个人简介

EducationPhD Mechanical Engineering (Biomedical Direction), University of Sciences and Technology of China, Hefei, China (2002)Academic and Professional Experience08/2017-present Associate Professor, Faculty of Health Sciences, University of Macau08/2013-08/2017 Assistant Professor, Faculty of Health Sciences, University of MacauResearch Field: Molecular Imaging and Neuroimaging.10/2012-06/2013 Clinical Assistant Professor, Department of Psychology/School of Communication, Arizona State UniversityResearch Field: EEG-fMRI fusion09/2007-10/2012 Research Assistant Professor, Biomedical Engineering Department, University of Florida.Research Field: Biomedical Imaging and Biomedical Optics01/2005-09/2007 Postdoctoral Research Associate, Biomedical Engineering Department, University of Florida, Gainesville, FL32611. Research Field: Biomedical Imaging and Signal Processing03/2004-01/2005 Postdoctoral Research Fellow, Department of Physics, Clemson University, SC29634Research Field: Biomedical Optical Imaging03/2002-03/2004 Postdoctoral Research Scientist, Institute of High performance Computing, National University of Singapore, Singapore 117523. Research Field: BioMEMS and BiomaterialsCourse OutlinesHSCI3000 Neuroscience and Neurodegenerative DiseasesAdvanced Biomedical and Chemical Engineering

研究领域

Neurosciences and NeuroimagingNeuroimagingBrain Disorders and Brain CognitionHyperscanningOptogenetics, Brain Intervention and Brain ModulationBiomedical Optics and Optical Molecular ImagingDiffuse Optical Tomography(DOT);Functional Near Infrared Spectroscopy (fNIRS);Photoacoustic Tomography/Photoacoustic Microscopy (PAT and PAM);Optical Coherence Tomography(OCT);Photothermal and Photodynamic Therapy;Molecular Imaging and Cancer Nanomedicine;

PatentsHybrid Photoacoustic Tomography (PAT) and Diffuse Optical Tomography (DOT): Methods and Algorithms, International Application No. PCT/US2008/055894.METHOD AND APPARATUS FOR TOMOGRAPHIC IMAGING OF ABSOLUTE OPTICAL ABSORPTION COEFFICIENT IN TURBID MEDIA USING COMBINED PHOTOACOUSTIC AND DIFFUSING LIGHT MEASUREMENTS (WO/2009/011934)一种融合光声显微，荧光显微和超声成像于一体的多模态显微成像系统。中国专利号201820951744.5。

近期论文

Representative PublicationsNeurophotonics and NeuroscienceXu, S. Y., Lu, F. M., Wang, M. Y., Hu, Z. S., Zhang, J., Chen, Z. Y., Armada-da-Silva, P. A. S., and Yuan, Z. (2020) Altered Functional Connectivity in the Motor and Prefrontal Cortex for Children with Down’s Syndrome: An fNIRS Study. Front Hum Neurosci 14, 6Wang, M. Y., Zhang, Z. M., Miao, X. C., Lin, X. H., and Yuan, Z. (2020) Electrophysiological Evidence of Attentional Avoidance in Sub-Clinical Individuals with Obsessive-Compulsive Symptoms. IEEE Access 8, 91020-91027Ieong, H. F.