个人简介

EducationPhD Department of Physics, National University of Singapore, 2006MSc Department of Physics, Hunan University, Changsha, China, 2002BSc Department of Physics, Hunan University, Changsha, China, 1996Academic and Professional Experience2016 – present Assistant Professor, State Key Laboratory of Analog and Mixed Signal VLSI, University of Macau2013 – 2015 Postdoctoral Fellow, State Key Laboratory of Analog and Mixed Signal VLSI, University of Macau2007 – 2011 Research Scientist, Department of Biology, Brandeis Unviersity2006 – 2007 Postdoctoral Fellow, Department of Physics, Brandeis University2006 Research Fellow, Department of Physics, National University of Singapore

研究领域

Microfluidics for biological and chemical applicationsPCR technology for disease diagnosticsAutomated point-of-care device for disease diagnostics

PatentsS. Fraden, H. Boukellal, Y. W. Jia, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, Manipulation of fluids, fluid components and reactions in microfluidic systems, US PATENT, No. 10357772, July 23, 2019S. Fraden, H. Boukellal, Y. W. Jia, S. Selimovic, A. Rowat, J.y Agresti, D. A. Weitz, Manipulation of fluids, fluid components and reactions in microfluidic systems, US PATENT, No. 10286396, May 14, 2019C. Dong, T. L. Chen, J. Gao, Y. W. Jia,P. I. Mak, M. I. Vai, R. Martins, Cooperative-electrode Driving Technique for Droplet-velocity Improvement of Digital Microfluidic Systems, US PATENT, No. 10016759 , Jul 10, 2018Y. W. Jia, H. R. Li, R. Shen, C. Dong, T. L. Chen, J. Gao, P. I. Mak, and R. Martins, A method for on-chip precise sample delivery in a microfluidic system, PCT/ UMPT161-2018, July 2018T. L. Chen, C. Dong, J. Gao, Y. W. Jia, P. I. Mak, M. I. Vai, R. Martins,一种检测和分析DNA的方法, PCT/CN2018/088762, 28 May 2018Y. W. Jia, L. Wan, et al., Ultrafast PCR on Digital Microfluidic Chip with Sloppy Temperature Control, US Provisional Patent, Application No. 62677071, 28 May 2018T. L. Chen, C. Dong, J. Gao, Y. W. Jia, P. I. Mak, M. I. Vai, R. Martins, 一种检测和分析DNA的方法, CHN PATENT, application number 201711499798.9, 29 Dec 2017T. L. Chen, C. Dong, J. Gao, Y. W. Jia, P. I. Mak, M. I. Vai, R. Martins, Electrode-voltage Waveform for Droplet-Velocity and Chip-lifetime Improvements of Digital Microfluidic Systems, US PATENT No. 9808800, Nov. 7, 2017L. J. Wangh, J. E. Rice, N. Rice, Y. W. Jia, Reagents and Methods for PCR, US PATENTNo. 9758813, Sept 12, 2017J. Gao, T. L. Chen, C. Dong, Y. W. Jia,P. I. Mak, M. I. Vai, R. Martins, Electronic Module for Real-time Droplet-position Sensing and Driving in Digital Microfluidic System, US PATENT No. 9751083, Sept 5, 2017S. Fraden, H. Boukellal, Y. W. Jia, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, Manipulation of Fluids, Fluid Components and Reactions in Microfluidic Systems, US PATENT No. 9588025, March 7, 2017Y. W. Jia, L. J. Wangh, J. A. Sanchez and J. Rice, Detecting Nucleic Acid Variations within Populations of Genomes, US PATENT No. 9169514, Oct. 23. 2015S. Fraden, H. Boukellal, Y. W. Jia, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, Manipulation of Fluids, Fluid Components and Reactions in Microfluidic Systems, US PATENT No. 9068699, Issued date: June 30, 2015L. J. Wangh, J. Rice, N. Rice and Y. W. Jia, Reagents and Methods for PCR, US PATENT No. 9034605, Issued Date: May 19, 2015S. Fraden, Y. W. Jia, H. Boukellal, S. Selimovic, A. Rowat, J. Agresti, D. A. Weitz, Manipulation of Fluids, Fluid Components and Reactions in Microfluidic Systems, US PATENT No. 8592221, Issued date: Nov. 23, 2013X. Y. Liu and Y. W. Jia, Method for Prediction de novo Biomacromolecule Crystallization Conditions and for Crystallization of the Same, SINGAPORE PATENT No. 124995 (WO2005/080422); Issued date: Sept. 28, 2007

