technology. He has trained over 60 graduate students and many of them own Yilida Prize, Daheng Prize, Excellent Graduated Students of University of Science and Technology of China and South China Excellent Student Prize. Part of his research results have obtained First Grade Prize of Natural Science of Guangdong Province (1996), First Grade Prize of Guangdong High Education Bureau (1996) and First Grade Prize of Science and Technology Progress Award (2011). The research fields of professor Jiye Cai include bionanotechnology, single molecule in situ detection on cell membrane and cell ultrastructures, Quantum Dots marked bio-molecule distribution, and the effect and mechanism of Chinese medicine against cell ultrastructures, etc. Education: 1962.8-1968.7, Studied at Beijing University, Department of Physics 1983.8-1987.7, PhD, Chinese academy of Science Professional Chronology： 1979.1-1998.6 Chinese Academy of Sciences, Anhui Institute of Optics and Fine Mechanics, research associate, associate professor, professor, advisor of doctoral students 1983.9-1985.10 Columbia University, Columbia Radiation laboratory; Visiting Scholar 1992.9-1994.1 Stanford University, Department of Chemistry, Senior Visiting Scholar 1994.2-1994.12 UWO University, Chemical Physics Center, Visiting Professor 1998.7-now Jinan University, Department of Chemistry, Professor, Vice Dean of College of Life Science and Technology 2013-now State Key Laboratory for Quality Research in Chinese Medicine, Macau University of Science and Technology, Distinguished Professor Teaching Subjects: (1) Bionanotechnology (For PhD students) (2) Nanoscience and technology (For graduated students)

研究领域

(1) Bionanotechnology (2) Single molecule in situ detection on cell membrane (3) Cell ultrastructures

Inventor Patent Number Patent Name 1 蔡继业、汪晨熙 ZL01127891.9 离子质谱违禁物品探测装置、方法及用途 2 蔡继业、陈勇 ZL01114802.0 制备氧化铬超细粉的方法及其装置 3 蔡继业、丁佩贤 ZL91101750.X 激光多光子离解法制备氧化铬超细粉及其装置 4 王浩、蔡继业 ZL200710032492.2 一种进场光学显微镜探针的制备方法 5 王浩、蔡继业 ZL200710032481.8 一种白色发光二极管的封装方法 6 胡安斌、蔡继业 ZL03139762.X 胚胎干细胞定向诱导分化为肝细胞的方法 7 杨培慧、蔡继业 ZL200510101264.7 5-氟尿嘧啶/壳聚糖纳米载药微球的制备方法 8 银东脂、蔡继业 ZL200510086599.6 胚胎干细胞源性肝卵圆细胞的体外诱导和分离提纯培养方法 9 蔡继业、钟丽云 ZL91108839.3 激光高温超导开关 10 蔡继业、赵毅 ZL200610165456.9 珍珠小分子团水及其制作方法和应用 11 郭文跃、蔡继业 98225813.5 外触发出光延时稳定的固体激光器的调 Q 电源 12 蔡继业、曾谷城 ZL200510033977.4 用于检测转铁蛋白的免疫电极的制备方法 13 蔡继业、曾谷城 ZL200510033976.X 量子点-转铁蛋白探针标记肿瘤细胞的方法 14 蔡怀鸿、蔡继业 ZL200810220081 复合型硅壳结构的荧光纳米粒子及其制备方法 15 蔡怀鸿、蔡继业 ZL200810220084 复合型硅壳结构的荧光纳米探针及其制备方法和应用

