个人简介

博士，教授，博士生导师，安徽省学术和科技带头人，安徽省第十三届人大常委会委员，安徽省第十三届人大常委会农业农村专业委员会委员，安徽省蚕学会常务理事，全国三八红旗手、国务院特殊津贴、安徽省青年科技奖获得者，安徽省蚕桑中药材产业创新体系蚕桑病虫害防控岗位专家。主持科研教学成就：主持国家863子课题1项，国家自然科学基金3项，其他省部级研究课题十多项；获安徽省科技进步奖二等奖1项（主持），国家科技进步二等奖1项，其他省级奖2项，省级科研成果4项；主持选育家蚕新品种2对，选育蚕蛹虫草新品种2个；在国内外学术期刊上发表研究论文三十余篇，其中SCI收录论文32篇，JCR1区文章14篇，累计影响因子超过55。学习经历：1991年毕业于安徽农业大学蚕学本科专业，2000年获安徽农业大学遗传育种专业硕士学位，2005年获江苏大学农产品加工及贮藏专业博士学位。工作简历：1992．2－2007．4安徽省农科院蚕桑研究所，从事桑树品种、家蚕品种选育，家蚕分子生物学研究工作。2007．5—至今，安徽农业大学生命科学学院，从事昆虫分子生物学、家蚕遗传育种等领域研究及教学工作。2006．12-2008.6中国科学院合肥物质科学研究院在职博士后，从事离子束生物技术研究。2011.12-2012.5美国堪萨斯州立大学高级访问研究，从事昆虫RNAi机理研究。2013.12-2014.11美国佛罗里达大学高级访问研究，从事昆虫-病原-植物蛋白互作研究。

研究领域

昆虫分子生物学、家蚕抗性遗传及资源利用

昆虫分子生物学、家蚕抗性遗传分子机制、蚕蛹虫草研发

近期论文

Shang-zhi Zhang, Jie Wang, Lin-bao Zhu, Shahzad Toufeeq, Xin Xu, Ling-ling You, Bing Li, Pei Hu, Jia-ping Xu*, Quantitative label-free proteomic analysis reveals differentially expressed proteins in the digestive juice of resistant versus susceptible silkworm strains and their predicted impacts on BmNPV infection, Journal of Proteomics, 2020 (210) 103527（IF: 3.537，JCR Q1） Shang-Zhi Zhang, Lin-Bao Zhu, Ling-Ling You, Jie Wang, Hui-Hua Cao, Ying-Xue Liu, Shahzad Toufeeq, Yu-Ling Wang, Xue Kong, Jia-Ping Xu*, A Novel Digestive Proteinase Lipase Member H-A in Bombyx mori Contributes to Digestive Juice Antiviral Activity Against B. mori Nucleopolyhedrovirus，Insects 2020, 11:154.（IF: 2.139，JCR Q1） Shang-zhi Zhang, Lin-bao Zhu, Dong Yu, Ling-ling You, Jie Wang, Hui-hua Cao, Ying-xue Liu, Yu-ling Wang, Xue Kong, Shahzad Toufeeq and Jia-ping Xu*, Identification and Functional Analysis of BmNPV-Interacting Proteins From Bombyx mori (Lepidoptera) Larval Midgut Based on Subcellular Protein Levels, Front. Microbiol. 2020, 11:1481. （IF: 4.235，JCR Q1） Bing Li, Pei Hu, Lin-Bao Zhu, Ling-Ling You, Hui-Hua Cao, Jie Wang, Shang-Zhi Zhang, Ming-Hui Liu, Shahzad Toufeeq, Shou-Jun Huang *, Jia-Ping Xu* , DNA Methylation Is Correlated with Gene Expression during Diapause Termination of Early Embryonic Development in the Silkworm (Bombyx mori), Int. J. Mol. Sci. 2020 ( 21): 671; doi:10.3390/ijms21020671 （IF: 4.183，JCR Q1） Li‐Ang Yang，Jie Wang，Shahzad Toufeeq，Lin‐Bao Zhu，Shang‐Zhi Zhang，Ling‐Ling You，Pei Hu，Hai‐Zhong Yu，Kang Zhao，Xin Xu, Jia-Ping Xu*, Identification of FerLCH, isolation of ferritin and functional analysis related to interaction with pathogens in Eri‐silkworm, Samia cynthia ricini, Arch Insect Biochem Physiol. 