-h., and Yuan, Z. (2019) Desynchronized Lower Alpha Rhythms Were Associated with Functional Ischemia in the Prefrontal Cortex in Heroin Patients after Protracted Abstinence: A Concurrent EEG-fNIRS Study. Biol Psychiat 85, S295-S296Ieong, H. F. H., Gao, F., and Yuan, Z. (2019) Machine Learning: Assessing Neurovascular Signals in the Prefrontal Cortex with Non-Invasive Bimodal Electro-Optical Neuroimaging in Opiate Addiction. Sci Rep 9, 18262Hu, Z. S., Zhang, J., Zhang, L. Y., Xiang, Y. T., and Yuan, Z. (2019) Linking Brain Activation to Topological Organization in the Frontal Lobe as a Synergistic Indicator to Characterize the Difference between Various Cognitive Processes of Executive Functions. Neurophotonics 6, 025008Hu, Z. S., Lam, K. F., and Yuan, Z. (2019) Effective Connectivity of the Fronto-Parietal Network During the Tangram Task in a Natural Environment. Neuroscience 422, 202-211Hu, Z. S., Lam, K. F., Xiang, Y. T., and Yuan, Z. (2019) Causal Cortical Network for Arithmetic Problem-Solving Represents Brain’s Planning Rather Than Reasoning. Int J Biol Sci 15, 1148-1160Wang, M. Y., Zhang, J., Lu, F. M., Xiang, Y. T., and Yuan, Z. (2018) Neuroticism and Conscientiousness Respectively Positively and Negatively Correlated with the Network Characteristic Path Length in Dorsal Lateral Prefrontal Cortex: A Resting-State fNIRS Study. Brain Behav, e01074Wang, M. Y., Lu, F. M., Hu, Z. S., Zhang, J., and Yuan, Z. (2018) Optical Mapping of Prefrontal Brain Connectivity and Activation During Emotion Anticipation. Behav Brain Res 350, 122-128Ren, H. H., Wang, M. Y., He, Y., Du, Z. C., Zhang, J., and Yuan, Z. (2018) A Novel Phase Analysis Method for Examining fNIRS Neuroimaging Data Associated with Chinese/English Sight Translation. Behav Brain Res 361, 151-158Lin, X. H., Sai, L. Y., and Yuan, Z. (2018) Detecting Concealed Information with Fused Electroencephalography and Functional near-Infrared Spectroscopy. Neuroscience 386, 284-294Lin, X. H., Lei, V. L. C., Li, D. F., and Yuan, Z. (2018) Which Is More Costly in Chinese to English Simultaneous Interpreting, “Pairing” or “Transphrasing”? Evidence from an fNIRS Neuroimaging Study. Neurophotonics 5, 025010Ieong, H. F. H., and Yuan, Z. (2018) Emotion Recognition and Its Relation to Prefrontal Function and Network in Heroin Plus Nicotine Dependence: A Pilot Study. Neurophotonics 5, 025011Hu, Z. S., Zhang, J., Couto, T. A., Xu, S. Y., Luan, P., and Yuan, Z. (2018) Optical Mapping of Brain Activation and Connectivity in Occipitotemporal Cortex During Chinese Character Recognition. Brain Topogr 31, 1014-1028Zhang, Z. M., Wang, M. Y., Guo, X. W., Miao, X. C., Zhang, T., Gao, D., and Yuan, Z. (2017) Attentional Avoidance of Threats in Obsessive Compulsive Disorder: An Event Related Potential Study. Behaviour Research and Therapy 97, 96-104Zhang, Z. M., Wang, M., Miao, X. C., Li, Y. J., Hitchman, G., and Yuan, Z. (2017) Individuals with High Obsessive-Compulsive Tendencies or Undermined Confidence Rely More on External Proxies to Access Their Internal States. Journal of Behavior Therapy and Experimental Psychiatry 54, 263-269Lu, F. M., Zhou, J. S., Wang, X. P., Xiang, Y. T., and Yuan, Z. (2017) Short-and Long-Range Functional Connectivity Density Alterations in Adolescents with Pure Conduct Disorder at Resting-State. Neuroscience 351, 96-107Liu, C. H. M., Xin, Yuan, Z., Song, L. P., Jing, B., Lu, H. Y., Tang, L. R., Fan, J. F., Walter, M., Liu, C. Z., Wang, L. H., and Wang, C. Y. (2017) Decreased Resting-State Activity in the Precuneus Is Associated with