个人简介

白丽萍博士于 2001年毕业于辽宁中医药大学，2004年于同校取得硕士学位。2008于香港浸会大学取得博士学位。2006年 10月至 2007年 1月期间，于日本大阪大学产业科学研究所做访问学者，主要从事苯并菲啶类生物碱与人端粒 G-四链体 DNA的相互作用研究。毕业后于香港浸会大学中医药学院进行博士后研究工作。2011年 9月受聘于澳门科技大学澳门药物及健康应用研究院，担任助理教授，于 2015年 7月被晋升为副教授。白博士的研究方向包括生物有机化学和天然药物化学。主要从事植物药中活性成分的提取分离，结构修饰及其与生物大分子（DNA, RNA, 多肽）的相互作用的机理研究。曾参与香港 31 种剧毒中药的显微鉴别研究工作。研究论文发表在 Organic Letters, European Journal of Medicinal Chemistry, Bioorganic Chemistry, International Journal of Molecular Sciences, Journal of Natural Products, RSC Advances, ChemBioChem, Analytical and Bioanalytical Chemistry和 Bioorganic & Medicinal Chemistry等国际学术刊物上。迄今，已获 17项国际专利授权（5项美国专利）。她的研究得到澳门科技发展基金和澳门基金会的资助。作为项目组成员，参与香港浸会大学基金，国家自然科学基金和广东省自然科学基金等项目。教学科目：中药化学；中药研究进展；中药化学选论；中药化学实验技术;学历2008.9 香港浸会大学哲学博士学位2004.7 辽宁中医药大学生药学硕士学位2001.7 辽宁中医药大学中药学（英语班,五年制）学士学位教学经验:2015.7-今 澳门科技大学药健院，副教授2011.9-2015.6 澳门科技大学药健院，助理教授2010.10-2011.8 香港浸会大学中医药学院，高级研究助理 2008.10-2010.9 香港浸会大学中医药学院，研究助理 2006.10-2007.1 日本大阪大学产业科学研究所，访问学者 2003.10-2005.4 香港浸会大学中医药学院，访问学者

研究领域

生物有机化学；天然药物化学

研究项目:1)2020.08-2023.08,新型 S1P1调节剂治疗特发性肺纤维化的创新药物研究，澳门科学技术发展基金与国家科技部联合科研资助项目0074/2019/AMJ，项目负责人2) 2020.04-2021.04, 抗新型冠状病毒肺炎的特效中药的研发，澳门科学技术发展基金项目0064/2020/A，项目负责人3) 2020.01-2023.01, 融合人工智能和多组学技术开展川贝母等六种中药的多维度质量控制研究，澳门科学技术发展基金重点研发项目0023/2019/AKP，子课题负责人4)2019.06-2022.06, 碱性鞘磷脂脂质体的构建及其用于 siRNA和化疗药物的联合递送研究，澳门科学技术发展基金0004/2019/A1，项目负责人5) 2014.01-2018.01, Calotropis 属药用植物中具有低氧诱导因子-1(HIF-1) 抑制活性的Cardenolide类成分研究, 澳门科学技术发展基金 056/2013/A2，项目负责人6)2012.06-2014.11, 共价键修饰 IKKβ的 Epoxide类中药化学成分的 GSH追踪分离及其抗炎活性评价,澳门科学技术发展基金 063/2011/A3 ，项目负责人7)2012.01-2012.12, ESI-TOF-MS和 MALDI-TOF-MS技术对黄烷醇和黄酮醇化合物与淀粉样多肽结合作用的比较研究,澳门基金会(#0205) ，项目负责人

近期论文

1) Xu, Ting; Zheng, Zhiyuan; Guo, Yong*; Bai, Li-Ping*. Semisynthesis of novel magnololbased Mannich base derivatives that suppress cancer cells via inducing autophagy. European JournalofMedicinalChemistry,2020,inpress. 2).Liu, Meixian; Li, Na; Zhang, Yida; Zheng, Zhiyuan; Zhuo, Yue; Sun,Baoqing; Bai,Li-Ping; Zhang, Mingming; Guo, Mingquan; Wu, Jianlin *. Characterization of Covalent Protein Modification by Triclosan in vivo and in vitro via Three-Dimensional Liquid Chromatography-Mass Spectrometry: New Insight into Its Adverse Effects. Environment International2020, 136,105423. 3).Wang,Zhihua;Wu,Wenbo;Guan,Xiangchen;Guo,Shuang;Li,Chaowen;Niu,Ruixue;Gao, Jie; Jiang, Min; Bai, Li-Ping; Leung, Elaine Laihan; Hou, Yuanyuan*; Jiang, Zhi-Hong*; Bai,Gang*. Multiomic analysis revealed 20(s)-protopanaxatriol promotes the binding of P53 and DNA to regulate the antitumornetwork. Acta Pharmaceutica Sinica B, 2020,10(6), 10201035. 