个人简介

1991年毕业于华东师范大学生物系，获理学学士学位，2002-2007年在中国科学技术大学、微尺度科学国家实验室、生命科学院硕博连读，获生化与分子生物学专业博士学位。2008-2014年在美国范德比尔特大学医学中心生物化学和神经病学系从事博士后研究、任博士后研究员及研究讲师职位。

研究领域

主要研究方向为基因工程（包括基因重组、基因突变）、重组蛋白在微生物体内的表达及纯化、蛋白质结构及功能的研究、蛋白质相互识别以及相互作用的机制研究、基于蛋白质结构的药物开发以及抑制剂的筛选、有毒中药对癌症的作用机制研究、中草药基因资源及蛋白质药物开发等。

近期论文

1. Miaomiao Liu, Xiqiang Wang, Dengke Yinb, Qingshan Yang, Yi Liao, Jiawen Wu*. Molecular cloning and expression analysis of two lectin genes in Sophora flavescens. GENE, 2016.11 Submitted. 2. 王希强，尹登科，储俊， 吴家文*，蛇床子三螺旋转录因子基因的克隆与表达分析，生物学杂志，第33卷，总第191期，2016（3），P24。 3. Jiawen Wu, Dungeng Peng, Yang Zhang, Zhenwei Lu, Markus Voehler,Charles R. Sanders, Jun Li. Biophysical Characterization of Interactions between the C-termini of Peripheral Nerve Claudins and the PDZ1 Domain of Zonula Occludens. Biochem Biophys Res Commun. 02/2015; 459(1). DOI: 10.1016/j.bbrc.2015.02.075 4. Jiawen Wu, Dungeng Peng, Markus Voehler, Charles R. Sanders, Jun Li. Structure and Expression of a Novel Compact Myelin Protein - Small VCP-Interacting Protein (SVIP). Biochem Biophys Res Commun. 2013 Oct 11;440(1):173-8 5. Jiasong Guo, Yang Zhang, Leiming Wang, Jiawen Wu, Sezgi Arpag, Bo Hu, Beat A. Imhof, Bruce D. Carter, Ueli Suter, Jun Li. Abnormal Junctions and Permeability of Myelin in PMP22 Deficient Nerves. Ann Neurol, 2014, 75(2):255-265 6. Jiawen Wu, Yinshan Yang, Jiahai Zhang, Peng Ji, Wenjing Du, Peng Jiang, Dinghai Xie, Hongda Huang, Mian Wu, Guangzhao Zhang, Jihui Wu, and Yunyu Shi. Domain-swapped Dimerization of the Second PDZ Domain of ZO2 May Provide a Structural Basis for the Polymerization of Claudins. J Biol Chem 2007 Dec 7; 282(49); 35988-35999. 7.Jiawen Wu, Solution Structure and Functional Study of the Second PDZ Domain of Human ZO2. http://www.dissertationtopic.net/doc/1643930 8. Hongda Huang, Jiahai Zhang, Weiqun Shen, Xingsheng Wang, Jiawen Wu, Jihui Wu, Yunyu Shi. Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails. BMC Structural Biology 2007, 7:57 9. Hui Chen, Shuilong Tong, Xu Li, Jiawen Wu, Zhiqiang Zhu, Liwen Niu, and Maikun Teng. Structure of the second PDZ domain from human zonula occludens 2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 April 1; 65(Pt 4): 327–330 10. Peng Ji, Guang Yang, Jiahai Zhang, Jiawen Wu, Zhengjun Chen, Qingguo Gong, Jihui Wu, and Yunyu Shi. Solution structure of the second PDZ domain of Zonula Occludens 1. Proteins: Structure, Function, and Bioinformatics Volume 79, Issue 4, pages 1342–1346, April 2011