个人简介

Dr Chunming Wang (CM) received his Bachelor and Master’s degrees in Biochemistry from Nanjing University (China), completing his Master thesis under the supervision of Junfeng Zhang. He obtained his PhD in Biomedical Engineering from Nanyang Technological University (Singapore) under the supervision of Dong-An Wang. Then, CM undertook his postdoctoral training at the University of Cambridge (UK), working between Wilhelm Huck’s group in the Chemistry Department and Fiona Watt’s lab at the Wellcome Trust Centre for Stem Cell Research. He later assisted Victor Nurcombe and Simon Cool at the Institute of Medical Biology (Singapore) on an industry-led drug discovery project. In Oct 2012, CM took the Assistant Professorship at ICMS, University of Macau, to continue his scientific exploration in developing bio-inspired materials for a wide range of medical applications. In Aug 2018, he secured promotion to Associate Professor which meant to him more an exciting chance to embrace tougher challenges than a more stable job.

研究领域

Cells and tissue microenvironment are like seeds and soil; the ‘soil’ supports the ‘seeds’ to grow, while the ‘seeds’ remodel the ‘soil’ through secretion. We aim to optimise the soil and thereby improve the seeds’ growth by targeting macrophages, which play central roles in wound healing and tissue repair. We design biomaterials tools and cell-based strategies to modulate macrophages’ phenotypes (e.g. via TLR-carbohydrate interaction), stabilise their secreted molecules (e.g. via growth factors-GAG interaction) and more generally create a pro-regenerative niche (e.g. by ‘utilising’ specifically induced macrophages). We are testing our concepts and designs with various models ranging from bone defects to dental implants to diabetic skin ulcers.To date, CM has as PI won 12 research grants from O Fundo para o Desenvolvimento das Ciências e da Tecnologia de Macau (FDCT), National Natural Science Foundation of China (NSFC), University of Macau Research Committee as well as several Mainland universities. One notable example is an FDCT-NSFC joint sponsorship in 2019. These generous supports have enabled the thriving of ‘Chun Ming Tong Sui’ (春明糖水), a young and vibrant team devoted to weaving sweet polymer chains into new medicines. The team effort of CMTS has enabled CM to see himself twice among the winners of the Natural Science Award at the Macao Science and Technology Awards – 2nd and 3rd Prize in 2016 and 2018, respectively. A start-up project specialised in wound healing, which has won several awards nationally and regionally, is also under the support of several parties from the local community.