Depressive Episodes in Recurrent Depression. The Journal of clinical psychiatry 78, E372-+He, Y., Wang, M. Y., Li, D. F., and Yuan, Z. (2017) Optical Mapping of Brain Activation During the English to Chinese and Chinese to English Sight Translation. Biomed Opt Express 8, 5399-5411Zhang, J., Li, Y. Y., Chen, H. F., Ding, J. R., and Yuan, Z. (2016) An Investigation of the Differences and Similarities between Generated Small-World Networks for Right-and Left-Hand Motor Imageries. Sci Rep-Uk 6, 36562Liu, C. H., Liu, C. Z., Zhang, J. H., Yuan, Z., Tang, L. R., Tie, C. L., Fan, J., and Liu, Q. Q. (2016) Reduced Spontaneous Neuronal Activity in the Insular Cortex and Thalamus in Healthy Adults with Insomnia Symptoms. Brain Res 1648, 317-324Yuan, Z. (2013) Combining Independent Component Analysis and Granger Causality to Investigate Brain Network Dynamics with fNIRS Measurements. Biomed Opt Express 4, 2629-2643Yuan, Z. (2013) Fusion of fNIRS and fMRI Data: Identifying When and Where Hemodynamic Signals Are Changing in Human Brains. Front Hum Neurosci 7, 676Optical Molecular ImagingWang, D., Xue, B., Ohulchanskyy, T. Y., Liu, Y., Yakovliev, A., Ziniuk, R., Xu, M. Z., Song, J., Qu, J. L., and Yuan, Z. (2020) Inhibiting Tumor Oxygen Metabolism and Simultaneously Generating Oxygen by Intelligent Upconversion Nanotherapeutics for Enhanced Photodynamic Therapy. Biomaterials 251, 120088Men, X. J., Wang, F., Chen, H. B., Liu, Y. B., Men, X. X., Yuan, Y., Zhang, Z., Gao, D. Y., Wu, C. F., and Yuan, Z. (2020) Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second near‐Infrared Photoacoustic Imaging and Photothermal Cancer Therapy. Adv Funct Mater, 1909673Fan, X. x., Xu, M. z., Leung, E. L. H., Jun, C., Yuan, Z., and Liu, L. (2020) ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria. Nano-Micro Lett 12, 76Zhang, B. Y., Wang, F., Zhou, H., Gao, D. Y., Yuan, Z., Wu, C. F., and Zhang, X. J. (2019) Polymer Dots Compartmentalized in Liposomes as Photocatalyst for in Situ Hydrogen Therapy. Angew Chem Int Edit 58, 2744-2748Xu, H., Ohulchanskyy, T. Y., Yakovliev, A., Zinyuk, R., Song, J., Liu, L. W., Qu, J. L., and Yuan, Z. (2019) Nanoliposomes Co-Encapsulating CT Imaging Contrast Agent and Photosensitizer for Enhanced, Imaging Guided Photodynamic Therapy of Cancer. Theranostics 9, 1323-1335Wang, S. C., Sheng, Z. H., Yang, Z. G., Hu, D. H., Long, X. J., Feng, G., Liu, Y. B., Yuan, Z., Zhang, J. J., Zheng, H. R., and Zhang, X. J. (2019) Activatable Small-Molecule Photoacoustic Probes That Cross the Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease. Angew Chem Int Ed Engl 58, 12415-12419Gao, D. Y., Zhang, B. Y., Liu, Y. B., Hu, D. H., Sheng, Z. H., Zhang, X. J., and Yuan, Z. (2019) Molecular Engineering of near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics. Theranostics 9, 5315-5331Chang, K. W., Gao, D. Y., Qi, Q. F., Liu, Y. B., and Yuan, Z. (2019) Engineering Biocompatible Benzodithiophene-Based Polymer Dots with Tunable Absorptions as High-Efficiency Theranostic Agents for Multiscale Photoacoustic Imaging-Guided Photothermal Therapy. Biomater Sci-Uk 7, 