近期论文

1) Huai-Hong Cai,Pei-Hui Yang, HuiWang, Lian-XiHuang, Shi-Xian Wu, Jiye Cai. Label-free oligonucleotide detection method based on a new L-cysteine- dihydroartemisinin complex electroactive indicator. Electrochemistry Communications. 2010, 12（10）:1294-1297. 2) MuWang, YuxiaRuan, XiaoboXing, QianChen, YuanPeng, JiyeCai. Curcumin induced nanoscale CD44 molecular redistribution and antigen–antibody interaction on HepG2 cell surface. Analytica Chimica Acta 2011, 697:83-89 3) Xiaofang Cai, Xiaoxi Yang, Jiye Cai, ShixianWu, Qian Chen.Atomic Force Microscope-Related Study Membrane-Associated Cytotoxicity in Human Pterygium Fibroblasts Induced by Mitomycin C. The Jornal of Physical Chemistry. 2010, 114(11):3833-3839. 4) Jiang Pi,Hua Jin, Jiye Cai, et al. Pathway of cytotoxicity induced by folic acid modified selenium nanoparticles in MCF-7 cells. Appl Microbiol Biotechnol (2013) 97:1051– 1062 5) Hua Jin, Jiang Pi, Jiye Cai, et al. BMP2 promotes migration and invasion of breast cancer cells via cytoskeletal reorganization and adhesion decrease: an AFM investigation Appl Microbiol Biotechnol (2012) 93:1715– 1723 6) Hua Jin, Jiang Pi, Xun Huang, Feicheng Huang,Wenxiang Shao, Shengpu Li, Yong Chen, Jiye Cai.BMP2 promotes migration and invasion of breast cancer cells via cytoskeletal reorganization and adhesion decrease: an AFM investigation. Appl Microbiol Biotechnol (2012) 93:1715–1723 7) Chen Y, Shao L, Ali Z, Cai J, Chen ZW. NSOM/QD-based nanoscale immunofluorescence imaging of antigen-specific T-cell receptor responses during an in vivo clonal V{gamma}2V{delta}2 T-cell expansion. Blood. 2008, 15;111 (8):4220-32. 8) Yueqin Qiu, Jianbo Chen, Hongying Liao, Yan Zhang, Hua Wang, Shaoyuan Li, Yanfen Luo, Danyun Fang, Guobao Li, Boping Zhou, Ling Shen, Crystal Y. Chen, Dan Huang, Jiye Cai, Kaiyuan Cao, Lifang Jiang, Gucheng Zeng, Zheng W Chen. Tim-3-expressing CD4+and CD8+T Cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions. PLoS Pathogens 8(11): e1002984. 9) Hua Jin, Peihui Yang, Jiye Cai, Jinhui Wang, Mei Liu. Photothermal effects of folate-conjugated Au nanorods on HepG2 cells. Appl Microbiol Biotechnol (2012) 94:1199–1208 10) Hua Jin, Xun Huang, Yong Chen, Hongxia Zhao, Hongyan Ye, Feicheng Huang, Xiaobo Xing, Jiye Cai. Photoinactivation effects of hematoporphyrin monomethyl ether on Gram-positive and -negative bacteria detected by atomic force microscopy. Appl Microbiol Biotechnol (2010) 88:761–770 11) Hua Jin, Xing Zhong, Zhiyong Wang, Xun Huang, Hongyan Ye, Shuyuan Ma, Yong Chen, Jiye Cai. Sonodynamic Effectsof Hematoporphyrin Monomethyl Ether on CNE-2 Cells Detected by Atomic Force Microscopy. Journal of Cellular Biochemistry 112:169–178 (2011) 12) H Zhao, H Jin, J Cai, S Ding. The process of collagen biomineralization observed by AFM in a model dual membrane diffusion system. Ultramicroscopy 110 (2010) 1306–1311 13) HuaJin, XingZhong, ZhiyongWang, XunHuang, HongyanYe, ShuyuanMa, YongChen, JiyeCai. Sonodynamic Effects of Hematoporphyrin Monomethyl EtheronCNE-2 Cells Detected by Atomic Force Microscopy. Journal of Cellular Biochemistry. 2011, 112:169–178. 14) Xiaofang Cai, Pengtao You, Jiye Cai, Xiaoxi Yang, QianChen, Feicheng Huang. ART-induced biophysical and biochemical alterations of Jurkat cell membrane. Micron. 2011,4:217-228. 15) JiananChen, Yin Pei, Zhengwei Chen, Jiye Cai. Quantum dot labeling based on near-field optical imaging of CD44 molecules. Micron. 2010, 41（3）:198-202 16) MuWang, YuxiaRuan, QianChen, ShengpuLi, QiulanWang, JiyeCai. Curcumin induced HepG2 cell apoptosis-associated mitochondrial membrane potential and intracellular free Ca2+ concentration. European Journal of Pharmacology. 2011, 650:41-47. 17) Wu, Yangzhe, Hu, Yi, Chen, Jianan, Cai, Jiye, He, Xianhui. Activation- induced Reorganization in Membrane Nanostructures and Alteration in Adhesion of CD4 + T Lymphocytes Exploited by AFM/LFM. CurrentNanoscience. 2011, 7(3):420-426. 18) Huai-Hong Cai, XingZhong, Pei-Hui Yang,WeiWei, Jianan Chen, Jiye Cai, Probing site-selective binding of rhodamine B to bovine serum albumin. Colloids and Surfaces A: Physicochem. Eng. Aspects. 2010, 372:35–40. 19) Hua Jin , Xiaobo Xing , Hongxia Zhao , Yong Chen, Xun Huang, Shuyuan Ma, Hongyan Ye , Jiye Cai. Detection of erythrocytes influenced by aging and type 2 diabetes using atomic force microscope. Biochemical and Biophysical Research Communications. 2010,391:1698–1702 20) Hu M, Chen J, Wang J, Wang X, Ma S, Cai J, Chen CY, Chen ZW. AFM- and NSOM-based Force Spectroscopy and Distribution Analysis of CD69 Molecules on Human CD4+ T Cell Membrane. Journal of Molecular Recognition. 2009, 22(6):516-520 21) Hua Jin, Hongxia Zhao, Xianxian Chen, Lina Ma, XunHuang, HongyanYe, JiyeCai. An easy method to detect the kinetics of CD44 antibody and its receptors on B16 cells using atomic force microscopy. Mol Biol Rep. 2010 1.875 22) Hua Jin, Shuyuan Ma, Bing Song, Lina Ma, Jiang Pi, Xianxian Chen, Yong Chen, AND Jiye Cai. Liposome Impaired the Adhesion and Spreading of HEK293 Cells: An AFM Study. Scanning. 2011, 33:1-6 23) XIE WeiLing, YANG PeiHui, ZENG Jin, WANG Hui, CAI HuaiHon, CAI JiYe. Visual characterization of targeted effect of holo- transferrin-tagged dihydroartemisinin on human breast cancer cells. 科学通报. 2010, 55(22):2390-2395. 24) Mou C, Chen L. Battle for Pluripotency: Derivation of Induced Pluripotent Stem Cells. Recent Patents on Regenerative Medicine. 2011, 1:123-130 25) Zhang Y, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells. Acta Biochim Biophys Sin. 2011,43(7)