个人简介

EducationPostdoctoral Fellow Division of Biology, California Institute of Technology, Pasadena, California, USA (1995-1998)PhD Department of Microbiology and Immunology, The University of British Columbia, Vancouver, Canada (1990-1995)MS Peking University, Department of Biology, Beijing, China (1982-1985)BS Peking University, Department of Biology, Beijing, China (1978-1982)Academic and Professional Experience2016.01 -present Professor, Faculty of Health Sciences, University of Macau2009.05–2015.12 Associate Professor, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore2003.12-2009.05 Visiting Assistant Professor, Bioengineering Graduate Program, Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Hong Kong1998.08–2003.12 Research Associate, Department of Biology, The Hong Kong University of Science and Technology, Hong Kong1989.09–1990.08 Research Assistant, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada1987.09-1989.08 Research Assistant, Department of Medicine, University of Colorado, Denver, Colorado, USAServices to University of MacauUniversity Level:Chair of Animal Research Ethics of UM (2016-present)Member of the UM Senate (2016-present)Research Committee of UM (2016-present)President of the Presidium of the General Assembly of the Academic Staff Association of UM (2017-2019)Ad Hoc Selection Committee for Emeritus Professor of UM (2017-present)UM-Selection Committee for Macao Fellow (2018-present)UM-Selection Committee for Macao Science and Technology Awards 2018 (Postgraduates)Chairing PhD Oral Defences for various faculty and academic units of UM (2018-present)Investigation Panel for Student Affairs (2019-present)Faculty-level Academic Staff Promotion Advisory Panel of AMSV (2017)Faculty-level Academic Staff Promotion Advisory Panel of ICMS (2019)Faculty Level:Faculty Executive Committee (FEC) (2016-present)Faculty Academic Personnel Committee (2017-present)Faculty Mentor Committee (2018-present)Faculty Contract Renewal Committee (2016-present)Selection Committee for Academic Faculty Recruitment (2019-present)Selection Committee for Macao Science and Technology Awards 2018 (Postgraduates)Selection Committee for UM Macao Talent Program (UMMTP) (2018-present)Selection Committee for Macau Fellow (2016-present)Chair of the Recruitment Committee for Administrative Staff (2018-present)Graduate Studies Committee (2016-present)Equipment Committee of FHS and ICMS (2016-present)Coordinator of Final Year Project (2016-present)Postgraduate Academic Committee (2016-present)Services to International Scientific CommunitiesEditorial BoardEditorial Board of Advances in Modern Oncology ResearchEditorial Board of AIMS BioengineeringReview Editor of Frontiers in EthnopharmacologyEditorial Board of Austin Chemical EngineeringConference CommitteesSession Chair, Precision Medicine Symposium. June 26-27, 2019, Macau, ChinaSession Chair, 6th Macau Symposium on Biomedical Sciences. June 12-13, 2019, Macau, ChinaSession Chair for the 5th Macau Symposium on Biomedical Sciences. June 8-9, 2018, Macau, ChinaOrganizing Committee, 3rd World Conference on the Pharmacology of Natural and Traditional Medicine 2015, July 22-24, SingaporeTechnical Program Committee (TPC) for MicroTAS 2014, October 26-30, 2014, San Antonio, Texas, USASession Chair, The 15th International Conference on Biomedical Engineering (ICBME 2013), December 4-7, 2013, SingaporeCoordinator of the NTU-SCBE Symposium on Drug Discovery, Drug Delivery and Regenerative Medicine at the 6th Annual BioPharma Asia Convention, March 19, 2013, SingaporeSession Chair, The HKUST International Conference on Biomedical Engineering, Jan 10-12, 2013, Hong KongOrganizing Committee, 2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2), August 2010, SingaporeSession Chair, International Conference on Recent Development in Chinese Herbal Medicine, January 2010, SingaporeOrganizing Committee, 7th International Conference of Modernization of Chinese Medicine & Health Products, August 2008, Hong KongOrganizing Committee, 6th International Conference of Modernization of Chinese Medicine & Health Products, August 2007, Hong KongReviewer for Grant ApplicationsEuropean Research Council Consolidator GrantMedical Research Council of UKResearch Grants Council (RGC) of Hong Kong, Funding Scheme: GRF / ECSNational Research Foundation of Singapore Competitive Research ProgrammeMinistry of Education, Singapore, Academic Research Fund Tier 2Ministry of Education, Singapore, Academic Research Fund Tier 1Ministry of Education, Singapore, Translation and Innovation FundAgency for Science, Technology and Research, Nanyang Technological University, and National Health Group Skin Research GrantNanyang Technological University iFood Research GrantCourse OutlinesHSCI4007 Translational MedicineHSCI7002 Biomedical Sciences

研究领域

Cancer biology Identify driver proteins that can increase cancer cells’ survival in circulation, metastasis and during chemotherapy.Anti-cancer drug discovery: Discover new agents against metastatic and drug resistant cancer cells.Metabolic diseases: Study diabetes-related endothelial cell dysfunction and discover new biomarkers for diagnosis and treatment of diabetes.Aging research and bio-detections: Generate transgenic zebrafish for aging and toxicity study.

