个人简介

EducationNSERC postdoctoral fellow National Institute for Basic Biology (NIBB), Okazaki, Japan (1993-1995)PhD University of Alberta, Edmonton, Canada (1988-1993)MSc Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China (1982-1985)BSc Department of Biology, Nanjing University, Nanjing, China (1978-1982)Academic and Professional Experience2019-present Vice Rector (Research), University of Macau2018-2019 Interim Dean, the Graduate School, University of Macau2013-2018 Associate Dean, Faculty of Health Sciences, University of Macau2013-present Chair Professor and Director of Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau2004-present Professor, School of Life Sciences, The Chinese University of Hong Kong2006-present Adjunct Professor, College of Life Sciences, Sun Yat-sen University, Guangzhou, China2009-present Adjunct Professor, School of Biomedical Sciences, The Chinese University of Hong Kong1999-2004 Associate Professor, Department of Biology, The Chinese University of Hong Kong1995-1999 Assistant Professor, Department of Biology, The Chinese University of Hong KongEditorial service for academic journalsAssociate editor, Frontiers in EndocrinologyAssociate editor, Marine and Freshwater Behaviour and PhysiologyEditorial board, General and Comparative Endocrinology (GCE) Editorial board, Asian Pacific Journal of ReproductionCourse OutlinesHSCI4002 Stem Cell Biology and Regenerative Medicine

研究领域

My research focuses on functional analysis of the brain-pituitary-ovary axis using zebrafish as the model. Our current interests include: (1) endocrine regulation of reproduction by the reproductive and growth axes; (2) intra-follicular paracrine/autocrine communication network in the ovary; (3) impacts of environmental endocrine-disrupting chemicals (EDCs) on reproduction and public health; and (4) zebrafish as a model for aging, human diseases and drug discovery. Our research involves using a variety of techniques in molecular and cell biology, physiology and genetics, including the newly-emerged genome-editing technologies, i.e., TALEN and CRISPR/Cas9.

