个人简介

Academic QualificationsB.Sc., Peking UniversityM.Phil., The Chinese University of Hong KongPh.D., The Chinese University of Hong KongVisiting Fellow, University of Cambridge, 2016TeachingPh.D Course: Advanced Pharmaceutics (CMED 805)M.Sc. Courses: Pharmaceutical Science (CMED 718)Biostatistics (CMED 7018)

研究领域

Formulation study on poorly-water soluble APIs (BCS II & IV) in Chinese Medicine, e.g. nanocrystals, nanoemulsions, , solid dispersion etc.;Topical delivery of poorly-water soluble drugs to treat psoriasis;Study transport and integrity of particles across biological barriers on normal and disease models, e.g. Intestinal barrier, blood brain barrier, skin barrier etc.;Crystal engineering on APIs in Chinese Medicine, e.g. polymorphism, cocrystals;TCM product development

近期论文

Publications in the recent 5 years (*corresponding author):Yuan He, Yingmin Liang , Judith Choi Wo Mak, Yonghong Liao, Ting Li, Ru Yan, Hai-Feng Li, Ying Zheng*. Size effect of curcumin nanocrystals on dissolution, airway mucosa penetration, lung tissue distribution and absorption by pulmonary delivery. Colloids and Surfaces B: Biointerfaces (in press).Tongkai Chen, Bing He, Jingsong Tao, Yuan He, Hailiang Deng, Xueqing Wang, Ying Zheng*. Application of Förster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines. Advanced drug delivery reviews, 2019 Mar;143:177-205 (Invited Review).Yuan He, Yingmin Liang, RunHan, Wan-Liang Lu, Judith Choi WoMak*, YingZheng*. Rational particle design to overcome pulmonary barriers for obstructive lung diseases therapy. Journal of Controlled Release, 2019 Nov;314:48-61 (Review).Li-Min Mu, Lei Liu, Rui Liu, Jia-Lun Duan, Shuang Ma, Xue-Qi Li, Yi-Nuo Cui, Zhan-Bo Su, Xiao Zhang, Jian-Xing Hu, Ying Xie, Ying Zheng & Wan-Liang Lu. Development of functional dendrisomes based on a single molecule of polyesterbenzylether dendrimer and their application in cancer stem cell therapy. NPG Asia Materials, 2019 Jul;11(1):34.Shikang Meng, Lin Sun, Lun Wang, Zibei Lin, Zeyu Liu, Long Xi, Zhenping Wang, Ying Zheng*. Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity. Colloids and Surfaces B: Biointerfaces, 2019 Oct;182:110352.Jinsong Tao, Shing Fung Chow, Ying Zheng*. Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles. Acta Pharmaceutica Sinica B, 2019 Jan;9:4-18 (Invited review).Zhengzheng Zhou, Mónica Calatayud*, Julia Contreras-García, Liang Li, Henry HY Tong, Ying Zheng*. X-ray Diffraction and Theoretical Calculation-Supported Formation of Polymorphic Cocrystals Discovered through Thermal Methods: A Case Study. Journal of Pharmaceutical Sciences, 2019 Oct;108:3340-3347.Shikang Meng, Zibei Lin, Yan Wang, Zhenping Wang, Ping Li, Ying Zheng*. Psoriasis therapy by Chinese medicine and modern agents. Chinese Medicine, 2018 Dec;13(1):16 (Invited review).Xiaoning Song, Rui Li, Hailiang Deng, Ye Li, Yanan Cui, Hua Zhang, Wenbing Dai, Bing He, Ying Zheng, Xueqing Wang, Qiang Zhang. Receptor mediated transcytosis in biological barrier: The influence of receptor character and their ligand density on the transmembrane pathway of active-targeting nanocarriers. Biomaterials, 2018 Oct;180:78-90.Lin Sun, Zeyu Liu, Zibei Lin, Dongmei Cun, Henry HY Tong, Ru Yan, Ruibing Wang, Ying Zheng*. Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles. International journal of nanomedicine, 2018 Sep;13: 5625.Liandi Chi, Lingxiao Chen, Jiwen Zhang, Jing Zhao, Shaoping Li, Ying Zheng*. Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis. Journal of pharmaceutical and biomedical analysis, 2018 Jul;156: 125-132.Ye Li, Tongkai Chen, Xiaoqing Miao, Xiang Yi, Xueqing Wang, Haitao Zhao, Simon Ming-Yuen Lee, Ying Zheng*. Zebrafish: a promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier. Pharmacological Research, 2017 Nov; 125: 246-257 (Review).Ye Li, Xiaoning Song, Xiang Yi, Ruibing Wang, Simon Ming-Yuen Lee, Xueqing Wang*, Ying Zheng*. Zebrafish: a visual model to evaluate the biofate of transferrin receptor-targeted 7peptide-decorated coumarin 6 micelles. ACS Applied Materials & Interfaces, 2017 Nov 8;9(44):39048-39058.Tongkai Chen, Ye Li, Chuwen Li, Xiang Yi, Ruibing Wang, Simon Ming-Yuen Lee, Ying Zheng*. Pluronic P85/F68 Micelles of Baicalein Could Interfere with Mitochondria to Overcome MRP2-Mediated Efflux and Offer Improved Anti-Parkinsonian Activity. Molecular Pharmaceutics. 2017 Oct 2;14(10):3331-3342.Tongkai Chen, Jian Li, Ting Chen, Changquan Calvin Sun*, Ying Zheng*. Tablets of Multi-Unit Pellet System for Controlled Drug Delivery. J Control Release. 2017 Jul 31;262:222-231 (Review).Ye Li, Xiaoqing Miao, Tongkai Chen, Xiang Yi, Ruibing Wang, Haitao Zhao, Simon Ming-Yuen Lee, Xueqing Wang, Ying Zheng*. Zebrafish as a visual and dynamic model to study transport of nanosized drug delivery systems across the biological barriers. Colloids and Surfaces B: Biointerfaces. 2017 Aug;156:227-235,.Lin Sun, Zeyu Liu, Lun Wang, Dongmei Cun, Henry HY Tong, Ru Yan, Xin Chen, Ruibing Wang, Ying Zheng*. Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel. Journal of Controlled Release. 2017 May; 254:44-54.Tongkai Chen, Chuwen Li, Ye Li, Xiang Yi, Ruibing Wang, Simon Ming-Yuen Lee, Ying Zheng*. Small-sized mPEG-PLGA Nanoparticles of Schisantherin A with Sustained Release for Enhanced Brain Uptake and Anti-Parkinsonian Activity. ACS Applied Materials & Interfaces. 2017 Mar;9(11):9516-9527.Chao Bi, Xiao Qing Miao, Sing Fung Chow, Wen Jin Wu, Ru Yan, YH Liao, Albert Hee-Lum Chow, Ying Zheng*. Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution. Nanomedicine: Nanotechnology, Biology and Medicine 2017 Apr;13(3):943–953Tongkai Chen, Chuwen Li, Ye Li, Xiang Yi, Simon Ming-Yuen Lee, Ying Zheng*. Oral Delivery of a Nanocrystal Formulation of Schisantherin A with Improved Bioavailability and Brain Delivery for the Treatment of Parkinson’s Disease. Molecular Pharmaceutics 2016 Oct;13(11):3864–3875.Zhengzheng Zhou, Wanying Li, Wei-Jhe Sun, Tongbu Lu, Henry H. Y. Tong, Changquan Calvin Sun*, Ying Zheng*. Resveratrol Cocrystals with Enhanced Solubility and Tabletability. International Journal of Pharmaceutics, 2016 Jul;509:391-9.Xiaoqing Miao, Ye Li, Xueqing Wang, Simon MY Lee, Ying Zheng*. Transport Mechanism of Coumarin 6 Nanocrystal In MDCKII Monolayer and Larval Zebrafish. ACS Applied Materials & Interfaces, 2016, 8(20):12620-30.Zhengzheng Zhou, Hok Man Chan, Herman H. Y. Sung, Henry H. Y. Tong*, Ying Zheng*. Identification of New Cocrystal Systems with Stoichiometric Diversity of Salicylic Acid Using Thermal Methods. Pharm. Res. 2016; 33(4):1030-9 (cover page).Chen Chen, Lisha Wang, Fangrui Cao, Xiaoqing Miao, Tongkai Chen, Qi Chang, Ying Zheng*. Formulation of 20(S)-protopanaxadiol nanocrystals to improve oral bioavailability and brain delivery. Int. J. Pharm. 