个人简介
Education Ph.D. Italian Ministry of University, ItalyM.S. Ohio State University, USA“LAUREA” B.S.+ M.S. University of Trieste, ItalyAcademic and Professional Experience2018-to date Adjunct professor, Faculty of Health Sciences, University of Macau, China2002-to date Promoted (2002) and then appointed (2005) Full Professor of Chemistry, University of Trieste, Italy2001-2002 Associate professor of Materials Science, University of Trieste, Italy2001 Visiting professor, Technical University of Dresden, Germany1998-2001 Associate professor of Materials Science, “La Sapienza” University, Rome, Italy1995 1996 Research Associate, Kyoto Institute of Technology, Japan1993 Research Associate, University of California at Santa Barbara, USA1990-1998 Assistant professor of Applied Chemistry, University of Trieste, Italy
研究领域
Presently, the main research activity of Prof. Sergo concerns the use of Raman vibrational spectroscopy for applications in Health and Life Sciences. Within this field, a long lasting effort is devoted to use Surface-Enhanced Raman Spectroscopy for quantitative determination of chemotherapeutic drugs circulating in the patients metabolic system. The final purpose is to arrive at a cheap, timely, drug quantification for achieving Therapeutic Drug Monitoring (TDM); so far encouraging results have been achieved for Methotrexate and Imatinib.Another area of investigation concerns the use of Raman SERS for large scale cancer screening: in this case the approach is to build a chemometric model from a large number of known samples of Plasma/serum from patients, and to place a new sample/patients in a population determined by Principal Component Analysis(Linear Discriminant Analysis (or other chemometric tools). So far the approach, very cheap and fast, is being tested on breast cancer and prosthate cancer.In the past efforts have been dedicated to mapping of histological sections for comparing the morphological with the biochemical information (lung diseases, coeliac diseases, for example).
PatentsPatent 102016000114276: “Substrate to carry out analysis and procedure to produce it”
近期论文
Representative PublicationsFornasaro, S., Marta, S.D., Rabusin, M., Bonifacio, A., Sergo, V. Toward SERS-based point-of-care approaches for therapeutic drug monitoring: The case of methotrexate (2016) Faraday Discussions, 187, pp. 485-499.Bonifacio, A., Cervo, S., Sergo, V. Label-free surface-enhanced Raman spectroscopy of biofluids: Fundamental aspects and diagnostic applications (2015) Analytical and Bioanalytical Chemistry, 407 (27), pp. 8265-8277.Cervo, S., Mansutti, E., Mistro, G.D., Spizzo, R., Colombatti, A., Steffan, A., Sergo, V., Bonifacio, A. SERS analysis of serum for detection of early and locally advanced breast cancer (2015) Analytical and Bioanalytical Chemistry, 407 (24), pp. 7503-7509.Bonifacio, A., Dalla Marta, S., Spizzo, R., Cervo, S., Steffan, A., Colombatti, A., Sergo, V. Surface-enhanced Raman spectroscopy of blood plasma and serum using Ag and Au nanoparticles: A systematic study (2014) Analytical and Bioanalytical Chemistry, 406 (9-10), pp. 2355-2365.