Funding Obtained as a PI at Nanyang Technological University in Singapore (S$2,466,542 = US$1,926,986)PI, S$683,842, Ministry of Education, Singapore, Academic Research Fund Tier 2 (MOE2014-T2-1-025). Common mechanisms promoting circulating tumour cell survival and chemoresistance. 01/02/2015 to 31/12/2015.PI, S$657,700, National Research Foundation Competitive Research Programme (NRF-CRP8-2011-05). Pharmacological fingerprinting of selected herbal products. 01/09/2012 to 31/12/2015.PI, S$200,000, Ministry of Education, Singapore, Academic Research Fund Tier 1 (2014-T1-001-053). Investigating the roles of stromal and endothelial cells on tumorigenesis of hepatocellular carcinoma in 3D co/tri-culture systems. 01/11/2014 to 31/12/2015.PI, S$192,000, Johns Hopkins Singapore Research Fund, RCA-13-243-JHS. Generating an intravenous dosage form of a new anti-breast cancer agent and determining its pharmacokinetic profile and in vivo toxicity. 01/07/2014 to 31/12/2015.PI, S$151,000, National Research Foundation-Environment and Water Industry Development Council-Incentive for Research and Innovation Scheme (NRF-EWI-IRIS) (1102-IRIS-05-02). Optofluidic system for bacterial detection and identification. 01/12/2012 to 30/11/2015.PI, S$200,000, Ministry of Education, Singapore, Academic Research Fund Tier 1 (RG45/09). Discovering new anticancer drug candidates from Chinese medicinal herbs by a novel FRET-based high-throughput apoptosis assay. 01/02/2010 to 28/02/2014.PI, S$64,000, Nanyang Technological University-National Health Group (NTU-NHG) Innovation Collaboration Grant (ICG/13008). A pilot study evaluating caspase-3 activation as a novel marker of systemic toxicity in breast cancer patients receiving chemotherapy. 01/04/2013 to 30/09/2015.PI, S$48,000, Nanyang Technological University-National Health Group (NTU-NHG) Innovation Seed Grant (ISG/11023). Evaluating the growth inhibition effect of a new anticancer agent in animal with xenografted tumor derived from breast cancer patients. 01/12/2011 to 31/12/2013.PI, S$70,000, Seed Funding from Nanyang Institute of Technology in Health and Medicine (RG47/07). Pharmacokinetic and toxicity studies of a new anti-breast cancer agent (ATA) in animal models. 01/05/2011 to 30/04/2012.PI, S$200,000, Start-up grant from SCBE of NTU. 04/05/2009 to 30/09/2012.Funding obtained as a Principal Investigator (PI) at HKUST of Hong Kong (HK$4,526,000 = US$580,256)PI, HK$3,800,000, Innovation and Technology, Commission of Hong Kong (ITF/006/08NP). Developing and manufacturing nano-structured oral dosage forms of isoflavone and insulin with improved bioavailability. 07/04/2009 to 06/06/2011.PI, HK$450,000, Research Project Competition of Hong Kong University of Science and Technology (RPC-07/08.EG19). Bioassay-guided systematic fractionation of TCM for rapid discovery of new anticancer compounds. 02/06/2008 to 31/05/2009.PI, HK$77,000, Research Grants Council of Hong Kong-Direct Allocation Grants (DAG04/05.EG37), Purification and application of isoflavones from soybeans as a substitute for treating women with postmenopausal symptoms. 30/06/2005 to 31/05/2009.PI, HK$149,000, University Grants Committee of Hong Kong-Continuous Learning & Improvement through Teaching Innovation (00386E). Bring a molecular cell biology laboratory into the classroom of HKUST. 1/11/2005 to 29/02/2008.PI, HK$50,000, University Grants Committee of Hong Kong-Continuous Learning & Improvement through Teaching Innovation (00407E), Hong Kong Bioinformatics in Bioengineering: Direct Experience with Interactive Learning. 06/12/2006 to 31/05/2008.