2016; 497:239-47.Lu Wang, Yafang Wang, Xueqing Wang, Lin Sun, Zhengzheng Zhou, Jinjian Lu*, Ying Zheng*. Encapsulation of Low Lipophilic and Slightly Water-Soluble Dihydroartemisinin in PLGA Nanoparticles with Phospholipid to Enhance Encapsulation Efficiency and In vitro Bioactivity. J. Microencapsulation 2015 Dec 1:1-10.Miao Xiaoqing, Zhou Jing, Li Jian, Liao Yonghong*, Zheng Ying*, Chinese Medicine in Inhalation Therapy: A Review of Clinical Application and Formulation Development. Current Pharmaceutical Design 2015;21(27):3917-31 (Invited review).Yancai Wang, Ju Song, Shing Fung Chow, Albert H. L. Chow* Ying Zheng*. Particle size tailoring of ursolic acid nanosuspensions for improved anticancer activity by controlled antisolvent precipitation. Int. J. Pharm. 2015 Oct 15;494(1):479-89.Xiaoqing Miao, Ye Li, Ian Wyman, Simon M. Y. Lee, Donal H. Macartney, Ying Zheng* and Ruibing Wang*. Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of curubituril. Med Chem Commun June 2015 6:1370-1374.Sun Lin, Liu Zeyu, Cun Dongmei, Henry Tong HY, Zheng Ying*. Application of Nano- and Micro-particles on the Topical Therapy of Skin-related Immune Disorders. Current Pharmaceutical Design 2015;21(19):2643-67 (Invited review).Zhengzheng Zhou, Henry H. Y. Tong*, Liang Li, Fanny L. Y. Shek, Yang Lv, Ying Zheng*. Synthesis, characterization and thermal analysis of ursolic acid solid forms. Crystal Research & Technology June 50(7), 538–548 (2015).Book chapterZhao Y, Zhou J, Liao YH, Zheng Y. Inhaled traditional Chinese medicine for respiratory diseases. Advances in Pulmonary Drug Delivery. CRC press.Chow, AHL, Tong, HY, & Zheng, Y. (06/2007). Stability Assessment and Formulation Characterization, In Shayne C. Gad (Ed). Handbook of Pharmaceutical Biotechnology. (pp. 371-416). USA: John Wiley & Sons.Research projectUniversity of Macau: “Inhalable Functional Nanocrystals of Poorly Water-soluble Active Components in Chinese Medicine for Chronic Obstructive Pulmonary Disease Therapy” (2020 – 2021).University of Macau: “Establishment of in-vivo quantification method of drugs as released and non-released forms after delivery of sustained-release nanocarriers and study on their relationship with pharmacodynamics” (2017 – 2020).University of Macau: “Purification, in vivo antidepressant disorder activity, transport and pharmacokinetic evaluations of inulin-type fructooligosaccharides in Morinda officinalis after oral administration” (2017 – 2019).University of Macau: “Development of Novel Targeted Nanoparticles with Immunosuppressive Chinese Medicine to Inhibit Skin Immune-response for Topical Therapy of Psoriasis” (2014 – 2017).University of Macau: “Novel Nanoparticle Development of Active Components in Herbal Medicines and Their Permeations across Blood-Brain Barrier on Cell Monolayers, Zebrafish and Rat Models” (2013 – 2016).FDCT: “Topical delivery of Chinese medicine to inhibit skin immune-response for psoriasis” (2019-2021).FDCT: “Solid State Characterization of Poorly Water-soluble Active Components in Chinese Medicine” (2014-2016).国家自然科学基金海外及港澳合作基金: “细胞和斑马鱼模型评价纳米制剂的跨膜转运机理和体内过程” (2016.1 – 2017.12).NSFC: “Transport Mechanism and In-vivo Biodistribution Study of Nanomedicine in Polarized Epithelial Cell Monolayer and Larval Zebrafish (No. 81528021, 2016 – 2017).ERASMUS MUNDUS, ERUASICAT: Advanced Education European-Asiatic Exchange Progromme in Materials Science and Catalysis. (No. 552067-EM-1-2014-1-ES-ERA MUNDUS-EMA22, 2014 – 2018, Academic coordinator of UM).