个人简介

薛挺，男，1979年10月出生，现任安徽农业大学生命科学学院教授，博导，微生物学博士点负责人，学院“微生物与动植物互作学科方向”负责人。近年来主要从事重要致病菌如金黄色葡萄球菌、致病性大肠杆菌及沙门氏菌致病性调控的分子机制研究，在细菌群体感应、二元信号系统、非编码小RNA的功能机制等热点领域开展了较为深入的研究工作。近年来发表SCI论文36篇，总影响因子>120，被引620余次，H因子为16。发表一作及通讯作者SCI论文20余篇，总影响因子>75，单篇最高影响因子17.878。主持国家自然科学基金3项，主持省部级科学基金7项，参与国家自然科学基金项目等多项。目前研究兴趣主要为畜禽条件致病菌生物膜形成与致病性、耐药性调控的分子机制及相关抑菌靶点的探索。学习经历1997.9-2001.7本科/学士安徽大学生命科学学院2004.9-2009.6硕博连读/博士中国科学技术大学生命科学学院工作经历2009.6-2011.5博士后中国科学技术大学生命科学学院2011.6-2013.6特任副教授中国科学技术大学生命科学学院2013.6-2016.12副教授安徽农业大学生命科学学院2016.12-教授安徽农业大学生命科学学院主讲课程：微生物学、微生物学实验等科研情况：主持与参与的科研项目：1.AI-2群体感应对禽致病大肠杆菌耐药性的调控机制研究，2017.1-2020.12，国家自然科学基金面上项目，批准号：31672571，主持。2.金黄色葡萄球菌非编码小RNA相互作用蛋白的探寻及功能研究,2014.1-2017.12,国家自然科学基金面上项目，批准号：31371324，主持。3.金黄色葡萄球菌gdpS基因调控致病靶基因的特殊分子机制研究,2013.1-2015.12,国家自然科学基金青年基金项目,批准号：31200107，主持。4.金葡菌非编码小RNA相互作用蛋白的探寻及功能研究,2013.7-2014.12，第六批中国博士后科学基金特别资助。主持。5.金黄色葡萄球菌二元信号系统的功能鉴定及其对致病性的调控研究，2012.7-2014.6，安徽省自然科学基金青年项目。批准号：1208085QC51，主持。6.金黄色葡萄球菌gdpS基因及其内含小RNA对致病性的调控研究,2011.1-2012.12，教育部下达中国科学技术大学青年创新基金,主持。7.金黄色葡萄球菌RNAgdpS对proteinA等致病因子的调控机理研究,2012.1-2013.6，第50批中国博士后科学基金面上资助。批准号：2011M501054，主持。8.金黄色葡萄球菌中新型smallRNA的发现及其与致病性相关的上下游调控通路的研究,2010.12-2011.12，第三批中国博士后科学基金特别资助。主持。9.金黄色葡萄球菌致病性调控通路的研究，第46批中国博士后科学基金面上资助。批准号：20090460735，2010.1-2011.6，主持。10.金黄色葡萄球菌KdpDE二元信号转导系统对致病性的调控研究，2011.1-2013.12，国家自然科学基金面上项目，批准号：31070116，主要参与者（排名第二）。11.金黄色葡萄球菌非编码小RNA的功能解析，2010.1-2012.12，国家自然科学基金面上项目，批准号：30970118，主要参与者（排名第二）。12.还原脱氯细菌的遗传操作系统的建立，2005.1-2007.12，国家自然科学基金面上项目，批准号：30470943，主要参与者。

