个人简介

EducationPhD Department of Physiology, University of Maryland Medical School, Baltimore, USA. (2002)MSc Institute of Hydrobiology, Academia Sinica, Wuhan, China (1987)BSc Department of Biology, West China Normal University, Nanchong, China (1982)Academic and Professional Experience2014-present Associate Professor, Faculty of Health Sciences, University of Macau1999-2014 Staff Scientist, Mammalian Genetics Section, Genetics of Development and Disease Branch, NIDDK1995-1999 Visiting associate, Genetics of Development and Disease Branch, NIDDK1992-1995 Visiting associate, Whitehead Institute for BiomedicalResearch, MIT, Nine Cambridge Center, Cambridge, MA 02142.1987-1992 Research associate, Department of Pathology, University of UtahCourse OutlinesHSCI4001 Cancer Biology and TherapyMethodologies in Biomedical Sciences

研究领域

Tumor suppressors Smad4, and Pten in mammalian development and tumorigenesis. Breast cancer associated gene 1 (BRCA1) in mammary gland development and tumorigenesis Interactions between estrogen signaling and BRCA1 in DNA replication and genome stability

近期论文

Representative PublicationsEicher, Eva M., Washburn, Linda L., Schork, Nicholas J., Lee, Barbara K., Shown, Elanie P., Xiaoling Xu, Dredge, Robert K., Pringle, M. Jodeane & Page, David C (1996). Sex-determining genes on mouse autosomes identified by linkage analysis of C57BL/B6J-Ypos sex reversal. Nature Genetics 14, 206-209.Xiaoling Xu, Michael Weinstein, Cuiling Li, Michael Naski, Rick I. Cohen, David M. Ornitz, Philip Leder and Chuxia Deng (1998). Fibroblast growth factor receptor 2 (FGFR2) mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125, 753-765.Xiaoling Xu, Michael Weinstein, Cuiling Li and Chu-Xia Deng (1999). Fibroblast growth factor receptors (FGFRs) and their roles in limb development. Cell&Tissue Research, 296, 33-43.Xiaoling Xu, Zoë Weaver, Steven P. Linke, Cuiling Li, Jessica Gotay, Xin-Wei Wang, Curtis C. Harris, Thomas Ried and Chu-Xia Deng (1999). Centrosome Amplification and a Defective G2-M Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform-Deficient Cells. Molecular Cell 3, 389-396.Xiaoling Xu, Cuiling Li, Katsu Takahashi, Harold C. Slavkin, Lillian Shum and Chuxia Deng (1999). Murine Fibroblast Growth Factor Receptor 1 Alpha (FGFR1) Isoforms Mediate Node Regression and Are Essential for Posterior Mesoderm Development. Developmental Biology, 208, 293-306.Xiaoling Xu, Kay-Uwe Wagner, Cuiling Li, Anthony Wynshaw-Boris, Lothar Hennighausen and Chu-Xia Deng (1999). Conditional knockout of BRCA1 in mammary glands results in abnormal ductal morphogenesis and tumor formation. Nature Genetics, 22, 37-43.Xiaoling Xu, Steven G. Brodie, Xiao Yang, Young-Hyuck Im, W. Tony Parks, Lin Chen, Yong-Xing Zhou, Jian-Wu Xie, Seong-Jin Kim and Chuxia Deng. (2000). Haploinsufficiency of the tumor suppressor Smad4/Dpc4 initiates gastrointestinal polyposis and cancer in mouse. Oncogene. 2000 19(15):1868-74.Xiaoling Xu, Cuiling Li, Lisa Garrett-Beal, Denise Larson, Anthony Wynshaw-Boris, and Chu-Xia Deng. (2001). Direct removal in the mouse of a floxed neo gene from a three-loxP conditional knockout allele by two novel approaches. Genesis, 30(1):1-6.Xiaoling Xu, Wenhui Qiao, Steven P. Linke, Wen-Mei Li, Cuiling Li, Pricilla A. Furth, Curtis C. Harris, and Chu-Xia Deng. (2001). Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle, genomic stability and tumorigenesis. Nature Genetics 28, 266-271.Xaioling Xu, Wenhui Qiao, Cuiling Li, and Chuxia Deng (2002). Generation of Fgfr1 conditional knockout mice. Genesis, 32, 85-6.Xiaoling Xu (corresponding author), Olga Aprelikova, Peter Moens, Chuxia Deng, and Priscilla A. Furth (2003). Impaired meiotic DNA damage repair and lack of crossing over during spermatogenesis in BRCA1 full-length isoform deficient mice. Development. 