个人简介

孟艳，女，博士、教授，博士生导师，中国农科院生物技术研究所客座研究员，安徽省蚕桑中药材产业技术体系岗位专家，安徽省蚕学会理事。教育背景2002-2006：日本信州大学生物机能工学专业，工学博士1997-2000：安徽农业大学特种经济动物饲养专业，农学硕士1993-1997：安徽农业大学蚕学专业，农学学士工作经历2009-至今：安徽农业大学讲席教授、教授2009-2012：东京大学农学生命科学研究科，农学共同研究员2007-2009：东京大学农学生命科学研究科，日本学术振兴会外国人特别研究员2006-2007：东京大学农学生命科学研究科，博士后2000-2002：安徽农业大学蚕业丝绸系助教、讲师主要教学经历与成果：主讲《遗传学》、《细胞生物学》、《昆虫生物化学》、《分子生物学》等研究生和本科生课程。

研究领域

昆虫生化与分子生物学，家蚕遗传与资源利用

以鳞翅目模式昆虫家蚕为研究对象，主要从事昆虫生理生化学、分子生物学与遗传学等方面的课题研究。在后基因组时代利用家蚕全基因组信息及丰富的突变体遗传资源，定位克隆控制家蚕重要品质性状基因、研究基因功能，开发家蚕蚕丝以外具有重要应用前景的研究领域具有学术专长并取得较好的研究进展。主要研究方向：1.定位克隆调控家蚕内源性体表色素形成的重要功能性基因，阐明其在昆虫氨基酸等物质代谢中的作用机制，探索利用家蚕突变体作为药用前体物质合成及人类疾病模型的应用价值；2.研究家蚕糖营养代谢过程中特异性蔗糖水解酶同源基因在不同鳞翅目昆虫中的进化特征、表达模式及其表达调控分子机制，从昆虫中肠消化酶的角度揭示植食性昆虫-寄主植物的互作规律与协同进化关系；3.以家蚕为模式，通过对主要卵黄蛋白受体基因的克隆与功能鉴定，研究鳞翅目昆虫受精卵形成前及胚胎发育过程中卵黄蛋白的内吞作用机理，为防治农林害虫寻求新靶标、提供新策略。