2020;e21659. doi.org/10.1002/arch.21659（IF: 1.198，JCR Q2） Shahzad Toufeeq, Jie Wang, Shang-Zhi Zhang, Bing Li, Pei Hu, Lin-Bao Zhu, Ling-Ling You and Jia-Ping Xu* , Bmserpin2 Is Involved in BmNPV Infection by Suppressing Melanization in Bombyx mori, Insects, 2019, 10, 399. （IF: 2.139，JCR Q1） Ping Li, Jing-wei Hu, Chao-wei Wen, Yang Hang, Zhuo-hua Zhou, Min Xie, Jia-cheng Lv, Chun-meng Wang, Ying-Hao Huang, Jia-ping Xu*, Ming-jie Deng* Sanguinarine caused larval lethality and growth inhibition by suppressing energy metabolism in silkworms, Bombyx mori, Pesticide Biochemistry and Physiology, 2019, (160): 154-162.（IF: 2.87，中科院分区昆虫学为1区）（IF: 3.44，JCR Q1） Xue-yang Wang, Zuo-min Shao, Ying-jian Zhang, Thi Thuy Vu, Yang-chun Wu, Jia-ping Xu*, Ming-jie Deng* A 1H NMR based study of hemolymph metabonomics in different resistant silkworms, Bombyx mori (Lepidotera), after BmNPV inoculation, Journal of Insect Physiology, 2019 (117): 103911（IF: 2.862，JCR Q1） Xue-yang Wang, Zuo-min Shao, Qian-ying Chen, Jia-ping Xu, Xia Sun, Zhen-ping Xu, Mu-wang Li, Yang-chun Wu*, Knockdown of BmTCP-1β delays BmNPV infection in vitro, Frontiers in Microbiology, section Virology, 2019, 22;10:578. doi: 10.3389/fmicb.2019.00578 （IF: 4.259，JCR Q1）（IF: 4.259，JCR Q1） Xue-yang Wang, Tao Li, Mapuranga Johannes, Jia-ping Xu, Xia Sun, Sheng Qin, Ping-zhen Xu, Mu-wang Li, Yang-chun Wu*, The regulation of silkworm Toll-like gene 18 wheeler to crecropin-A and gloverin 2 in immune response, Journal of Invertebrate Pathology, 2019, 164:49-58. （IF: 2.511，JCR Q1） Xue-yang Wang#, Zuo-min Shao#, Ying-jian Zhang, THI THUY VU, Yang-chun Wu, Jia-ping Xu*, Ming-jie Deng*, A 1H-NMR based study of hemolymph metabonomics in different resistant silkworms, Bombyx mori (Lepidotera), after BmNPV inoculation, Journal of Insect Physiology, 2019, 4;117:103911. doi: 10.1016/j.jinsphys （IF: 2.862，JCR Q1） Azharuddin Muhammd，Shahzad Toufeeq#, Hai-Zhong Yu, Jie Wang, Shang-Zhi Zhang, Bing Li, Zhen Li, Li-Ang Yang, Pei Hu, Yan Ma, Jia-Ping Xu*, Molecular characterization of two mitogen-activated protein kinases: p38 MAP kinase and ribosomal S6 kinase from Bombyx mori, and insight into their roles in response to BmNPV infection, Journal of Insect Science, 2019, 19(1):15; 1-11（IF: 1.324，JCR Q2） Bing Li, Pei Hu#, Shang-Zhi Zhang, Shahzad Toufeeq, Jie Wang, Kang Zhao, Xin Xu, Jia-Ping Xu*, Shou-jun Huang*， DNA methyltransferase BmDnmt1 and BmDnmt2 in silkworm (Bombyx mori) and the regulation of silkworm embryonic development. Archives of Insect Biochemistry and Physiology，2018; e21529（IF: 1.316，JCR Q2） Hai-zhong Yu, Jie Wang#, Shang-zhi Zhang, Shahzad Toufeeq, Bing Li, Zhen Li, Li-ang Yang, Pei Hu, Jia-ping