4) Jin, Jing#*; Xue, Nina#; Liu, Yuan; Fu, Rong; Wang, Mingjin; Ji, Ming; Lai, Fangfang; Hu, Jinping; Wang, Xiaojian; Xiao, Qiong; Zhang, Xiaoying; Yin, Dali; Bai, Li-Ping; Chen, Liping *; Rao, Shuan *. A novel S1P1 modulatorIMMH002 ameliorates psoriasis in multiple animalmodels,ActaPharmaceuticaSinicaB,2020,10(2),276-288. 5) Chen, Qi; Liu, Juan; Zhuang, Yuxin; Bai, Li-Ping; Yuan, Qing; Zheng, Silin; Liao, Kangsheng; Khan,Md.Asaduzzaman;Wu,Qibiao;Luo, Cheng;Liu,Liang; Wang, Hui*;Li, Ting *. Identification ofan IKKβ inhibitorfor inhibition of inflammation in vivo and in vitro. PharmacologicalResearch,2019,149,104440.6) Zhou, X. B#.; Chen, L.#; Jiang, Z.-H.; Chen, X. Y.; Luo, P.*; Bai, L.-P.*, Synthesis of 21Alkylidenes and 21-Alkylol Analogues of Uscharin and Their Effects on Intracellular CalciuminCardiacCells.Chemistryselect2019,4(19),5512-5517. 7) Liu, X.; Yang, J.; Yao, X.; Yang, X.; Fu, J.; Bai, L.-P.; Liu, L.; Jiang, Z.-H. *; Zhu, G.-Y. *, Linderalides A-D, Disesquiterpenoids Geranylbenzofuranone Conjugates from Lindera aggregate.JOrgChem2019,84(12),8242-8247. 8) Liu,J.;Bai,L.-P.;Yang,F.;Yao,X.;Lei,K.;KeiLam,C.W.;Wu,Q.;Zhuang,Y.;Xiao,R.; Liao, K.; Kuok, H.; Li, T.*; Liu, L.*, Potent Antagonists of RORgammat, Cardenolides from Calotropis gigantea, Exhibit Discrepant Effects on the Differentiation of T LymphocyteSubsets.MolPharm2019,16(2),798-807. 9) Qin, H.-Y. *; Kou, J.-X.; Rao, Z.; Zhang, G.-Q.; Wang, X.-H.; Bai, L.-P.; Wei, Y.-H., Nacetyltransferase Activity Assay and Inhibitory Compounds Screening by Using Living Human Hepatoma HepaRG Cell Model. International Journal of Pharmacology 2019,15 (2), 229-237. 10)Fan, D.; Li, T.; Zheng, Z.; Zhu, G.-Y.; Yao, X.; Jiang, Z.-H.*; Bai, L.-P.*, Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii. J Nat Med 2019, 73 (1),23-33.11)Zhu, G.-Y.*; Yang, J.;Yao, X. J.; Yang, X.; Fu, J.;Liu, X.;Bai,L.-P.;Liu, L.; Jiang, Z.-H.*, (+/-)-Sativamides A and B, Two Pairs of Racemic Nor-Lignanamide Enantiomers from the FruitsofCannabissativa.JOrgChem2018,83(4),2376-2381.12)Zhou, X.#; Qu, Y. Q.#; Zheng, Z.; Law, B. Y. K.; Mok, S. W. F.; Jiang, Z.-H.*; Wong, V. K. W.*; Bai, L.-P.*, Novel dauricine derivatives suppress cancer via autophagy-dependent cell death.BioorgChem2018,83,450-460.13)Sun, B.; Liang, Z.; Xie, B. P.; Li, R. T.; Li, L. Z.; Jiang, Z.-H.; Bai, L.-P.; Chen, J. X.*, Fluorescence sensing platform based on ruthenium(II) complexes as high 3S (sensitivity, specificity, speed) and "on-off-on" sensors for the miR-185 detection. Talanta 2018, 179, 658-667. 