30, 2001-12.James MA Turner*, Olga Aprelikova*, Xiaoling Xu* (*equal contribution), Ruihong Wang, Sangsoo Kim, Paul S Burgoyne, and Chuxia Deng (2004). BRCA1 interacts with ATR and H2AX and plays an essential role in meiotic sex chromosome inactivation during spermatogenesis. Current Biology. 14(23):2135-42.Chuxia Deng, and Xiaoling Xu (2004). Generation and analysis of Brca1 conditional knockout mice. Methods Mol Biol. 280:185-200.James MA Turner, Shantha K Mahadevaiah, Fernandez-Capetillo O, Nussenzweig A, Xiaoling Xu, Chuxia Deng and Paul S Burgoyne (2005). Silencing of unsynapsed meiotic chromosomes in the mouse. Nature Genetics. 37(1):41-7.Ruihong Wang, Cuiling Li, Xiaoling Xu, Yin Zheng, Cuiying Xiao, Patricia Zerfas, Sharon Cooperman, Michael Eckhaus, Tracey Rouault, Lope Mishra, and Chuxia Deng. (2005). A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metabolism. 2(6):399-409.Xiaoling Xu, S. Kobayashi, W. Qiao, C. Li, C. Xiao, S. Radaeva, B. Stiles, R.H. Wang, N. Ohara, T. Yoshino, D. LeRoith, M.S. Torbenson, G.J. Gores, H. Wu, B. Gao and Chuxia Deng (2006). Induction of intrahepatic cholangiocellular carcinoma by liver specific disruption of Smad4 and Pten in mice. Journal of Clinic Investigation, 116(7):1843-1852.Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim SS, Xiaoling Xu, Zheng Y, Chilton B, Jia R, Zheng ZM, Appella E, Wang XW, Ried T, and Chuxia Deng (2008). Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14, 312–323.Wang RH, Zheng Y, Kim HS, Xiaoling Xu, Cao L, Luhasen T, Lee MY, Xiao C, Vassilopoulos A, Chen W, Man YG, Hung MC, Finkel T, and Chuxia Deng (2008). Interplay among BRCA1, SIRT1, and SURVIVIN during BRCA1-associated Tumorigenesis. Mol. Cell 32, 11–20.Jie Liu*, Liu Cao* (*Equal contribution), Jichun Chen, Shiwei Song, In Hye Lee, Bong-Hyun Ahn, Neil G. Kumar, Long-Yue Cao, Hongjun Liu, Ilsa I. Rovira, Keyvan Keyvanfar, Xiaoling Xu, Maarten van Lohuizen, Noboru Motoyama, Chu-Xia Deng and Toren Finkel (2009). Deletion of Bmi1 activates a redox-sensitive DNA damage response pathway. Nature, 459(7245):387-92.Liu Cao, Xiaoling Xu, Samuel F. Bunting, Rui-Hong Wang, Jie Liu, Longyue L. Cao, Junjie Chen, Andre Nussenzweig, Chu-Xia Deng* (*Corresponding author) and Toren Finkel* (*Corresponding author) (2009). A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Molecular Cell, 35(4):534-41.Xiaoling Xu, Beeta Ehdaie, Nobuya Ohara, Tadashi Yoshino, and Chu-Xia Deng (2010). Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice. Oncogene, 4;29(5):674-86.Samuel Bunting, Nancy Wong, Hua-Tang Chen, Federica Polato, Oscar Fernandez-Capetillo, Jeremy M. Stark, Liu Cao, Xiaoling Xu, Chu-Xia Deng, Toren Finkel, Elsa Callén1, André Nussenzweig (2010). Loss of 53BP1 rescues homologous recombination in Brca1-deficient cells. Cell, 141(2):243-54.Su N*, Xiaoling Xu * (Equal contribution), Li C, He Q, Zhao L, Li C, Chen S, Luo F, Yi L, Du X, Huang H, Chu-Xia Deng*, Chen L* (Corresponding author). (2010). Generation of Fgfr3 conditional knockout mice, Int J Biol Sci. 6(4):327-32.Hyun-Seok Kim, Cuiying Xiao, Rui-Hong Wang, Tyler Lahusen, Xiaoling Xu, Athanassios Vassilopoulos, Guelaguetza Vazquez-Ortiz, Won-Il Jeong, Ogyi Park, Sung Hwan Ki, Bin Gao, and Chu-Xia Deng. (2010). Hepatic specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metabolism, 12(3):224-36.Hyun-Seok Kim, Athanassios Vassilopoulos, Rui-Hong Wang, Tyler Lahusen, Zhen Xiao, Xiaoling Xu, Cuiling Li, Timothy D. Veenstra, Bing Li, Hongtao