个人简介

EducationPhD 2013 College of Animal Science and Technology, China Agricultural UniversityBS 2007 Institute of Life Science and Technology, Hebei Normal University of Science & TechnologyAcademic and Professional Experience2017-Present Research Assistant Professor, Faculty of Health Sciences, University of Macau2014-2017 Postdoctoral Fellow, Faculty of Health Sciences, University of Macau

研究领域

Genome-wide screening and identification of genetic drivers that cooperate with mutant Brca1 in breast cancer progression and metastasis

PatentsTian JH, Miao K, Guo M, Wu ZH, Wang XY, Wang C. Method of produce transgenic embryos and mice with low-titer lentivirus. (ZL 2009 1 0237357.0)Tian JH, Wu ZH, Miao K, Zhao HC, Wang R, Wang ZL. Culture Device. (ZL 2010 2 0504203.1)

近期论文

Representative PublicationsKai Miao, Xin Zhang, Sek Man Su, Jianming Zeng, Zebin Huang, Un In Chan, Xiaoling Xu, Chu-Xia Deng, Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-G374R mutation in achondroplasia in mice, J Biol Chem. 2019 Jan 25;294(4):1142-1151Xiaoling Xu, Eric Chen, Lihua Mo, Lei Zhang, Fangyuan Shao, Kai Miao, Jianlin Liu, Sek Man Su, Monica Valecha, Un In Chan, Hongping Zheng, Mark Chen, Weiping Chen, Qiang Chen, Haiqing Fu, Mirit I Aladjem, Yanzhen He, Chu-Xia Deng, BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1–MCM2 signaling during pregnancy, Hum Mol Genet. 2019 Mar 1;28(5):842-857Tyler J Lahusen, Seung-Jin Kim, Kai Miao, Zebin Huang, Xiaoling Xu, Chu-Xia Deng, BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis, Oncogene. 2018 Apr;37(17):2343-2350Guangyin Xi, Lei An, Zhenwei Jia, Kun Tan, Jiaxin Zhang, Zhuqing Wang, Chao Zhang, Kai Miao, Zhonghong Wu, Jianhui Tian, Natriuretic peptide receptor 2 (NPR2) localized in bovine oocyte underlies a unique mechanism for C-type natriuretic peptide (CNP)-induced meiotic arrest, Theriogenology. 2018 Jan 15;106:198-209Likun Ren, Chao Zhang, Li Tao, Jing Hao, Kun Tan, Kai Miao, Yong Yu, Linlin Sui, Zhonghong Wu, Jianhui Tian, Lei An, High-resolution profiles of gene expression and DNA methylation highlight mitochondrial modifications during early embryonic development, J Reprod Dev. 2017 Jun 21;63(3):247-261Si Chen*, Heng Sun*, Kai Miao*, Chu-Xia Deng, CRISPR-Cas9: from Genome Editing to Cancer Research, Int J Biol Sci. 2016; 12(12):1427-1436 (*They contributed equally to this work)Kun Tan*, Lei An*, Kai Miao*, Likun Ren, Zhuocheng Hou, Li Tao, Zhenni Zhang, Xiaodong Wang, Wei Xia, Jinghao Liu, Zhuqing Wang, Guangyin Xi, Shuai Gao, Linlin Sui, Desheng Zhu, Shumin Wang, Zhonghong Wu, Ingolf Batch, Dong-bao Chen, Jianhui Tian, Impaired imprinted X-chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization, Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3197-3202 (*They contributed equally to this work)Kun Tan, Zhenni Zhang, Kai Miao, Yong Yu, Linlin Sui, Jianhui Tian and Lei An, Dynamic integrated analysis of DNA methylation and gene expression profiles in in vivo and in vitro fertilized mouse post-implantation extraembryonic and placental tissues, Mol Hum Reprod. 2016 Jul;22(7):485-498Kun Tan, Xiaodong Wang, Zhenni Zhang, Kai Miao, Yong Yu, Lei An2, and Jianhui Tian, Downregulation of miR-199a-5p Disrupts the Developmental Potential of In Vitro-Fertilized Mouse Blastocysts, Biol Reprod. 