Xu*. Molecular characterisation of Apolipophorin-III gene in Samia cynthia ricini and its roles in response to bacterial infection. Journal of Invertebrate Pathology, 2018 (159):61-70（IF: 2.511，JCR Q1） Peng-cheng Yan, Chao-wei Wen, Shang-zhi Zhang, Zhi-da Zhang, Jia-ping Xu*, Ming-jie Deng, A toxicological, metabonomic and transcriptional analysis to investigate the property of mulberry 1-deoxynojirimycin against the growth of Samia cynthia ricini，Pesticide Biochemistry and Physiology, 2018 (152):45-54（IF: 3.440，JCR Q1） Dong-qiong Fei, Hai-zhong Yu, Jia-ping Xu∗, Shang-zhi Zhang, Jie Wang, Bing Li, Li-ang Yang, Pei Hu, Xin Xu, Kang Zhao, Toufeeq Shahzad, Isolation of ferritin and its inter action with BmNPV in the silkworm, Bombyx mori, Developmental and Comparative Immunology, 2018, 86: 130–137（IF: 2.913，JCR Q1，中科院分区动物学1区） Shang-Zhi Zhang, Hai-Zhong Yu, Ming-Jie Deng, Yan Ma, Dong-Qiong Fei, Jie Wang, Zhen Li, Yan Meng, Jia-Ping Xu*, Comparative transcriptome analysis reveals significant metabolic alterations in eri- silkworm (Samia cynthia ricini) haemolymph in response to 1-deoxynojirimycin, PLoS ONE 2018,13(1): e0191080（IF: 2.766，JCR Q1） Hai-zhong Yu, Yan Ma, Shang-zhi Zhang, Dong-qiong Fei, Bing Li, Li-ang Yang, Azharuddin Muhammada, Jia-ping Xu*, Comparative transcriptome analysis of ATP-binding cassette (ABC) transporter genes in eri-silkworm, Samia cynthia ricini in response to 1- deoxynojirimycin，Journal of Asia-Pacific Entomology，2018, 21: 168–178 （IF: 1.046，JCR Q2） Hai-Zhong Yu, Xue-Yang Wang, Jia-Ping Xu*, Yan Ma, Shang-Zhi Zhang, Dong Yu, Dong-Qiong Fei, Azharuddin Muhammad. iTRAQ-based quantitative proteomics analysis of molecular mechanisms associated with Bombyx mori (Lepidoptera) larval midgut response to BmNPV in susceptible and near-isogenic, Journal of Proteomics, 2017, 165: 35-50. (IF:3.914, JCR Q1). Hai-Zhong Yu, Shang-Zhi Zhang, Yan Ma, Li-Ang Yang, Bing Li, Dong-Qiong Fei, Jie Wang, Zhen Li, Azharuddin Muhammad, Jia-Ping Xu *, Molecular characterization and functional analysis of a ferritin heavy chain subunit from the eri-silkworm, Samia cynthia ricini, Int. J. Mol. Sci, 2017, 18, 2126; doi:10.3390/ijms18102126 (IF：3.257, JCR Q1) Xue-Yang Wang, Hai-Zhong Yu, Jia-Ping Xu*, Shang-Zhi Zhang, Dong Yu, Ming-hui Liu, Lin-Ling Wang. Comparative Subcellular Proteomics Analysis of Susceptible and Near-isogenic Resistance Bombyx mori (Lepidoptera) Larval Midgut Response to BmNPV infection, Scientific Report, 2017, 7:45690. DOI: 10.1038/srep45690 (IF:5.228, JCR Q1) Ming-Jie Deng, Xiao-Dong