个人简介

EducationPhD Graduate Institute of Photonics & Optoelectronics, National Taiwan University (2004)BS Department of Electrical Engineering, National Taiwan University (1999)Academic and Professional Experience2016/08-present Associate Professor, Faculty of Health Sciences, University of Macau2013/08-2016/07 Associate Professor, Inst. of Biomedical Engineering, National Taiwan University2012/02-2012/12 Visiting Scientist, Wellman Center for Photomedicine, Massachusetts General Hospital, USA2009/08-2013/07 Assistant Professor, Inst. of Biomedical Engineering, National Taiwan University2005/01-2009/07 Postdoctoral Researcher, Grad. Inst. of Photonics & Optoelectronics, National Taiwan UniversityTeaching experienceCorner stone coursesOptical microscopyLaser principles and engineeringFundamentals of opticsCapstone coursesClinical observation & finding unmet needsMedical innovation with electronicsBiomedical innovation & commercialization (Incubate 1 startups and train 48 innovation teams)Quality system of medical devicesCourse OutlinesHSCI4007 Translational MedicineHSCI7004 Healthcare AnalyticsGEST1002 Quantitative Reasoning for Social Sciencess

研究领域

We are biomedical optics lab using lasers for the observation of cells in vivo, the sensing of metabolic molecules, the diagnosis of diseases, and the development of medical devices. For the observation, we integrated home-build femtosecond lasers, scanning electronics, and microscopes into an in vivo microscopy system. On this platform, we studied embryonic development, tumor microenvironment, pharmacokinetics of nanomedicines, and in vivo cytometry of leukocytes. For the tracking of cells or drug delivery, we developed multiphoton contrast agents with nanomaterials like Si quantum dots, gold nanorod-in-shell, insulin-gold nanodot, iron oxide, and iron-platinum alloy. Exploiting the laser excited autofluorescence of metabolic molecules, we are developing spectroscopic methods for disease diagnosis. Through the discovery of characteristic optical properties in biomedical context, we aim to develop medical devices to solve the unmet clinical needs.

PatentsC.-K. Sun, T.-M. Liu, Y.-C. Huang, and G.-W. Chern, “Method and System for Measuring an Ultrashort Optical Pulse,” USA patent US6,734,976 B2, May 11, 2004.