1486-1492Zhang, D., Xu, H., Zhang, X. L., Liu, Y. B., Wu, M., Li, J., Yang, H. H., Liu, G., Liu, X. L., Liu, J. F., and Yuan, Z. (2018) Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second near-Infrared Window Photochemotherapy. Acs Appl Mater Inter 10, 25203-25212Sun, K., Yang, Y. K., Zhou, H., Yin, S. Y., Qin, W. P., Yu, J. B., Chiu, D., Yuan, Z., Zhang, X. J., and Wu, C. F. (2018) Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring Via a Smartphone. Acs Nano 12, 5176-5184Gao, D. Y., Zhang, P. F., Liu, Y. B., Sheng, Z. H., Chen, H. J., and Yuan, Z. (2018) Protein-Modified Conjugated Polymer Nanoparticles with Strong near-Infrared Absorption: A Novel Nanoplatform to Design Multifunctional Nanoprobes for Dual-Modal Photoacoustic and Fluorescence Imaging. Nanoscale 10, 19742-19748Gao, D. Y., Ji, X., Wang, J. L., Wang, Y. T., Li, D. L., Liu, Y. B., Chang, K. W., Qu, J. L., Zheng, J., and Yuan, Z. (2018) Engineering a Protein-Based Nanoplatform as an Antibacterial Agent for Light Activated Dual-Modal Photothermal and Photodynamic Therapy of Infection in Both the NIR I and II Windows. J Mater Chem B 6, 732-739Chang, K. W., Liu, Y. B., Hu, D. H., Qi, Q. F., Gao, D. Y., Wang, Y. T., Li, D. L., Zhang, X. J., Zheng, H. R., Sheng, Z. H., and Yuan, Z. (2018) Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy. Acs Appl Mater Inter 10, 7012-7021Zhang, J., Chen, H. B., Zhou, T., Wang, L. M., Gao, D. Y., Zhang, X. J., Liu, Y. B., Wu, C. F., and Yuan, Z. (2017) A PIID-DTBT Based Semi-Conducting Polymer Dots with Broad and Strong Optical Absorption in the Visible-Light Region: Highly Effective Contrast Agents for Multiscale and Multi-Spectral Photoacoustic Imaging. Nano Res 10, 64-76Gao, D. Y., Sheng, Z. H., Liu, Y. B., Hu, D. H., Zhang, J., Zhang, X. J., Zheng, H. R., and Yuan, Z. (2017) Protein-Modified CuS Nanotriangles: A Potential Multimodal Nanoplatform for in Vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging. Adv Healthc Mater 6Chen, H. B., Zhang, J., Chang, K. W., Men, X. J., Fang, X. F., Zhou, L. B., Li, D. L., Gao, D. Y., Yin, S. Y., Zhang, X. J., Yuan, Z., and Wu, C. F. (2017) Highly Absorbing Multispectral near-Infrared Polymer Nanoparticles from One Conjugated Backbone for Photoacoustic Imaging and Photothermal Therapy. Biomaterials 144, 42-52Chang, K. W., Liu, Z. H., Fang, X. F., Chen, H. B., Men, X. J., Yuan, Y., Sun, K., Zhang, X. J., Yuan, Z., and Wu, C. F. (2017) Enhanced Phototherapy by Nanoparticle-Enzyme Via Generation and Photolysis of Hydrogen Peroxide. Nano Lett 17, 4323-4329Biomedical Optics and Optical ImagingLiu, Y. B., Zhang, L. Y., Li, S. S., Han, X. N., and Yuan, Z. (2018) Imaging Molecular Signatures for Clinical Detection of Scleroderma in the Hand by Multispectral Photoacoustic Elastic Tomography. J Biophotonics 11, e201700267Liu, Y. B., Gao, D. Y., Xu, M. Z., and Yuan, Z. (2018) Multispectral Photoacoustic Imaging of Cancer with Broadband CuS Nanoparticles Covering Both NIR-I and NIR-II Biological Windows. J Biophotonics, e201800237Zhang, J., Liu, J., Wang, L. M., Li, Z. Y., and Yuan, Z. (2017) Retroreflective-Type Janus Microspheres as a Novel Contrast Agent for Enhanced