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陈飞虎
2023-03-07 13:14
近期热点

资料介绍

个人简介

安徽医科大学药学院院长,安徽省学术技术带头人,安徽省高校教学名师,安徽省药理学会秘书长,安徽省医药生物技术协会副理事长兼秘书长。主要从事抗炎免疫药理学、分子药理学、临床药理学等教学与研究工作。承担国家自然科学基金《ASICs 的表达与开放在佐剂性关节炎(AA)大鼠关节软骨细胞凋亡中的作用及其机制》、《内抑素对大鼠佐剂性关节炎滑膜细胞作用的分子机制》和《类风湿关节炎软骨细胞酸敏感离子通道的药理学特性研究》、国家十一五计划科技重大专项“重大新药创制”专项项目《治疗肝纤维化新药鬼针草总黄酮的临床前研究》、国家十二五计划科技重大专项“重大新药创制”平台项目《企业创新药物孵化基地建设》等国家、省部级项目10余项,发表学术论文200余篇,以第一完成人申请国家专利《鬼针草总黄酮在制备防治肝纤维化药物中的应用》(专利证书号:第497408号)、《 鬼针草总黄酮在制备防治病毒性肝炎药物中的应用》(专利证书号:第497407号)等5项及《类维甲酸衍生物及其药物组合物与用途》(国际专利号US8,110,703,B2)国际专利1项,在申请专利3项,获安徽省科技进步一、三等奖各1项,3项研究成果通过省级鉴定。

研究领域

主要从事抗炎免疫药理学、分子药理学、临床药理学等教学与研究工作。

近期论文

1.Feng-Lai Yuan , Xia Li ,Wei-Guo Lu , Rui-Sheng Xu, Yi-Qing Zhao, Cheng-Wan Li, Jian-Ping Li , Fei-Hu Chen . Regulatory T cells as a potent target for controlling bone loss. Biochemical and Biophy- sical Research Communications. 2010,402(2):173-6.(通讯作者) 2. Feng-Lai Yuan , Wei Hu , Wei-Guo Lu , Xia Li , Jian-Ping Li, Rui-Sheng Xu, Cheng-Wan Li, Fei-Hu Chen, Cheng Jin. Targeting interleukin-21 in rheumatoid arthritis. Mol Biol Rep. 2011, 38(3):1717-21(通讯作者) 3. Feng-Lai Yuan , Fei-Hu Chen, Wei-Guo Lu, Xia Li, Jian-ping Li • Cheng-Wan Li, Rui-Sheng Xu, Fan-Rong Wu, Wei Hu, Teng-Yue Zhang. Inhibition of acid-sensing ion channels in articular chondrocytes by am- iloride attenuates articular cartilage destruction in rats with adjuvant arthritis. Inflamm. Res. 2010,59(11):939–47. (通讯作者) 4. Feng-Lai Yuan, Fei-Hu Chen, Wei-Guo Lu, Xia Li, Fan-Rong Wu,Jian-Ping Li, Cheng-Wan Li, Yu Wang, Teng-Yue Zhang, Wei Hu. Acid-sensing ion channel 1a mediates acid-induced increases in intracellular calcium in rat articular chondrocytes. Mol Cell Biochem 2010,340(1-2):153-9.. (通讯作者) 5. Feng-Lai Yuan, Fei-Hu Chen, Wei-Guo Lu, Xia Li. Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis. Mol Biol Rep. 2010,37(7):3233-8. (通讯作者) 6. juan shen,fei hu chen. Synthesis and anti-tumor activity of all-trans retinoic acid derivatives. Chinese chemical letters. 2009,20(7):809-11(通讯作者) 7.Xiao-ling Ma, Fei-hu Chen, Xin Zhou, Wen-jiao Chang, Yuan-yuan Dai. Molecular characteristic of staphylococcus aureus isolates in a chinese teaching hospital [J]. African Journal of Microbiology Research, 2011,5(19):2969-2974(通讯作者) 8. Xiao-ling Ma, Wei-xiong Zhao, Jia-qiang Zhao, Na Li, Hai-yang Zheng, Li Fang, Fei-hu Chen, Wei-jun Zhang. Improving the discrimination capability of bioaerosols using a dual-channel ultraviolet aerodynamic particle sizer spectrometer [J]. Aerobiologia. 2012, 28(2):241-248(通讯作者) 9.Chao Rong, Wei Hu, Fan-rong Wu, Xiao-juan Cao, Fei-hu Chen. Interleukin-23 as a potential therapeutic target for rheumatoid arthritis [J]. Mol Cell Biochem. 2012 ,361(1-2):243-8(通讯作者) 10.Rong C, Chen FH, Jiang S, Hu W, Wu FR, Chen T. Inhibition of acid-sensing ion channels by amiloride protects rat articular chondrocytes from acid-induced apoptosis via a mitochondrial-mediated pathway. Cell Biol Int.. 2012 ,36(7):635-41 (通讯作者) 11. Rong C, Hu W, Wu FR, Chen FH.Targeting interleukin-33 in rheumatoid arthritis. Rheumatol Int. 2012 , 361(1-2):243-8(通讯作者) 12.Hu KW, Chen FH, Ge JF, Cao LY, Li H.Retinoid receptors in gastric cancer: expression and influence on prognosis[J].Asian Pac J Cancer Prev 2012;13(5):1809-17 13.Hu W, Xia LJ, Chen FH, Wu FR, Tang J, Chen CZ, Jiang S, Chen HH.Recombinant human endostatin inhibits adjuvant arthritis by down-regulating VEGF expression and suppression of TNF-α, IL-1β production[J].Inflamm Res 2012 Aug;61(8):827-35 14.Xia Q, Wang X, Xu DJ, Chen XH, Chen FH.Inhibition of platelet aggregation by curdione from Curcuma wenyujin essential Oil[J].Thromb Res 2012 Sep;130(3):409-14 15.Hu W, Chen FH, Yuan FL, Zhang TY, Wu FR, Rong C, Jiang S, Tang J, Zhang CC, Lin MY. Blockade of acid-sensing ion channels protects articular chondrocytes from acid-induced apoptotic injury[J].Inflamm Res 2012 Apr;61(4):327-35

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