14)Zhou, X. B.#; Chen, M.#; Zheng, Z. Y.; Zhu, G.-Y.; Jiang, Z.-H.*; Bai, L.-P.*, Synthesis and evaluation of novel 12-aryl berberine analogues with hypoxia-inducible factor-1 inhibitory activity. RSCAdvances2017,7(43),26921-26929.15)Yang, S. P.; Zhao, W.; Hu, P. P.; Wu, K. Y.; Jiang, Z.-H.; Bai, L.-P.; Li, M. M.; Chen, J. X., Lanthanum-Based Metal-Organic Frameworks for Specific Detection of Sudan Virus RNA Conservative Sequences down to Single-Base Mismatch. Inorg Chem 2017, 56 (24), 1488014887. 16)Sun, B.; Zhao, H. Q.; Xie, B. P.; Bai, L.-P.; Jiang, Z.-H.; Chen, J. X., Sequence-specific fluorometric recognition of HIV-1 ds-DNA with zwitterionic zinc(II)-carboxylate polymers. J InorgBiochem2017,176,17-23. 17)Qiu, G. H.; Lu, W. Z.; Hu, P. P.; Jiang, Z.-H.; Bai, L.-P.; Wang, T. R.; Li, M. M.; Chen, J.X.*, A metal-organic framework based PCR-free biosensor for the detection of gastric cancer associatedmicroRNAs.JInorgBiochem2017,177,138-142. 18)Fan, D.; Zhou, S.; Zheng, Z.; Zhu, G.-Y.; Yao, X.; Yang, M. R.; Jiang, Z.-H.; Bai, L.-P.*, New Abietane and Kaurane Type Diterpenoids from the Stems of Tripterygium regelii. Int J MolSci2017,18(1),147.19)Xie, B.-P.#; Qiu, G.-H.#; Hu, P.-P.; Liang, Z.; Liang, Y.-M.; Sun, B.; Bai,L.-P.; Jiang, Z.-H.; Chen, J.-X.*, Simultaneous detection of Dengue and Zika virus RNA sequences with a threedimensional Cu-based zwitterionic metal–organic framework, comparison of single and synchronousfluorescenceanalysis.SensorsandActuatorsB:Chemical2017,254,1133-1140.20)Yan, F.; Yang, F.; Wang, R.; Yao, X. J.; Bai, L.-P.; Zeng, X.; Huang, J.; Wong, V. K.; Lam, C. W.; Zhou, H.; Su, X.; Liu, J.; Li, T.*; Liu, L.*, Isoliquiritigenin suppresses human T Lymphocyte activation via covalently binding cysteine 46 of IkappaB kinase. Oncotarget 2017,8(21),34223-34235. 21)Wong, V. K. W.; Dong, H.; Liang, X.; Bai, L.-P.; Jiang, Z.-H.; Guo, Y.; Kong, A. N. T.; Wang, R.; Kam, R. K. T.; Law, B. Y. K.; Hsiao, W. W. L.; Chan, K. M.; Wang, J. R.; Chan, R. W. K.; Guo, J. R.; Zhang, W.; Yen, F. G.; Zhou, H.; Leung, E. L. H.; Yu, Z. L.; Liu, L.*, Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells.Oncotarget2016,7(9),9907-9924. 22)Wang, J. R.; Tong, T. T.; Yau, L. F.; Chen, C. Y.; Bai, L.-P.; Ma, J.; Hu, M.; Liu, L.; Jiang, Z.-H., Characterization of oxygenated metabolites of ginsenoside Rg1 in plasma and urine of rat.JChromatogrBAnalytTechnolBiomedLifeSci2016,1026,75-86. 23)Parhira, S.; Zhu, G.-Y.; Li, T.; Liu, L.; Bai, L.-P.