2016 Sep;95(3):54Xia Wei, Zhang Xiaoling, Miao Kai, Wang Rui, Xu Jing, Guo Mim, Wu Zhonghong, Tian Jianhui, Zhang Xxinyu, An Lei, Characterization and comparative analyses of transcriptomes for in vivo and in vitro produced peri-implantation conceptuses and endometria from sheep, J Reprod Dev. 2016 Jun 17;62(3):279-87Kun Tan, Lei An, Shu-Min Wang, Xiao-Dong Wang, Zhen-Ni Zhang, Kai Miao, Lin-Lin Sui, Shu-Zhi He, Jing-Zhou Nie, Zhong-Hong Wu, Jian-Hui Tian, Actin Disorganization Plays a Vital Role in Impaired Embryonic Development of In Vitro-Produced Mouse Preimplantation Embryos, PLoS One. 2015 Jun 15;10(6):e0130382Ren Likun, Wang Zhuqing, An Lei, Zhang Zhennan, Tan Kun, Miao Kai, Tao Li, Cheng Linghua, Zhang Zhenni, Yang Mingyao, Wu Zhonghong, Tian Jianhui, Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes between in vivo and in vitro fertilized early mouse embryos, Human Reproduction. 2015, 30(12):2892-2911Zhao Haichao, Sui Linlin, Miao Kai, An Lei, Wang Dong, Hou Zhuocheng, Wang Rui, Guo Min, Wang Zhilong, Xu Jiqiang, Wu Zhonghong, Tian Jianhui, Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period, J Anim Sci Biotechnol. 2015, 6(1):18Di Ke-Qian, Gao Shuai, Cui Li-Fang, Chang Gang, Wu Fu-Jia, Ren Li-Kun, An Lei, Miao Kai, Tan Kun, Tao Li, Chen Hui, Wang Zhi-Long, Wang Shu-Min, Wu Zhong-Hong, Gao Shaorong, Li Xiang-Yun, Tian Jian-Hui, Generation of fully pluripotent female murine-induced pluripotent stem cells, Biol Reprod. 2015, 92(5):123Sui Linlin, An Lei, Tan Kun, Wang Zhuqing, Wang Shumin, Miao Kai, Ren Likun, Tao Li, He Shuzhi, Yu Yong, Nie Jinzhou, Liu Qian, Xing Lei, Wu Zhonghong, Hou Zhuocheng, Tian Jianhui, Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas, Biology of Reproduction. 2014, 91(6):155Chang Gang, Gao Shuai, Hou Xinfeng, Xu Zijian, Liu Yanfeng, Kang Lan, Tao Yu, Liu Wenqiang, Huang Bo, Kou Xiaochen, Chen Jiayu, An Lei, Miao Kai, Di Keqian, Wang Zhilong, Tan Kun, Cheng Tao, Cai Tao, Gao Shaorong, Tian Jianhui, High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells, Cell Res. 2014, 24(3):293-306Nie Jingzhou*, An Lei*, Miao Kai*, Hou Zhuocheng, Yu Yong, Tan Kun, Sui Linlin, He Shuzhi, Wu Zhonghong, Tian Jianhui, Comparative Analysis of Dynamic Proteomic Profiles between In Vivo In Vitro Produced Mouse Embryos during Post implantation, J Proteome Res. 2013, 12(9):3843-3856 (*They contributed equally to this work)An Lei, Pang Yun-Wei, Gao Hong-Mei, Tao Li, Miao Kai, Wu Zhong-Hong, Tian Jian-Hui, Heterologous expression of C. elegans fat-1 decreases the n-6/n-3 fatty acid ratio and inhibits adipogenesis in 3T3-L1 cells, Biochemical and Biophysical Research Communications. 2012, 428(3):405-410Ma Wenzhi, An Lei, Wu Zhonghong, Wang Xiaoying, Guo Min, Miao Kai, Ma Wei, Tian Jianhui, Efficient and safe recipient preparation for transplantation of mouse spermatogonial stem cells: pretreating testes with heat shock, Biol Reprod. 2011, 85(4):670-677Miao Kai, Guo Min, An Lei, Xu Xiao Ling, Wu Han, Wang Dong, Wu Zhong Hong, Tian Jian Hui, A new method to efficiently produce transgenic embryos and mice from low-titer lentiviral vectors, Transgenic Res. 2011, 20(2):357-363