个人简介

EducationPhD Biochemistry and molecular biology, Peking Union Medical College, Tsinghua University, Beijing, China (2006)Master Genetics, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China (2003)Bachelor Biology, School of life sciences, University of Inner Mongolia, Huhehaote, China (2000)Academic and Professional Experience2018-present Associate Professor, Faculty of Health Sciences, University of Macau2013-2018 Assistant Professor, Faculty of Health Sciences, University of Macau2007-2012 Visiting Fellow and Research Fellow, National Cancer Institute, National Institutes of Health, USA2006-2007 Postdoc Fellow, Biochemistry Department, University of Texas, Health Science Center at San Antonio, USACourse OutlinesHSCI4001 Cancer Biology and TherapyGEGA1007 Nutrition in Health and Disease

研究领域

My research interest mainly focus on the mechanisms of transcriptional regulation of gene expression and gene expression regulatory network. I am also interested in understanding the mechanisms of human diseases such as cancer by exploring the aberrant gene expression associated with these diseases. For instance, the current on-going projects focus on transcriptional factors such as BRCA1 and CtBP by illustrating their important role in alteration cell metabolism which may associates with cancer development. The research strategy relies on both high throughput screening technologies such as NGS, gene expression microarray etc and individual gene study. The conclusion from cell based studies will be validated in other relevant model system such engineered mouse models.

近期论文

Representative PublicationsLi, P., Meng, Y., Wang, L., Di, LJ., BioID: a proximity-dependent labeling approach in proteomics study, Methods Mol Biol. 2019;1871:143-151Zhao, Z., Hao, D., Wang, L., Li, J., Meng, Y., Li, P., Wang, Y., Zhang, C., Zhou, H., Gardner, K., Di, LJ., CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-b signaling, Oncogene. 2018 Nov 15.Wang, L., Wang, Y., Zhang, C., Li, J., Meng, Y., Dou, M., Noguchi, CT, Di, LJ., Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2103-2116Hao, D., Liu, J., Chen, M., Li, J., Wang, L., Li, X., Zhao, Q., Di, LJ., Immunogenomic analyses of advanced serous ovarian cancer reveal immunoscore is a strong prognostic factor and a predictor of chemo-sensitivity. Clin. Cancer Res. 2018 Aug 1;24(15):3560-3571Wang, L., Wang, Y., Meng, Y., Zhang, C., Di, LJ., GSK3 activated STAT5 regulates expression of SFRPs to modulate adipogenesis. FASEB J. 2018 Sep;32(9):4714-4726Wang, L., Li, J., Guo, L., Li, P., Zhao, Z., Zhou, H., Di, LJ., Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4., Oncogenesis. 2018 Mar 13;7(3):26Hao, D., Li, J., Jia, S., Meng, Y., Zhang, C., Wang, L., Di, LJ., Integrated analysis reveals tubal and ovarian originated serous ovarian cancer and predicts differential therapeutic responses, Clin. Cancer Res. 2017 Dec 1;23(23):7400-7411.Li, J., Hao, D., Wang, L., Wang, H., Wang, Y., Zhao, Z., Li, P., Deng, C., Di, LJ.. Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy. Sci Rep. 2017 Jun 22;7(1):4035Li, P., Li, J., Wang, L., Di, LJ., Proximity labeling of interacting proteins: Application of BioID as a discovery tool. Proteomic. 2017 Oct;17(20)Hao, D., Wang, L., Di, LJ., Distinct mutation accumulation rates among tissues determine the variation in cancer risk, Scientific Report. 2016, Jan 20;6:19458Wang, L., Di, LJ.. Wnt/β-catenin mediates AICAR effect in increasing GATA3 expression and inhibiting adipogenesis. J Biol Chem. 2015 Aug 7;290(32):19458-68.Wang, L., Zhou, HS., Wang, YT., Cui, GZ., Di, LJ., CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4. Cell Death Diseases. 2015 Jan 29;6:e1620,Wang, L., Di, LJ., BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact? Int J Biol Sci. 2014 14;10(5):566-75,Wang, L., Di, LJ., Noguchi CT. Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci. 2014 Aug 23;10(8):921-39.Wang, L., Di, LJ.(Co-first), Noguchi, CT. AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes. Int J Biochem Cell Biol. 2014 Sep;54:1-9,Wang, L., Teng, R., Di, LJ., Rogers, H., Wu, H., Kopp, JB., Noguchi, CT.. PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes. 2013 Dec;62(12):4122-31.Di, LJ., Byun, J., Wong, M., Wakano, C., Hunter, K., Olopade, OI., Perou, C., Evan, M., Chou, JW., Gardner, K., CtBP integrates genome scale targeting of genome stability, EMT pathways and stem cell fate in breast cancer, Commun. 2013 4:1449).Wakano, C., Byun, J., Di, LJ., Gardner, K., The Dual Lives of Bidirectional Promoters. BBA-Gene Regul Mech. 2012 Jul;1819(7):688-93,Di, LJ., Fernandez, A., De Siervi, A., Longo, DL., Gardner, K., Regulation of BRCA1 transcription by a metabolic switch. Struct. Mol. Biol. 2010 Dec;17(12):1406-13,De Siervi, A., De Luca, P., Byun, JS., Di, LJ., Fufa, T., Haggerty, CM, Vazquez, E., Moiola, C., Longo, DL., Gardner, K.., Transcriptional autoregulation by BRCA1. Cancer Res. 2009 70:532-42,Di, LJ., Wang, L., Lv X., Zheng W., Xue Z., Guo Zhi-Chen., Liu, DP & Liang, CC., Inter-MARs’ association mediated by SATB1 contributes to active transcriptional looping events in human -globin gene cluster. PLoS ONE. 4(2):e4629. 2009,Di, LJ., Wang, L., Zhou, GL., Wu, XS., Guo, ZC., Ke, XS., Liu, DP & Liang, CC., Identification of long range regulatory elements of mouse alpha-globin gene cluster by quantitative associated chromatin trap (QACT). Cell. Biochem. 105:301-312. 2008,Zhou, GL., Xin, L., Song, W., Di, LJ., Liu, G., Wu, XS., Liu, DP & Liang, CC., Active chromatin hub of the mouse alpha-globin locus forms in a transcription factory of clustered housekeeping genes. Mol Cell Biol. 26:5096-5105, 2006.