*; Jiang, Z.-H.*, Inhibition of IKK-beta by epidioxysterolsfromtheflowersofCalotropisgigantea(Niujiaogua).ChinMed2016,11,9. 24)Parhira, S.; Zhu, G.-Y.; Chen, M.; Bai, L.-P.*; Jiang, Z.-H.*, Cardenolides from Calotropis gigantea as potent inhibitors of hypoxia-inducible factor-1 transcriptional activity. J Ethnopharmacol2016,194,930-936. 25)Li, J. X.; Sakata, A.; He, H. P.; Bai, L.-P.; Murata, A.; Dohno, C.; Nakatani, K.*, Naphthyridine-Benzoazaquinolone: Evaluation of a Tricyclic System for the Binding to (CAG)(n)RepeatDNAandRNA.Chemistry-anAsianJournal2016,11(13),1971-1981.26)Li, J. X.; Matsumoto, J.; Bai, L.-P.; Murata, A.; Dohno, C.; Nakatani, K.*, A Ligand That Targets CUG Trinucleotide Repeats. Chemistry-a European Journal 2016, 22 (42), 1488114889.27)Fan,D. S.;Zhu, G.-Y.; Li, T.;Jiang, Z.-H.*; Bai,L.-P.*, DimacrolideSesquiterpene Pyridine AlkaloidsfromtheStemsofTripterygiumregelii.Molecules2016,21(9),1146. 28)Fan,D. S.;Zhu,G.-Y.; Chen, M.;Xie,L. M.;Jiang,Z.-H.; Xu, L.; Bai,L.-P.*, Dihydro-betaagarofuran sesquiterpene polyesters isolated from the stems of Tripterygium regelii. Fitoterapia2016,112,1-8. 29)Fan, D. S.; Parhira, S.; Zhu, G.-Y.; Jiang, Z.-H.; Bai, L.-P.*, Triterpenoids from the stems of Tripterygiumregelii.Fitoterapia2016,113,69-73. 30)Chen, C. Y.; Bai,L.-P.; Ke, Z. F.; Liu, Y.; Wang, J. R.*; Jiang, Z.-H.*, G-Quadruplex DNAbinding quaternary alkaloids from Tylophora atrofolliculata. RSC Advances 2016, 6 (115), 114135-114142. 31)Wang, R.; Zhang, C. Y.; Bai, L.-P.; Pan, H. D.; Shu, L. M.; Kong, A. N. T.; Leung, E. L. H.; Liu, L.; Li, T.*, Flavonoids derived from liquorice suppress murinemacrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation. International Immunopharmacology2015,28(2),917-924. 32)J.-R. Wang, L.-F. Y., T.-T. Tong, Q.-T. Feng, L.-P. Bai, J. Ma, M. Hu, L. Liu, Z-H. Jiang*, Characterization of Oxygenated Metabolites of Ginsenoside Rb1 in Plasma and Urine of Rat. JournalofAgriculturalandFoodChemistry2015,63,2689-2700. 33)Zhu, G.-Y.; Yao, X. J.; Liu, L.; Bai, L.-P.*; Jiang, Z.-H.*, Alistonitrine A, a Caged Monoterpene Indole Alkaloid from Alstonia scholaris. Organic Letters 2014, 16 (4), 10801083.34)Zhu, G.-Y.; Chen, G. Y.; Liu, L.; Bai, L.-P.*; Jiang, Z.-H.*, C-17 Lactam-Bearing Limonoids from the Twigs and Leaves of Amoora tsangii. Journal of Natural Products 2014, 77(4),983-989.35)Zhu, G.-Y.; Bai,L.-P.; Liu, L.*; Jiang, Z.-H.*, Limonoids from the fruits of Melia toosendan andtheirNF-kappaBmodulatingactivities.Phytochemistry2014,107,175-181. 36)Yang, Z. F.