个人简介

EducationPh.D. Department of Biological Sciences, National University of Singapore (2007)M.Sc. Institute of Genetics and Cytology, Northeast Normal University, Changchun, China (2002)B.Sc. School of Life Science, Northeast Normal University, Changchun, China (1999)Positions2015.1-present Assistant Professor, Faculty of Health Sciences, University of Macau2013.4-2014.12 Senior Scientist /Team Leader, Vela Diagnostics, Singapore2012.1-2013.3 Scientist, Vela Diagnostics, Singapore2009.9-2011.12 Research Fellow, Novartis Institute for Tropical Diseases, Singapore2008.3-2009.8 Research Fellow, Dept. of Microbiology and Molecular Genetics, Harvard Medical School, USA

研究领域

Mechanism of bacterial deathThe crisis of antibiotics resistance calls for urgent actions to develop new antibiotics. One efficient way to achieve this goal is to understand how the current antibiotics act on bacteria and how bacteria respond to antibiotic killing as well as how bacteria develop antibiotic resistance. Such effort could lead to the identification of novel candidates as a target for new chemical identities with novel mode of action. With Acinetobacter baumannii and Escherichia coli as the model microorganisms, we employ a diverse toolkit, including genetics, biochemical, chemical genetic and metabolomic profiling, for key factors leading to bacterial tolerance to antibiotic killing. Our goal is to identify new targets for the development of more effective chemotherapies.Bacterial pathogenesisWe attempt to understand the molecular mechanism that bacterial pathogens use to attack and exploit hosts. Currently we mainly focus on type VI secretion system (T6SS), a complex molecular nanomachine for translocation of effector proteins to eukaryotic cells or prokaryotic competitors. With Vibrio parahaemolyticus as a model, we are dedicating to the role of T6SSs during bacterial survival and infection as well as the underlying mechanism of action of the effectors.Development of new antibacterialsWe look for new antibacterial reagent for resistant bacterial pathogens and are interested in multi-discipline collaborations.

