个人简介

Academic QualificationsBE, Zhejiang UniversityPhD, Shanghai Institute of Materia Medica, Chinese Academy of SciencesPostdoc associate, Baylor College of MedicineTeachingBIOB114, Fundamental ChemistryBIOB353, PhytochemistryCMED717, Development of Drugs and Health ProductsCMED722, Advanced Natural Products ChemistryCMED810, Chinese Medicine and Drug DiscoveryCMED821, Chemistry of Natural Medicine

研究领域

Natural Products Chemistry, development of new methods in isolation, structural elucidation, modification and analysis of bioactive natural products.Screening of novel lead compounds for treatment of obesity, diabetes and aging.Mechanism study for diet-related metabolic disorder.

PatentYe, Y., Lin, G., Lin, L-G., Anthony, J.R., Li, X.-Q., Tang, C.-P., Ke, C.-Q. Use of alkaloids compounds in preparingof medicament for treating cough. CN 200710045498.3. 2009.Ye, Y., Lin, G., Lin, L-G., Anthony, J., Li, X.-Q., Tang, C.-P., Ke, C.-Q. Total alkaloid extract, and extraction method thereof and use in preparing medicament for treating cough. CN 200710046888.2. 2009.Ye, Y., Lin, G., Lin, L-G., Anthony, J.R., Li, X.-Q., Tang, C.-P., Ke, C.-Q. The use of alkaloids in preparation of medicament for treating cough. WO 2009//030116. 2009.Lin, L-G., Lu, J.-J., Feng, Z.-L., Zhang, L.-L., Liu, Q.-Y. Norditerpenoids from Podocarpus nagi and application thereof in preparation of anti-tumor drugs. China patent, application number 2017102208690. 2017.Lin, L-G., Huang, L., Li, D. An extract from the seeds of Clausena lansium with anti-hyperglycemia, weight losing and anti-hyperlipidemia effects, and preparation method and application thereof. China patent, application number 201710909565.5, 2017.Lu, J.-J., Lin, L.-G. Li, A., Zhang, L.-L. Norditerpenoids from Podocarpus nagi and application thereof in preparation of drugs for treating pulmonary fibrosis. China patent, application number 201810346526.3, 2018.Zhou, C.-X., Gan, L.-S., Zhang, L.-S., Sheng, R., Wu, H.-S., Lin, L.-G., Mo, J.-X. Benzofurans from Eupatorium chinense, preparation and application. China patent, application number 201811197098, 2018.Lin, L.-G., Pan, R.-L., Shen, S.-N.. Diarylheptanoids from Myrica rubra with anti-hyperglycemia, weight losing and anti-hyperlipidemia effects, and preparation method and application thereof. China patent, application number 201910291027.3, 2019.

近期论文

Study on obesity and diabetes: (#co-first author; *corresponding author)Lin, L.-G., Saha, P.K., Ma, X.-J., Henshaw, I.O., Shao, L.-J., Chang, B.H.J., Bura,s E.D., Tong, Q., Chan, L., McGuinness, O.P., and Sun, Y.-X. (2011) Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell, 10, 996-1010.Lin, L.-G., Pang, W.-J., Chen, K.-Y., Wang, F., Gengler, J., Sun, Y.-X. and Tong, Q. (2012) Adipocyte expression of PU.1 transcription factor causes insulin resistance through up-regulation of ROS production and inflammatory cytokine gene expression. American Journal of Physiology-Endocrinology and Metabolism, 302, E1550-E1559.Pang, W.-J., Lin, L.