个人简介
安徽大学生命科学学院教授，博士生导师。先后于安徽农业大学、安徽大学和合肥工业大学获农学学士、理学硕士和工学博士学位。1991年安徽大学研究生毕业留校任教，历任讲师、副教授、教授、生物实验教学中心主任、生命科学学院副院长。现为安徽省生态工程与生物技术重点实验室主任，安徽省学术和技术带头人，安徽省生物化学与分子生物学学会副理事长，安徽省食用菌技术协会副会长。
研究领域
主要1、真菌活性多糖的结构与功能；2、天然活性产物的抗肿瘤/抗衰老作用机制；3、功能食品/保健品的开发与研究。
近期论文
Wen-Na Zhang, Ri-Na Su, Li-Li Gong, Wei-Wei Yang, Juan Chen, Rui Yang, Ya Wang, Wen-Juan Pan, Yong-Ming Lu, Yan Chen*. Structural characterization and in vitro hypoglycemic activity of a glucan from Euryale ferox Salisb. Seeds, Carbohydrate Polymers. 2019,209 :363–371Wei-Wei Yang, Li-MingWang, Li-Li Gong, Yong-Ming Lu, Wen-Juan Pan, Ya Wang, Wen-Na Zhang*, Yan Chen*. Structural characterization and antioxidant activities of a novel polysaccharide fraction from the fruiting bodies of Craterellus cornucopioides, International Journal of Biological Macromolecules. 2018,117:473–482Wan Li, Zheng-Nan Cai, Shomaila Mehmood, YaWang,Wen-Juan Pan, Wen-Na Zhang, Yong-Ming Lu*,Yan Chen*. Polysaccharide isolated from Sarcodon aspratus induces RAW264.7 activity via TLR4-mediated NF-κB and MAPK signaling pathways, International Journal of Biological Macromolecules. 2018,120:1039–1047Zheng-Nan Cai, Wan Li, Shomaila Mehmood, Wen-Juan Pan, Ya Wang, Fan-Ju Meng, Xiao-Fang Wang, Yong-Ming Lu*, Yan Chen*. Structural characterization, in vitro and in vivo antioxidant activities of aheteropolysaccharide from the fruiting bodies of Morchella esculenta, Carbohydrate Polymers. 2018,195:29-38Mingzhu Zhang, Rina Su, Qiong Zhang, Lei Hu, Xiaohe Tian, Yan Chen*. Hongping Zhou, Jieying Wu, Yupeng Tian*,Ultra-bright intercellular lipids pseudo di-BODIPY probe with lowmolecular weight, high quantum yield and large two-photon actioncross-sections, Sensors and Actuators B: Chemical, Sensors and Actuators B. 2018,261 :161-168Sajid Hussain, Wei Du,Mingzhu Zhang, Bin Fang, Guocui Zhang, Rina Su,Keqian Nan, Qiong Zhang, Xiaohe Tian*, Yupeng Tian* and Yan Chen*. A series of two-photon absorption pyridinium sulfonate inner salts targeting endoplasmic reticulum (ER), inducing cellular stress and mitochondria-mediated apoptosis in cancer cells Journal of Materials Chemistry B. 2018,6, 1943-1950Wen-Juan Pan, Qiu-Ying Ding, Ya Wang, Dan-Dan Wang, Yong-Ming Lu, Wei-Wei Yang, Zheng-Nan Cai, Xiao-Du Cheng, Wen-Na Zhang, Yan Chen*.A bioactive polysaccharide TLH-3 isolated from Tricholoma lobayense .protects against oxidative stress-induced premature senescence in cells and mice , Journal of Functional Foods. 2018,42:159-170Mingzhu Zhang, Xiaohe Tian, Ya Wang, Dandan Wang, Wan Li , Lei Chen, Wenjun Pan, Shomaila Mehmood,Yan Chen*. Immunomodulating activity of the polysaccharide TLH-3 from Tricholomalobayense in RAW264.7 macrophages, International Journal of Biological Macromolecules. 