个人简介

Academic QualificationsB. Med Zhejiang University, Clinical MedicineMPhil The Chinese University of Hong Kong, NeurosciencePhD The University of Hong Kong , NeuroscienceTeachingUndergraduate CoursesBiomedical StatisticsAnatomy and Physiology IAnatomy and Physiology IIFinal Year ProjectsPostgraduate CoursesTargets and Models for Drug ScreenResearch EthicsFunctional Food Product Development in Chinese Medicine

研究领域

1.Investigating beneficial effects of omega-3 polyunsaturated fatty acids and finding effective treatments for cerebral small vessel disease and vascular dementia2.Studying glymphatic functions in brain disorders3.Establishing human induced pluripotent stem cells (iPSCs)-based cell models to elucidate pathogenic mechanisms in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis.

Research Projects as principle investigator (PI)(1). Mechanistic studies on cell cycle and cell division during cell reprograming (Ministry of Science and Technology 973 program of China; Project Code: 2012CB966802; Duration: 2012, 01-2016, 12). PI.(2). Application of induced pluripotent stem cells in treatment of multiple sclerosis (Start-up Research Grant (SRG) 2012; Project Code: SRGO14.ICMS12-SHX; Duration: 2012, 01-2012, 12). PI.(3). Using patient-derived induced pluripotent stem cells for drug screens for efficacy and preclinical predictive toxicology (Multi-year research grant from the University of Macau; Project Code: MYRG122 (Y1-L3)-ICMS12-SHX; Duration: 2012, 06-2015, 05). PI.(4). Therapeutic potentials of ginsenoside and neural progenitor cell transplantation in stroke (Multi-year research grant from the University of Macau; Project Code: MYRG110 (Y1-L2)-ICMS13-SHX; Duration: 2013, 05-2016, 04). PI.(5). Therapeutic potentials of a combination of ginsenoside Rd administration and neural progenitor cell transplantation in stroke (Macao Science and Technology Development Fund; Project Code: FDCT 003/2012/A; Duration: 2012, 10-2014, 04). PI.(6). Using patient-specific induced pluripotent stem cells to establish drug screening platforms for neurodegenerative diseases (Macao Science and Technology Development Fund; Project Code: FDCT 018/2013/A1; Duration: 2014, 01-2016, 12). PI.(7). Driving metabolite clearance from the brain to maintain its homeostasis via activating the Glymphatic System and exploring its underlying mechanisms (Macao Science and Technology Development Fund; Project Code: FDCT 063/2015/A2; Duration: 2016, 01-2018, 06). PI.(8). Mechanistic studies on the development of cerebral small vessel diseases and therapeutic potentials of omega-3 polyunsaturated fatty acids in the treatment of cerebral small vessel diseases and vascular cognition impairment (Macao Science and Technology Development Fund; Project Code: FDCT 020/2017/A1; Duration: 2017, 08-2020, 07). PI.(9). Driving metabolite clearance from the brain to maintain its homeostasis via activating the Glymphatic System (Multi-year research grant from the University of Macau; Project Code: MYRG2016-00184-ICMS-QRCM; Duration: 2017, 01-2019, 12). PI.(10). Roles and action mechanisms of SENP3 in autism (FDCT-NSFC; Project Code: FDCT 039/2017/AFJ; Duration: 2018, 01-2020, 12). PI.(11). Study of neprilysin gene therapy targeting the glymphatic pathway for the treatment of Alzheimer’s disease and cerebral amyloid angiopathy (Multi-year research grant from the University of Macau; Project Code: MYRG2018-00242-ICMS; 2018, 09-2021, 08). PI.