-G., Xiong, Y., Wei, N., Wang, Y., Shen, Q.-W., Yang, G.-S. (2013) Knockdown of PU.1 as IncRNA inhibits adipogenesis through enhancing PU.1 mRNA translation Journal of Cellular Biochemistry, 114, 2500-2512.Ma, X.-J., Lin, L.-G.#, Yue, J., Pradhan, G., Qiu, G.-J., Minze, L.J., Wu, H.-Z., Sheikh-Hamad, D., Smith, C.W., Sun, Y.-X. (2013) Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance Nutrition & Diabetes, 3 e99.Lin, L.-G., Chen, K.-Y., Khalek, W.A., Ward, J.L., Yang, H., Chantal, B., Wrutniak-Cabello, C., Tong, Q. (2014) Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3 Plos One, 9(1), e85636.Lin, L.-G., Nuotio-Antar, A. M., Ma, X.-J., Liu, F., Fiorotto, M. L., Sun, Y.-X. (2014). Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake, Journal of Nutrition, 144, 1349-1355.Lin L.-G., Lee J. H., Bongmba O. Y., Ma X.-J., Zhu X.-W., Sheikh-Hamad D., Sun Y.-X., (2014). The suppression of ghrelin signaling mitigates age-associated thermogenic impairment, Aging, 6(12), 1019-1032.Liu, Q.-Y., Wang, Y.-T., Lin, L.-G.* (2015). New insights into the anti-obesity activity of xanthones from Garcinia mangostana, Food & Function, 6, 383-393.Lin, L.-G., Lee, J. H., Buras, E. D., Yu, K.-J., Wang, R.-T., Smith, C. W., Wu, H.-Z., Sheikh-Hamad, D., Sun, Y.-X. (2016). Ghrelin receptor regulates adipose tissue inflammation in aging, Aging, 8(1), 178-191.Lee, J. H., Lin, L.-G., Xu, P.-W., Saito, K., Wei, Q., Meadows, A., Bongmba, O., Pradhan, G., Zheng, H., Xu, Y., Sun, Y.-X. (2016). Neuronal deletion of ghrelin receptor almost completely prevents diet-induced obesity, Diabetes, 65, 2169-2178.Wu, C.-S., Bongmba, O. Y. N., Yue, J., Lee, J. H., Lin L.-G., Saito, K., Pradhan, G., Li, D.-P., Pan, H.-L., Xu, A., Guo, S.-D., Xu, Y., Sun, Y.-X. (2017). Suppression of GHS-R in AgRP neurons mitigates diet-induced obesity by activating thermogenesis. International Journal of Molecular Sciences, 18, 832.Ma, X.-J., Lin L.-G.#, Yue, J., Wu, C.-S., Guo, C. A., Wang, R.-T., Yu, K.-J., Devaraj, S., Murano, P., Chen, Z., Sun, Y.-X. (2017). Suppression of ghrelin exacerbates HFCS-induced adiposity and insulin resistance. International Journal of Molecular Sciences, 18, 1302.Liu, J.-X., Li, D., Zhang, T., Tong, Q., Ye, R. D., Lin L.-G.* (2017). SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity. Cell Death and Disease 8, e3158.Wang, A.-Q., Li, D., Wang, S.-P., Zhou, F.-Y., Li, P., Wang, Y.-T., Lin, L.-G.* (2018). γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction. Journal of Functional Foods 40, 544-553.Zhou, F.-Y., Wang, A.-Q., Li, D., Wang, Y.-T., Lin, L.-G.* (2018). Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SIRT3-TGF-β-Smad signaling pathway. Toxicology and Applied Pharmacology 341, 38-50.Wang, A.-Q., Wang, S.-P., Zhou, F.-Y., Li, P., Wang, Y.-T., Gan, L.-S., Lin, L.-G.* (2018). Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Biomedicine & Pharmacotherapy 101, 334-341.Li, D., Liu, Q.-Y., Sun, W., Chen, X.-P., Wang, Y., Sun, Y.-X., Lin, L.-G.* (2018). 