近期论文

Zou, J., Kou, S. H., Xie, R. Q., VanNieuwenhze, M. S., Qu, J. X., Peng, B., and Zheng, J. (2020) Non-Walled Spherical Acinetobacter Baumannii Is an Important Type of Persisters Upon Beta-Lactam Antibiotics Treatment. Emerg Microbes Infect 9 (1), 1149-1159Zheng, J. (2020) SARS-CoV-2: An Emerging Coronavirus That Causes a Global Threat. Int J Biol Sci 16 (10), 1678-1685Zhang, W. W., Xie, R. Q., Zhang, X. H. D., Lee, L., Zhang, H. J., Yang, M. H., Peng, B., and Zheng, J. (2020) Organism Dual RNA-Seq Reveals the Importance of BarA/UvrY in Vibrio Parahaemolyticus Virulence. Faseb JJiang, M., Yang, L. F., Chen, Z. G., Lai, S. S., Zheng, J., and Peng, B. (2020) Exogenous Maltose Enhances Zebrafish Immunity to Levofloxacin-Resistant Vibrio Alginolyticus. Microb Biotechnol 13 (4), 1213-1227Ji, X., Zou, J., Peng, H. B., Stolle, A.-S., Xie, R. Q., Zhang, H. J., Peng, B., Mekalanos, J. J., and Zheng, J. (2019) Alarmone Ap4A Is Elevated by Aminoglycoside Antibiotics and Enhances Their Bactericidal Activity. P Natl Acad Sci Usa 116 (19), 9578-9585Zou, J., Zhang, W. W., Zhang, H. J., Zhang, X. H. D., Peng, B., and Zheng, J. (2018) Studies on Aminoglycoside Susceptibility Identify a Novel Function of KsgA to Secure Translational Fidelity During Antibiotic Stress. Antimicrob Agents Ch 62 (10), e00853-00818Zhang, Y. C., Faucher, F., Zhang, W. W., Wang, S., Neville, N., Poole, K., Zheng, J., and Jia, Z. C. (2018) Structure-Guided Disruption of the Pseudopilus Tip Complex Inhibits the Type II Secretion in Pseudomonas Aeruginosa. Plos Pathog 14 (10), e1007343Ye, J.-Z., Su, Y.-B., Lin, X.-M., Lai, S.-S., Li, W.-X., Ali, F., Zheng, J., and Peng, B. (2018) Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis. Front Microbiol 9, 29Ye, J. Z., Lin, X. M., Cheng, Z. X., Su, Y. B., Li, W. X., Ali, F. M., Zheng, J., and Peng, B. (2018) Identification and Efficacy of Glycine, Serine and Threonine Metabolism in Potentiating Kanamycin-Mediated Killing of Edwardsiella Piscicida. J Proteomics 183, 34-44Xie, R. Q., Zhang, X. H. D., Zhao, Q., Peng, B., and Zheng, J. (2018) Analysis of Global Prevalence of Antibiotic Resistance in Acinetobacter Baumannii Infections Disclosed a Faster Increase in OECD Countries. Emerg Microbes Infect 7 (1), 31Wang, S., Li, Z., Liu, Y., Feng, G., Zheng, J., Yuan, Z., and Zhang, X. (2018) Activatable Photoacoustic and Fluorescent Probe of Nitric Oxide for Cellular and in Vivo Imaging. Sensors and Actuators B: Chemical 267, 403-411Gao, D. Y., Ji, X., Wang, J. L., Wang, Y. T., Li, D. L., Liu, Y. B., Chang, K. W., Qu, J. L., Zheng, J., and Yuan, Z. (2018) Engineering a Protein-Based Nanoplatform as an Antibacterial Agent for Light Activated Dual-Modal Photothermal and Photodynamic Therapy of Infection in Both the NIR I and II Windows. J Mater Chem B 6 (5), 732-739Li, S. K., Jiang, N., Zhao, W. X., Ding, Y. F., Zheng, Y., Wang, L. H., Zheng, J., and Wang, R. B. (2017) An Eco-Friendly in Situ Activatable Antibiotic Via Cucurbit[8]Uril-Mediated Supramolecular Crosslinking of Branched Polyethylenimine. Chem Commun 53 (43), 5870-5873Kuok, K. I., In Ng, P. C., Ji, X., Wang, C. M., Yew, W. W., Chan, D., Zheng, J., Lee, S., and Wang, R. B. (2017) Supramolecular Strategy for Reducing the Cardiotoxicity of Bedaquiline without Compromising Its Antimycobacterial Efficacy. Food Chem Toxicol 119, 425-429Zhang, M., Kong, X., Zheng, J., Wan, J. B., Wang, Y., Hu, Y., and Shao, R. (2016) Research and Development of Antibiotics: Insights from Patents and Citation Network. Expert Opin Ther Pat 26 (5), 617-627Moradigaravand, D., Grandjean, L., Martinez, E., Li, H., Zheng, J., Coronel, J., Moore, D., Torok, M. E., Sintchenko, V., Huang, H., Javid, B., Parkhill, J., Peacock, S. J., and Koser, C. U. (2016) dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium Tuberculosis Beijing Strains. Antimicrob Agents Chemother 60 (6), 3864-3867Li, S., Chan, J. Y., Li, Y., Bardelang, D., Zheng, J., Yew, W. W., Chan, D. P., Lee, S. M., and Wang, R. (2016) Complexation of Clofazimine by Macrocyclic Cucurbit[7]Uril Reduced Its Cardiotoxicity without Affecting the Antimycobacterial Efficacy. Org Biomol Chem 14 (31), 7563-7569Zheng, J., Rubin, E. J., Bifani, P., Mathys, V., Lim, V., Au, M., Jang, J., Nam, J., Dick, T., Walker, J. R., Pethe, K., and Camacho, L. R. (2013) para-Aminosalicylic Acid Is a Prodrug Targeting Dihydrofolate Reductase in Mycobacterium Tuberculosis. J Biol Chem 288 (32), 23447-23456Mak, P. A., Rao, S. P., Ping Tan, M., Lin, X., Chyba, J., Tay, J., Ng, S. H., Tan, B. H., Cherian, J., Duraiswamy, J., Bifani, P., Lim, V., Lee, B. H., Ling Ma, N., Beer, D., Thayalan, P., Kuhen, K., Chatterjee, A., Supek, F., Glynne, R., Zheng, J., Boshoff, H. I., Barry, C. E., 3rd, Dick, T., Pethe, K., and Camacho, L. R. (2012) A High-Throughput Screen to Identify Inhibitors of ATP Homeostasis in Non-Replicating Mycobacterium Tuberculosis. Acs Chem Biol 7 (7), 1190-1197Zheng, J., Ho, B., and Mekalanos, J. J. (2011) Genetic Analysis of Anti-Amoebae and Anti-Bacterial Activities of the Type VI Secretion System in Vibrio Cholerae. PLoS One 6 (8), e23876