Lin, Chao-Wei Wen, Min-Jian Dong, Qiu-Ting Lin, Shang-Zhi Zhang, Jia-Ping Xu*. Metabolic changes in the midgut of Eri silkworm after oral administration of 1-deoxynojirimycin: A 1H-NMR-based metabonomic study, PLoS ONE,2017, 12(3): e0173213. doi:10.1371/journal.pone.0173213 (IF：3.057, JCR Q1). Bing Li, Hai-Zhong Yu, Chong-Jun Ye, Yan Ma, Xing Li, Tao Fan, Fu-Sheng Chen, Jia-Ping Xu*. Bombyx mori Serpin6 regulates prophenoloxidase activity and the expression of antimicrobial proteins, Gene, 2017, 610: 64–70, doi: 10.1016/j. gene. 2017.02.011 (IF：2.319, JCRQ3). Hai-Zhong Yu, Jia-Ping Xu*，Xue-Yang Wang，Yan Ma, Dong Yu, Dong-Qiong Fei, Shang-zhi Zhang, Wan-Ling Wang. Identification of four ATP-binding cassette transporter genes in Cnaphalocrocis medinalis and their expression in response to insecticide treatment. Journal of Insect Sciences, 2017, 17 (2): 1-8 (IF: 0.65, JCRQ3). Xue-Yang Wang, Shang-Zhi Zhang, Ming-Hui Liu, Dong-Yu, Yan-Ma, Qiong-Dong Fei, Hai-Zhong Yu, Jia-Ping Xu*. BmARM-like from silkworm, Bombyx mori (Lepidoptera) is putatively involved in embryonic development and response against BmNPV infection, Pakistan Journal of Zoology, 2017, 49(6): 2181-2191 (IF: 0.478, JCRQ4). Xue-Yang Wang, Hai-Zhong Yu, Lei Geng, Jia-Ping Xu*, Dong Yu, Shang-Zhi Zhang, Yan Ma, Dong-Qiong Fei. Comparative Transcriptome Analysis of Bombyx mori (Lepidoptera) Larval Midgut Response to BmNPV in Susceptible and Near- Isogenic Resistant Strains, PLoS ONE, 2016, 11(5): e0155341. doi:10.1371/journal.pone.0155341 (IF：3.057, JCRQ1). Hai-Zhong Yu, Xue-Yang Wang, Xin Yang, Wan-Ling Wang, Lei Geng, Dong Yu, Xue-Lan Liu, Gui-Ying Liu, Jia-Ping Xu＊. Identification and expression profiles of chitin deacetylase genes in the rice leaf folder, Cnaphalocrocis medinalis, Journal of Asia-Pacific Entomology, 2016，19: 691–696 (IF：0.824, JCRQ3). Ming-Jie Deng, Xiao-Dong Lin, Qiu-Ting Lin, De-Fu Wen, Mei-Ling Zhang, Xian-Qin Wang, Hong-Chang Gao, Jia-Ping Xu*. A 1H-NMR Based Study on Hemolymph Metabolomics in Eri Silkworm after Oral Administration of 1-Deoxynojirimycin, PLoS ONE, 2015, 10 (7): e0131696, doi: 10.1371/journal.pone.0131696 (IF：3.534, JCRQ1). Hai-Zhong Yu, De-Fu Wen, Wan-Lin Wang, Lei Geng, Yan Zhang, Jia-Ping Xu*. Identification of Genes Putatively Involved in Chitin Metabolism and Insecticide Detoxification in the Rice Leaf Folder (Cnaphalocrocis medinalis) Larvae through Transcriptomic Analysis, Int. J. Mol. Sci, 2015, 16: 21873-21896, doi: 10.3390/ijms160921873 (IF：3.257, JCRQ2). Yang Cheng, Xue-Yang Wang, Hao