个人简介

Education1996 – 1998 Postdoctoral fellow, Laboratory of Dr. Janet Rowley, Department of Medicine, University of Chicago1994 – 1996 Postdoctoral fellow, laboratory of Dr. Richard Morimoto, Department of Molecular Sciences, Northwestern University1989 — 1994 Doctor of Medicine, Swiss Institute for Experimental Cancer Research (ISREC), University of Lausanne, Switzerland1986 – 1989 Assistant Researcher, Department of Immunology, Institute for Basic Research, China Academy of Traditional Chinese Medicine, Beijing, China1983 — 1986 Master of Medicine, Shandong Medical University, China1978 — 1983 Bachelor of Medicine, Jiangxi Medical College, ChinaAcademic and Professional Experience2017 – presentProfessor, Faculty of Health Sciences, University of Macau2010 – 2016Associate Professor, Department of Genetics, Cell Biology & Anatomy,University of Nebraska Medical Center, Nebraska, USA2008 – 2010Adjunct Professor, McCormick School of Engineering and Applied Science, Northwestern University, Illinois, USA2004 – 2009Assistant Professor, Northwestern University;Director, Center for Functional Genomics, ENH Research Institute, Illinois, USA1998 – 2003Research Assistant Professor, Department of Medicine, University of Chicago, USAJournal reviewerAnalytical Biochemistry, Biochemistry Research International, Bioinformatics, BioTechniques, BMC Cancer, BMC Developmental Biology, BMC Evolutionary Biology, BMC Genomics, BMC Bioinformatics, BMC Medical Genetics, BMC Medical Genomics, Case Reports in Obstetrics and Gynecology, Cell Cycles, Cell Death and Differentiation, Current Medicinal Chemistry, Cancer Genetics, Cancer Biomarkers, Cancer Medicine, Differentiation, Experimental Hematology, Familial Cancer, The Breast Journal, FEBS Letters, Gene, Genes, Chromosomes & Cancer, Genome Biology, Genetics, Genome Research, Genomics, In Silico Bioinformatics, Insect MicroRNAs, Molecular Biology, Journal of Africa Biotechnology, Journal of Biology, Journal of Biotechnology, Journal of Biomedicine and Biotechnology, Molecular Pharmacology, Nature, Nature Biotechnology, Nature Communication, Nature Methods, Nature Review of Genetics, Nature Protocol, Neurotoxicity Research, Nucleic Acid Research, Oncogene, Oncotarget, Pathology – Research and Practice, Physiological Genomics, PLOS One, PNAS, Proteomics, Science, Stem CellCourse OutlinesHSCI3004 Genomics and BioinformaticsHSCI7004 Healthcare AnalyticsAdvanced Genetics and Bioinformatics

研究领域

Cancer genomics and geneticsHereditary breast cancerNext-generation DNA sequencingBioinformaticsWhole genome sequencingExome sequencingTranscriptome

