个人简介
安徽省学术与技术带头人、安徽省杰青、安徽省特支计划领军人才、安徽省教科文卫系统师德先进个人；新加坡南洋理工大学访问教授；“Current Medicinal Chemistry”编委；安徽省药物化学专委会主任、安徽省药学会常务理事。先后主持973子课题1项、国家自然科学基金3项、中国博士后基金等省部级课题10余项。以第一/通讯作者在药物化学主流SCI期刊发表论文近50篇，先后获安徽省青年科技奖、安徽省科技进步三等奖。国家自然科学基金、芬兰国家自然科学基金、教育部等基金评议人；药物化学领域数十本主流SCI期刊审稿人,European Journal of Medicinal Chemistry、Bioorganic & Medicinal ChemistryLetters、中国科学-B等刊优秀审稿人；安徽医药编委。
近期论文
24)Shi-Chao Chen, Guo-Liang Qiu, Bo Li, Jing-Bo Shi,Xin-Hua Liu*, Wen-Jian Tang*,Tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one scaffoldderivatives: Synthesis andbiological evaluation as selective BuChEinhibitors,European Journal of Medicinal Chemistry,2018, 147, 194-204. 23)Qin Li, Juping Zhang, Liu Zeng Chen, Jie Quan Wang, Hai PingZhou, Wen Jian Tang, WeiXue*,Xin Hua Liu*, New pentadienoneoxime ester derivatives:Synthesis andanti-inflammatory activity,Journal Of Enzyme Inhibition And Medicinal Chemistry,2018, 33, 130-138. 22)Ban-Feng Ruan, Wei-Wei Ge, Hui-Jie Cheng, Qing-Shan Li*,Xin-HuaLiu*,Resveratrol-based cinnamic ester hybrids: synthesis, characterization and anti-inflammatory activity,Journal Of Enzyme Inhibition And Medicinal Chemistry,2017,32, 1282-1290. 21)Bo Li, Shi Cai, Yong-An Yang, Shi-Chao Chen, Rui Chen, Jing-Bo Shi,Xin-Hua Liu*, Wen-Jian Tang*, novel unsaturated glycyrrhetic acids derivatives: Design, synthesis and anti-inflammatory activity,European Journal of Medicinal Chemistry,2017, 139, 337-348. 20)Xiu Cheng, Jing Bo Shi, Hao Liu, Liu Zeng Chen, Yang Wang, Wen Jian Tang*,Xin Hua Liu*, Discovery of (4-bromophenyl)(3-hydroxy-4-methoxyphenyl)methanone through Up-Regulating hTERTInducesCell Apoptosis and ER stress,Cell Death & Disease,2017,8, e3016. 19)Liu Zeng Chen, Wei Wei Sun, Li Bo, Jie Quan Wang, Cheng Xiu, Wen Jian Tang, Jing Bo Shi, Hai Pin Zhou,Xin Hua Liu*,New arylpyrazoline-coumarins: Synthesis and anti-inflammatoryActivity,European Journal of Medicinal Chemistry,2017,138, 170-181. 18) Cheng Xiu, Zhou Hua, Xiao Bao sheng, Wen Jian Tang, Hai Pin Zhou,Xin Hua Liu*,Novel benzopyran derivatives and their therapeutic applications: a patent review (2009-2016),Expert Opinion on Therapeutic Patents,2017,27, 1031-1045. 17) Zhi Sen Wang, Liu Zen Cheng,Hai Pin Zhou,Xin Hua Liu*, Fei Hu Chen*, Diarylpentadienone derivatives (Curcumin analogues): synthesis and anti-inflammatory activity, Bioorganic & Medicinal Chemistry letters,2017,27, 1803-1807. 16)Jing Bo Shi, Liu Zeng Chen, Yang Wang, Cheng Xiou,Wen Jian Tang, Hai Pin Zhou, Xin Hua Liu * Qi Zheng Yao **, Benzophenone-nucleoside derivatives as telomerase inhibitors: design, synthesis and anticancer evaluation in vitro and in vivo,European Journal of Medicinal Chemistry,2016,124, 729-736. 15)Hua Zhou, Jiang-Qun Cheng, Zhi-Sen Wang, Fei-Hu Chen* andXin-Hua Liu*, Oxazole: A Promising Building Block for the Development of Potent Antitumor Agents,Current Topics in Medicinal Chemistry,2016,16 (30), 3582-3589. 14)Yang Wang, Fei Xiong Cheng,Xiao Long Yuan,Wen Jian Tang, Jing Bo Shi, Chen Zhong Liao,Xin Hua Liu*, Dihydropyrazole derivatives as telomerase inhibitors: structure-based design, synthesis, SAR and anticancer evaluationin vitro andin vivo,European Journal of Medicinal Chemistry,2016,112, 231-251. 13) Yan Yan Chen, Xiao Qin Wu, Wen Jian Tang, Jing Bo Shi, Jun Li,Xin Hua Liu*, Novel dihydropyrazole-chromen: Design andmodulates hTERT inhibition proliferation of MGC-803,European Journal of Medicinal Chemistry,2016,110, 65-75. 12)Wei Xue , Bao-An Song*, Hong Ju Zhao, Xing Bao Qi, Yin Jiu Huang,Xin Hua Liu*,Novel myricetin derivatives: design、synthesis and anticancer activity,European Journal of Medicinal Chemistry,2015,97, 155-163. 11)Wen-Jian Tang, Jing Wang, Xu Tong, Jing-Bo Shi,Xin-Hua Liu*, Jun Li*, Design and synthesis of celastrol derivatives as anticancer agents,European Journal of Medicinal Chemistry,2015,95, 166-173. 10)Xu Tong, Rui Chen, Tong-Tian Zhang, Yan Han, Wen-Jian Tang*,Xin-Hua Liu*, Design and synthesis of novel 2-pyrazoline-1-ethanone derivatives as selective MAO inhibitors,Bioorganic & Medicinal Chemistry,2015,23, 515-525. 9)Jing Bo Shi*,Wen Jian Tang, Xing Bao qi, Rong Li,Xin Hua Liu*, Novel pyrazole-5-carboxamide and pyrazole-pyrimidine derivatives:synthesis and anticancer activity.European Journal of Medicinal Chemistry,2015, 90, 889-896. 8)Tang, Wen-Jian,Yang,Yong-An, He Xu, Shi jing-Bo, Liu Xin-Hua*, Synthesis and discovery of 18a-GAMG as anticancer agentin vitro andin vivo via down expression of protein p65,Scientific Reports,2014,4, 7106. 7)Xu He, Yan-Yan Chen, Jing-Bo Shi, Zhi-Xiang Pan, Zhi-Qiang Dong, Bao-An Song, Jun Li*,Xin-Hua Liu*.New coumarin derivatives: design、synthesis and use as inhibitors of hMAO.Bioorganic & Medicinal Chemistry,2014,22, 3732-3738 6)Zhi-Xiang Pan, Xu He, Yan-Yan Chen, Wen-Jian Tang, Jing-Bo Shi, Yu-Lan Tang, Bao-An Song,Xin-Hua Liu*.New 2H-chromene-3-carboxamide derivatives: design、synthesis and use as inhibitors of hMAO.European Journal of Medicinal Chemistry,2014,80, 278-284 5)Dong zhi Qiang, Jing Bo Shi, Bao An Song,Xin Hua Liu*, Novel2H-chromen derivatives: Design、synthesis and anticancer activity,RSC Advances,2014, 4, 5607-5617