近期论文

（#，通讯作者）25) Gan, Q.*, Zhang, X.W.*, Zhang, D.B., Shi, L., Zhou, Y., Sun, T.T., Jiang, S., Gao, J.S., and Meng, Y.# (2018) BmSUC1 is essential for glycometabolism modulation in the silkworm, Bombyx mori. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1861 (6), 543-553.24) Gan, Q., Li, X., Zhang, X.W., Wu,L.L., Ye, C.J., Wang, Y., Gao, J.S., and Meng, Y.# (2018) D181A site-mutagenesis enhances both the hydrolyzing and transfructosylating activities of BmSUC1, a novel β-fructofuranosidase in the silkworm Bombyx mori. International Journal of Molecular Sciences, 19 (3), 683 (doi: 10.3390/ijms19030683).23）Gao, J.S., Wu, F.F., Shen, Z.L., Meng, Y., Cai, Y.P., and Lin, Y. (2016) A putative molybdate transporter LjMOT1 is required for molybdenum transport in Lotus japonicus. Physiologia Plantarum, 158, 331–340. 22）Li, W.T., Gong, M.X., Shu, R., Li, X., Gao, J.S., and Meng, Y.# (2015) Molecular and enzymatic characterization of two enzymes BmPCD and BmDHPR involving in the regeneration pathway of tetrahydrobiopterin from the silkworm Bombyx mori. Comparative Biochemistry and Physiology-Part B, 186，20-27.21）Gao, J.S., Hu, L., Xie, P., Meng, Y., Cai, Y.P., and Lin, Y. (2014) Isolation and molecular characterization of an ethylene response factor NtERF1-1 in Nicotiana tabacum cv. Xanthi. Journal of Biosciences, 39, 887-897. 20）Gao, J.S., Wang, J., Wang, W.J., Liu, C.L.#, and Meng, Y.# (2013) Isolation, purification and identification of an important pigment sepiapterin from integument of the lemon mutant of silkworm, Bombyx mori. Journal of Insect Science, 13, 118.19）Hirayama, C., Ono, H., Meng, Y., Shimada, T., and Daimon, T. (2013) Flavonoids from the cocoon of Rondotia menciana. Phytochemistry, 94, 108-112.18）Lin, Y.*, Meng, Y.*, Wang, Y.X.*, Luo, J., Katsuma, S., Yang, C.W., Banno, Y., Kusakabe, T., Shimada, T., and Xia, Q.Y. (2013) Vitellogenin receptor mutation leads to the oogenesis mutant phenotype ‘scanty vitellin’ of the silkworm, Bombyx mori. Journal of Biological Chemistry, 288，13345-13355. (*co-first author)17）Wang, W.J., Gao, J.S., Wang, J., Liu, C.L.#, and Meng, Y.# (2012) Cloning, expression and enzymatic properties analysis of dihydrofolate reductase gene from the silkworm, Bombyx mori. Molecular Biology Reports, 39, 10285–10291.16) Qian, C., Liu, C.L., Zhu, B.J., Meng Y., and Wei, G.Q. (2011) Identification and expression analysis of vitellogenin from silk-producing insect, Actias selene Hubner. African Journal of Biotechnology, 10, 999-1010.15) Gao, J.S., Meng, Y., Sasaki, N., Kanegae, H., Hayashi, N., and Nyunoya, H. (2010) Characterization and cloning of TMV resistance gene N homologues from Nicotiana tabacum. African Journal of Biotechnology, 9, 7998-8006.14) Daimon, T., Hirayama, C., Kanai, M., Ruike, Y., Meng, Y., Kosegawa, E., Nakamura, M., Tsujimoto, M., Katsuma, S., and Shimada, T. (2010) The silkworm Green b locus encodes a quercetin 5-O-glucosyltransferase that produces green cocoons with UV-shielding properties. Proceedings of the National Academy of Sciences USA, 107, 11471-11476.13) Meng, Y., Katsuma, S., Daimon, T., Banno, Y., Uchino, K., Sezutsu, H., Tamura, T., Mita, K., and Shimada, T. (2009) The silkworm mutant lemon (lemon lethal) is a potential insect model for human Sepiapterin reductase deficiency. Journal of Biological Chemistry, 284, 11698-11705.12) Meng, Y., Katsuma, S., Mita, K., and Shimada, T. (2009) Abnormal red body coloration of the silkworm, Bombyx mori, is caused by a mutation in a novel kynureninase. Genes to Cells, 14, 129-40.11) Kawaoka, S., Katsuma, S., Meng, Y., Hayashi, N., Mita, K., and Shimada, T. (2009) Identification and characterization of globin genes from two lepidopteran insects, Bombyx mori and Samia cynthia ricini. Gene, 431, 33-38.10) Daimon, T., Taguchi, T., Meng, Y., Katsuma, S., Mita, K., and Shimada, T. (2008) Beta-fructofuranosidase genes of the silkworm, Bombyx mori: Insight into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex. Journal of Biological Chemistry, 283, 15271-15279.9) Futahashi, R*., Sato, J*., Meng, Y*., Okamoto, S., Daimon, T., Yamamoto, K., Suetsugu, Y., Narukawa, J., Takahashi, H., Banno, Y., Katsuma, S., Shimada, T., Mita, K., and Fujiwara, H. (2008) yellow and ebony are the responsible genes for the larval color mutants of the silkworm Bombyx mori. Genetics, 180, 1995-2005. (*co-first author).8) Meng, Y., Omuro, N., Funaguma, S., Daimon, T., Kawaoka, S., Katsuma, S., and Shimada, T. (2008) Prominent down-regulation of storage protein genes after bacterial challenge in eri-silkworm, Samia cynthia ricini. Archives of Insect Biochemistry and Physiology, 67, 9-19.7) Meng, Y., Liu, C.L., Shiomi, K., Nakagaki, M., and Kajiura, Z. (2008) Purification and cDNA cloning of vitellogenin of the wild silkworm, Saturnia japonica (Lepidoptera: Saturniidae). Journal of Insect Biotechnology and Sericology, 77, 35-44.6) Miao, Y.G., Zhang, Y.S., Nakagaki, K., Zhao, T.F., Zhao, A.C., Meng, Y., Nakagaki, M., Park, E.Y, and Maenaka, K. (2006) Expression of spider flagelliform silk protein in Bombyx mori cell line by a novel Bac-to-Bac/BmNPV baculovirus expression system. Applied Microbiology and Biotechnology, 71, 192–199.5) Miao, Y.G., Zhao, A.C., Zhang, Y.S., Nakagaki, K., Meng, Y., Zhao, T.F., and Nakagaki, M. (2006) Silkworm, Bombyx mori larvae expressed the spider silk protein through a novel Bac-to-Bac/BmNPV baculovirus. Journal of Applied Entomology, 130, 297–301.4) Meng, Y., Liu, C.L., Shiomi, K., Nakagaki, M., Banno, Y., and Kajiura, Z. (2006) Genetic variations in the vitellogenin of Japanese populations of the wild silkworm, Bombyx mandarina. Journal of Insect Biotechnology and Sericology, 75, 127–134.3) Meng, Y., Liu, C.L., Zhao, A.C., Shiomi, K., Nakagaki, M., and Kajiura, Z. (2006) Vitellogenin gene organization of Antheraea yamamai and promoter analysis. International Journal of Wild Silkworm & Silk, 11, 29–40.2) 孟艳，徐厚镕，赵正龙，鲁成，向仲怀. 氮离子束注入家蚕卵的生化效应及其RAPD分析.蚕业科学，2001,27, 227–231.1) 孟艳，徐厚镕，赵正龙，姚建铭. 氮离子束注入家蚕卵对血液SOD 活性的影响. 蚕业科学，2000,26, 271–273.