1,3,6,7-Tetrahydroxy-8-prenylxanthone ameliorates inflammatory responses resulting from the paracrine interaction of adipocytes and macrophages. British Journal of Pharmacology 175, 1590-1606.Zhang, L.-L., Feng, Z.-L., Su, M.-X., Jiang, X.-M., Chen, X.-P., Wang, Y.-T., Li, A., Lin, L.-G.*, Lu, J.-J.* (2018). Downregulation of cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells. European Journal of Pharmacology 830, 17-25.Shen, S.-N., Liao, Q.-W., Huang, L., Li, D., Zhang, Q.-W., Wang, Y.-T., Lee, S. M.-Y., Lin, L.-G.* (2018). Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice. Journal of Functional Foods 47, 192-199.Liu, J.-X., Shen, S.-N., Tong, Q., Wang, Y.-T., Lin, L.-G.* (2018). Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3. European Journal of Pharmacology 834, 176-187.Lin, L.-G., Lee, J. H., Wang, R.-T., Wang, R., Sheikh-Hamad, D., Zang, Q. S., Sun, Y.-X.* (2018). aP2-Cre mediated ablation of GHS-R attenuates adiposity and improves insulin sensitivity during aging. International Journal of Molecular Sciences, 19, 3002.Shen, S.-N., Liao, Q.-W., Feng, Y., Liu, J.-X., Pan, R.-L., Lee, S. M.-Y., Lin, L.-G.* (2019). Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase. Food Chemistry 270, 305-314.Zhang, L.-L., Jiang, X.-M., Huang, M.-Y., Feng, Z.-L, Chen, X.-P., Wang, Y.-T., Li, H., Li, A., Lin, L.-G.*, Lu, J.-J.* (2019). Nagilactone E suppressed TGF-β1-induced epithelial-mesenchymal transition, migration and invasion in non-small cell cancer cells. Phytomedicine 52, 32-39.Wang, A.-Q., Zhou, F.-Y., Li, D., Lu, J.-J., Wang, Y.-T., Lin, L.-G.* (2019). γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis. Toxicology and Applied Pharmacology 363, 142-153.Liu, J.-X., Lin, L.-G.* (2019). Small molecules for fat combustion: targeting thermosensory and satiety signals in the central nervous system. Drug Discovery Today 24, 300-306.Liu, J.-X., Wang, Y.-T., Lin, L.-G.* (2019). Small molecules for fat combustion: targeting obesity. Acta Pharmaceutica Sinica B 9, 220-236.Shen, S.-N., Liao, Q.-W., Liu, J.-X., Pan, R.-L., Lee, S. M.-Y., Lin, L.-G.* (2019). Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism. Journal of Cachexia, Sarcopenia and Muscle 10, 429-444.Study on natural products chemistry:Lin, L.-G.; Zhong, Q.-X.; Cheng, T.-Y.; Tang, C.-P.; Ke, C.-Q.; Lin, G.; Ye, Y. (2006). Stemoninines from the Roots of Stemona tuberosa Journal of Natural Products, 69, 1051-1054.Lin, L.-G.; Tang, C.-P.; Xu, R.-S.; Ye, Y. (2007). Cochinchistemonine, an unprecedented skeleton alkaloid from Stemona cochinchinensis, Tetrahedron Letters. 48, 1559-1561.Lin, L.-G.; Pham, H.-D.; Tang, C.-P.; Ke, C.-Q.; Yang, X.-Z.; Ye, Y. (2007). Alkaloids from the roots of Stemona cochinchinensis, Helv. Chim. Acta. 90, 2167-2175.Lin, L.-G.; Yang, X.-Z.; Tang, C.-P.; Ke, C.-Q.; Zhang, J.-B.; Ye, Y. (2008). Antibacterial stilbenoids from the roots of Stemona tuberosa, Phytochemistry. 69, 457-463.Lin, L.-G.; Tang, C.-P.; Ke, C.-Q.; Zhang, Y.; Ye, Y. (2008). Terpenoids from stems of Cipadessa baccifera, Journal of Natural Products. 