Optical Coherence Tomography. J Biophotonics 10, 878-886Liu, Y. B., and Yuan, Z. (2016) Multi-Spectral Photoacoustic Elasticity Tomography. Biomed Opt Express 7, 3323-3334Liu, Y. B., Jiang, H. B., and Yuan, Z. (2016) Two Schemes for Quantitative Photoacoustic Tomography Based on Monte Carlo Simulation. Med Phys 43, 3987-3997Zhang, J., Ge, W., and Yuan, Z. (2015) In Vivo Three-Dimensional Characterization of the Adult Zebrafish Brain Using a 1325 Nm Spectral-Domain Optical Coherence Tomography System with the 27 Frame/S Video Rate. Biomed Opt Express 6, 3932-3940Yuan, Z., Zhang, J., Wang, X. D., and Li, C. Q. (2014) A Systematic Investigation of Reflectance Diffuse Optical Tomography Using Nonlinear Reconstruction Methods and Continuous Wave Measurements. Biomed Opt Express 5, 3011-3022Yuan, Z., and Jiang, H. (2012) A Calibration-Free, One-Step Method for Quantitative Photoacoustic Tomography. Med Phys 39, 6895-6899Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2010) High-Resolution X-Ray Guided Three-Dimensional Diffuse Optical Tomography of Joint Tissues in Hand Osteoarthritis: Morphological and Functional Assessments. Med Phys 37, 4343-4354Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2010) Image-Guided Optical Spectroscopy in Diagnosis of Osteoarthritis: A Clinical Study. Biomed Opt Express 1, 74-86Yuan, Z., and Jiang, H. (2009) Quantitative Photoacoustic Tomography. Philos Trans A Math Phys Eng Sci 367, 3043-3054Yuan, Z., and Jiang, H. (2009) Simultaneous Recovery of Tissue Physiological and Acoustic Properties and the Criteria for Wavelength Selection in Multispectral Photoacoustic Tomography. Opt Lett 34, 1714-1716Yuan, Z., Hu, X. H., and Jiang, H. (2009) A Higher Order Diffusion Model for Three-Dimensional Photon Migration and Image Reconstruction in Optical Tomography. Phys Med Biol 54, 65-88Yuan, Z., Zhang, Q., Sobel, E. S., and Jiang, H. (2008) Tomographic X-Ray-Guided Three-Dimensional Diffuse Optical Tomography of Osteoarthritis in the Finger Joints. J Biomed Opt 13, 044006Yuan, Z., Zhang, Q., Sobel, E., and Jiang, H. (2007) Three-Dimensional Diffuse Optical Tomography of Osteoarthritis: Initial Results in the Finger Joints. J Biomed Opt 12, 034001Yuan, Z., Wang, Q., and Jiang, H. (2007) Reconstruction of Optical Absorption Coefficient Maps of Heterogeneous Media by Photoacoustic Tomography Coupled with Diffusion Equation Based Regularized Newton Method. Opt Express 15, 18076-18081Yuan, Z., and Jiang, H. (2007) Three-Dimensional Finite-Element-Based Photoacoustic Tomography: Reconstruction Algorithm and Simulations. Med Phys 34, 538-546Yuan, Z., Zhang, Q., and Jiang, H. (2006) Simultaneous Reconstruction of Acoustic and Optical Properties of Heterogeneous Media by Quantitative Photoacoustic Tomography. Opt Express 14, 6749-6754Yuan, Z., and Jiang, H. (2006) Quantitative Photoacoustic Tomography: Recovery of Optical Absorption Coefficient Maps of Heterogeneous Media. Appl Phys Lett 88Yuan, Z., Wu, C., Zhao, H., and Jiang, H. (2005) Imaging of Small Nanoparticle-Containing Objects by Finite-Element-Based Photoacoustic Tomography. Opt Lett 30, 3054-3056