近期论文

Selected from over 70 publications (Citations: 4,008, h-index: 32, i10-index: 55 from Google Scholar)Wang Q, Luo M, Wei N, Chang A, Luo KQ* (2019) Development of a liposomal formulation of acetyltanshinone IIA for breast cancer therapy. Molecular Pharmaceutics, 16:3873-3886. DOI: 10.1021/acs.molpharmaceut.9b00493.Ma S, Fu A, Lim S, Chiew GGY, Luo KQ* (2018) MnSOD mediates shear stress-promoted tumor cell migration and adhesion. Free Radical Biology and Medicine, 129:46-58. DOI: 10.1016/j.freeradbiomed.2018.09.004.Regmi S, Fung TS, Lim S, Luo KQ* (2018) Fluidic shear stress increases the anti-cancer effects of ROS-generating drugs in circulating tumor cells. Breast Cancer Research and Treatment, 172(2):297-312. DOI: 10.1007/s10549-018-4922-8.Fu A, Peh YM, Ngan W, Wei N, Luo KQ* (2018) Rapid identification of anti-micrometastases drugs using integrated model systems with 2D monolayer, 3D spheroids and zebrafish xenotransplantation tumors. Biotechnology and Bioengineering, 115(11):2828-2843. DOI: 10.1002/bit.26816.Chiew GGY, Wei N, Sultania S, Lim S, Luo KQ* (2017) Bioengineered three-dimensional co-culture of cancer cells and endothelial cells: a model system for dual analysis of tumor growth and angiogenesis. Biotechnology and Bioengineering, 114(8):1865–1877, DOI: 10.1002/bit.26297.Ma S, Fu A, Chiew GGY, Luo KQ* (2017) Hemodynamic shear stress stimulates migration and extravasation of tumor cells by elevating cellular oxidative level. Cancer Letters, 388: 239-248. DOI: 10.1016/j.canlet.2016.12.001.Wang Q, Wei N, Liu X, Luo KQ* (2017) Enhancement of the bioavailability of a novel anticancer compound (acetyltanshinone IIA) by encapsulation within mPEG-PLGA nanoparticles: a study of formulation optimization, toxicity, and pharmacokinetics. Oncotarget, 8(7):12013-12030. DOI: 10.18632/oncotarget.14481.Regmi S, Fu A, Luo KQ* (2017) High shear stresses under exercise condition destroy circulating tumor cells in a microfluidic system. Scientific Reports, 7:39975. DOI: 10.1038/srep39975.Fu A, Ma SJ, Wei N, Tan BXX, Tan EY, Luo KQ* (2016) High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin. Oncotarget, 7(31):50239-50257. DOI: 10.18632/oncotarget.10360.Anand P, Fu A, Teoh SH, Luo KQ* (2015) Application of a fluorescence resonance energy transfer (FRET)-based biosensor for detection of drug-induced apoptosis in a 3D breast tumor model. Biotechnology and Bioengineering, 112(8):1673-1682. http://www.ncbi.nlm.nih.gov/pubmed/25728592.Geraldine Giap Ying Chiew, Afu Fu, Luo KQ* (2015) Physical supports from liver cancer cells are essential for differentiation and remodeling of endothelial cells in a HepG2-HUVEC co-culture model. Scientific Reports, 5:10801. http://www.ncbi.nlm.nih.gov/pubmed/26053957.Zheng XT, Ananthanarayanan A, Luo KQ, Chen P (2015) Glowing graphene quantum dots and carbon dots: properties, syntheses, and biological applications. Small, 11(14):1620-1636. http://www.ncbi.nlm.nih.gov/pubmed/25521301.Feng C, Huang SX, Gao XM, Xu HX*, Luo KQ* (2014) Characterization of proapoptotic compounds from the bark of Garcinia oblongifolia. Journal of Natural Products, 77(5):1111-1116. http://www.ncbi.nlm.nih.gov/pubmed/24754786.Yu T, Zhou Z, Mu Y, Lopes G, Luo KQ* (2014) A novel anti-cancer agent, acetyltanshinone IIA, inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor. Cancer Letters, 346(1):94-103. http://www.ncbi.nlm.nih.gov/pubmed/24374015.Liu XF, Yu JQ, Dalan R, Liu AQ, Luo KQ* (2014) Biological factors in plasma from diabetes mellitus patients enhance hyperglycaemia and pulsatile