近期论文

YC Yao, CM Wang*. Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine. NPJ Regenerative Medicine, 2020, in press;YM Niu, LT Wang, N Yu, PF Xing, ZZ Wang, ZF Zhong, YX Feng, L Dong, CM Wang*. An all-in-one scaffold targeting macrophages to direct endogenous bone repair in situ. Acta Biomaterialia, 2020, 111: 153-69;LT Wang, CM Wang*, ZZ Wang, JJ Gan, CY Liu, SH Xia, YM Niu, DH Chen, JF Zhang*, L Dong*. Transforming the spleen into a liver-like organ in vivo. Science Advances, 2020, 6: eaaz9974;PF Xing, YM Niu, RY Mu, ZZ Wang, DP Xie, HL Li, L Dong, CM Wang*. A pocket-escaping design to prevent the common interference with near-infrared fluorescent probes in vivo, Nature Communications, 2020, 11; 1573;W He, JZ Xu, RY Mu, Q Li, DL Lv, Z Huang, JF Zhang*, CM Wang*, L Dong*. High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation, Nature Communications, 2020, 11; 1732;YX Feng, RY Mu, ZZ Wang, PF Xing, JF Zhang, L Dong*, CM Wang *. A toll-like receptor agonist mimicking microbial signals to generate tumor-suppressive macrophages. Nature Communications, 2019, 10: 2272;JJ Gan, CY Liu, HL Li, SC Wang, ZZ Wang, ZQ Kang, Z Huang, JF Zhang, CM Wang, DL Lv*, L Dong*. Accelerated wound healing in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors. Biomaterials, 2019, 219: 119340;ZZ Wang, XY Rui, JN Qiu, YQ Yan, JJ Gan, S Liu, LT Wang, JF Zhang*, CM Wang *, L Dong*. Growing trans-species islets in tumor extract-remodeled testicles. Advanced Science, in press;YC Shi, LT Wang, YM Niu, N Yu, PF Xing, L Dong*, CM Wang *. Fungal component coating enhances titanium implant-bone integration. Advanced Functional Materials, 2018, 28: 1804483;~ Featured: Cover StoryPF Xing, Z Zhang, YM Niu, YN Qi, L Dong*, CM Wang *. Water solubility is essential for fluorescent probes to image hypochlorous acid in live cells. Chemical Communication, 2018,54, 9889-9892~ Featured: Cover StoryJJ Gan, YY Dou, YR Li, ZZ Wang, LT Wang, S Liu, Q Li, HR Yu, CY Liu, CW Han, Z Huang, JF Zhang*, CM Wang *, L Dong*. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors. Biomaterials, 2018, 178: 95-108;YM Niu, Q Li, Y Ding, L Dong*, CM Wang *. Engineered delivery strategies for enhanced control of growth factor activities in wound healing. Advanced Drug Delivery Reviews, 2019, 146: 190-208;CM Wang, ZZ Wang, L Dong. Translating current bioanalytical techniques for studying corona activity. Trends in Biotechnology, 2018, 36: 661-672;PF Xing, YX Feng, YM Niu, Q Li, Z Zhang, L Dong*, CM Wang *. A water-soluble, two-photon probe for imaging endogenous hypochlorous acid in live tissue. Chemistry – A European Journal, 2018, 22: 5748-53;ZZ Wang, CM Wang *, A Abudukeremu, X Rui, S Liu, XY Zhang, M Zhang, JF Zhang*, L Dong*. Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells. Advanced Science, 2018, 5: 1700666;Q Li, YM Niu, H Diao, LT Wang, XP Chen, YT Wang, L Dong*, CM Wang *. In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing. Biomaterials, 2017, 148: 54-68;YM Niu, Q Li, RY Xie, S Liu, R Wang, PF Xing, YC Shi, YT Wang, L Dong*, CM Wang *. Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: design of a glucomannan coating material. Biomaterials, 2017, 139: 39-55;YX Feng, Q Li, D Wu, YM Niu, C Yang, L Dong*, CM Wang *. A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis. Biomaterials, 2017, 134: 128-42;H Yin, F Dumur, YM Niu, MM Ayhan, O Grauby, W Liu, CM Wang, D Siri, R Rosas, A Tonetto, D Gigmes, R Wang, D Bardelang, O Ouari. Chameleonic dye adapts to various environments shinning on macrocycles of peptide and polysaccharide aggregates. ACS Applied Materials & Interfaces, 2017, 9: 33220-8;Y Wang, GX Guo, YX Feng, HY Long, DL Ma, CH Leung, L Dong*, CM Wang *. A tumour microenvironment-responsive polymeric complex for targeted depletion of tumour-associated macrophages. Journal of Materials Chemistry B, 2017, 5: 7307-18;~ Featured: Hot Paper 2017Q Li, YX Feng, W He, LT Wang, R Wang, L Dong, CM Wang*. Post-screening characterisation and in vivoevaluation of an anti-inflammatory polysaccharide fraction from Eucommiaulmoides. Carbohydrate Polymers, 2017, 169: 304-14;W He #, CM Wang #, RY Mu, P Liang, Z Huang, JF Zhang*, L Dong*. MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles. Oncogene, 2017, 36: 4212-23;ZZ Wang, CM Wang*, S Liu, W He, LT Wang, JJ Gan, Z Huang, ZH Wang, HY Wei, JF Zhang*, L Dong*. Specifically formed corona on silica nanoparticles enhances transforming growth factor-β1 activity in triggering lung