近期论文

Representative PublicationsSM Wang, JD Rowley. A Strategy for Gene Identification: Integrated Procedure for Gene Identification. Proc. Natl. Acad. Sci. USA 95: 11909-11914, 1998J Chen, JD Rowley, SM Wang. Generation of longer cDNA fragments from serial analysis of gene expression tags for gene identification. Proc. Natl. Acad. Sci. USA 97: 349-353, 2000SM Wang, SC Fears, L Zhang, J-J Chen, JD Rowley. Screening poly dA/dT(-) cDNAs for gene identification. Proc. Natl. Acad. Sci. USA 97:4162-4167, 2000. (Commentary by KJ Martin and AB Pardee. Identifying expressed genes. Proc. Natl. Acad. Sci. USA 97: 3789-3791, 2000)S Lee, G Zhou, T Clark, J Chen, JD Rowley, SM Wang. The pattern of gene expression in human CD15+ myeloid progenitor cells. Proc. Natl. Acad. Sci. USA 98: 3340-3345, 2001G Zhou, J Chen, S Lee, T Clark, JD Rowley, SM Wang. The pattern of gene expression in human CD34+ hematopoietic stem/progenitor cells. Proc. Natl. Acad. Sci. USA 98: 13966-13971, 2001D Nam, S Lee, G Zhou, X Cao, C Wang, J Chen, T Clark, JD Rowley, SM Wang. Oligo dT primer generates a high frequency of truncated cDNAs through internal poly A priming during reverse transcription. Proc. Natl. Acad. Sci. USA. 99: 6152-6156, 2002T Clark, S Lee, LR Scott, SM Wang. Computational analysis of gene identification with SAGE. Journal of Computational Biology 3: 513-526, 2002M Müschen, S Lee, G Zhou, N Feldhahn, VS Barath, J Chen, C Moers, M Krönke, JD Rowley, SM Wang. Molecular portraits of B cell lineage commitment. Proc. Natl. Acad. Sci. USA 99:10014-10019, 2002J Chen, M Sun, S Lee, G Zhou, JD Rowley, SM Wang. Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags. Proc. Natl. Acad. Sci. USA 99: 12257-12262, 2002S Lee, J Bao, G Zhou, J Shapino, J Xu, RZ Shi, X Lu, T Clark, D Johnson, YC Kim, C Wing, C Tseng, M Sun, W Lin, J Wang, W Du, CI Wu, X Zhang, SM Wang. Detecting novel low-abundant transcripts in Drosophila. RNA 11: 939-946, 2005S Lee, J Chen, G Zhou, RZ Shi, G Bouffard, M Kocherginsky, X Ge, M Sun, N Jayathilaka, YC Kim, N Emmanuel, S Bohlander, M Minden, J Kline, O Ozer, R Larson, M LeBeau, E Green, J Trent, T Karrison, P Liu, SM Wang, JD Rowley. Gene Expression Profiles in Acute Myeloid Leukemia with Common Translocations using SAGE, Proc. Natl. Acad. Sci. USA 103: 1030-1035, 2006X Ge, Q Wu, YC Jung, J Chen, SM Wang. A large quantity of novel human antisense transcripts detected by LongSAGE. Bioinformatics. 22: 2475-2479, 2006. (“the Hot Paper in Computer Science” in 2008 by Essential Science Indicators of Thompson Scientific)S Lee, J Hwang, J Ulaszek, YC Kim, H Dong, HS Kim, JW Seok, BK Suh, SJ Yim, D Johnson, NH Choe, KT Chang, ZY Ryoo, CC Tseng, A Wickrema, SM Wang. Stable transcriptional status in the apoptotic erythroid genome. Biochem Biophys Res Commun. 359: 556-562, 2007SM Wang. Understanding SAGE data. Trends in Genetics 23: 42-50, 2007J Lu, Y Shen, Q Wu, S Kumar, B He, RW Carthew, SM Wang, CI Wu. The birth and death of microRNA genes in Drosophila. Nature Genetics 40: 351-355, 2008.J Chen, YC. Kim, Y-C Jung, Z Xuan, G Dworkin, Y Zhang, MQ Zhang, SM Wang. Scanning the human genome at kilobase resolution. Genome Research 18: 751-762, 2008Q Wu, YC Kim, J Lu, Z Xuan, J Chen, YL Zheng, T Zhou, MQ Zhang, CI Wu, SM Wang. Poly A- transcripts expressed in HeLa cells. PLoS ONE 3: e2803, 2008YC. Kim, Q Wu, J Chen, Z Xuan, Y-C Jung, MQ Zhang, JD Rowley, SM Wang. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Proc. Natl. Acad. Sci. USA 106: 8278-8283, 2009X Huang, H Guo, S Tammana, YC Jung, E Mellgren, P Bassi, L Ma, ZJ Tu, SC Ekker, X Wu, SM Wang, XZ Zhou. Gene Transfer Efficiency and Genome-Wide Integration Profiling of Sleeping Beauty, Tol2 and PiggyBac Transposons in Human Primary T Cells. Molecular Therapy. 18(10):1803-13, 2010Wen H, Li Y, Malek SN, Kim YC, Xu J, Chen P, Xiao F, Huang X, Zhou X, Xuan Z, Mankala S, Hou G, Rowley JD, Zhang MQ, SM Wang. New fusion transcripts identified in normal karyotype acute myeloid leukemia. PLoS One 7:e51203, 2012Lynch H, Wen H, Kim YC, Snyder C, Kinarsky Y, Chen PX, Xiao F, Goldgar D, Cowan KH, SM Wang. Can unknown predisposition in familial breast cancer be family-specific? The Breast Journal, 19:520-528, 2013COMPLEXO, Southey MC, Park DJ, Nguyen-Dumont T, Campbell I, Thompson E, Trainer AH, Chenevix-Trench G, Simard J, Dumont M, Soucy P, Thomassen M, Jønson L, Pedersen IS, Hansen TV, Nevanlinna H, Khan S, Sinilnikova O, Mazoyer S, Lesueur F, Damiola F, Schmutzler R, Meindl A, Hahnen E, Dufault MR, Chris Chan T, Kwong A, Barkardóttir R, Radice P, Peterlongo P, Devilee P, Hilbers F, Benitez J, Kvist A, Törngren T, Easton D, Hunter D, Lindstrom S, Kraft P, Zheng W, Gao YT, Long J, Ramus S, Feng BJ, Weitzel JN, Nathanson K, Offit K, Joseph V, Robson M, Schrader K, SM Wang, Kim YC, Lynch H, Snyder C, Tavtigian S, Neuhausen S, Couch FJ, Goldgar DE. COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration. Breast Cancer Res. 15(3):402, 2013Xiao F, Kim YC, Snyder C, Wen H, Chen PX, Luo J, Becirovic D, Downs B, Cowan KH, Lynch H, SM Wang. Genome instability in blood cells of a BRCA1+ breast cancer family. BMC Cancer 14:342, 2014.Wen H, Kim Y, Snyder C, Xiao F, Fleissner EA, Becirovic D, Luo J, Downs B, Sherman S, Cowan KH, Lynch HT, SM Wang. Family-specific, novel, deleterious germline variants provide a rich source to identify genetic predispositions for BRCAx familial breast cancer. BMC Cancer, 14:470, 2014.Lynch H, Synder C, SM Wang. Considerations for comprehensive assessment of genetic predisposition in familial breast cancer. Breast J. 21(1):67-75, 2015.Angulo-Ibáñez M, Rovira-Clavé X, Downs B, Kim YC, SM Wang, Tournier C, Reina M, Espel E. Erk5 contributes to balance cellular nucleotide levels and avoid replicative stress, Cell Cycle, 14(24):3864-76, 2015.Kim KC, Zhao L, Zhang H, Huang Y, Cui J, Xiao F, Downs F, SM Wang. Prevalence and spectrum of BRCA germline variants in mainland Chinese familial breast and ovarian cancer patients. Oncotarget 7(8):9600-12, 2016.Cui J, Luo L, KimYC, Synder C, Becirovic D, Downs B, Lynch H, SM Wang. Differences of variable number tandem repeats in XRCC5 promoter are associated with increased or decreased risk of familial breast cancer. Frontiers in Oncology, 6:00092, 2016.Zhang Y, Zhang Y, Geng L, Yi H, Huo W, Talmon G, Kim YC, SM Wang, Wang J. Transforming growth factor β mediates drug resistance by regulating expression of pyruvate dehydrogenase kinase 4 in colorectal cancer. JBC 291(33):17405-16, 2016.Kim YC, Cui J, Luo J, Xiao F, Downs B, Wang SM. Exome-based Variant Detection in Core Promoters. Sci Rep. 6:30716, 2016.SAGE: Current Technologies and Applications. p1-375. Horizon Scientific Press, UK. Editor: SM Wang, 2005