研究领域

分子微生物

近期论文

1. Xue, T., Zhao, L., Sun, H., Zhou, X. & Sun, B*. (2009). LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing. Cell Research 19:1258-1268. （IF=17.878，中科院分区1区）2. Shang, F.﹟, Xue, T.﹟, Sun, H., Xing, L., Zhang, S., Yang, Z., Zhang, L. & Sun, B*. (2009). The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner. Infection and Immunity 77:2849-2856. (﹟共一作，IF=3.603，中科院分区2区)3. Xue, T.*, You, Y., Hong, D., Sun, H. & Sun, B*. (2011). The Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming. Infection and Immunity 79:2154-2167. (IF=3.603，中科院分区2区)4. Xue, T.*, You, Y., Shang, F. & Sun, B*. (2012). Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325. Medical Microbiology and Immunology 201:81-92. (IF=3.093，中科院分区3区)5.Xue, T.*, Zhao, L. & Sun, B. (2013). LuxS/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC8325. International Journal of Antimicrobial Agents 41:85-89. (IF=4.307，中科院分区2区)6. Sun, H., Yang, Y., Xue, T.* & Sun, B.* (2013). Modulation of cell wall synthesis and susceptibility to vancomycin by the two component system AirSR in Staphylococcus aureus. BMC Microbiology. 13:286. (*共通讯，IF=2.644，中科院分区3区)7. Xue, T., Zhang, X., Sun, H. & Sun, B*. (2014). ArtR, a novel sRNA of Staphylococcus aureus, regulates α-toxin by targeting the 5’ UTR of sarT mRNA. Medical Microbiology and Immunology. 203:1-12. (IF=3.093，中科院分区3区)8. Xue, T. *, Chen, X., & Shang F. (2014). Effects of lactose and milk on the expression of biofilm-associated genes in Staphylococcus aureus strains isolated from a dairy cow with mastitis. Journal of Dairy Science. 97(10):6129-6134. (IF=2.474，中科院分区1区)9. Zhang X, Zhu Q, Tian T, Zhao C, Zang J, Xue T*, Sun B* (2015). Identification of RNAIII-binding proteins in Staphylococcus aureus using tethered RNAs and streptavidin aptamers based pull-down assay. BMC Microbiology 15:102.(*共通讯,IF=2.644，中科院分区3区)10. Chen C, Zhang X, Shang F, Sun H, Sun B, Xue T *(2015). The Staphylococcus aureus protein-coding gene, gdpS, modulates sarS expression in an mRNA-mRNA interaction manner. Infection and Immunity. 83:3302-3310. (IF=3.603，中科院分区2区)11. Xue T*, Ni J, Shang F, Chen X, Zhang M (2015). Autoinducer2 increases biofilm formation via an ica-and bhpdependent manner in Staphylococcus epidermidis RP62A. Microbes and Infection. 17:345-352. (IF=2.152，中科院分区3区)12. Chen, X., Shang F., Meng Y., Li L., Cui, Y., Zhang, M., Qi, K*., Xue, T*(2015). Ethanol extract of Sanguisorba officinalis L. inhibits biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) in an ica-dependent manner. Journal of Dairy Science. 98(12):8486-8491. (IF=2.474，中科院分区1区)13. Xue T*, Yu L, Shang F, Ni J, Zhang M, Chen X (2016).Role of AI-2 on antibiotic resistance regulation in an Escherichia coli strain isolated from a dairy cow with mastitis. Journal of Dairy Science. 99：4693–4698. (IF=2.474，中科院分区1区)14. Yu L, Li W, Zhang M, Cui Y, Chen X, Ni J, Yu L, Shang F, Xue T*(2018). Imidazole decreases the ampicillin resistance of an Escherichia coli strain isolated from a cow with mastitis by inhibiting the function of AI-2. Journal of Dairy Science. Accepted. (IF=2.474，中科院分区1区)15. Yu L, Li W, Zhang M, Cui Y, Chen X, Ni J, Cui Y, Yu L, Shang F, Xue T*(2018). Autoinducer2 affects trimethoprim-sulfamethoxazole susceptibility in avian pathogenic Escherichia coli dependent on the folate synthesis-associate pathway. MicrobiologyOpen. Accepted. (IF= 2.747，中科院分区2区)16. Shang F, Xue T*, Wang M, Chen X, Yu L, and Zhang M (2017). Serratia bozhouensis sp. nov., Isolated from Sewage Samples of a Dairy Farm. Current microbiology. 74:827–83117. Ma R, Qiu S, Jiang Q, Sun H, Xue T, Cai G, Sun B (2017). AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus. International Journal of Medical Microbiology 307(4-5):257-267.18. Tu J, Xue T, Qi K, Shao Y, Huang B, Wang X, Zhou X (2016). The irp2 and fyuA genes in High Pathogenicity Islands are involved in the pathogenesis of infections caused by avian pathogenic Escherichia coli (APEC). Polish journal of veterinary sciences 2016, 19(1):21-29.19. Tu J, Huang B, Zhang Y, Zhang Y, Xue T, Li S, Qi K (2016). Modulation of virulence genes by the two-component system PhoP-PhoQ in avian pathogenic Escherichia coli. Polish journal of veterinary sciences 2016, 19(1):31-40.20. Yang Y, Sun H, Liu X, Wang M, Xue T, Sun B (2016). Regulatory mechanism of the three-component system HptRSA in glucose-6-phosphate uptake in Staphylococcus aureus. Medical Microbiology and Immunology. 205(3):241-253.21. Bao, Y., Zhang, X., Jiang, Q., Xue, T., and Sun, B. (2015) Pfs promotes autolysis-dependent release of eDNA and biofilm formation in Staphylococcus aureus. Medical Microbiology and Immunology. 204:215-226.22. Tu J, Qi K, Xue T, Wei H, Zhang Y, Wu Y, Zhou X, Lv X (2015). Construction of Recombinant Pichia pastoris Carrying a Constitutive AvBD9 Gene and Analysis of Its Activity. Journal of microbiology and biotechnology, 25(12):2082-2089.23. You Y, Xue T, Cao L, Zhao L, Sun H, Sun B (2014). The Staphylococcus aureus glucose-induced biofilm accessory proteins, GbaAB, influence biofilm formation in a PIA-dependent manner. International Journal of MedicalMicrobiology.304:603-612.24. Yang Y, Jiang Y, Zhang J, Wang L, Bai X, Zhang S, RenY, Li N, Zhang Y, Zhang Z, Gong Q, Mei Y, Xue T, Zhang J, Chen Y, Zhou, C.(2014) Structural Insights into SraP-Mediated Staphylococcus aureus Adhesion to Host Cells. PLoS Pathogens 10(6): e1004169.25. Bao, Y., Li, Y., Jiang, Q., Xue, T., Hu, B., & Sun, B*. (2013). Pfs of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system. International Journal of Medical Microbiology 303:190-200.26. Yu, D., Zhao, L., Xue, T. & Sun, B*. (2012). Staphylococcus aureus autoinducer-2 quorum sensing decreases biofilm formation in an icaR-dependent manner. BMC Microbiology 12:288.27. Zhao, L., Xue, T., Shang, F., Sun, H. & Sun, B*. (2010). Staphylococcus aureus AI-2 quorum snsing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence. Infection and Immunity 78:3506-3515.28. Fei, E., Ma, X., Zhu, C., Xue, T., Yan, J., Xu, Y., Zhou, J. & Wang, G*. (2010). Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression. The Journal of biological chemistry 285:38630-38640.29. Ma, J., Ren, Z., Ma, Y., Xu, L., Zhao, Y., Zheng, C., Fang, Y., Xue, T., Sun, B. & Xiao, W*. (2009). Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. The Journal of biological chemistry 284: 34600-34606.30. Wang, X., Sahr, F., Xue, T. & Sun, B*. (2007). Methylobacterium salsuginis sp. nov., isolated from seawater. International Journal of Systematic Environmental Microbioly 57:1699-703.