近期论文

Representative Publications* Corresponding authorJ. Zhai, H. R. Li, A. H. H. Wong, C. Dong, S. H. Yi, Y. W. Jia*, P. I. Mak, C. X. Deng and R. P. Martins, A digital microfluidic system with 3D microstructures for single-cell culture, Microsystems and Nanoengineering, in press.Y. J. Zhu, Q. M. Chen, L. Y. Shao, Y. W. Jia, and X. M. Zhang, Microfluiidc immobilized enzyme reactors for continuous biocatalysis, Reaction Chemistry and Engineering, in press.Y. J. Zhu, Z. Huang, Q. Chen, Q. Wu, X. Huang, P. So, L. Shao, Z. Yao, Y. W. Jia, Z. Li, W. Yu, Y. Yang, A. Jian, S. Sang, W. Zhang, X. M. Zhang, Continuous artificial synthesis of glucose precursor using enzyme-immobilized microfluidic reactors, Nature Communications, 10, 4049, 2019.J. Zhai, S. H. Yi, Y. W. Jia*, P. I. Mak, R. P. Martins, Cell-based drug screening on microfluidics, Trends in Analytical Chemistry, 117, 231-241, 2019.M. Z. Li, C. Dong, M. K. Law*, Y. W. Jia*, P. I. Mak and R. P. Martins, Hydrodynamic-flow-enhanced rapid mixer for isothermal DNA hybridization kinetics analysis on digital microfluidics platform, Sensors and Actuators B, 287, 390-397, 2019.L. Wan, J. Gao, T. L. chen, C. Dong, H. R. Li, Y. Z. Wen, Z. R. Lun, Y. W. Jia*, P. I. Mak, R. P. Martins, LampPort: a handheld digital microfluidic device for loop-mediated isothermal amplification (LAMP), Biomedical Microdevices, 21:9, 2019.R. Shen, L. Wan, and Y. W. Jia*, Applications of microfluidic technology in clinical diagnosis, Journal of Molecular Diagnostics and Therapy, 10(5), 289, 2018.J. Zhai, Y. W. Jia, L. N. Zhao, Q. Yuan, F. P. Gao, X. C. Zhang, P. J. Cai, L. Gao, J. J. Guo, S. H. Yi, Z. F. Chai, Y. L. Zhao and X. Y. Gao, Turning on/off the anti-tumor effect of the Au cluster via atomically controlling its molecular size, ACS Nano, 12(5), 4378-4386, 2018.L. Wan, T. L. Chen, J. Gao, C. Dong, A. H. H. Wong, Y. W. Jia*, P. I. Mak, C. X. Deng and R. Martins, A digital microfluidic system for loop-mediated isothermal amplification and sequence specific pathogen detection, Scientific Reports, 7, 14586, 2017.A. H. H. Wong, H. R. Li, Y. W. Jia, P. I. Mak, R. P. Martins, Y. Liu, C. M. Vong, H. C. Won, P. K. Wong, H. T. Wang, H. Sun, C. X. Deng, Drug screening of cancer cell lines and human primary tumors using droplet microfluidics,Scientific Reports,7, 9109, 2017.C. Xu, Y. L. Wang, C. Y. Zhang, Y. W. Jia, Y. J. Luo and X. Y. Gao, AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging, Nanoscale, 9, 4620-4628, 2017.C. Dong, Y. W. Jia*, J. Gao, T. L. Chen, P. I. Mak, M. I. Vai and R. P. Martins, A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips, Lab on a Chip, 17, 896-904, 2017.T. L. Chen, Y. W. Jia, C. Dong, J. Gao, P. I. Mak, and R. P. Martins, Sub-7-second genotyping of single-nucleotide polymorphism by high-resolution melting curve analysis on a thermal digital microfluidic device, Lab on a Chip, 16, 743-752, 2016.J. Gao, T. L. Chen, C. Dong, Y. W. Jia, P. I. Mak, M. I. Vai and R. P. Martins, Adhesion