个人简介
中国科学院上海药物研究所研究员、课题组长、博士研究生导师，安徽中医药大学兼职教授；
研究领域
率先开展了药物制剂结构研究与新结构给药系统设计。传统的剂型结构表征方法多为定性评价，张继稳课题组及其合作伙伴率先将同步辐射光源大科学装置与药物输送系统的评价需求相结合，在亚微米、微米、毫米等多尺度上给制剂和微粒做CT，提出了制剂定量结构的新理论和分形维度定量方法，把制剂的释放特征与其复杂结构定量地关联起来；提出了药物制剂四级结构划分，形成了较为系统的结构药剂学理论，为设计和优化给药系统提供了新的方法和手段，创制新结构制剂。
近期论文
[1] Xian-Zhen Yin, Ti-Qiao Xiao, Ashwini Nangia, Shuo Yang, Xiao-Long Lu, Hai-Yan Li, Qun Shao, You He, Peter York & Ji-Wen Zhang*. In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures, Scientific Reports, 2016 Apr 21; 6: 24763. [2] Tao Guo, Haiyan Li, Li Wu, Zhen Guo, Xianzhen Yin, Caifen Wang, Lixin Sun, Qun Shao, Jingkai Gu, Peter York, and Jiwen Zhang*. Prediction of Rate Constant for Supramolecular Systems with Multiconfigurations. J. Phys. Chem. A, 2016, 120 (7), pp 981–991. [3] Xian-Zhen Yin, Li Wu, Ying Li, Tao Guo, Hai-Yan Li, Ti-Qiao Xiao, Peter York, Ashwini Nangia, Shuang-Ying Gui & Ji-Wen Zhang*. Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting. Scientific Reports, 2016, Feb 25; 6: 21770. [4] Li Wu, Xianzhen Yin, Zhen Guo, Yajun Tong, Jing Feng, Peter York, Tiqiao Xiao, Min Chen, Jingkai Gu, Jiwen Zhang*. Hydration induced material transfer in membranes of osmotic pump tablets measured by synchrotron radiation based FTIR. European Journal of Pharmaceutical Sciences, 2016, 84:132-138. [5] Caifen Wang, Xiaobo Wang, Xiaonan Xu, Botao Liu, Xu Xu, Lixin Sun, Haiyan Li, Jiwen Zhang*. Simultaneous high-throughput determination of interaction kinetics for drugs and cyclodextrins by high performance affinity chromatography with mass spectrometry detection. Analytica Chimica Acta, 2016, 909:75-83. [6] Zhen Guo, Xianzhen Yin, Congbiao Liu, Li Wu, Weifeng Zhu, Qun Shao, Peter York, Laurence Patterson, Jiwen Zhang*. Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres. Int J Pharmaceut, 2016,499, 47-57. [7] Liandi Chi, Delin Wu, Zhuo Li, Minmin Zhang, Hongchun Liu, Caifen Wang, Shuangying Gui, Meiyu Geng, Haiyan Li, and Jiwen Zhang*. Modified Release and Improved Stability of Unstable BCS II Drug by Using Cyclodextrin Complex as Carrier To Remotely Load Drug into Niosomes, Mol. Pharmaceutics, 2016, 13 (1), pp 113–124. [8] X. Ren, C. Wang, L. Wu, H. Li, L. Chi, L. Sun, B.Wang, H. Cui, L. Angiolini, A. Bianchi, P. Caccia, S. Xing, X. Fu, J. Zhang*. Bioactivity assay of porcine relaxin based on cAMP accumulation in THP-1 cells quantified by LC-MS/MS, Journal of Pharmaceutical and Biomedical Analysis, 2015; 111:320-3. [9] Manli Wang, Xiaolong Lu, Xianzhen Yin, Yajun Tong, Weiwei Peng, Li Wu, Haiyan Li, Yan Yang, Jingkai Gu, Tiqiao Xiao, Min Chen, Jiwen Zhang*. Synchrotron radiation-based Fourier-transform infrared spectromicroscopy for characterization of the protein/peptide distribution in single microspheres. Acta Pharmaceutica Sinica B, 2015, 5(3):270–276. [10] Chi L, Liu R, Guo T, Wang M, Liao Z, Wu L, Li H, Wu D, Zhang J*. Dramatic improvement of the solubility of pseudolaric acid B by cyclodextrin complexation: Preparation, characterization and validation. Int J Pharm, 2015, 479(2):349-356. [11] Wang C, Ge J, Zhang J, Guo T, Chi L, He Z, Xu X, York P, Sun L, Li H. Multianalyte determination of the kinetic rate constants of drug-cyclodextrin supermolecules by high performance affinity chromatography. J Chromatogr A, 2014, 1359: 287-295. [12] Xue Li, Haiyan Li, Qun Xiao, Liuyi Wang, Manli Wang, Xiaolong Lu, Peter York, Senlin Shi, Jiwen Zhang*. Two-way effects of surfactants on Pickering emulsions stabilized by the self-assembled microcrystals of α-cyclodextrin and oil. Physical Chemistry Chemical Physics, 2014;16(27) :14059-69. [13] Shuo Yang, Xianzhen Yin, Caifen Wang, Haiyan Li, You He, Tiqiao Xiao, Lixin Sun, Jiasheng, Peter York, Jun He, Jiwen Zhang*. Release behaviour of single pellets and internal fine 3D structural features co-define the in vitro drug release profile of Tamsulosin sustained release capsules. AAPS J, 2014, 16(4): 860-871. [14] Ying Li, Liuyi Wang, Li Wu, Xueju Zhang, Xue Li, Zhen Guo, Haiyan Li, Peter York, Shuangying Gui, Jiwen Zhang*. Bio-mimetic drug delivery systems designed to help the senior population reconstruct melatonin plasma profiles similar to those of the healthy younger population. Acta Pharmaceutica Sinica B, 2014, 4: 60-66.