#; Bai,L.-P.#; Huang, W. B.; Li, X. Z.; Zhao, S. S.; Zhong, N. S.*; Jiang, Z.-H.*,Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses andstructure-activityrelationshipanalysis.Fitoterapia2014,93,47-53. 37)Parhira, S.; Zhu, G.-Y.; Jiang, R. W.; Liu, L.; Bai, L.-P.*; Jiang, Z.-H.*, 2 '-Epi-uscharin from theLatex ofCalotropisgigantea withHIF-1 Inhibitory Activity. ScientificReports 2014, 4,4748. 38)Parhira, S.; Yang, Z. F.; Zhu, G.-Y.; Chen, Q. L.; Zhou, B. X.; Wang, Y. T.; Liu, L.; Bai, L.P.*; Jiang, Z.-H.*, In Vitro Anti-Influenza Virus Activities of a New Lignan Glycoside from theLatexofCalotropisgigantea.PlosOne2014,9(8),e104544. 39)Law, B. Y. K.; Chan, W. K.; Xu, S. W.; Wang, J. R.; Bai, L.-P.; Liu, L.; Wong, V. K. W., Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosisdefectivecells.ScientificReports2014,4. 40)Bai, L.-P.; Liu, J.; Han, L.; Ho, H. M.; Wang, R. X.; Jiang, Z.-H.*, Mass spectrometric studies on effects of counter ions of TMPyP4 on binding to human telomeric DNA and RNA G-quadruplexes.AnalyticalandBioanalyticalChemistry2014,406(22),5455-5463. 41)Bai, L.-P.; Hagihara, M.; Nakatani, K.; Jiang, Z.-H.*, Recognition of Chelerythrine to HumanTelomericDNAandRNAG-quadruplexes.ScientificReports2014,4,6767.42)Bai, L.-P.; Ho, H. M.; Ma, D. L.; Yang, H.; Fu, W. C.; Jiang, Z.-H.*, Aminoglycosylation Can Enhance the G-Quadruplex Binding Activity of Epigallocatechin. Plos One 2013, 8 (1), e53962. 43)Yang, W. G.; Wong, Y.; Ng, O. T. W.; Bai,L.-P.; Kwong, D. W. J.; Ke, Y.; Jiang, Z.-H.; Li, H. W.*; Yung, K. K. L.*; Wong, M. S.*, Inhibition of Beta-Amyloid Peptide Aggregation by Multifunctional Carbazole-Based Fluorophores. Angewandte Chemie-International Edition 2012,51(8),1804-1810. 44)He, H.;Bai,L.-P.;Jiang, Z.-H.*, Synthesisand humantelomeric G-quadruplex DNA-binding activity ofglucosaminosides ofshikonin/alkannin. Bioorganic& Medicinal Chemistry Letters 2012,22(4),1582-1586.45)Man, B. Y. W.; Chan, H. M.; Leung, C. H.; Chan, D. S. H.; Bai, L.-P.; Jiang, Z.-H.; Li, H. W.; Ma, D. L.*, Group 9 metal-based inhibitors of beta-amyloid (1-40) fibrillation as potentialtherapeuticagentsforAlzheimer'sdisease.ChemicalScience2011,2(5),917-921.46).Ma,D.L.;Kwan, M.H.T.;Chan, D.S.H.;Lee,P.;Yang,H.;Ma, V.P.Y.;Bai,L.-P.;Jiang, Z.-H.; Leung, C. H., Crystal violet as a fluorescent switch-on probe for i-motif: label-free DNA-basedlogicgate.Analyst2011,136(13),2692-2696. 47)Dong, H.#; Bai, L.-P.#; Wong, V. K. W.; Zhou, H.; Wang, J. R.; Liu, Y.; Jiang, Z.-H.*; Liu, L.