Yu, Junfang Ji, Xin Wei Wang, Seong-Hoon Park, Yong I. Cha, David Gius, and Chu-Xia Deng. (2011). SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity. Cancer Cell, 20, 487–499.Seung Min Jeong* (equal contribution), Cuiying Xiao* (equal contribution), Lydia W.S Finley, Tyler Lahusen, Amanda L. Souza, Kerry Pierce, Ying-Hua Li, Xiaoxu Wang, Gaëlle Laurent, Natalie J. German, Xiaoling Xu, Cuiling Li, Rui-Hong Wang, Jaewon Lee, Alfredo Csibi, Richard Cerione, John Blenis, Clary B. Clish, Alec Kimmelman, Chu-Xia Deng* (Corresponding authors) & Marcia C. Haigis* (Corresponding authors) (2013). SIRT4 is a tumor suppressor that regulates cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell, 23(4):450-63.Hongping Zheng, Fangyuan Shao, Scots Martin, Xiaoling Xu, and Chu-Xia Deng. (2017). WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance. Scientific Reports. Mar 6;7:43517.Qiang Chen, Wenhui Hao, Cuiying Xiao, Ruihong Wang, Xiaoling Xu, Huiyan Lu, Weiping Chen, Chu-Xia Deng (2017). SIRT6 is Essential for Adipocyte Differentiation through Regulating Mitotic Clonal Expansion. Cell Reports. Mar 28;18(13):3155-3166.Liu J, Adhav R, Xiaoling Xu (2017). Current Progresses of Single Cell DNA Sequencing in Breast Cancer Research. Int J Biol Sci. Jul 18;13(8):949-960.Tyler J. Lahusen, Seung-Jin Kim, Kai Miao, Zebin Huang, Xiaoling Xu, and Chu-Xia Deng. (2018). BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis. Oncogene, Apr;37(17):2343-2350.Cristine L Chisholm, Haitao Wang, Ada Hang-Heng Wong, Guelaguetza Vazquez-Ortiz, Weiping Chen, Xiaoling Xu, Chu-Xia Deng. (2016). Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin. Oncotarget. 7(51):84439-84452.Takaaki Masuda, Xiaoling Xu, Emilios K Dimitriadis, Tyler Lahusen, Chu-Xia Deng. (2016). “DNA Binding Region” of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint. Int J Biol Sci. 12(2):133-43.Wei Xu, Fengtao Luo, Quan Wang, Qiaoyan Tan, Junlan Huang, Siru Zhou, Zuqiang Wang, Xianding Sun, Liang Kuang, Min Jin, Nan Su, Wanling Jiang, Liang Chen, Huabing Qi, Ying Zhu, Bo Chen, Hangang Chen, Shuai Chen, Yu Gao, Xiaoling Xu, Chuxia Deng, Lin Chen, Yangli Xie, Xiaolan Du. (2017). Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation. J Bone Miner Res. 32(11):2194-2206.LFengtao Luo, Yangli Xie, Zuqiang Wang, Junlan Huang, Qiaoyan Tan, Xianding Sun, Fangfang Li, Can Li, Mi Liu, Dali Zhang, Meng Xu, Nan Su, Zhenhong Ni, Wanling Jiang, Jinhong Chang, Hangang Chen, Shuai Chen, Xiaoling Xu, Chuxia Deng, Zhugang Wang, Xiaolan Du, Lin Chen. (2018). Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model. Mol Ther Nucleic Acids. 13:291-302.Baoyuan Zhang, Junfang Lyu, Yifan Liu, Changjie Wu, Eun Ju Yang, Lakhansing Pardeshi, Kaeling Tan, Koon Ho Wong, Qiang Chen, Xiaoling Xu, Chu-Xia Deng, Joong Sup Shim. (2018). BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition. Oncogene. 37(49):6341-6356.Heng Sun, Zhengqiang Miao, Xin Zhang, Un In Chan, Sek Man Su, Sen Guo, Chris Koon Ho Wong, Xiaoling Xu, Chu-Xia Deng. (2018). Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia. J Biol Chem. 293(22):8315-8329.Kai Miao, Xin Zhang, Sek Man Su, Jianming Zeng, Zebin Huang, Un In Chan, Xiaoling Xu, Chu-Xia Deng. (2018). Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-Gly374Arg mutation in achondroplasia in mice. J Biol Chem. pii: jbc.RA118.006496.Xiaoling Xu, Eric Chen, Lihua Mo, Lei Zhang, Fangyuan Shao, Kai Miao, Jianlin Liu, Sek Man Su, Monica Valecha, Un In Chan, Hongping Zheng, Mark Chen, Weiping Chen, Qiang Chen, Haiqing Fu, Mirit I Aladjem, Yanzhen He, Chu-Xia Deng. (2018). BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy. Hum Mol Genet.