个人简介

Academic QualificationsBSc (Hon), University College London, U.K.PhD, Pharmacology, University of Cambridge, U.K.TeachingBSc CoursesCMED701 Pharmacology and Safety EvaluationMSc CoursesCMED827 Research WritingCMED804 Advanced Pharmacokinetics

研究领域

Drug discovery and drug screeningCardiovascular and cerebrovascular pharmacologyAngiogenesis and endothelial dysfunctionsMetabolic Disorders

近期论文

1.Yang, B. R., Cheung, K. K., Zhou, X., Xie, R. F., Cheng, P. P., Wu, S., Zhou, Z. Y., Tang, J. Y., Hoi, P. M., Wang, Y. H. & Lee, S. M.* Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis. Journal of ethnopharmacology 181, 50-58, doi:10.1016/j.jep.2016.01.022 (2016).2.Vong, C. T., Tseng, H. H., Kwan, Y. W., Lee, S. M. &  Hoi, P. M.* (Corresponding author) Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells. Frontiers in pharmacology 7, 67, doi:10.3389/fphar.2016.00067 (2016).3.Seto, S. W.*, Kiat, H., Lee, S. M., Bensoussan, A., Sun, Y. T., Hoi, M. P. & Chang, D. Zebrafish models of cardiovascular diseases and their applications in herbal medicine research. Eur J Pharmacol, doi:10.1016/j.ejphar.2015.10.031 (2015).4.Li, S., Zhou, X. L., Dang, Y. Y., Kwan, Y. W., Chan, S. W., Leung, G. P., Lee, S. M. & Hoi, P. M.* (Corresponding author)  Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochim Biophys Acta 1850, 373-384, doi:10.1016/j.bbagen.2014.10.023 (2015).5.Li, S., Dang, Y., Zhou, X., Huang, B., Huang, X., Zhang, Z., Kwan, Y. W., Chan, S. W., Leung, G. P., Lee, S. M. & Hoi, P. M.* (Corresponding author) Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway. Sci Rep 5, 16815, doi:10.1038/srep16815 (2015).6.Hoi, P. M.* (Corresponding author), Li, S., Vong, C. T., Tseng, H. H., Kwan, Y. W. & Lee, S. M. Recent advances in structure-based drug design and virtual screening of VEGFR tyrosine kinase inhibitors. Methods 71, 85-91, doi:10.1016/j.ymeth.2014.09.004 (2015).7.Cui, G., Shan, L., Guo, L., Chu, I. K., Li, G., Quan, Q., Zhao, Y., Chong, C. M., Zhang, Z., Yu, P., Hoi, P. M.* (Corresponding author), Sun, Y., Wang, Y. & Lee, S. M. Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy. Sci Rep 5, 10353, doi:10.1038/srep10353 (2015).8.Tam, I. L., Wang, Y. & Hoi, P. M.* (Corresponding author) Mogrosides extract from Siraitia grosvenori enhances the endothelial function of rat mesenteric arteries in hyperglycemic environments. Pharmacology and Clinics of Chinese Materia Medica  30, 97-100 (2014).9.Li, S., Dang, Y. Y., Oi Lam Che, G., Kwan, Y. W., Chan, S. W., Leung, G. P., Lee, S. M. & Hoi, P. M.* (Corresponding author) VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. Toxicol Appl Pharmacol 280, 408-420, doi:10.1016/j.taap.2014.09.005 (2014).10.Li, Y. B., Zhong, Z. F., Chen, M. W., Bao, J. L., Wu, G. S., Zhang, Q. W., Lee, S. M., Hoi, P. M.* (Corresponding author) & Wang, Y. T.* Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med 2013, 851714, doi:10.1155/2013/851714 (2013).11.Cui, G., Shan, L., Hung, M., Lei, S., Choi, I., Zhang, Z., Yu, P., Hoi, P. M.* (Corresponding author), Wang, Y.* & Lee, S. M.* A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Int J Cardiol 168, 1349-1359, doi:10.1016/j.ijcard.2012.12.012 (2013).12.Zhou, X., Chan, S. W., Tseng, H. L., Deng, Y., Hoi, P. M., Choi, P. S., Or, P. M., Yang, J. M., Lam, F. F., Lee, S. M., Leung, G. P., Kong, S. K., Ho, H. P., Kwan, Y. W. & Yeung, J. H.* Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions. Phytomedicine 19, 1263-1269, doi:10.1016/j.phymed.2012.08.011 (2012).13.Hu, G., Mahady, G. B., Li, S., Hoi, M. P., Wang, Y. H. & Lee, S. M.* Polysaccharides from astragali radix restore chemical-induced blood vessel loss in zebrafish. Vasc Cell 4, 2, doi:10.1186/2045-824X-4-2 (2012).14.Tang, J. Y., Li, S., Li, Z. H., Zhang, Z. J., Hu, G., Cheang, L. C., Alex, D., Hoi, M. P., Kwan, Y. W., Chan, S. W., Leung, G. P. & Lee, S. M.* Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. PLoS One 5, e11822, doi:10.1371/journal.pone.0011822 (2010).15.Hoi, P. M., Visintin, C., Okuyama, M., Gardiner, S. M., Kaup, S. S., Bennett, T., Baker, D., Selwood, D. L. & Hiley, C. R.* Vascular pharmacology of a novel cannabinoid-like compound, 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide (VSN16) in the rat. Br J Pharmacol 152, 751-764, doi:10.1038/sj.bjp.0707470 (2007).