fibrosis. ACS Nano, 2017, 11: 1659-72;WI Chan, GP Zhang, X Li, CH Leung, DL Ma, L Dong*, CM Wang*. Carrageenan activates monocytes via type-specific binding with interleukin-8: an implication for design of immune-active biomaterials. Biomaterials Science, 2017, 5: 403-7;~ Featured: Cover StoryLT Wang, Q Chen, HX Qi, CM Wang, C Wang, JF Zhang* and L Dong*. Doxorubicin-induced systemic Inflammation is driven by upregulation of Toll-like receptor TLR4 and endotoxin leakage.Cancer Research, 2016, 76: 6631-42;Q Li, GX Guo, FC Meng, H Wang, YM Niu, QW Zhang, JF Zhang, YT Wang, L Dong, CM Wang*. A naturally-derived, growth factor-binding polysaccharide for therapeutic angiogenesis. ACS Macro Letters, 2016, 5: 617-21;Z Huang, JJ Gan, ZY Long, GX Guo, XF Shi, CM Wang, YH Zang, Z Ding, JN Chen, JF Zhang*, L Dong*. Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection. Biomaterials, 2016, 90: 72-84;Z Huang, JJ Gan, LX Jia, GX Guo, CM Wang, YH Zang, Z Ding, JN Chen, JF Zhang*, L Dong*. An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease. Biomaterials, 2015, 48: 26-36;JJ Liu, XD Zhan, JB Wan, YT Wang, CM Wang *. Review for carrageenan-based pharmaceutical biomaterials: Favourable physical features versusadverse biological effects. Carbohydrate Polymers, 2015, 121: 27-36;CM Wang, L Dong. Exploring ‘new’ bioactivities of polymers at the nano-bio interface. Trends in Biotechnology, 2015, 33: 10-14;XD Zhan, LX Jia, YM Niu, HX Qi, XP Chen, QW Zhang, JF Zhang, YT Wang, L Dong*, CM Wang *. Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy. Biomaterials, 2014, 35: 10046-57;YM Niu, J Bai, RD Kamm, YT Wang*, CM Wang *. Validating anti-metastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment. Molecular Pharmaceutics, 2014, 11: 2022-29;CM Wang, S Poon, S Murali, CY Koo, TJ Bell, SF Hinkley, HQ Yeong, K Bhakoo, V Nurcombe, SM Cool*. Engineering a vascular endothelial growth factor-165-binding heparan sulfate for vascular therapy. Biomaterials, 2014, 35: 6776-86;L Dong, CM Wang *. Harnessing the power of macrophages/monocytes for enhanced bone tissue engineering. Trends in Biotechnology, 2013, 31: 342-6;JE Gautrot, CM Wang, X Liu, SJ Goldie, B Trappmann, WTS Huck*, FM Watt*. Engineered micro-epidermis mimics normal tissue architecture and perturbation in cancer. Biomaterials, 2012, 33: 5221-9;K Su, YH Gong, CM Wang, DA Wang*. A novel shell-structure cell microcarrier (SSCM) for cell transplantation and bone regeneration medicine. Pharmaceutical Research, 2011, 28:1431-41;~ Featured: Cover StoryCM Wang, RR Varshney, DA Wang*. Therapeutic cell delivery and fate control in hydrogels and hydrogel hybrids. Advanced Drug Delivery Reviews, 2010, 62: 699-710;~ Featured: Cover StoryCM Wang, DA Wang*. An injectable, nanoaggregate-based system for mesenchymal stem cell (MSC) delivery: enhancement of cell adhesion and prevention of cytotoxicity. Journal of Materials Chemistry, 2010, 20: 3166-70;CM Wang, GN Adrianus, N Sheng, SK Toh, YH Gong, DA Wang*. In vitro performance of an injectable hydrogel / microsphere based immunocyte delivery system for localised anti-tumour activity. Biomaterials, 2009, 30: 6986-95;CM Wang, YH Gong, Y Zhong, YC Yao, K Su, DA Wang*. The control of anchorage- dependent cell behavior within a hydrogel / microcarrier system in an osteogenic model. Biomaterials, 2009, 30: 2259-69;YC Yao #, CM Wang #(#co-first author), RR Varshney, DA Wang*. Antisense makes sense in engineered regenerative medicine. Pharmaceutical Research, 2009, 26:263-75;YH Gong, CM Wang, RC Lai, K Su, F Zhang, DA Wang*. A novel injectable polysaccharide hydrogel: modified gellan gum for long-term tissue regeneration in vitro. Journal of Materials Chemistry, 2009, 19: 1968 – 1977;~ Featured: Cover Story of Journal of Materials Chemistry, Vol. 19, Issue 14, 2009;~ Quoted: in “Application Highlights”, Chemical Technology, 6(2009), 3: T20.CM Wang, YH Gong, YM Lin, JB Shen, DA Wang*. A novel gellan gel-based microcarrier for anchorage-dependent cell delivery. Acta Biomaterialia, 2008, 4: 1226-34;CM Wang, J Bai, YH Gong, F Zhang, JB Shen, DA Wang*. Enhancing cell affinity of non-adhesive hydrogel substrate: the role of silica hybridization. Biotechnology Progress, 2008, 24: 1142-6;~ Featured: Cover Image of Biotechnology Progress, Vol. 25.TT Jiang, JB Chang, CM Wang, Z Ding, JF Zhang, ET Kang. Adsorption of plasmid DNA onto poly 2-(dimethylamino) ethyl-methacrylate grafted PLLA for promotion of gene delivery. Biomacromolecules, 2007, 8: 1951-7;