个人简介
唐汝培（博士，教授，博士生导师），男，生于1977年8月。1999年6月本科毕业于武汉大学化学与环境科学学院，获理学学士学位；1999年9月至2002年6月在武汉大学资源与环境科学学院学习获理学硕士学位，研究方向为基于天然聚多糖的环境友好材料；2002年9月至2005年6月在中国科学院化学研究所学习并获理学博士学位，研究方向为新型聚合物电致发光材料的设计、合成及性能研究。2005年8月至2006年5月在武汉理工大学化学与工程学院任讲师、副教授。2006年6月至2009年11月在美国明尼苏达大学生物医学工程系从事生物材料及药物传递等方面的博士后研究工作。2009年12月至2013年4月在江南大学药学院工作，任教授，硕士研究生导师，主要从事生物材料与缓释给药技术研究；2013年5月至今，安徽大学生命科学学院工作，任教授，博士生导师。2010年12月入选江苏省高校“青蓝工程”优秀青年骨干教师培养对象，2011年12月入选教育部“新世纪优秀人才”支持计划。
研究领域
从事具有良好生物相容性、特异靶向性及药物缓控释放特性的多功能生物材料的设计、制备与性能研究，主要研究方向包括生物可降解大分子材料的分子设计和可控合成、靶向药物控释制剂及纳米药物制剂等，所开展的研究课题基本上处于生物大分子、天然产物及药学等交叉领域的前沿，已在Biomaterials、Journal of Controlled Release、ACS Applied Materials & Interfaces、Acta Biomaterialia、Biomacromolecules、Polymer Chemistry、Macromolecular Bioscience等SCI期刊发表六十余篇研究论文。目前主要从事环境响应型生物材料的应用基础研究，在生物材料的生物相容性和生物（药学）功能性方面开展了较为系统的研究，形成了基于酸敏感原酸酯键构建具有环境响应性新型生物材料的研究特色；研究发现基于原酸酯构建的生物材料具有环境刺激响应性，能对外界环境pH及温度的细微变化做出（超）灵敏反应；其作为药物及基因传递载体，可根据需要赋予载体环境刺激响应性，发挥智能载体的协调性，促进药物和治疗基因从载体材料中释放，有助于药物与目标靶点的相互作用，增强基因表达的水平以及实现缓释给药。
近期论文
Jun Wang, Yu Lu, Shuting Li, Xin Wang, Yan Huang, Rupei Tang*, pH-sensitive amphiphilic triblock copolymers containing ortho ester mainchains as efficient drug delivery platforms, Materials Science & Engineering C 2019, 94, 169–178. Le He, Min Sun, Xu Cheng, Yong Xu, Xiaodong Lv, Xin Wang*, Rupei Tang*, pH/redox dual-sensitive platinum (IV)-based micelles with greatly enhanced antitumor effect for combination chemotherapy, Journal of Colloid and Interface Science 2019, 541, 30–41.Min Sun, Le He, Xin Wang, Rupei Tang*, Acid-breakable TPGS-functionalized and diallyl disulfide-crosslinked nanogels for enhanced inhibition of MCF-7/ADR solid tumours, Journal of Materials Chemistry B 2019, 7, 240–250.Jiejie Qin, Yan Huang, Guoqing Yan, Jun Wang, Liefeng Hu, Panpan Zhang, Rupei Tang*, Phenylboronic acid-functionalized ultra-pH-sensitive micelles for enhanced tumor penetration and inhibition in vitro, Journal of Materials Science 2019, 54, 5695–5711. Shuting Li, Liefeng Hu, Dapeng Li, Xin Wang, Panpan Zhang, Jun Wang, Guoqing Yan, Rupei Tang*, Carboxymethyl chitosan-based nanogels via acid-labile ortho ester linkages mediated enhanced drug delivery, International Journal of Biological Macromolecules 2019, 129, 477–487.Min Sun, Xin Wang, Xu Cheng, Le He, Guoqing Yan, Rupei Tang*, TPGS-functionalized and ortho ester-crosslinked dextran nanogels for enhanced cytotoxicity on multidrug resistant tumor cells, Carbohydrate Polymers 2018, 198, 142–154. Xu Cheng, Jiejie Qin, Xin Wang, Qian Zha, Weijing Yao, Shengxiang Fu, Rupei Tang*, Acid-degradable lactobionic acid-modified soy protein nanogels crosslinked by ortho ester linkage for efficient antitumor in vivo, European Journal of Pharmaceutics and Biopharmaceutics 2018, 128, 247–258. Xin Wang, Jie Luo, Le He, Xu Cheng, Guoqing Yan, Jun Wang, Rupei Tang*, Hybrid pH-sensitive nanogels surface-functionalized with collagenase for enhanced tumor penetration, Journal of Colloid and Interface Science 2018, 525, 269–281.Xin Wang, Le He, Bing Wei, Guoqing Yan, JunWang, Rupei Tang*, Bromelain-immobilized