近期论文

Representative PublicationsQin, M., Zhang, Z., Song, W., Wong, W.-L., Chen, W. and Ge, W. 2018 Roles of Figla/figla in juvenile ovary development and follicle formation during zebrafish gonadogenesis. Endocrinology (in press)Zhang, Y., Zhang, Z. and Ge, W. 2018 An efficient platform for generating somatic point mutations with germline transmission in the zebrafish by CRISPR/Cas9-mediated knock-in. Journal of Biological Chemistry 293:6611Lu, H., Cui, Y., Jiang, L. and Ge, W. 2017 Functional analysis of nuclear estrogen receptors (nERs) in zebrafish reproduction by genome editing approach. Endocrinology 158:2292–2308(#This article received a special coverage by the journal with a news and commentary article: Endocrinology 2017; 158:2082-2083)Wong, Q.W.-L., Sun, M.-A., Lau, S.-W., Parsania, C., Zhou, S., Zhong, S. and Ge, W. 2017 Identification and characterization of a specific 13-miRNA expression signature during follicle activation in the zebrafish ovary. Biology of Reproduction 98:42-53Chen, W., Lau, S.-W., Fan, Y., Wu, R.S.S. and Ge, W. 2017 Juvenile exposure to bisphenol a promotes ovarian differentiation but suppresses its growth – potential involvement of pituitary follicle-stimulating hormone. Aquatic Toxicology 193:111-121Chen, W., Liu, L. and Ge, W. 2017 Expression analysis of growth differentiation factor 9 (Gdf9/gdf9), anti-Müllerian hormone (Amh/amh) and aromatase (Cyp19a1a/cyp19a1a) during gonadal differentiation of the zebrafish, Danio rerio. Biology of Reproduction 96:401-13Lau, E.S.-W., Zhang, Z., Qin, M. and Ge, W. 2016 Knockout of zebrafish ovarian aromatase gene (cyp19a1a) by TALEN and CRISPR/Cas9 leads to all-male offspring due to failed ovarian differentiation. Scientific Reports 6:37357Zhang, Z., Lau, S.-W., Zhang, L. and Ge, W. 2015 Disruption of zebrafish follicle-stimulating hormone receptor (fshr) but not luteinizing hormone receptor (lhcgr) gene by TALEN leads to failed follicle activation in females followed by sexual reversal to males. Endocrinology 156:3747-3762(#This article received a special coverage by the journal with a news and commentary article: Endocrinology 2015; 156:3490-3493)Yao, K. and Ge, W. 2015 Differential Regulation of Kit Ligand A (kitlga) Expression in the Zebrafish Ovarian Follicle Cells – Evidence for the Existence of a Cyclic Adenosine 3′, 5′ Monophosphate-Mediated Binary Regulatory System During Folliculogenesis. Molecular and Cellular Endocrinology 402:21-31Zhang, Z., Zhu, B. and Ge, W. 2015 Genetic Analysis of Zebrafish Gonadotropin (FSH and LH) Functions by TALEN-mediated Gene Disruption. Molecular Endocrinology 29:76-98Yao, K., Lau, S.-W. and Ge, W. 2014 Differential regulation of Kit ligand A expression in the ovary by IGF-I via different pathways. Molecular Endocrinology 28:138-150Li, C.W. and Ge, W. 2013 Regulation of the activin-inhibin-follistatin system by bone morphogenetic proteins in the zebrafish ovary. Biology of Reproduction 89:1-10Chen, W. and Ge, W. 2013 Gonadal differentiation and puberty onset in the zebrafish – evidence for dependence of puberty onset on body growth but not age in females. Molecular Reproduction and Development 80:384-392Chung, C.-K. and Ge, W. 2012 Epidermal growth factor differentially regulates activin subunits in the zebrafish ovarian follicle cells via diverse signaling pathways. Molecular and Cellular Endocrinology 361:133-142Chen, W. and Ge, W. 2012 Ontogenic expression profiles of gonadotropins (fshb and lhb) and growth hormone (gh) during sexual differentiation and puberty onset in female zebrafish. Biology of Reproduction 86:1-11Liu, K.-C., Lin, S.-W. and Ge, W. 2011 Differential regulation of gonadotropin receptors (fshr and lhcgr) by estradiol in the zebrafish ovary involves nuclear estrogen receptors that are likely located on the plasma membrane. Endocrinology 152:4418-4430Zhou, R., Tsang, A.H.K., Lau, S.-W. and Ge, W. 2011 Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in the zebrafish ovary – evidence for potential dual roles of pacap in controlling final oocyte maturation. Biology of Reproduction 85:615-625 (Cover story)Li, C.W. and Ge, W. 2011 Spatiotemporal expression of bone morphogenetic protein family ligands and receptors in the zebrafish ovary – a potential paracrine signaling mechanism for oocyte-follicle cell communication. Biology of Reproduction 85:977-986Yao, K. and Ge, W. 2010 Kit system in the zebrafish ovary – Evidence for functional divergence of two isoforms of kit (kita and kitb) and kit ligands (kitlga and kitlgb) during folliculogenesis. Biology of Reproduction 82:1216-1226Poon, S.-K., So, W.-K., Yu, X., Liu, L. and Ge, W. 2009 Characterization of inhibin a subunit (inha) in the zebrafish: evidence for a potential feedback loop between the pituitary and ovary. Reproduction 138:1-12Liu, L. and Ge, W. 2007 Growth differentiation factor 9 and its spatiotemporal expression and regulation in the zebrafish ovary. Biology of Reproduction 76:294-302Ge, W. 2005 Intrafollicular paracrine communication in the zebrafish ovary: The state of the art of an emerging model for the study of vertebrate folliculogenesis. Molecular and Cellular Endocrinology 237:1-10 (Invited At-the-Cutting-Edge review)Kwok, H.-F., So, W.-K., Wang, Y. and Ge, W. 2005 Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors (Fshr and Lhr) – Evidence for their distinct functions in follicle development. Biology of Reproduction 72:1370-81So, W.-K., Kwok, H.-F. and Ge, W. 2005 Zebrafish gonadotropins and their receptors: II. Cloning and characterization of zebrafish follicle-stimulating hormone (FSH) and luteinizing hormone (LH) subunits – Their spatial-temporal expression patterns and receptor specificity. Biology of Reproduction 72:1382-96Wang, Y. and Ge, W. 2004 Developmental profiles of activin βA, βB and follistatin expression in the zebrafish ovary – evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction 71:2056-2064Wang, Y. and Ge, W. 2004 Cloning of epidermal growth factor (EGF) and EGF receptor (EGFR) from the zebrafish ovary and its potential roles in the regulation of ovarian activin/follistatin system. Biology of Reproduction 71:749-760Wang, Y., Wong, A.O.L. and Ge, W. 2003 Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology 144:4799-4810Wang, Y. and Ge, W. 2003 Involvement of cyclic adenosine 3’,5’-monophosphate in the differential regulation of activin bA and bB expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology 144:491-499Pang, Y. and Ge, W. 2002 Epidermal growth factor (EGF) and transforming growth factor-a (TGF-a) promote zebrafish oocyte maturation in vitro: potential role of the ovarian activin regulatory system. Endocrinology 143:47-54Pang, Y. and Ge, W. 2002 Gonadotropin and activin enhance maturational competence of the oocytes in the zebrafish, Danio rerio. Biology of Reproduction 66:259-265