近期论文

Selective recent publications (* corresponding author)Tan Y, Ke M, Huang Z, Chong C, Cen X, Lu JH, Yao X*, Qin D*, Su H*. Hydroxyurea facilitates manifestation of disease relevant phenotypes in patients-derived iPSCs-based modeling of late-onset Parkinson’s disease. Aging and disease. 2019 http://dx.doi.org/10.14336/AD.2018.1216.Yan L, Xie Y, Satyanarayanan SK, Zeng H, Liu Q, Huang M, Ma Y, Wan JB, Yao X, Su KP, Su H*. Omega-3 polyunsaturated fatty acids promote brain-to-blood clearance of β-Amyloid in a mouse model with Alzheimer’s disease. Brain Behav Immun. 2019 May 24. pii: S0889-1591(18)31175-9.Shi Z, Xie Y, Ren H, He B, Wang M, Wan J, Yuan TF*, Yao X*, Su H*. Fish oil treatment reduces chronic alcohol exposure induced synaptic changes. Addiction Biology. 2019 July, 24, 577-589.Habib MR, Li H, Kong Y, Liang T, Obaidulla SM, Xie S, Wang S, Ma X, Su H*, Xu M*. Tunable photoluminescence in a van der Waals heterojunction built from a MoS2 monolayer and a PTCDA organic semiconductor. Nanoscale. 2018 Aug 30;10(34):16107-16115.Chong CM, Ke M, Tan Y, Huang ZJ, Zhang K, Ai N, Ge W, Qin DJ, Lu JH, Su H*. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling. Cell Death Dis. 2018 Aug 29;9(9):879.Luo C, Ren H, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su KP, Su H*. Enriched Brain Omega-3 Polyunsaturated Fatty Acids Confer Neuroprotection against Microinfarction. EBioMedicine. 2018 Jun;32:50-61.Chong CM, Ai N, Ke M, Tan Y, Huang Z, Li Y, Lu JH, Ge W, Su H*. Roles of Nitric Oxide Synthase Isoforms in Neurogenesis. Mol Neurobiol. 2018 Mar;55(3):2645-2652.He B, Zheng M, Liu Q, Shi Z, Long S, Lu X, Pei Z, Yuan TF, Su H*, Yao X*. Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice. Mol Neurobiol. 2018 Feb;55(2):1703-1713.Shi Z, Ren H, Huang Z, Peng Y, He B, Yao X, Yuan T, Su H*. Fish oil prevents Lipopolysaccharide -induced depressive-like behavior by inhibiting neuroinflammation. Mol Neurobiol. 2017 54:7327-7334.Luo C, Liang F, Ren H, Yao X, Liu Q, Li M, Qin D, Yuan TF, Pei Z, Su H*. Collateral blood flow in different cerebrovascular hierarchy provides endogenous protection in cerebral ischemia. Brain Pathology. 2017 Nov;27(6):809-821Huang X, Chen Y-Y, Shen Y, Cao Y, Li A, Liu Q, Li Z, Zhang L-B, Dai W, Tan T, Arias-Carrion O, Xue Y-X, Su H* and Yuan T-F*. Methamphetamine abuse impairs motor cortical plasticity and function. Molecular Psychiatry 2017 Sep;22(9):1274-1281.Ren H, Yang Z, Luo C, Zeng H, Li P, Kang JX, Wan JB, He C, Su H*. Enriched Endogenous Omega-3 Fatty Acids in Mice Ameliorate Parenchymal Cell Death After Traumatic Brain Injury. Mol Neurobiol. 2017 Jul;54(5):3317-3326.Ren H, Luo C, Feng Y, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su H*. Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system. FASEB J, 2017 Jan;31(1):282-293.Shi Z, Ren H, Luo C, Yao X, Li P, He C, Kang JX, Wan JB, Yuan TF, Su H*. Enriched Endogenous Omega-3 Polyunsaturated Fatty Acids Protect Cortical Neurons from Experimental Ischemic Injury. Mol Neurobiol. 2016 Nov;53(9):6482-6488.Luo C, Yao X, Li J, He B, Liu Q, Ren H, Liang F, Li M, Lin H, Peng J, Yuan TF, Pei Z, Su H*. Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control. Cell Death Dis. 2016 Mar 31;7:e2160.Tan Y, Ren H, Shi Z, Yao X, He C, Kang JX, Wan JB, Li P, Yuan TF, Su H*. Endogenous Docosahexaenoic Acid (DHA) prevents Aβ1–42 oligomers induced neuronal injury. Mol Neurobiol. 2016 Jul;53(5):3146-53.Yang X, Li J, Liang T, Chen H, Hanagata N, Su H*, and Xu M*. Antibacterial activity of two-dimensional MoS2 sheets. Nanoscale 2014 Aug 7;6 (17):10126-33.Luo C, Ren H, Wan JB, Yao X, Zhang X, He C, So KF, Kang JX, Pei Z, Su H*. Enriched endogenous omega-3 fatty acids in mice protect against global ischemia injury. J Lipid Res. 2014 May 29; 55 (7):1288-1297.