71, 628-632.Lin, L.-G.; Cheng, T.-Y.; Tang, C.-P.; Ke, C.-Q.; Rudd, J. A.; Lin, G.; Ye, Y. (2008). Anti-tussive alkaloids from roots of Stemona tuberosa, Journal of Natural Products. 71, 1107-1110.Lin, L.-G.; Xie, H.; Li, H.-L.; Tong, L.-J.; Tang, C.-P.; Ke, C.-Q.; Lin, L.-P.; Geng, M.-Y.; Jiang, H.-L.; Zhao, W.-M.; Ding, J.; Ye, Y. (2008). Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening, Journal of Medicinal Chemistry. 71, 628-632.Lin, L.-G., Leung, H. P.-H.; Zhu, J.-Y.; Tang, C.-P.; Ke, C.-Q.; Rudd, J. A.; Lin, G.; Ye, Y. (2008). Croomine- and tuberostemonine-type alkaloids from roots of Stemona tuberosa and their antitussive activity, Tetrahedron. 64, 10155-10161.Lin, L.-G.*, Liu, Q.-Y., Ye, Y. (2014). Naturally occurring homoisoflavonoids and their pharmacological activities, Planta Medica, 80, 1053-1066.Lin, L.-G.*, Han, B., Wang, A.-Q., Tang, C.-P., Dien, P.-H., Ye, Y. (2014). Two new N-oxide alkaloids from Stemona cochinchinensis, Molecules, 19, 20257-20265.Guo, Y.-P., Lin, L.-G.*, Wang, Y.-T. (2015). Chemistry and pharmacology of the herb pair Flos Lonicerae japonicae-Forsythiae fructus, Chinese Medicine, 10, 16.Wang, A.-Q., Lin, L.-G.*, Wang, Y.-T. (2015). Traditional Chinese Herbal Medicine Penthorum chinense Pursh: A Phytochemical and Pharmacological Review, American Journal of Chinese Medicine, 43(4), 601-620.Wang, A.-Q., Liu, Q.-Y., Ye, Y., Wang, Y.-T., Lin, L.-G.* (2015). Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells, Food & Function, 6, 3013-3021.Chen, M.-H., Chen, X.-J., Wang, M., Lin, L.-G.*, Wang, Y.-T. (2016). Ophiopogon japonicus-A phytochemical, ethnomedicinal and pharmacological review, Journal of Ethnopharmacolgy, 181, 193-213.Wang, A.-Q., Wang, S.-P., Jiang, Y., Chen, M.-W., Wang, Y.-T., Lin, L.-G.* (2016). Bio-assay guided identification of hepatoprotective polyphenols from Penthorum chinense Pursh on t-BHP induced oxidative stress injured LO2 cells, Food & Function, 7, 2074-2083.Bao, H., Zhang, L.-L., Liu, Q.-Y., Feng, L., Ye, Y., Lu, J.-J., Lin, L.-G.* (2016). Cytotoxic and pro-apoptotic effects of cassane diterpenoids from the seeds of Caesalpinia sappan in cancer cells, Molecules, 21, 791.Liu, Q.-Y., Li, D., Wang, A.-Q., Dong, Z., Yin, S., Zhang, Q.-W., Ye, Y., Li, L.-C., Lin, L.-G.* (2016). Nitric oxide inhibitory xanthones from the pericarps of Garcinia mangostana. Phytochemistry, 131, 115-123.Lin, L.-G.*, Ung, O. L. C., Feng, Z.-L., Huang, L., Hu, H. (2016). Naturally occurring diterpenoid dimers: source, biosynthesis, chemistry and bioactivities. Planta Medica, 82, 1309-1328.Huang, X.-H., Tao, L.-X., Ke, C.-Q., Tang, C.-P., Zhang, H.-Y., Ye, Y., Lin, L.-G.*, Yao, S. (2017). Taxodikaloids A and B, two dimeric abietane-type diterpenoids from Taxodium ascendens possessing an oxazoline ring linkage. Organic Letters, 19, 556-559.Wu, J.-W., Tang, C.-P., Ke, C.-Q., Yao, S., Liu, H.-C., Lin L.-G.*, Ye, Y. (2017). Dicarabrol A, dicarabrone C and dipulchellin A, unique sesquiterpene lactone dimers from Carpesium abrotanoides. RSC Advances, 7, 4639-4644.Bao, H., Zhang, Q.