shear stress-induced endothelial cell apoptosis. Integrative Biology, 6(5):511-522. http://www.ncbi.nlm.nih.gov/pubmed/24643402.Yu JQ, Liu XF, Chin LK, Liu AQ, Luo KQ* (2013) Study of endothelial cell apoptosis using fluorescence resonance energy transfer (FRET) biosensor cell line with hemodynamic microfluidic chip system. Lab on a Chip, 13(14):2693-2700. http://www.ncbi.nlm.nih.gov/pubmed/23620256.Feng C, Zhou LY, Yu T, Xu G, Tian HL, Xu JJ, Xu HX*, Luo KQ* (2012) A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. International Journal of Cancer, 131(6):1445-1454. http://www.ncbi.nlm.nih.gov/pubmed/22116711.Zhu XM, Fu AF, Luo KQ* (2012) A high-throughput fluorescence resonance energy transfer (FRET)-based endothelial cell apoptosis assay and its application for screening vascular disrupting agents. Biochemical and Biophysical Research Communications, 418(4):641-646. http://www.ncbi.nlm.nih.gov/pubmed/22290227.Yu Y, Liu J, Zhao Z, Ng KM, Luo KQ*, Tang BZ* (2012) Facile preparation of non-self-quenching fluorescent DNA strands with the degree of labeling up to the theoretic limit. Chemical Communications, 48(51):6360-6362. http://www.ncbi.nlm.nih.gov/pubmed/22618018.Yu Y, Feng C, Hong Y, Liu J, Chen S, Ng KM, Luo KQ*, Tang BZ* (2011). Cytophilic fluorescent bioprobes for long-term cell tracking. Advanced Materials, 23(29):3298-3302. http://www.ncbi.nlm.nih.gov/pubmed/21671445.Chin LK, Yu JQ, Fu Y, Yu T, Liu AQ, Luo KQ* (2011) Production of reactive oxygen species in endothelial cells under different pulsatile shear stresses and glucose concentrations. Lab on a Chip, 11(11):1856-1863. http://www.ncbi.nlm.nih.gov/pubmed/21373653.Tian HL, Yu T, Xu NN, Feng C, Zhou LY, Luo HW, Chang DC, Le XF, Luo KQ* (2010) A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway. Cancer Letters, 297(1):18-30. http://www.ncbi.nlm.nih.gov/pubmed/20494511.Wei B, Cheng I, Luo KQ, Mi YL (2008) Capture and release of protein by a reversible DNA-induced sol-gel transition system. Angewandte Chemie-International Edition, 47(2):331-333. http://www.ncbi.nlm.nih.gov/pubmed/18033711.Zhang EJ, Ng KM, Luo KQ* (2007) Extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities. Journal of Agricultural and Food Chemistry. 55(17):6940-6950, http://www.ncbi.nlm.nih.gov/pubmed/17658826.Tian H, Ip L, Luo H, Chang DC, Luo KQ* (2007) A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine. British Journal of Pharmacology, 150(3):321-334. http://www.ncbi.nlm.nih.gov/pubmed/17179946.Luo KQ*, Chang DC (2004) The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region. Biochemical and Biophysical Research Communications, 318(1):303-310. http://www.ncbi.nlm.nih.gov/pubmed/15110788.Chang DC, Xu NH, Luo KQ (2003) Degradation of cyclin B is required for the onset of anaphase in mammalian cells. Journal of Biological Chemistry, 278(39):37865-37873. http://www.ncbi.nlm.nih.gov/pubmed/12865421.Luo KQ*, Yu VC, Pu YM, Chang DC (2003) Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNF alpha-induced apoptosis. Biochemical and Biophysical Research Communications, 304(2):217-222. http://www.ncbi.nlm.nih.gov/pubmed/12711301.Luo KQ*, Yu VC, Pu YM, Chang DC (2001) Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells. Biochemical and Biophysical Research Communications, 283(5):1054-1060. http://www.ncbi.nlm.nih.gov/pubmed/11355879.Luo KQ*, Michaelis C, Weeks G (1994) Overexpression of a truncated cyclin B gene arrests Dictyostelium cell-division during mitosis. Journal of Cell Science, 107:3105-3114. http://www.ncbi.nlm.nih.gov/pubmed/7699009.