Hu, Nabil Killiny, Jia-Ping Xu*. A Hypothetical Model of Crossing Bombyx moriNucleopolyhedrovirus through Its Host Midgut Physical Barrier, PLoS ONE, 2014, 9(12):e115032. doi:10.1371/journal.pone.0115032 (IF：3.534, JCRQ1). Da Xiao, Xi Wu Gao , Jia Ping Xu , Xiao Liang , Qingqing Li , Jian Xiu Yao, Kun Yan Zhu*. Clathrin-dependent endocytosis plays a predominant role in cellular uptake of double-stranded RNA in the red flour beetle, Insect Biochemistry and Molecular biology, 2015, 60: 68-77, doi: 10.1016/j.ibmb.2015.03.009 (IF：3.45, JCRQ1) Yang Cheng, Xue-yang Wang, Chang Du, Juan Gao, Jia-ping Xu*. Expression analysis of several antiviral related genes to BmNPV in resistant strains of the silkworm, Bombyx mori. Journal of Insect Science, 2014, 14:1-9, doi: 10.1093/jis/14.1.76 (IF: 0.92, JCRQ2). Identification of a new Bombyx mori nucleopolyhedrovirus and analysis of its bro gene family, Virus Genes, doi: 10.1007/s11262-012-0721-1 2012，44:539-547（通讯作者）(IF：1.845, JCRQ3) Expression of Bombyx mori Cecropin B in Silkworm Larvae using BmNPV/Bac-to-Bac Expression System, JOURNAL OF PURE AND APPLIED MICROBIOLOGY, 2013, 7(3): 1577-1584. （通讯作者）(SCI 收录) Silkworm eggs: An ideal model for studying the biological effects of low energy Ar+ ion interaction in animals，Nuclear Instruments and Methods in Physics Research B，2011，269：1997–2000（通讯作者）(IF：1.211, JCRQ2) Subcellular localization of Bombyx mori ribosomal protein S3a and effect of its over-expression on BmNPV infection. African Journal of Biotechnology. 2010, 9(14): 2056-2061. （通讯作者）(IF：0.589, JCRQ4 ) Biological effects of low energy Ar+ ion bombardment on silkworm egg, a novel animal model. Plasma Science & Technology. 2009, 11(3) ：359-363. （第一作者）(IF：0.596, JCRQ4) Identification and characterization of Bms3a in Bombyx mori L., African Journal of Biotechnology，2008，7 (19): 3424-3430. (IF：0.589, JCRQ4) Identification and characterization of an NPV infection related gene Bmsop2 in Bombyx mori L., Journal of Applied Entomology, 2005,129（8）: 425-431. （第一作者）(IF：1.701, JCRQ3 ) Fluorescent differential display analysis of gene expression for NPV resistance in Bombyx mori L., Journal of Applied Entomology, 2005,129（1）：27－31. （第一作者）(IF：1.701, JCRQ3) 余海中，黄克慧，汪婉玲，杨鑫, 张彦, 徐家萍* , 2015, 稻纵卷叶螟几丁质合成酶及合成通路相关酶基因的鉴定及表达分析, 应用昆虫学报, 52(5): 1181- 1194. 家蚕抗NPV相关新基因s3a的分离与序列分析，昆虫学报，2005，48（3）：347-352 家蚕Bms3a基因真核表达载体的构建及其在家蚕细胞和蚕体中的表达，激光生物学报，2011, 20(2):39-45 家蚕和果蝇的抗菌肽cecropin B基因的原核表达及抑菌活性分析，蚕业科学，2011,37(2):0246-0253 抗菌肽Thanatin基因与多角体蛋白Polyhedrin基因的融合表达及产物的抑菌活性分析，蚕业科学，2011,37(6):1008-1013.