Promoter for Multi-dielectric-layer on digital microfluidic chip, RSC Advances, 5, 48626-48630, 2015.C. Dong, T. L. Chen, J. Gao. Y. W. Jia. P. I. Mak, M. I. Vai and R. P. Martins, On the droplet velocity and electrode lifetime of digital microfluidics: voltage actuation techniques and comparison, Microfluidics and Nanofluidics, 18, 673-683, 2015.T. L. Chen, C. Dong, J. Gao, Y. W. Jia, P. I. Mak, M. I., Vai and R. P. Martins, Natural discharge after pulse and cooperative electrodes to enhance droplet velocity in digital microfluidics, AIP Advances, 4, 047129, 2014.Y. W. Jia, J. A. Sanchez, L. J. Wangh, Kinetic Hairpin Oligonucleotide Blockers for Selective Amplification of Rare Mutations, Scientific Reports, 4, 5921, 2014.Y. W. Jia, P. I. Mak, C. Massey, R. P. Martins and L. J. Wangh, Construction of a Microfluidic Chip for LATE-PCR Amplification and Detection of Single-Stranded DNA using Dried-Down Reagents, Lab on a Chip, 13, 4635-4641, 2013Y. W. Jia, A. Osborne, J. E. Rice and L. J. Wangh, Dilute-‘N’-Go Dideoxy Sequencing of All DNA Strands Generated in Multiplexed LATE-PCR Assays, Nucleic Acids Research, 38 (11), e119, 2010.Y. W. Jia, C. Hartshorn, O. Hartung and L. J. Wangh, Heat Shock Memory in Preimplantation Mouse Embryos, Fertility and Sterility, 93 (8), 2760-2763, 2010.H. Boukellal, S. Selimovic, Y. W. Jia, G. Cristobal and S. Fraden, Simple, Robust Storage of Drops and Fluids in a Microfluidic Device, Lab on a Chip, 9, 331-338, 2009.S. Selimovic, Y. W. Jia and S. Fraden, Measuring the Nucleation Rate of Lysozyme Using Microfluidics, Crystal Growth & Design, 9, 1808-1810, 2009.J.-uk Shim, G. Cristobal, D. Link, T. Thorsen, Y. W. Jia, K. Piatelli and S. Fraden, Control and Measurement of the Phase Behavior of Aqueous Solutions Using Microfluidics, Journal of the American Chemical Society, 129, 8825-8835, 2007. (Highlighted byLab on a Chip7, 1091-1093, 2007; SCIENCE317, 18, 2007)C. Hartshorn, A. Anshelevich, Y. W. Jia and L. J. Wangh, Early Onset of Heat-Shock Response in Mouse Embryos Revealed by Quantification of Stress-Inducible hsp70i RNA, Gene Regulation and Systems Biology, 1, 365-373,2007.Y. W. Jia and X. Y. Liu, From Surface Self-assembly to Crystallization: Prediction of Protein Crystallization Conditions, Journal of Physical Chemistry B,110, 6949-6955, 2006.Y. W. Jia, J. Narayanan, X. Y. Liu and Y. Liu, Investigation of the Mechanism of Crystallization of Soluble Protein in the Presence of Nonionic Surfactant, Biophysical Journal89, 4245-4251, 2005.Y. W. Jia and X. Y. Liu, Prediction of Protein Crystallization Based on Interfacial and Diffusion Kinetics,Applied Physics Letters 87(10), 103902, 2005.Y. W. Jia and X. Y. Liu, Self-assembly of Protein at Aqueous Solution Surface in Correlation to Protein Crystallization, Applied Physics Letters 86(2), 023903, 2005.Q. H. Liu, Y. W. Jia, W. H. Qi, Z. C. Ou-Yang, Static Bistable Helices in Generalized Helfrich Elastic Theory of a Chiral Filament, Physics Letters A, 317, 401-405, 2003