近期论文

Representative PublicationsY. Li and T.-M. Liu*, “Discovering Macrophage Functions Using In Vivo Optical Imaging Techniques,” Frontiers in Immunology 9, 502 (2018).T.-M. Liu*, J. Conde*, T. Lipiński, A. Bednarkiewicz, C.-C. Huang*, “Smart NIR linear and nonlinear optical nanomaterials for cancer theranostics: Prospects in photomedicine,” Progress in Materials Science 88, 89-135 (2017).J.-Y. Huang, L.-Z. Guo, J.-Z. Wang, T.-C. Li, H.-J. Lee, P.-K. Chiu, L.-H. Peng, and T.-M. Liu*, “Fiber-based 1150-nm femtosecond laser source for the minimally invasive harmonic generation microscopy,” Journal of Biomedical Optics 22, 036008 (2017).C.-H. Wu, T.-D. Wang*, C.-H. Hsieh, S.-H. Huang, J.-W. Lin, S.-C. Hsu, H.-T. Wu, Y.-M. Wu*, and T.-M. Liu* “Imaging Cytometry of Human Leukocytes with Third Harmonic Generation Microscopy,” Scientific Reports 6, 37210 (2016).T.-M. Liu*, J. Conde*, T. Lipiński, A. Bednarkiewicz, C.-C. Huang*, “Revisiting the classification of NIR absorbing/emitting Nanomaterials for in vivo bio-applications,” NPG Asia Materials 8, e295 (2016).S.-W. Chou, C.-L. Liu, T.-M. Liu*, Y.-F. Shen, L.-C. Kuo, C.-H. Wu, T.-Y. Hsieh, P.-C. Wu, M.-R. Tsai, C.-C. Yang, K.-Y. Chang, M.-H. Lu, P.-C. Li, S.-P. Cheng, Y.-H. Wang, C.-W. Lu, Y.-A. Chen, C.-C. Huang, C.-R. Chris Wang, J.-K. Hsiao,* M.-L. Li*, and P.-T. Chou*, “Infrared-active quadruple contrast FePt nanoparticles for multiple scale molecular imaging,” Biomaterials 85, 54-64 (2016).C.-C. Huang* and T.-M. Liu, “Controlled Au-polymer nanostructures for multiphoton imaging, prodrug delivery, and chemo-photothermal therapy platforms,” ACS Applied Materials & Interfaces 7, 25259-25269 (2015).Y.-F. Shen, M.-R. Tsai, S.-C. Chen, Y.-S. Leung, C.-T. Hsieh, Y.-S. Chen, F.-L. Huang, R. P. Obena, M. M. L. Zulueta, H.-Y. Huang, W.-J. Lee, K.-C. Tang, C.-T. Kung, M.-H. Chen, D.-B. Shieh, Y.-J. Chen, T.-M. Liu*, P.-T. Chou*, and C.-K. Sun*, “Imaging Endogenous Bilirubins with Two-Photon Fluorescence of Bilirubin Dimers,” Analytical Chemistry 87, 7575-7582 (2015).P.-C. Wu, T.-Y. Hsieh, Z.-U. Tsai, and T.-M. Liu*, “In vivo Quantification of the Structural Changes of Collagens in a Melanoma Microenvironment with Second and Third Harmonic Generation Microscopy,” Scientific Reports 5, 8879 (2015).C.-L. Liu, T.-M. Liu*, T.-Y. Hsieh, H.-W. Liu, Y.-S. Chen, C.-K. Tsai, H.-C. Chen, J.-W. Lin, R.-B. Hsu, T.-D. Wang, C.-C. Chen, C.-K. Sun, and P.-T. Chou*, “In vivo Metabolic Imaging of Insulin with Multiphoton Fluorescence of Human Insulin-Au Nanodots,” Small 9, 2103-2110 (2013).M.-Y. Liao, C.-H. Wu, P.-S. Lai, J. Yu, H.-P. Lin, T.-M. Liu*, and C.-C. Huang,* “Surface State Mediated NIR Two-Photon Fluorescence of Iron Oxides for Nonlinear Optical Microscopy,” Advanced Functional Materials 23, 2044-2051 (2013).C.-K. Tsai, T.-D. Wang*, J.-W. Lin, R.-B. Hsu, L.-Z. Guo, S.-T. Chen, and T.-M. Liu*, “Virtual Optical Biopsy of Human Adipocytes with third harmonic generation microscopy,” Biomedical Optics Express 4, 178-186 (2013).C.-K. Chen and T.-M. Liu*, “Imaging morphodynamics of human blood cells in vivo with video-rate third harmonic generation microscopy,” Biomedical Optics Express 3, 2860-2865 (2012).C.-K. Tsai, Y.-S. Chen, P.-C. Wu, T.-Y. Hsieh, H.-W. Liu, C.-Y. Yeh, W.-L. Lin, J.-S. Chia, and T.-M. Liu*, “Imaging granularity of leukocytes with third harmonic generation microscopy,” Biomedical Optics Express 3, 2234-2243 (2012).K. Wang#, T.-M. Liu#, J. Wu, N. G. Horton, C. P. Lin*, and C. Xu*, “Three-color femtosecond source for simultaneous excitation of three fluorescent proteins in two-photon fluorescence microscopy,” Biomedical Optics Express 3, 1972-1977 (2012). Co-first authorS.-H. Chia, T.-M. Liu*, A. A. Ivanov, A. B. Fedotov, A. M. Zheltikov, M.-R. Tsai, M.-C. Chan, C.-H. Yu, and C.-K. Sun*, “A sub-100fs self-starting Cr:forsterite laser generating 1.4W output power,” Optics Express 18, 24085- 24091 (2010).C.-Y. Lin, T.-M. Liu, C.-Y. Chen, Y.-L. Huang, W.-K. Huang, C.-K. Sun, F.-H. Chang*, and W.-L. Lin*, “Quantitative and qualitative investigation into the impact of focused ultrasound with microbubbles on the triggered release of nanoparticles from vasculature in mouse tumors,” Journal of Controlled Release 146, 291-298 (2010).K.-W. Hu, T.-M. Liu, K.-Y. Chung, K.-S. Huang, C.-T. Hsieh, C.-K. Sun, and C.-S. Yeh*, “Efficient near-IR hyperthermia and intense nonlinear optical imaging contrast on the gold nanorod-in-shell nanostructures,” Journal of the American Chemical Society 131, 14186-14187 (2009).T.-M. Liu, H.-P. Chen, L.-T. Wang, J.-R. Wang, T.-N. Luo, Y.-J. Chen, S.-I. Liu, and C.-K. Sun*, “Microwave resonant absorption of viruses through dipolar coupling with confined acoustic vibrations,” Applied Physics Letters 94, 043902 (2009).T.-M. Liu, M.-C. Chan, I.-H. Chen, S.-H. Chia, and C.-K. Sun*, “Miniaturized multiphoton microscope with a 24Hz frame-rate,” Optics Express 16, 10501-10506 (2008).T.-M. Liu, J.-Y. Lu, H.-P. Chen, C.-C. Kuo, M.-J. Yang, C.-W. Lai, P.-T. Chou, M.-H. Chang, H.-L. Liu, Y.-T. Li, C.-L. Pan, S.-H. Lin, C.-H. Kuan, and C.-K. Sun*, “Resonance-enhanced dipolar interaction between terahertz photons and confined acoustic phonons in nanocrystals,” Applied Physics Letters 92, 093122 (2008).T.-M. Liu, M.-J. Yang, C.-W. Lai, P.-T. Chou, M.-H. Chang, H.-L. Liu, and C.-K. Sun*, “Piezoelectricity-induced terahertz photon absorption by confined acoustic phonons in wurtzite CdSe nanocrystals,” Physical Review B. 77, 085428 (2008).S.-P. Tai, Y. Wu, D.-B. Shieh, L.-J. Chen, K.-J. Lin, C.-H. Yu, S.-W. Chu, C.-H. Chang, X.-Y. Shi, Y.-C. Wen, K.-H. Lin, T.-M. Liu, and C.-K. Sun*, “Molecular imaging of cancer cells using plamon-resonant-enhanced third-harmonic-generation in silver nanoparticles,” Advanced Materials 19. 4520-4523 (2007).T.-M. Liu, S.-P. Tai, C.-H. Yu, Y.-C. Wen, S.-W. Chu, L.-J. Chen, M. R. Prasad, K.-J. Lin, and C.-K. Sun*, “Measuring plasmon-resonance enhanced third-harmonicχ(3) of Ag nanoparticles,” Applied Physics Letters 89, 043122 (2006).S.-W. Chu, I-H. Chen, T.-M. Liu, P.-C. Chen, C.-K. Sun*, and B.-L. Lin, “Multimodal nonlinear spectral microscopy based on a femtosecond Cr:forsterite laser,” Optics Letters 26, 1909-1911 (2001).Book ChapterY. Li, C.-W. Lee, Y.-C. Wang, C.-C. Huang, T.-M. Liu, “Single and Multiphoton Responsive Nanomaterials for the Investigation of Cancer Microenvironment,” Ch3 in Handbook of Nanomaterials for Cancer Theranostics, 1st Ed., Elsevier 2018.