and lactobionic acid-modified chitosan nanoparticles for enhanced drug penetration in tumor tissues, International Journal of Biological Macromolecules 2018, 115, 129–142. Guanqing Yang, Shengxiang Fu, Xin Wang , Jun Wang, Rupei Tang*, pH-triggered poly(ethylene glycol) nanogels prepared through orthoester linkages as potential drug carriers, International Journal of Polymeric Materials and Polymeric Biomaterials 2018, 67, 1059–1068. Weijing Yao, Xu Cheng, Shengxiang Fu, Guoqing Yan, Xin Wang, Rupei Tang*, Low molecular weight polyethyleniminegrafted soybean protein gene carriers with low cytotoxicity and greatly improved transfection in vitro, Journal of Biomaterials Applications 2018, 32, 957–966.Yan Huang, Jiejie Qin, Jun Wang, Guoqing Yan, Xin Wang, Rupei Tang*, Dual-stimuli-sensitive poly(ortho ester disulfide urethanes)-based nanospheres with rapid intracellular drug release for enhanced chemotherapy, Science China Chemistry 2018, 61, 1447–1.Guoqing Yan, Jun Wang, Liefeng Hu, Xin Wang, Guanqing Yang, Shengxiang Fu, Xu Cheng, Panpan Zhang, Rupei Tang*，Stepwise targeted drug delivery to liver cancer cells for enhanced therapeutic efficacy by galactose-grafted, ultra-pH-sensitive micelles, Acta Biomaterialia 2017, 51, 363–373.Guanqing Yang, Xin Wang, Shengxiang Fu, Rupei Tang*, Jun Wang, pH-triggered chitosan nanogels via an ortho ester-based linkage for efficient chemotherapy, Acta Biomaterialia 2017, 60, 232–243.Guoqing Yan, Jun Wang, Panpan Zhang, Liefeng Hu, Xin Wang, Guanqing Yang, Shengxiang Fu, Xu Cheng, Rupei Tang*, Tunable dynamic fluorinated poly(ortho ester)-based drug carriers for greatly enhanced chemotherapeutic efficacy, Polymer Chemistry 2017, 8, 2063–2073.Liefeng Hu, Panpan Zhang, Xin Wang, Xu Cheng, Jiejie Qin, Rupei Tang*, pH-sensitive carboxymethyl chitosan hydrogels via acid-labile ortho ester linkage for potential biomedical applications, Carbohydrate Polymers 2017, 178, 166–179. Xin Wang, Bing Wei, Xu Cheng, Jun Wang, Rupei Tang*, 3-Carboxyphenylboronic acid-modified carboxymethyl chitosan nanoparticles for improved tumor targeting and inhibitory, European Journal of Pharmaceutics and Biopharmaceutics 2017, 113, 168–177.Shengxiang Fu, Guanqing Yang, Jun Wang, Xin Wang, Xu Cheng, Qian Zha, Rupei Tang*, pH-sensitive poly(ortho ester urethanes) copolymers with controlled degradation kinetic: Synthesis, characterization, and in vitro evaluation as drug carriers, European Polymer Journal 2017, 95, 275–288.Xin Wang, Di Zhang, Jun Wang, Rupei Tang*, Bing Wei, Qiong Jiang, Succinyl pullulan-crosslinked carboxymethyl chitosan sponges for potential wound dressing, International Journal of Polymeric Materials and Polymeric Biomaterials 2017, 66, 61–70. Zhipeng Cao, Xin Wang, Xu Cheng, Jun Wang, Rupei Tang*, In vitro and in vivo anti-tumor study of folic acid-conjugated carboxymethyl chitosan and phenylboronic acid-based nanoparticles for in vitro and in vivo anti-tumor study, International Journal of Polymeric Materials and Polymeric Biomaterials 2017, 66, 495–506.