*, The in Vitro Structure-Related Anti-Cancer Activity of Ginsenosides and Their Derivatives.Molecules2011,16(12),10619-10630. 48)Chan,D.S.H.;Yang,H.;Kwan,M.H.T.;Cheng, Z.;Lee,P.;Bai,L.-P.;Jiang,Z.-H.;Wong, C. Y.; Fong, W. F.; Leung, C. H.*; Ma, D. L.*, Structure-based optimization of FDAapproved drug methylene blue as a c-myc G-quadruplex DNA stabilizer. Biochimie 2011, 93 (6),1055-1064.49)Chu,C.;Xia,L.;Bai,L.-P.;Li, Q.;Li, P.;Chen,H.B.;Zhao,Z.Z.*,Authenticationofthe31 Species of Toxic and Potent Chinese Materia Medica by Light Microscopy, Part 3: Two Species of T/PCMM from Flowers and Their Common Adulterants. Microscopy Research andTechnique2009,72(6),454-463. 50)Xia, L.; Bai, L.-P.; Chu, C.; Li, P.; Jiang, Z.-H.; Zhao, Z. Z.*, Authentication of the 31 species of Toxic and Potent Chinese Materia Medica (T/PCMM) by microscopic technique, Part 2: Three species of seed T/PCMM. Microscopy Research and Technique 2008, 71 (4), 325-333. 51)Bai, L.-P.; Hagihara, M.; Jiang, Z.-H.*; Nakatani, K.*, Ligand Binding to Tandem G QuadruplexesfromHumanTelomericDNA.ChemBioChem2008,9(16),2583-2587.52)Bai, L.-P.; Cai, Z. W.; Zhao, Z. Z.; Nakatani, K.; Jiang, Z.-H.*, Site-specific binding of chelerythrine and sanguinarine to single pyrimidine bulges in hairpin DNA. Analytical and BioanalyticalChemistry2008,392(4),709-716. 53).Xia, L.; Bai,L.-P.;Yi, L.; Liu, B. B.;Chu,C.;Liang, Z. T.;Li, P.;Jiang,Z.-H.; Zhao,Z. Z.*, Authentication of the 31 species of toxic and potent chinese materia medica (T/PCMM) by microscopic technique, part 1: Three kinds of toxic and potent animal CMM. Microscopy ResearchandTechnique2007,70(11),960-968. 54)Long,Y.H.#;Bai,L.-P.#; Qin,Y.;Pang, J.Y.;Chen,W.H.;Cai,Z. W.;Xu,Z.L.;Jiang, Z.H., Spacer length and attaching position-dependent binding of synthesized protoberberinedimers to double-stranded DNA. Bioorganic & Medicinal Chemistry 2006, 14 (13), 46704676. 55)Bai, L.-P.; Zhao, Z. Z.; Cai, Z. W.; Jiang, Z.-H.*, DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine.Bioorganic&MedicinalChemistry2006,14(16),5439-5445. 56)Bai, L.-P.; Jiang, H.; Kang, T.; Zhang, H.; Jiang, Z.-H.; Zhao, Z.*, Pharmacognostical Evaluation of Arctii Fructus (5): Chemical Constituents from Fruits of Amorpha fruticosa L. Natural Medicines (The present journal name: Journal of Natural Medicines) 2004, 58, 275277.著作:1)白丽萍（助编）,《天然产物资源化学》,何兰姜志宏主编,科学出版社,北京,2008.2)白丽萍（编辑助理）,《百药鉴别》,赵中振、李应生主编,万里机构万里书店出版,香港, 2008.3)白丽萍（编辑助理）,《当代药用植物典》第一、二卷,赵中振、肖培根主编,香港赛马会中药研究院有限公司出版,香港,2006.4)白丽萍（编辑助理）,《香港容易混淆中药》,赵中振、李应生主编,香港中药联商会督印,香港,2005.