-W., Ye, Y., Lin L.-G.* (2017). Naturally occurring furanoditerpenoids: distribution, chemistry and their pharmacological activities. Phytochemistry Review, 16, 235-270.Niu, B., Ke, C.-Q., Li, B.-H., Li, Y.-Y., Yi, Y.-J., Luo, Y.-W., Shuai, L., Yao, S., Lin L.-G., Li, J., Ye, Y. (2017). Cucurbitane glucosides from the crude extract of Siraitia grosvenorii with moderate effects on PGC-1α promoter activity. Journal of Natural Products, 80, 1428-1435.Feng, Z.-L., Zheng, L.-L., Zheng, Y.-D., Liu, Q.-Y., Liu, J.-X., Feng, L., Huang, L., Zhang, Q.-W., Lu, J.-J., Lin, L.-G.* (2017), Norditerpenoids and dinorditerpenoids from the seeds of Podocarpus nagi as cytotoxic agents and autophagy inducers. Journal of Natural Products, 80, 2110-2117.Huang, L., Li, D., Xu, Y.-S., Feng, Z.-L., Meng, F.-C., Zhang, Q.-W., Gan, L.-S., Lin L.-G.* (2017). Clausoxamine, an alkaloid possessing a 1,3-oxazine-4-one ring from the seeds of Clausena lansiu and the anti-obesity effect of lansiumamide B ASC advances 7, 46900-46905.Wang, S.-P., Wang, A.-Q., Shao, M., Lin L.-G., Li, P., Wang, Y.-T. (2017). Schisandrin B reverses doxorubicin resistance through inhibiting P-glycoprotein and promoting proteasome-mediated degradation of survivin. Scientific Reports 7, 8419.Xu, X.-H., Liu, Q.-Y., Li, T., Liu, J.-L., Chen, X., Huang, L., Qiang, W.-A., Chen, X.-P., Wang, Y.-T., Lin L.-G.*, Lu, J.-J. (2017). Garcinone E induces apoptosis and inhibits migration and invasion in ovarian cancer cells. Scientific Reports 7, 10718.Meng, F.-C., Liu, H., Huang, X.-J., Chang, Y., Ren, D., Lin, L.-G., Zeng, Q.-Q., Zhang, Q.-W. (2017). Four new norlignan glycoside isomers from the twigs of Cephalotaxus oliveri Mast. Tetrahedron: Asymmetry 28, 1686-1689.Feng, Z.-L., Zhang, T., Liu, J.-X., Chen, X.-P., Gan, L.-S., Ye, Y., Lin, L.-G.* (2018). New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect. Journal of Natural Medicines, 72, 882-889.Fang, Z.-J., Shen, S.-N., Wang, J.-M., Wu, Y.-J., Zhou, C.-X., Mo, J.-X., Lin, L.-G.*, Gan, L.-S.* (2019). Triterpenoids from Cyclocarya paliurus that enhance glucose uptake in 3T3-L1 adipocytes. Molecules, 24, 187.Fang, Z.-J., Zhang, T., Chen, S.-X., Wang, Y.-L., Zhou, C.-X., Mo, J.-X., Wu, Y.-J., Xu, Y.-K., Lin, L.-G.*, Gan, L.-S.* (2019). Cycloartane triterpenoids from Actaea vaginata with anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages. Phytochemistry 160, 1-10.Ke, J.-H., Zhang, L.-S., Chen, S.-X., Shen, S.-N., Zhang, T., Zhou, C.-X., Mo, J.-X., Lin, L.-G.*, Gan, L.-S.* (2019). Benzofurans from Eupatorium chinense enhance insulin-stimulated glucose uptake in C2C12 myotubes and suppress inflammatory response in RAW264.7 macrophages. Fitoterapia 134, 346-354Zhang, L.-S., Shen, S.-N., Gao, Y.-L., Shi, S.-Y., Zhou, C.-X., Mo, J.-X., Xu, Y.-K., Lin, L.-G.*, Gan, L.-S.* (2019). Tautomerism and bioactivities of curcumenol, a common sesquiterpenoid widely existing in edible plants. Food & Function 10, 1288-1294.