2018,107:2679-2685 Wan Li, Zheng-Nan Cai, Shomaila Mehmood, Ya Wang,Wen-Juan Pan, Wen-Na Zhang,Yong-Ming Lu*,Yan Chen*,Polysaccharide FMP-1 from Morchella esculenta attenuates cellular oxidative damage in human alveolar epithelial A549 cells through PI3K/AKT/Nrf2/HO-1 pathway, International Journal of Biological Macromolecules, 2018,120 :865–875Dan-Dan Wang, Qing-Xi Wu, Wen-Juan Pan, Sajid Hussain, Shomaila Mehmood and Yan Chen*, A novel polysaccharide from the Sarcodon aspratus triggers apoptosis in Hela cells via induction of mitochondrial dysfunction, Food & Nutrition Research, 2018,62:1285Qing-Xi Wu*, Jun-Qi Yu, Wei Ying, Ting Su, Xiao-Du Cheng, Jin Zhao and Yan Chen*. Cultivation of the Wild Ganoderma gibbosum Mycelia via Submerged Liquid Fermentation for Inter/Extra-Cellular Polysaccharides,International Journal of Agriculture and Biology.2018,20(5): 1218-1224Qing-Xi Wu, Dan-Dan Wang,Ting Su, Xiao-Du Cheng, Xin Xu .Yan Chen*. Self-assembly of polyelectrolyte complexes microcapsules with natural polysaccharides for sustained drug release, Cellulose. 2017, 24:4949-4962Xiaohe Tian , Sajid Hussain, Hui Wang , Qiong Zhang , Meng Zhao ,Junyang Chen , Hui Zhang , Hongping Zhou , Yan Chen*, Yupeng Tian*.A series of water-soluble pyridinium derivatives with two-photon absorption in the near infrared region for mitochondria targeting under stimulated emission depletion (STED) nanoscopy, Dyes and Pigments. 2017, 147: 90-98Yan Chen*, Xue-Hui Li, Li-Yuan Zhou, Wan Li, Liu Liu, Dan-Dan Wang, Wen-Na Zhang,Sajid Hussain, Xiao-He Tian, Yong-Ming Lu*. Structural elucidation of three antioxidative polysaccharides fromTricholoma lobayense, Carbohydrate Polymers. 2017,157 : 484–492 Liming Wang & Yan Chen*. Efficient Biotransformation of Astragaloside IV to Cycloastragenol by Bacillus sp. LG-502, Applied Biochemistry and Biotechnology. 2017,183(4):1488-1502Yong-Ming Lu,Qiao-Yue Yang,Li-Ming Wang,Ming-Zhu Zhang,Wen-Qiang Guo,Zheng-Nan Cai,Dan-Dan Wang,Wei-Wei Yang,Yan Chen*. Enhanced Activity of Immobilized Horseradish Peroxidase by Carbon Nanospheres for Phenols Removal, CLEAN-Soil Air Water. 2017, 45(2):1600077 Zhenyu Yue, Hai-Tao Li, Yabing Yang, Sajid Hussain, Chun-Hou Zheng, Junfeng Xia*, Yan Chen*.Identification of breast cancer candidate genes using gene co-expression and protein-protein interaction information, Oncotarget. 2016,7(24) : 36092 -36100Qiuying Ding, Dan Yang, Wenna Zhang, Yongming Lu, Mingzhu Zhang, Liming Wang,Xuehui Li, Liyuan Zhou, Qingxi Wu, Wenjuan Pan, Yan Chen*. Antioxidant and anti-aging activities of the polysaccharide TLH-3from Tricholoma lobayense, International Journal of Biological Macromolecules. 2016, 85: 133-140Xuehui Li, Yongming Lu, Wenna Zhang, Shixiong Yuan, Liyuan Zhou, Liming Wang,Qiuying Ding, Dandan Wang, Weiwei Yang, Zhengnan Cai, Yan Chen*. Antioxidant capacity and cytotoxicity of sulfated polysaccharideTLH-3 from Tricholoma lobayense, International Journal of Biological Macromolecules. 2016, 82: 913-919.Wenna Zhang, Yongming Lu, Yaping Zhang, Qiuying Ding, Sajid Hussain, Qingxi Wu, Wenjuan Pan & Yan Chen*. Antioxidant and antitumour activities of exopolysaccharide from liquid-cultured Grifola frondosa by chemical modification. International Journal of Food Science and Technology. 2016,51(4) : 1055-1061
